Abstract:
:Amiodarone is a potent antiarrhythmic drug with a prolonged half life. The administration of amiodarone for 6 weeks in rabbits caused a significant elevation of serum lipids. We measured serum lipoproteins in 24 patients before, 30 and 90 days after treatment with amiodarone. Serum triglycerides decreased for all patients from 140.1 +/- 11.6 to 122.7 +/- 10.2 (p less than 0.05) whilst total cholesterol decreased from 211.4 +/- 19.5 to 194.4 +/- 13.3 (p = 0.08) in female patients only. There was no change in high density lipoprotein concentrations. These data are in contrast to those found in rabbits and are probably due to the smaller doses of amiodarone used on our patients.
journal_name
Cardiologyjournal_title
Cardiologyauthors
Sonnenblick M,Gottlieb S,Goldstein R,Abraham ASdoi
10.1159/000173998subject
Has Abstractpub_date
1986-01-01 00:00:00pages
147-50issue
3eissn
0008-6312issn
1421-9751journal_volume
73pub_type
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