Activated polymorphonuclear leukocytes and monocytes in the peripheral blood of patients with ischemic heart and brain conditions correspond to the presence of multiple risk factors for atherothrombosis.

Abstract:

OBJECTIVE:Risk factors like hypertension, diabetes mellitus, dyslipidemia and smoking contribute to the pathogenesis of atherothrombosis. We investigated whether the multiplicity of risk factors for atherothrombosis is associated with leukocyte activation. METHODS:We examined the availability of CD11b/CD18 antigen on the surface of peripheral blood polymorphonuclear leukocytes and monocytes in patients with acute ischemic heart and brain conditions. RESULTS:There was a highly significant (p<0.00001) increment in the availability of the CD11b/CD18 antigen on the surface of the polymorphonuclear leukocytes in patients with multiple (2 or more) vascular risk factors [mean fluorescence intensity (MFI) +/- SD, 210+/-102] as opposed to individuals with none or 1 risk factor for atherothrombosis (MFI 159+/-73). Similar results were observed on the monocytes: 309+/-151 and 235+/-97, respectively (p<0. 00001). CONCLUSION:The multiplicity of risk factors for atherothrombosis is associated with the up-regulation of CD11b/CD18 antigen on the surface of peripheral blood polymorphonuclear leukocytes and monocytes, suggesting the presence of an increased inflammatory response and leukocyte activation in these individuals.

journal_name

Cardiology

journal_title

Cardiology

authors

Berliner S,Rogowski O,Rotstein R,Fusman R,Shapira I,Bornstein NM,Prochorov V,Roth A,Keren G,Eldor A,Zeltser D

doi

10.1159/000007041

subject

Has Abstract

pub_date

2000-01-01 00:00:00

pages

19-25

issue

1

eissn

0008-6312

issn

1421-9751

pii

7041

journal_volume

94

pub_type

临床试验,杂志文章
  • Dyspnea and reversibility of antiplatelet agents: ticagrelor, elinogrel, cangrelor, and beyond.

    abstract:CONTEXT:Oral reversible platelet P2Y12 receptor inhibitors (ticagrelor and elinogrel) cause double-digit rates of dyspnea, while irreversible oral antiplatelet drugs (aspirin, ticlopidoine, clopidogrel, and prasugrel) or intravenous glycoprotein IIb/IIIa inhibitors (abciximab, eptifibatide, or tirofiban) do not increas...

    journal_title:Cardiology

    pub_type: 杂志文章,meta分析,评审

    doi:10.1159/000354876

    authors: Serebruany VL,Sibbing D,DiNicolantonio JJ

    更新日期:2014-01-01 00:00:00

  • The "Burden" of Malignancy in a Tertiary Hospital Intensive Cardiovascular Care Unit.

    abstract:OBJECTIVES:During the past decade, the most common causes of mortality and morbidity were cardiovascular diseases and malignancies. The aim of the current study was to describe the incidence, course of admission, and short-term (30-day) prognosis of patients with and without malignancy, admitted to a tertiary center in...

    journal_title:Cardiology

    pub_type: 杂志文章

    doi:10.1159/000477840

    authors: Mazin I,Matetzky S,Shemer L,Fourey D,Fefer P,Segev A,Abu-Much A,Beigel R,Asher E,Platelets and Thrombosis in Sheba (PLATIS) Study Group.

    更新日期:2017-01-01 00:00:00

  • Early cardiac evaluation of thoracically conjoined twins.

    abstract::Thoracopagus conjoined twins were delivered at 31 weeks gestation by cesarean section. Although there was a single heart, the possibility of salvaging one twin only was contemplated. Echocardiography revealed an A-V canal and suspected transposition of the great vessels. To determine the possibility of surgery, cardia...

    journal_title:Cardiology

    pub_type: 杂志文章

    doi:10.1159/000173585

    authors: Kaplan M,Glaser J,Eidelman AI

    更新日期:1983-01-01 00:00:00

  • Survey of physician's attitudes and practices toward lipid-lowering management strategies.

    abstract:BACKGROUND:The purpose of the present study was to examine physician's attitudes and practices toward the use of different lipid-lowering management strategies in patients at increased risk for coronary heart disease (CHD). AIMS/METHODS:An internet-based questionnaire was completed by 78 general internists and family ...

