The role of enoximone in the treatment of cardiogenic shock.

Abstract:

:Low cardiac output in acute heart failure can result in a functional impairment of organs, when tissue hypoxia occurs and cardiogenic shock develops. To restore cardiac output, various forms of therapy can be considered. Fluid replacement is sometimes beneficial in acute situations where oedema can reduce effective plasma volume. Vasodilators are often contra-indicated in shock, when arterial pressure is usually low. Inotropic therapy consists primarily of the administration of adrenergic agents. Dopamine and noradrenaline can be indicated in severe hypotension, to maintain coronary perfusion. Dobutamine is the catecholamine of choice to increase myocardial contractility. However, decreased responsiveness of the myocardial receptors to adrenergic stimulation rapidly becomes an important limitation. Phosphodiesterase inhibitors represent an interesting option to increase contractility, also by increasing cyclic AMP levels in the myocardium. In this respect, the combination of phosphodiesterase inhibitors with adrenergic agents is attractive. The additional vasodilatory properties of these agents can contribute to the increase in cardiac output with limited risk of further reduction in arterial pressure. In 13 patients with cardiogenic shock persisting despite the use of adrenergic agents, the addition of enoximone, 0.5 mg/kg, resulted in significant increases in cardiac index and stroke volume index and a significant decrease in pulmonary artery balloon occlusion pressure without consistent change in mean arterial pressure. In 8 patients, a second infusion of 0.5 g/kg amplified these effects. All but one of these patients survived the episode of cardiogenic shock, and 5 patients were discharged alive. In some cases, even lower doses of enoximone resulted in dramatic increases in cardiac output and oxygen transport in patients already treated with dobutamine with limited success.

journal_name

Cardiology

journal_title

Cardiology

authors

Vincent JL,Léon M,Berré J

doi

10.1159/000174667

subject

Has Abstract

pub_date

1990-01-01 00:00:00

pages

21-6; discussion 27-33

eissn

0008-6312

issn

1421-9751

journal_volume

77 Suppl 3

pub_type

临床试验,杂志文章
  • Heart disease indicators in patients with aortocoronary bypass operation.

    abstract::The incidence of cardiovascular disease risk factors and other indicators of cardiac impairment were studied in 478 patients prior to their aortocoronary vein bypass operation and 194 patients who had angiographic examination but did not undergo the operation because the clinical and coronary angiographic findings wer...

    journal_title:Cardiology

    pub_type: 杂志文章

    doi:10.1159/000169758

    authors: Barboriak JJ,Rimm AA,Anderson AJ,Tristani FE,Walker JA,Flemma RJ

    更新日期:1976-01-01 00:00:00

  • Tiapamil in the treatment of lidocaine-resistant ventricular arrhythmias complicating acute myocardial infarction.

    abstract::The antiarrhythmic effects of tiapamil were investigated in 48 patients, mean age 54, with acute myocardial infarction and ventricular arrhythmias. 9 had ventricular tachycardia, 6 ventricular fibrillation, and 33 multifocal premature ventricular contractions. Before and after therapy, ECG parameters, left ventricular...

    journal_title:Cardiology

    pub_type: 杂志文章

    doi:10.1159/000173556

    authors: Lessem J

    更新日期:1982-01-01 00:00:00

  • Fibrinolytic therapy and n-acetylocysteine in the treatment of patients with acute myocardial infarction: its influence on authentic plasma hydroperoxide levels and polymorphonuclear neutrophil oxygen metabolism.

    abstract::Recently it has been demonstrated that the administration of n-acetylocysteine (NAC), in combination with streptokinase, significantly diminished oxidative stress in patients with myocardial infarction. The aim of our study was to assess the influence of NAC treatment, as adjunct therapy in an evolving myocardial infa...

    journal_title:Cardiology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1159/000006878

    authors: Sajkowska A,Wykretowicz A,Szczepanik A,Kempa M,Minczykowski A,Wysocki H

    更新日期:1999-01-01 00:00:00

  • Nitrate therapy in heart failure.

    abstract::Nitrates are drugs of first choice in patients with acute heart failure. Acute pulmonary edema can be successfully treated with single or repeated doses of sublingual nitroglycerin. In cases of prolonged acute heart failure, e.g. in the setting of acute myocardial infarction, nitroglycerin or isosorbide dinitrate can ...

