Abstract:
:In earlier studies by our group it was shown that the urinary tetrahydroaldosterone excretion is a more reliable test for the diagnosis of primary aldosteronism than aldosterone-18-glucuronide ('urinary aldosterone'). However, in several patients with primary aldosteronism even the tetrahydroaldosterone values remained in the normal range. As the possible cause for this observation, the role of intestinal bacteria was considered which may transform tetrahydroaldosterone into 21-deoxytetrahydroaldosterone. Using a 21-deoxytetrahydroaldosterone radioimmunoassay, this hypothesis could be confirmed. The sums of the urinary 21-deoxytetrahydroaldosterone and tetrahydroaldosterone excretions revealed to be of better diagnostic value than the tetrahydroaldosterone values alone.
journal_name
Cardiologyjournal_title
Cardiologyauthors
Abdelhamid S,Lewicka S,Vecsei P,Winter Jdoi
10.1159/000173954subject
Has Abstractpub_date
1985-01-01 00:00:00pages
102-6eissn
0008-6312issn
1421-9751journal_volume
72 Suppl 1pub_type
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