    journal_title:Cardiology

    pub_type: 杂志文章

    doi:10.1159/000099066

    authors: Goldberg RJ,Rosen J,Roselli A,Lewis B

    更新日期:2007-01-01 00:00:00

  • Coronary reperfusion for the treatment of acute myocardial infarction: postischemic ventricular dysfunction.

    abstract::There has been recent interest in treating acute myocardial infarction with coronary reperfusion by fibrinolytic therapy. Experimental studies have shown that myocardial infarct size can be reduced by coronary reperfusion. However, return of cardiac function, high energy phosphate metabolism, and cardiac ultrastructur...

    journal_title:Cardiology

    pub_type: 杂志文章,评审

    doi:10.1159/000173600

    authors: Kloner RA,Ellis SG,Carlson NV,Braunwald E

    更新日期:1983-01-01 00:00:00

  • Extreme all-cause mortality in JUPITER requires reexamination of vital records.

    abstract:OBJECTIVE:To compare all-cause mortality in JUPITER with other statin trials at 21 months of follow-up. BACKGROUND:Outcome advantages including all-cause mortality reduction yielded from the JUPITER trial support aggressive use of rosuvastatin and, perhaps by extension, other statins for primary prevention. Despite en...

    journal_title:Cardiology

    pub_type: 社论

    doi:10.1159/000330507

    authors: Serebruany VL

    更新日期:2011-01-01 00:00:00

  • Patterns of use and clinical utility of exercise thallium-201 single photon emission-computed tomography in a community hospital.

    abstract::Single photon emission computed tomographic (SPECT) imaging with thallium-201 was evaluated in 492 consecutive, unselected patients to ascertain the patterns of use and additive value to the exercise electrocardiogram in the diagnosis of myocardial ischemia in a community hospital setting. Myocardial perfusion images ...

    journal_title:Cardiology

    pub_type: 杂志文章

    doi:10.1159/000177076

    authors: McClellan JR,Dugan TM,Heller GV

    更新日期:1996-03-01 00:00:00

  • Hemodynamic comparison of combined therapy by nitroglycerin tape and ibopamine with combination of nitroglycerin tape and nifedipine.

    abstract::Fifteen congestive heart failure patients (NYHA: class III or IV) were enrolled in the study and were classified into two groups. Six patients (group I) received combined therapy by nitroglycerin tape (5 mg) and ibopamine (100 mg), while the remaining 9 patients (group II) were given nitroglycerin tape (5 mg) and nife...

    journal_title:Cardiology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1159/000174696

    authors: Taniguchi K,Tsujibayashi T,Itoh H

    更新日期:1990-01-01 00:00:00

  • Comparison of adenosine, dobutamine, and exercise radionuclide ventriculography in the detection of coronary artery disease.

    abstract::The diagnostic values of adenosine, dobutamine, and exercise radionuclide ventriculography (RNVG) in the detection of coronary artery disease (CAD), and the characteristics of those patients who showed myocardial ischemia during the infusion of adenosine or dobutamine were assessed in 41 patients with suspected CAD. S...

    journal_title:Cardiology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1159/000177327

    authors: Nagaoka H,Isobe N,Kubota S,Iizuka T,Imai S,Suzuki T,Nagai R

    更新日期:1997-03-01 00:00:00

  • Perceived patient comprehension in acute and chronic cardiovascular clinical trials.

    abstract::An anonymous patient perception comprehension and satisfaction questionnaire was sent to 438 patients 1-3 months after they had participated in a clinical cardiovascular trial to examine the level of patient comprehension as perceived by the patient. We compared perceived comprehension in acute (acute myocardial infar...

    journal_title:Cardiology

    pub_type: 临床试验,杂志文章

    doi:10.1159/000069729

    authors: Yuval R,Halon DA,Flugelman MY,Lewis BS

    更新日期:2003-01-01 00:00:00

  • Value of three-dimensional echocardiography as an adjunct to conventional transesophageal echocardiography.

    abstract::Three-dimensional imaging of cardiac structures could enhance the functional understanding and the interpretation of pathologies. Limited processing capabilities, relocation problems and inadequate two-dimensional image quality have previously limited its applicability. Recently, an integrated echocardiographic comput...

    journal_title:Cardiology

    pub_type: 杂志文章

    doi:10.1159/000177116

    authors: Binder T,Globits S,Zangeneh M,Gabriel H,Röthy W,Glogar D,Maurer G,Baumgartner H

