Myocardial turnover of endogenous opioids and calcitonin-gene-related peptide in the human heart and the effects of spinal cord stimulation on pacing-induced angina pectoris.

Abstract:

:Earlier studies have shown that spinal cord stimulation (SCS) has antianginal and anti-ischemic effects in severe coronary artery disease. In the present study, 14 patients were subjected to right-sided atrial catheterization and atrial pacing. The patients were paced to angina during a control session and during spinal cord stimulation. Myocardial extraction of beta-endorphin (BE) during control pacing (8 +/- 22%) changed to release at the maximum pacing rate during treatment (-21 +/- 47%, a negative value representing release). Furthermore, the results indicate local myocardial turnover of leuenkephalin, BE and calcitonin-gene-related peptide. In addition, it is implied that SCS may induce myocardial release of BE which could explain the beneficial effects in myocardial ischemia.

journal_name

Cardiology

journal_title

Cardiology

authors

Eliasson T,Mannheimer C,Waagstein F,Andersson B,Bergh CH,Augustinsson LE,Hedner T,Larson G

doi

10.1159/000006783

subject

Has Abstract

pub_date

1998-03-01 00:00:00

pages

170-7

issue

3

eissn

0008-6312

issn

1421-9751

pii

crd89170

journal_volume

89

pub_type

杂志文章
  • The role of enoximone in the treatment of cardiogenic shock.

    abstract::Low cardiac output in acute heart failure can result in a functional impairment of organs, when tissue hypoxia occurs and cardiogenic shock develops. To restore cardiac output, various forms of therapy can be considered. Fluid replacement is sometimes beneficial in acute situations where oedema can reduce effective pl...

    journal_title:Cardiology

    pub_type: 临床试验,杂志文章

    doi:10.1159/000174667

    authors: Vincent JL,Léon M,Berré J

    更新日期:1990-01-01 00:00:00

  • Comparing beta-blocking effects of bisoprolol, carvedilol and nebivolol.

    abstract:OBJECTIVE:Bisoprolol, carvedilol and nebivolol have been shown to be effective in the treatment of heart failure. However, the beta-blocking effects of these drugs have never been compared directly. METHODS:Therefore, we performed a randomized, double-blind, placebo-controlled, cross-over trial in 16 healthy males. Su...

    journal_title:Cardiology

    pub_type: 杂志文章,随机对照试验

    doi:10.1159/000093060

    authors: Stoschitzky K,Stoschitzky G,Brussee H,Bonelli C,Dobnig H

    更新日期:2006-01-01 00:00:00

  • N-terminal pro-B-type natriuretic peptide in risk stratification after acute myocardial infarction in patients on long-term beta-adrenergic receptor blocker therapy.

    abstract:BACKGROUND:N-terminal pro-B-type natriuretic peptide (NT-proBNP) appears to be a strong risk marker of mortality in patients with acute coronary syndrome. However, little information is available on NT-proBNP as a predictor of long-term serious cardiovascular events beyond that of left ventricular ejection fraction in ...

    journal_title:Cardiology

    pub_type: 杂志文章

    doi:10.1159/000092743

    authors: Jonsson G,Abdelnoor M,Landaas S,Muller C,Kjeldsen SE,Os I,Westheim A

    更新日期:2006-01-01 00:00:00

  • Specificity of cardiac troponin I and creatine kinase-MB isoenzyme in asymptomatic long-term hemodialysis patients and effect of hemodialysis on these cardiac markers.

    abstract:OBJECTIVES:The objectives of this study were: (1) to evaluate the specificity of cardiac troponin I and creatine kinase-MB isoenzyme in ambulatory asymptomatic chronic renal failure patients on long-term hemodialysis, and (2) to evaluate the effect of hemodialysis on the serum levels of cardiac troponin I and creatine ...

    journal_title:Cardiology

    pub_type: 杂志文章

    doi:10.1159/000006859

    authors: Tun A,Khan IA,Win MT,Hussain A,Hla TA,Wattanasuwan N,Vasavada BC,Sacchi TJ

    更新日期:1998-01-01 00:00:00

  • OPG/RANK/RANKL axis in stabilization of spontaneously restored sinus rhythm in permanent atrial fibrillation patients after mitral valve surgery.

    abstract:OBJECTIVE:To investigate the expression of the osteoprotegerin (OPG)/receptor activator of nuclear factor-ĸB (RANK)/RANK ligand (RANKL) axis in the stabilization of spontaneously restored sinus rhythm (SR) in permanent atrial fibrillation (AF) patients after mitral valve (MV) surgery and study its clinical significance...

