Abstract:
OBJECTIVES:β-Thalassemias are inherited hemolytic anemias with a broad phenotype and an increased rate of vascular complications despite a near absence of coronary artery disease. METHODS:We investigated the presence of endothelial dysfunction and subclinical atherosclerosis in non-transfusion-dependent patients with β-thalassemia intermedia (β-TI) by means of flow-mediated (FMD) and flow-independent (FID) brachial artery dilatation and carotid artery intima-media thickness. RESULTS:In 20 nondiabetic young adults with β-TI, FMD (6.6 ± 3.7 vs. 10.3 ± 3.1%; p = 0.002) and FID (14.0 ± 4.7 vs. 18.0 ± 5.6%; p = 0.02) were both lower relative to the values in 20 matched control subjects, whereas the intima-media thickness was increased (0.51 ± 0.09 vs. 0.46 ± 0.07 mm; p = 0.049). Fibrin generation, soluble endothelial activation markers, and proinflammatory proteins were higher in the patient group, while the plasma cholesterol level was lower. CONCLUSIONS:These findings indicate premature atherosclerosis among patients with β-TI; this is in accord with the high incidence of noncoronary vascular episodes in β-TI.
journal_name
Cardiologyjournal_title
Cardiologyauthors
Hahalis G,Kalogeropoulos A,Terzis G,Tselepis AD,Kourakli A,Mylona P,Grapsas N,Alexopoulos Ddoi
10.1159/000327997subject
Has Abstractpub_date
2011-01-01 00:00:00pages
159-63issue
3eissn
0008-6312issn
1421-9751pii
000327997journal_volume
118pub_type
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