    journal_title:Cardiology

    pub_type: 杂志文章,评审

    doi:10.1159/000174917

    authors: Schneider W,Bussmann WD,Hartmann A,Kaltenbach M

    更新日期:1991-01-01 00:00:00

  • Impaired exercise capacity in diabetic patients after coronary bypass surgery: effects of diastolic and endothelial function.

    abstract:OBJECTIVES:The aims of this study were to clarify the influence of cardiac diastolic and peripheral vascular function on the exercise capacity of patients with coronary bypass surgery (CABG) and diabetes mellitus (DM) by tissue Doppler imaging (TDI) and flow-mediated vasodilatation (FMD), and to investigate interrelati...

    journal_title:Cardiology

    pub_type: 杂志文章

    doi:10.1159/000111929

    authors: Wu YW,Hsu CL,Wang SS,Tsai MW,Chu SH,Chen YS,Yang WS,Wu YT

    更新日期:2008-01-01 00:00:00

  • Echocardiographic features of intrapericardial bronchogenic cyst.

    abstract::Advances in echocardiography have made possible simple, noninvasive evaluation of the heart. We report the echocardiographic findings in a case of intrapericardial bronchogenic cyst. The patient, a 36-year-old woman, was hospitalized because of pericarditis. Echocardiography revealed a large unilocular cystic structur...

    journal_title:Cardiology

    pub_type: 杂志文章

    doi:10.1159/000174616

    authors: Shimizu M,Takeda R,Mifune J,Tanaka T

    更新日期:1990-01-01 00:00:00

  • Acute effects of biventricular pacing in heart failure patients with a normal ejection fraction and mechanical dyssynchrony.

    abstract:OBJECTIVES:We tested the acute effects of resynchronization in heart failure patients with a normal (>50%) left ventricular (LV) ejection fraction (HFNEF) and mechanical dyssynchrony. METHODS:Twenty-four HFNEF patients (72 ± 6 years, 5 male) with mechanical dyssynchrony (standard deviation of electromechanical time de...

    journal_title:Cardiology

    pub_type: 杂志文章

    doi:10.1159/000368795

    authors: Wang YC,Yu CC,Chiu FC,Splett V,Klepfer R,Hilpisch K,Tsai CT,Lai LP,Hwang JJ,Lin JL

    更新日期:2015-01-01 00:00:00

  • Effect of alpha-allocryptopine on transient outward potassium current in rabbit ventricular myocytes.

    abstract:OBJECTIVE:To investigate the mechanism of alpha-allocryptopine-induced inhibition of the transient outward potassium current (I(to)) in rabbit left-ventricular myocytes. METHODS:We used the whole-cell patch-clamp technique to record the I(to) in the myocytes, which were isolated from the rabbit left ventricle by a Lan...

    journal_title:Cardiology

    pub_type: 杂志文章

    doi:10.1159/000127443

    authors: Li Y,Wang S,Liu Y,Li Z,Yang X,Wang H,Wen Y,Chen Y

    更新日期:2008-01-01 00:00:00

  • The kinetocardiogram during the isoproterenol test for the assessment of coronary heart disease.

    abstract::50 patients, 20 without heart disease and 30 with coronary heart disease (CHD), were studied by kinetocardiography (KCG), before and after administration of isoproterenol (initial dose 2 microgram/min, maximum dose 6 microgram/min). In the control subjects the KCG was unaffected by the drug. In contrast, in most of th...

    journal_title:Cardiology

    pub_type: 杂志文章

    doi:10.1159/000169861

    authors: Strozzi C,Cocco G

    更新日期:1977-01-01 00:00:00

  • Flushing profile of extended-release niacin/laropiprant at initiation of therapy in Asian lipid clinic patients.

    abstract:OBJECTIVE:Niacin is underutilized due to flushing, which occurs in over 90% of niacin-treated patients. Laropiprant (LRPT) reduces flushing associated with niacin. This study compared flushing with a combination tablet of extended-release (ER) niacin (ERN)/LRPT to niacin ER (N-ER; without LRPT) during the first week of...

    journal_title:Cardiology

    pub_type: 杂志文章,随机对照试验

    doi:10.1159/000228585

    authors: Kush D,Hu DY,Ye P,Kim HS,Chen E,Sirah W,McCrary Sisk C,Paolini JF,Maccubbin D