    journal_title:Cardiology

    pub_type: 杂志文章

    doi:10.1159/000342784

    authors: Xi L,Cao H,Zhu J,Røe OD,Li M,Wu Y,Wang D,Chen Y

    更新日期:2013-01-01 00:00:00

  • The use of low-dose insulin in cardiogenic shock due to combined overdose of verapamil, enalapril and metoprolol.

    abstract::We describe a case of severe heart failure due to the combined effect of verapamil and enalapril overdose in a patient treated regularly with metoprolol. The patient was dependent for 2 days on glucagon and dopamine infusion but remained oliguric, with deteriorating renal function. Marked improvement in all hemodynami...

    journal_title:Cardiology

    pub_type: 杂志文章

    doi:10.1159/000093191

    authors: Hasin T,Leibowitz D,Antopolsky M,Chajek-Shaul T

    更新日期:2006-01-01 00:00:00

  • Prognostic value of ischemia monitoring with on-line vectorcardiography in patients with unstable coronary artery disease.

    abstract:AIM:The aim of this study was to determine whether on-line vectorcardiography (VCG) gives independent prognostic information, regarding death, myocardial infarction (MI), and revascularization in patients with unstable coronary artery disease, i.e. unstable angina or non-Q-wave MI. METHODS AND RESULTS:One hundred and ...

    journal_title:Cardiology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1159/000007024

    authors: Lundin P,Jensen J,Lindahl B,Wallentin L,Eriksson SV

    更新日期:2000-01-01 00:00:00

  • Calcium antagonists.

    abstract::At present nitrates remain the initial treatment for relief or prevention of angina in patients with coronary artery disease. In cases where nitrates and beta blockers have been used and are ineffective for managing effort angina, calcium antagonists may be substituted or added to the beta-blocking treatment. When the...

    journal_title:Cardiology

    pub_type: 杂志文章,评审

    doi:10.1159/000173886

    authors: Conti CR,Pepine CJ,Feldman RL,Hill JA

    更新日期:1985-01-01 00:00:00

  • Grade III ischemia on presentation with acute myocardial infarction predicts rapid progression of necrosis and less myocardial salvage with thrombolysis.

    abstract::We assessed the relation between baseline electrocardiographic ischemia grades and initial myocardial area at risk (AR) and final infarct size (IS) in 49 patients who had undergone (99m)Tc sestamibi single-photon emission computed tomography before and 6 +/- 1 days after thrombolysis. Patients were classed as having g...

    journal_title:Cardiology

    pub_type: 临床试验,杂志文章

    doi:10.1159/000063334

    authors: Birnbaum Y,Mahaffey KW,Criger DA,Gates KB,Barbash GI,Barbagelata A,Clemmensen P,Sgarbossa EB,Gibbons RJ,Rahman MA,Califf RM,Granger CB,Wagner GS,AMISTAD (Acute Myocardial Infarction Study of Adenosine) Investigators.

    更新日期:2002-01-01 00:00:00

  • Left Ventricular Ejection Fraction Recovery in Patients with Heart Failure and Reduced Ejection Fraction Treated with Sacubitril/Valsartan.

    abstract:BACKGROUND:A significant number of heart failure (HF) patients with reduced left ventricular ejection fraction (LVEF) experience ventricular function recovery during follow-up. We studied the variables associated with LVEF recovery in patients treated with sacubitril/valsartan (SV) in clinical practice. METHODS:We ana...

    journal_title:Cardiology

    pub_type: 杂志文章,多中心研究

    doi:10.1159/000505148

    authors: Díez-Villanueva P,Vicent L,de la Cuerda F,Esteban-Fernández A,Gómez-Bueno M,de Juan-Bagudá J,Iniesta ÁM,Ayesta A,Rojas-González A,Bover-Freire R,Iglesias D,García-Aguado M,Perea-Egido JÁ,Salamanca J,Martínez-Sellés M

    更新日期:2020-01-01 00:00:00

  • Left-ventricular unloading by transvalvular axial flow pumping in experimental cardiogenic shock and during regional myocardial ischemia.

    abstract::The efficacy of the transfemoral left-ventricular assist device Hemopump (HP; 21 Fr outer diameter) was examined in experiments with adult sheep in two different models of cardiogenic shock (tachycardia shock; ischemia shock), and during ventricular fibrillation. During tachycardia (high frequency pacing-induced; n = ...