    更新日期:1996-07-01 00:00:00

  • Association of mannan-binding lectin deficiency with venous bypass graft occlusions in patients with coronary heart disease.

    abstract::We investigated the effect of mannan-binding lectin (MBL) deficiency on the susceptibility to bypass graft occlusion in 62 patients with coronary heart disease. MBL deficiency appeared to be associated with occlusion (p = 0.0099). A high level of anti-cardiolipin IgG as well as the number of venous bypass grafts were ...

    journal_title:Cardiology

    pub_type: 杂志文章

    doi:10.1159/000066313

    authors: Limnell V,Aittoniemi J,Vaarala O,Lehtimäki T,Laine S,Virtanen V,Palosuo T,Miettinen A

    更新日期:2002-01-01 00:00:00

  • Muscle fiber disarray in patients without hypertrophic cardiomyopathy.

    abstract::Muscle fiber disarray (MFD) has been described as the histologic feature of hypertrophic cardiomyopathy (HC), but it was also found in normal and other abnormal conditions. Its distribution related to the topography of the myocardium has not been described. In this paper, the incidence of MFD in hearts free from HC, t...

    journal_title:Cardiology

    pub_type: 杂志文章

    doi:10.1159/000173850

    authors: Milei J,Migliore R,Guerrero F,Pedroza C,Storino R

    更新日期:1985-01-01 00:00:00

  • The kinetocardiogram during the isoproterenol test for the assessment of coronary heart disease.

    abstract::50 patients, 20 without heart disease and 30 with coronary heart disease (CHD), were studied by kinetocardiography (KCG), before and after administration of isoproterenol (initial dose 2 microgram/min, maximum dose 6 microgram/min). In the control subjects the KCG was unaffected by the drug. In contrast, in most of th...

    journal_title:Cardiology

    pub_type: 杂志文章

    doi:10.1159/000169861

    authors: Strozzi C,Cocco G

    更新日期:1977-01-01 00:00:00

  • Heart disease indicators in patients with aortocoronary bypass operation.

    abstract::The incidence of cardiovascular disease risk factors and other indicators of cardiac impairment were studied in 478 patients prior to their aortocoronary vein bypass operation and 194 patients who had angiographic examination but did not undergo the operation because the clinical and coronary angiographic findings wer...

    journal_title:Cardiology

    pub_type: 杂志文章

    doi:10.1159/000169758

    authors: Barboriak JJ,Rimm AA,Anderson AJ,Tristani FE,Walker JA,Flemma RJ

    更新日期:1976-01-01 00:00:00

  • Sleep quality and quality of life in patients with hypertrophic cardiomyopathy.

    abstract:OBJECTIVES:To evaluate clinical predictors of poor sleep quality and quality of life (QOL) in patients with hypertrophic cardiomyopathy (HCM). METHODS:Consecutive stable patients with HCM were evaluated for the risk of obstructive sleep apnea (OSA) by the Berlin Questionnaire, daytime sleepiness by the Epworth Sleepin...

    journal_title:Cardiology

    pub_type: 杂志文章

    doi:10.1159/000321718

    authors: Pedrosa RP,Lima SG,Drager LF,Genta PR,Amaro AC,Antunes MO,Arteaga E,Mady C,Lorenzi-Filho G

    更新日期:2010-01-01 00:00:00

  • Effect of subadipose tissue on the variables of signal-averaged electrocardiograms in healthy subjects.

    abstract::Ventricular late potentials are obtained by signal averaging of surface electrocardiograms. Late potentials have been reported to be affected by body size or left ventricular mass. However, the effect of subadipose tissue, which is known to influence QRS amplitudes of surface ECG, on the variables of late potentials h...

    journal_title:Cardiology

    pub_type: 杂志文章

    doi:10.1159/000175854

    authors: Masui A,Tsuji H,Tamura K,Sugiura T,Matsui Y,Iwasaka T,Inada M

    更新日期:1993-01-01 00:00:00

  • Prevention of Aortic Dissection Suggests a Diameter Shift to a Lower Aortic Size Threshold for Intervention.

    abstract:BACKGROUND:Multiple studies have quantified the relationship between aortic size and risk of dissection. However, these studies estimated the risk of dissection without accounting for any increase in aortic size from the dissection process itself. OBJECTIVES:This study aims to compare aortic size before and after diss...

