Fibrinolytic therapy and n-acetylocysteine in the treatment of patients with acute myocardial infarction: its influence on authentic plasma hydroperoxide levels and polymorphonuclear neutrophil oxygen metabolism.

Abstract:

:Recently it has been demonstrated that the administration of n-acetylocysteine (NAC), in combination with streptokinase, significantly diminished oxidative stress in patients with myocardial infarction. The aim of our study was to assess the influence of NAC treatment, as adjunct therapy in an evolving myocardial infarction, on the polymorphonuclear count, superoxide anion and hydrogen peroxide levels and nitric oxide production by PMNs and authentic plasma hydroperoxide (ROOH). Treatment of patients with NAC in addition to reperfusion therapy was accompanied by a significant decrease in the number of circulating polymorphonuclear neutrophils. However, the oxygen metabolism of PMNs was not affected by NAC administration. The concentration of authentic plasma hydroperoxide was significantly reduced by the administration of NAC which suggests diminished oxidative stress during acute myocardial infarction.

journal_name

Cardiology

journal_title

Cardiology

authors

Sajkowska A,Wykretowicz A,Szczepanik A,Kempa M,Minczykowski A,Wysocki H

doi

10.1159/000006878

subject

Has Abstract

pub_date

1999-01-01 00:00:00

pages

60-5

issue

1

eissn

0008-6312

issn

1421-9751

pii

6878

journal_volume

91

pub_type

临床试验,杂志文章,随机对照试验
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    pub_type: 评论,杂志文章

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