    journal_title:Cardiology

    pub_type: 杂志文章

    doi:10.1159/000176399

    authors: Scholz KH,Hering JP,Schröder T,Uhlig P,Kreuzer H,Hellige G

    更新日期:1994-01-01 00:00:00

  • Clinical, angiographic and hemodynamic characteristics of patients with a strongly positive exercise test.

    abstract::To determine the clinical, angiographic and hemodynamic characteristics of patients with a strongly positive exercise test, 37 subjects demonstrating greater than or equal to 3 mm S-T segment depression were identified among 892 consecutive diagnostic treadmill evaluations. Typical angina by history was present in 78%...

    journal_title:Cardiology

    pub_type: 杂志文章

    doi:10.1159/000170871

    authors: Williams DO,Most AS

    更新日期:1980-01-01 00:00:00

  • Protease-Activated Receptor 1 Contributes to Angiotensin II-Induced Cardiovascular Remodeling and Inflammation.

    abstract:BACKGROUND:Angiotensin II (Ang II) plays an important role in cardiovascular disease. It also leads to the activation of coagulation. The coagulation protease thrombin induces cellular responses by activating protease-activated receptor 1 (PAR-1). We investigated whether PAR-1 contributes to Ang II-induced cardiovascul...

    journal_title:Cardiology

    pub_type: 杂志文章

    doi:10.1159/000452269

    authors: Antoniak S,Cardenas JC,Buczek LJ,Church FC,Mackman N,Pawlinski R

    更新日期:2017-01-01 00:00:00

  • Percutaneous transluminal coronary angioplasty in unstable and stable angina pectoris: a comparison of immediate success and complications.

    abstract::To determine the success rate and the safety of percutaneous transluminal coronary angioplasty in patients with unstable angina pectoris (group 1) versus stable angina (group 2), we studied 299 consecutive patients who underwent coronary angioplasty of 373 consecutive lesions. Of these patients, 149 had unstable angin...

    journal_title:Cardiology

    pub_type: 杂志文章

    doi:10.1159/000175811

    authors: Ilia R,Kolansky D,Setaro J,Brennan J,Cabin H,Cleman M,Remetz M

    更新日期:1992-01-01 00:00:00

  • QT prolongation and torsade de pointes induced by fluoroquinolones: infrequent side effects from commonly used medications.

    abstract::Although very useful agents, fluoroquinolones are associated with a number of adverse events, some with considerable clinical significance. Prolongation of the QT interval, for example, is an adverse effect associated with the use of fluoroquinolones. Fluoroquinolones prolong the QT interval by blocking voltage-gated ...

    journal_title:Cardiology

    pub_type: 杂志文章,评审

    doi:10.1159/000334441

    authors: Briasoulis A,Agarwal V,Pierce WJ

    更新日期:2011-01-01 00:00:00

  • Rheumatic Mitral Stenosis: Long-Term Follow-Up of Adult Patients with Nonsevere Initial Disease.

    abstract:INTRODUCTION:There is no consensus regarding the natural history of rheumatic mitral stenosis (MS) among adults presenting with nonsevere disease. This study aims to describe the progression of stenosis among adult rheumatic MS patients, to identify predictive factors for progression, and to assess the incidence of com...

    journal_title:Cardiology

    pub_type: 杂志文章

    doi:10.1159/000505481

    authors: Bitan A,Mazor-Dray E,Weinstein JM,Carmel S,Ilia R

    更新日期:2020-01-01 00:00:00

  • Cold pressure test producing coronary spasm, coronary thrombosis and myocardial infarction in a patient with IgM antibodies against Coxsackie B virus.

    abstract::Several lines of evidence have shown that viral infections are capable of causing coronary spasm and precipitating or mimicking clinical myocardial infarction. Here we report the case of a 41-year-old woman with recurrent angina who was admitted to our hospital because of ventricular tachycardia. Laboratory examinatio...

    journal_title:Cardiology

    pub_type: 杂志文章

    doi:10.1159/000006987

    authors: Haberbosch W,Roerich N,Neuzner J

    更新日期:1999-01-01 00:00:00

  • Tracking coronary calcification and atherosclerotic lesions in patients with stable angina pectoris undergoing nifedipine therapy.

    abstract:AIMS:The objective of the Coronary Calcification (CC) study was to determine in patients with chronic symptomatic coronary artery disease, if, in addition to standard therapy, nifedipine GITS, relative to placebo, would arrest or slow down the progression of calcium or the development of new atherosclerotic lesions in ...

    journal_title:Cardiology

    pub_type: 杂志文章

    doi:10.1159/000095308

    authors: Motro M,Kirwan BA,de Brouwer S,Poole-Wilson PA,Shemesh J,ACTION CC side-arm study.

