21-Deoxytetrahydroaldosterone excretion in primary hyperaldosteronism.

Abstract:

:In earlier studies by our group it was shown that the urinary tetrahydroaldosterone excretion is a more reliable test for the diagnosis of primary aldosteronism than aldosterone-18-glucuronide ('urinary aldosterone'). However, in several patients with primary aldosteronism even the tetrahydroaldosterone values remained in the normal range. As the possible cause for this observation, the role of intestinal bacteria was considered which may transform tetrahydroaldosterone into 21-deoxytetrahydroaldosterone. Using a 21-deoxytetrahydroaldosterone radioimmunoassay, this hypothesis could be confirmed. The sums of the urinary 21-deoxytetrahydroaldosterone and tetrahydroaldosterone excretions revealed to be of better diagnostic value than the tetrahydroaldosterone values alone.

journal_name

Cardiology

journal_title

Cardiology

authors

Abdelhamid S,Lewicka S,Vecsei P,Winter J

doi

10.1159/000173954

subject

Has Abstract

pub_date

1985-01-01 00:00:00

pages

102-6

eissn

0008-6312

issn

1421-9751

journal_volume

72 Suppl 1

pub_type

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