    更新日期:2009-01-01 00:00:00

  • Safety of fenofibrate--US and worldwide experience.

    abstract::Fenofibrate is a fibric acid derivative with enhanced potency and specificity of action on lipids. Preclinical toxicology reveals minimal toxic effects; dose-related changes occurred seldom, with only hepatic effects in rodents (mainly enzyme changes), some renal effects in dogs, and no reactions in monkeys. Teratogen...

    journal_title:Cardiology

    pub_type: 临床试验,杂志文章,评审

    doi:10.1159/000174488

    authors: Roberts WC

    更新日期:1989-01-01 00:00:00

  • Effect of subadipose tissue on the variables of signal-averaged electrocardiograms in healthy subjects.

    abstract::Ventricular late potentials are obtained by signal averaging of surface electrocardiograms. Late potentials have been reported to be affected by body size or left ventricular mass. However, the effect of subadipose tissue, which is known to influence QRS amplitudes of surface ECG, on the variables of late potentials h...

    journal_title:Cardiology

    pub_type: 杂志文章

    doi:10.1159/000175854

    authors: Masui A,Tsuji H,Tamura K,Sugiura T,Matsui Y,Iwasaka T,Inada M

    更新日期:1993-01-01 00:00:00

  • Haemodynamic changes in essential hypertension in young subjects.

    abstract::The haemodynamic changes in essential hypertension were investigated in 7 girls and 4 boys under the age of 18 years. The Fick method was used for the estimation of cardiac output (CO). The cardiac indices (CIs) ranged form 2.8 to 6.6 litres/min/m2 and the total peripheral resistance (TPR) from 1,100 to 2,860 dyn/s/cm...

    journal_title:Cardiology

    pub_type: 杂志文章

    doi:10.1159/000173507

    authors: Uhari M,Paavilainen T

    更新日期:1982-01-01 00:00:00

  • [Are nitrates to be recommended in acute myocardial infarct? Towards a conclusive answer].

    abstract::The early administration of nitrates in acute myocardial infarction (AMI) may lower myocardial oxygen demand and increase blood supply to the ischemic myocardium. Actually, nitrates are the drugs most largely used in AMI patients, but no definite proof of their clinical benefits had been reported before GISSI 3 and IS...

    journal_title:Cardiology

    pub_type: 杂志文章,meta分析

    doi:10.1159/000176441

    authors: Tavazzi L

    更新日期:1994-01-01 00:00:00

  • Ergometry in the assessment of arterial hypertension.

    abstract::The blood pressure behavior during and after ergometric exercise was investigated in 552 males in order to clarify if this standardized procedure is suitable for differentiating between normotensive subjects and hypertensive patients. Patients suffering from mild hypertension showed significantly (p less than 0.001) h...

    journal_title:Cardiology

    pub_type: 杂志文章,评审

    doi:10.1159/000173856

    authors: Franz IW

    更新日期:1985-01-01 00:00:00

  • A rare case of aortic valve myxoma: an unusual cause of embolic stroke.

    abstract::Aortic valve myxoma is an extremely rare cardiac tumour. We describe a 60-year-old woman found to have an aortic valve myxoma and a patent foramen ovale (PFO) presenting as a stroke. In view of the recurrent cerebral ischaemic events, the aortic valve myxoma was surgically removed and the PFO was closed. To the best o...

    journal_title:Cardiology

    pub_type: 杂志文章

    doi:10.1159/000327081

    authors: Koyalakonda SP,Mediratta NK,Ball J,Royle M

    更新日期:2011-01-01 00:00:00

  • Tracking coronary calcification and atherosclerotic lesions in patients with stable angina pectoris undergoing nifedipine therapy.

    abstract:AIMS:The objective of the Coronary Calcification (CC) study was to determine in patients with chronic symptomatic coronary artery disease, if, in addition to standard therapy, nifedipine GITS, relative to placebo, would arrest or slow down the progression of calcium or the development of new atherosclerotic lesions in ...

    journal_title:Cardiology

    pub_type: 杂志文章

    doi:10.1159/000095308

    authors: Motro M,Kirwan BA,de Brouwer S,Poole-Wilson PA,Shemesh J,ACTION CC side-arm study.

