Abstract:
:There has been recent interest in treating acute myocardial infarction with coronary reperfusion by fibrinolytic therapy. Experimental studies have shown that myocardial infarct size can be reduced by coronary reperfusion. However, return of cardiac function, high energy phosphate metabolism, and cardiac ultrastructure may be delayed within tissue which is salvaged by coronary reperfusion. This postischemic ventricular dysfunction is transient and has been termed the 'stunned myocardium' phenomenon. Although reperfused infarcts are hemorrhagic, the hemorrhage is confined well within tissue which is already necrotic and does not appear to exacerbate the extent of necrosis. Clinical trials designed to assess the benefits of reperfusion for the therapy of acute myocardial infarction should concentrate on long-term rather than short-term changes in cardiac function.
journal_name
Cardiologyjournal_title
Cardiologyauthors
Kloner RA,Ellis SG,Carlson NV,Braunwald Edoi
10.1159/000173600subject
Has Abstractpub_date
1983-01-01 00:00:00pages
233-46issue
5eissn
0008-6312issn
1421-9751journal_volume
70pub_type
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