Exercise capacity in patients with left ventricular dysfunction following acute myocardial infarction: relation to systolic and diastolic function and intervention with captopril.

Abstract:

:Patients with acute or chronic heart disease may have limited exercise capacity if they have reduced left ventricular function. Indexes of reduced left ventricular function during exercise are a predictor of subsequent survival although left ventricular ejection fraction is a poor predictor of physical endurance. We evaluated the effect of captopril on physical endurance in 48 males with left ventricular dysfunction following myocardial infarction. On the 7th day following myocardial infarction patients were randomized to either captopril 50 mg daily or corresponding placebo. Patients were followed up by means of serial echocardiography and exercise stress testing for a period of 180 days. Exercise capacity was significantly improved in the captopril group. Changes in exercise capacity were significantly correlated to changes in left ventricular (LV) volumes and compliance. The beneficial effect of captopril on exercise capacity was probably mediated via improvement in LV performance and compliance.

journal_name

Cardiology

journal_title

Cardiology

authors

Søgaard P,Gøtzsche CO,Ravkilde J,Nørgaard A,Thygesen K

doi

10.1159/000176419

subject

Has Abstract

pub_date

1994-01-01 00:00:00

pages

322-30

issue

4-5

eissn

0008-6312

issn

1421-9751

journal_volume

84

pub_type

临床试验,杂志文章,随机对照试验
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