    更新日期:2007-01-01 00:00:00

  • Dilated cardiomyopathy: an unusual presentation of aortic coarctation in an infant.

    abstract::Coarctation of the aorta commonly presents in infancy as congestive heart failure, or later in childhood as hypertension or as a heart murmur. However, we experienced a unique infant case of isolated coarctation presenting with acute decompensation of a dilated cardiomyopathy, which recovered completely 8 months posto...

    journal_title:Cardiology

    pub_type: 杂志文章

    doi:10.1159/000092600

    authors: Hwang MS,Chu JJ,Chang YS,Su WJ

    更新日期:2006-01-01 00:00:00

  • Pulmonary artery aneurysm as a cause for chest pain in a patient with Noonan's syndrome: a case report.

    abstract::A pulmonary artery aneurysm is defined as pulmonary artery dilatation >4 cm. Pulmonary artery aneurysms are rare findings and are usually not associated with chest pain. This is the first report of a case of pulmonary artery aneurysm causing chest pain in a patient with Noonan's syndrome. Chest X-ray showed cardiomega...

    journal_title:Cardiology

    pub_type: 杂志文章

    doi:10.1159/000112408

    authors: Brown JR,Plotnick G

    更新日期:2008-01-01 00:00:00

  • Metoprolol-mediated amelioration of sympathetic nerve sprouting after myocardial infarction.

    abstract:OBJECTIVES:Systemic or local inflammation causes cardiac nerve sprouting and consequent arrhythmia. Metoprolol can prevent sympathetic nerve remodeling after myocardial infarction (MI), but the underlying mechanism is unclear. In this study, we evaluated the role of metoprolol in ameliorating sympathetic sprouting. ME...

    journal_title:Cardiology

    pub_type: 杂志文章

    doi:10.1159/000351074

    authors: Wang Y,Liu J,Suo F,Hu HS,Xue M,Cheng WJ,Xuan YL,Yan SH

    更新日期:2013-01-01 00:00:00

  • Percutaneous transluminal coronary angioplasty in unstable and stable angina pectoris: a comparison of immediate success and complications.

    abstract::To determine the success rate and the safety of percutaneous transluminal coronary angioplasty in patients with unstable angina pectoris (group 1) versus stable angina (group 2), we studied 299 consecutive patients who underwent coronary angioplasty of 373 consecutive lesions. Of these patients, 149 had unstable angin...

    journal_title:Cardiology

    pub_type: 杂志文章

    doi:10.1159/000175811

    authors: Ilia R,Kolansky D,Setaro J,Brennan J,Cabin H,Cleman M,Remetz M

    更新日期:1992-01-01 00:00:00

  • Pioglitazone improves endothelial function in non-diabetic patients with coronary artery disease.

    abstract:OBJECTIVE:To test the hypothesis that pioglitazone, a peroxisome proliferator-activated receptor-gamma agonist, will improve endothelial function in non-diabetic subjects with coronary artery disease, we conducted a prospective study to evaluate the effect of this medication on the brachial artery vasomotor function an...

    journal_title:Cardiology

    pub_type: 临床试验,杂志文章

    doi:10.1159/000096601

    authors: Staniloae C,Mandadi V,Kurian D,Coppola J,Bernaski E,El-Khally Z,Morlote M,Pinassi E,Ambrose J

    更新日期:2007-01-01 00:00:00

  • Efficacy and safety of clopidogrel 600 mg administered pre-hospitally to improve primary percutaneous coronary intervention in patients with acute myocardial infarction (CIPAMI): study rationale and design.

    abstract::Clopidogrel, in combination with acetylsalicylic acid, has become a mainstay of the pharmacological therapy for patients with acute coronary syndromes, especially in those undergoing percutaneous coronary interventions (PCI). While a series of studies has shown that pre-treatment with a loading dose of clopidogrel 300...

    journal_title:Cardiology

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1159/000096988

    authors: Zeymer U,Arntz HR,Darius H,Huber K,Senges J

    更新日期:2007-01-01 00:00:00

  • Failed Maximal Defibrillation Threshold Testing in the Subcutaneous Implantable Cardioverter Defibrillator.

    abstract::The subcutaneous implantable cardioverter defibrillator (S-ICD) registry included very few patients with a body mass index (BMI) greater than 40. We present a case of a 40-year-old male with a BMI of 44 and ejection fraction of 25% who underwent S-ICD implantation for primary prevention of sudden cardiac death in the ...