    journal_title:Cardiology

    pub_type: 杂志文章

    doi:10.1159/000481930

    authors: Mansour AM,Peterss S,Zafar MA,Rizzo JA,Fang H,Charilaou P,Ziganshin BA,Darr UM,Elefteriades JA

    更新日期:2018-01-01 00:00:00

  • Detection of Björk-Shiley convexo-concave heart valve outlet strut single leg separations: consensus image acquisition and interpretation using two different cineradiographic imaging technologies.

    abstract:BACKGROUND:Conventional cineradiology has been used clinically to detect partially broken outlet struts (single leg separations, SLSs) in normally functioning Björk-Shiley convexo-concave (C/C) heart valves. The value of radiographic screening has, however, been debated in the medical literature. This study uses the sa...

    journal_title:Cardiology

    pub_type: 杂志文章

    doi:10.1159/000006887

    authors: Hopper KD,Gilchrist IC,Landis JR,Localio AR,Wilson RP,Pae WE Jr,Kunselman AR,Griffith JW,Pierce WS,Potok PS,TenHave TR

    更新日期:1999-01-01 00:00:00

  • Specificity of cardiac troponin I and creatine kinase-MB isoenzyme in asymptomatic long-term hemodialysis patients and effect of hemodialysis on these cardiac markers.

    abstract:OBJECTIVES:The objectives of this study were: (1) to evaluate the specificity of cardiac troponin I and creatine kinase-MB isoenzyme in ambulatory asymptomatic chronic renal failure patients on long-term hemodialysis, and (2) to evaluate the effect of hemodialysis on the serum levels of cardiac troponin I and creatine ...

    journal_title:Cardiology

    pub_type: 杂志文章

    doi:10.1159/000006859

    authors: Tun A,Khan IA,Win MT,Hussain A,Hla TA,Wattanasuwan N,Vasavada BC,Sacchi TJ

    更新日期:1998-01-01 00:00:00

  • Prognostic Role of Hyponatremia in Heart Failure Patients Depending on Renal Disease: Clinical Evidence.

    abstract:AIM:Hyponatremia is very often associated with renal disease in patients with heart failure (HF) and, when present, determines a poor outcome. We investigated the role of hyponatremia in HF patients in whom the presence or absence renal insufficiency was accurately predefined. METHODS:This was a cohort study based on ...

    journal_title:Cardiology

    pub_type: 杂志文章,多中心研究

    doi:10.1159/000502566

    authors: Arévalo-Lorido JC,Carretero-Gómez J,Robles NR,Llácer P,Carrera M,Suárez-Pedreira I,Álvarez-Rocha P,Manzano-Espinosa L,Cepeda-Rodrigo JM,Montero-Pérez-Barquero M,on behalf of the RICA Investigators Group.

    更新日期:2019-01-01 00:00:00

  • Diffuse narrowing of coronary arteries in diabetic patients: the earliest phase of coronary artery disease.

    abstract::Coronary arteries in diabetic patients appear to be narrower than in normal subjects, but this has not been examined systematically. To investigate this hypothesis we reviewed the data of 711 consecutive patients with angiographically 'normal coronary arteries'. Excluded were patients with valvular, myocardial or peri...

    journal_title:Cardiology

    pub_type: 杂志文章

    doi:10.1159/000006764

    authors: Mosseri M,Nahir M,Rozenman Y,Lotan C,Admon D,Raz I,Gotsman MS

    更新日期:1998-01-01 00:00:00

  • Plasma atrial natriuretic peptide levels for predicting the outcome of atrial fibrillation.

    abstract::The predictive value of plasma atrial natriuretic peptide (ANP) on the cardioversion outcome was evaluated in 46 hospitalized patients with recent-onset atrial fibrillation (AF). Cardioversion was successful in 42 (91%) patients, 7 (15%) of them regained sinus rhythm spontaneously. After 12 months, 14 (33%) cardiovert...

    journal_title:Cardiology

    pub_type: 杂志文章

    doi:10.1159/000047349

    authors: Arad M,Shotan A,Weinberger A,Aurbach I,Rabinowitz B

    更新日期:2001-01-01 00:00:00

  • Nitrate therapy in heart failure.