    journal_title:Cardiology

    pub_type: 杂志文章

    doi:10.1159/000447484

    authors: Levine JD,Ellins C,Winn N,Kim R,Hsu SS,Catanzaro JN

    更新日期:2017-01-01 00:00:00

  • [Physiology of orthostatic regulation].

    abstract::The arterial blood pressure is integrated into a feedback control system and practically depends on three parameters, i. e. blood volume, heart dynamics, and peripheral resistance. When circulation is disturbed in the orthostatic, the correcting elements heart and vessels have to adapt themselves according to this dem...

    journal_title:Cardiology

    pub_type: 杂志文章

    doi:10.1159/000169794

    authors: Rieckert H

    更新日期:1976-01-01 00:00:00

  • Sirolimus- versus paclitaxel-eluting stent implantation for unprotected left main coronary artery stenosis.

    abstract::We performed this study in order to compare the immediate and mid-term outcomes of sirolimus-eluting stents (SES) and paclitaxel-eluting stents (PES) in lesions of the unprotected left main coronary artery (LMCA). We assessed 54 patients from 5 centers who had undergone unprotected LMCA stenting (35 SES and 19 PES). T...

    journal_title:Cardiology

    pub_type: 杂志文章,多中心研究

    doi:10.1159/000088106

    authors: Lee SH,Ko YG,Jang Y,Kwon HM,Lee SH,Yoon JH,Park SH,Kim BO,Jeon DW,Yang JY,Ryu SK,Korean Multicenter Angioplasty Team (KOMATE) Investigators.

    更新日期:2005-01-01 00:00:00

  • Efficacy and Safety of Adjunctive Trimetazidine Therapy for Acute Myocardial Infarction: A Systematic Review and Meta-Analysis.

    abstract:BACKGROUND:Several lines of evidence support the clinical use of trimetazidine as an adjunctive therapy in cardioischemic patients. Therefore, we assessed here the efficacy and safety of adjunctive trimetazidine therapy in acute myocardial infarction (MI) patients by a systematic review and meta-analysis of the current...

    journal_title:Cardiology

    pub_type: 杂志文章,meta分析,评审

    doi:10.1159/000446640

    authors: Li Y,Wang D,Hu C,Zhang P,Zhang D,Qin S

    更新日期:2016-01-01 00:00:00

  • Left atrial passive emptying function is preserved in patients with permanent atrial fibrillation--a 320-slice multidetector computed tomography study.

    abstract:OBJECTIVE:Left atrial (LA) mechanical function is thought to be virtually inexistent in patients with permanent atrial fibrillation (AF). Due to recent advances in multidetector computed tomography (MDCT) technology, it is now possible to acquire images of the entire heart in a single heartbeat. The objective of this s...

    journal_title:Cardiology

    pub_type: 杂志文章

    doi:10.1159/000365915

    authors: Agner BF,Kühl JT,Kofoed KF,Engstrøm T,Jensen GB,Dixen U

    更新日期:2014-01-01 00:00:00

  • Effect of body characteristics on the variables of signal-averaged electrocardiogram in healthy teenage subjects.

    abstract::Ventricular late potentials are obtained by signal-averaged surface electrocardiography. Late potentials have been reported to be affected by body characteristics or left ventricular mass. To evaluate late potentials in relation to body characteristics, 52 healthy Japanese young volunteers (21 girls, 31 boys) aged 15-...

    journal_title:Cardiology

    pub_type: 杂志文章

    doi:10.1159/000175950

    authors: Iwasaka T,Usui H,Masui A,Tamura K,Sugiura T,Karakawa M,Inada M

    更新日期:1993-01-01 00:00:00

  • Evaluation of the exercise test in patients with angiographically documented coronary artery disease.

    abstract::100 male patients with at least 75% obstruction of one or more coronary arteries were subjected to submaximal exercise tests. Among the 73 subjects who had positive tests, 92% of those with one-vessel obstruction had an ST depression of 1 mm, none having more than 2 mm; by contrast, 44% of those with three-vessel dise...

    journal_title:Cardiology

    pub_type: 杂志文章

    doi:10.1159/000169871

    authors: Friedmann J,Agmon J,Cherbakoff A,Aygen M,Wurzel M

    更新日期:1977-01-01 00:00:00