    abstract::Nitrates are drugs of first choice in patients with acute heart failure. Acute pulmonary edema can be successfully treated with single or repeated doses of sublingual nitroglycerin. In cases of prolonged acute heart failure, e.g. in the setting of acute myocardial infarction, nitroglycerin or isosorbide dinitrate can ...

    journal_title:Cardiology

    pub_type: 杂志文章,评审

    doi:10.1159/000174917

    authors: Schneider W,Bussmann WD,Hartmann A,Kaltenbach M

    更新日期:1991-01-01 00:00:00

  • ACP1 genetic polymorphism and coronary artery disease: an association study.

    abstract:OBJECTIVES:Assuming an immune component in the pathogenesis of atherosclerosis, we have investigated a possible association between coronary artery disease (CAD) and the acid phosphatase locus 1 (ACP1) genetic polymorphism, which has previously been found to be associated with immune disorders. METHODS:226 subjects ad...

    journal_title:Cardiology

    pub_type: 杂志文章

    doi:10.1159/000203405

    authors: Banci M,Saccucci P,D'Annibale F,Dofcaci A,Trionfera G,Magrini A,Bottini N,Bottini E,Gloria-Bottini F

    更新日期:2009-01-01 00:00:00

  • Premature atherosclerosis in non-transfusion-dependent β-thalassemia intermedia.

    abstract:OBJECTIVES:β-Thalassemias are inherited hemolytic anemias with a broad phenotype and an increased rate of vascular complications despite a near absence of coronary artery disease. METHODS:We investigated the presence of endothelial dysfunction and subclinical atherosclerosis in non-transfusion-dependent patients with ...

    journal_title:Cardiology

    pub_type: 杂志文章

    doi:10.1159/000327997

    authors: Hahalis G,Kalogeropoulos A,Terzis G,Tselepis AD,Kourakli A,Mylona P,Grapsas N,Alexopoulos D

    更新日期:2011-01-01 00:00:00

  • [Physiology of orthostatic regulation].

    abstract::The arterial blood pressure is integrated into a feedback control system and practically depends on three parameters, i. e. blood volume, heart dynamics, and peripheral resistance. When circulation is disturbed in the orthostatic, the correcting elements heart and vessels have to adapt themselves according to this dem...

    journal_title:Cardiology

    pub_type: 杂志文章

    doi:10.1159/000169794

    authors: Rieckert H

    更新日期:1976-01-01 00:00:00

  • Does chronic ST segment elevation following Q wave myocardial infarction exclude tissue viability?

    abstract:PURPOSE:Electrocardiographic (ECG) ST segment elevation lasting 2 or more weeks following Q wave myocardial infarction has been associated with 'ventricular aneurysm' and absence of tissue viability. Regional systolic dysfunction may reflect either viable myocardium or scar. Positron emission-tomographic (PET) imaging ...

    journal_title:Cardiology

    pub_type: 杂志文章

    doi:10.1159/000072386

    authors: Saber W,Nishime EO,Brunken RC,Apperson-Hansen C,Mills RM

    更新日期:2003-01-01 00:00:00

  • Effect of intravenous glibornuride and tolbutamide on myocardial contractility.

    abstract::The acute effects of therapeutic doses of intravenous tolbutamide and glibornuride on the systolic time intervals (QS2c, LVETc, PEPc and PEP/LVET) were examined in 5 healthy volunteers. Blood sugar was maintained constant throughout the study. No significant changes of these intervals as well as of heart rate and bloo...

    journal_title:Cardiology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1159/000170617

    authors: Dubach UC,Burckhardt D,Raeder EA,Forgo I,Amrein R,Bückert A

    更新日期:1979-01-01 00:00:00

  • Effect of gallopamil on myocardial microperfusion in patients with stable effort angina: a randomized, cross-over, double-blind, placebo-controlled trial.

    abstract::We evaluated the efficacy and safety of daily administration of gallopamil 150 mg/day and its effects on myocardial perfusion in a medium-term, randomized, double-blind, cross-over, placebo-controlled trial. We studied 19 patients (17 males and 2 females; mean age 57 +/- 6.8 years) with stable effort angina, angiograp...

    journal_title:Cardiology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1159/000177359

    authors: Acanfora D,Vitale DF,Rengo C,Iannuzzi GL,Furgi G,Picone C,Rossi M,Trojano L,Rengo F

    更新日期:1997-07-01 00:00:00