    更新日期:2007-01-01 00:00:00

  • Molecular genetic studies in atrial fibrillation.

    abstract::Atrial fibrillation is a complex disease. Its etiologies are diverse and genetic factors may also contribute to this disease. With the advent of modern molecular biology technology, it is now possible to explore the genetic components in the pathogenesis of atrial fibrillation. Past molecular genetic studies on atrial...

    journal_title:Cardiology

    pub_type: 杂志文章,评审

    doi:10.1159/000073910

    authors: Lai LP,Lin JL,Huang SK

    更新日期:2003-01-01 00:00:00

  • The association between nonalcoholic fatty liver disease, metabolic syndrome and arterial stiffness in nondiabetic, nonhypertensive individuals.

    abstract:OBJECTIVES:To assess the relationship between nonalcoholic fatty liver disease (NAFLD) and arterial stiffness in nondiabetic, nonhypertensive individuals with and without metabolic syndrome (MetS). METHODS:Hepatic ultrasound and brachial-ankle pulse wave velocity (baPWV) were investigated in 4,467 individuals. The sub...

    journal_title:Cardiology

    pub_type: 杂志文章

    doi:10.1159/000341248

    authors: Kim BJ,Kim NH,Kim BS,Kang JH

    更新日期:2012-01-01 00:00:00

  • Exercise training in mild hypertension: effects on blood pressure, left ventricular mass and coagulation factor VII and fibrinogen.

    abstract::The aim of this study was to assess the effects of aerobic exercise on resting and 24-hour blood pressure (BP), left ventricular mass (LVM), plasma fibrinogen and factor VII (FVII). For this purpose 14 sedentary subjects with untreated diastolic BP between 90 and 104 mm Hg completed a 12-week supervised exercise progr...

    journal_title:Cardiology

    pub_type: 杂志文章

    doi:10.1159/000177378

    authors: Zanettini R,Bettega D,Agostoni O,Ballestra B,del Rosso G,di Michele R,Mannucci PM

    更新日期:1997-09-01 00:00:00

  • Liver cirrhosis with ascites: pathogenesis of resistance to diuretics and long-term efficacy and safety of torasemide.

    abstract::In a prospective randomized short-term study, the efficacy and safety of xipamide and a combination of spironolactone and furosemide were compared in the treatment of hepatic cirrhotic ascites. Twenty-two patients were randomized to either xipamide, 20 mg/day (group I), or spironolactone, 200 mg/day, combined with fur...

    journal_title:Cardiology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1159/000176461

    authors: Knauf H,Mutschler E

    更新日期:1994-01-01 00:00:00

  • Meta-analysis of trials comparing oral anticoagulation and aspirin versus dual antiplatelet therapy after coronary stenting. Clues for the management of patients with an indication for long-term anticoagulation undergoing coronary stenting.

    abstract::The combination of oral anticoagulation (OAC) and aspirin was the antithrombotic treatment initially adopted after coronary stenting (PCI-S). Although dual antiplatelet therapy with aspirin and a thienopyridine subsequently proved safer and more effective, OAC and aspirin combination is still used in patients with an ...

    journal_title:Cardiology

    pub_type: 杂志文章,meta分析

    doi:10.1159/000086918

    authors: Rubboli A,Milandri M,Castelvetri C,Cosmi B

    更新日期:2005-01-01 00:00:00

  • Postmarketing surveillance versus clinical trials: which benefits the patient?

    abstract::Both randomized controlled clinical trials and observational postmarketing surveillance studies have a place in providing information to physicians and patients on effectiveness and safety of new medicines. Prelicensing is the realm of the basic scientist producing a medicine which is available for investigation by cl...

    journal_title:Cardiology

    pub_type: 杂志文章

    doi:

    authors: Lawson DH

    更新日期:1994-01-01 00:00:00

  • Mechanisms of lipid-lowering agents.

    abstract::Lipid-lowering agents are used with the purpose of ameliorating hyperlipoproteinemias, in order to prevent arterial disease. Lipid-lowering drugs can be classified into absorbable agents and into nonabsorbable compounds, acting within the gastrointestinal lumen. Absorbable drugs (fibric acids, nicotinic acid, probucol...

    journal_title:Cardiology

    pub_type: 杂志文章,评审

    doi:10.1159/000174789

    authors: Sirtori CR,Manzoni C,Lovati MR

    更新日期:1991-01-01 00:00:00

  • Novel Clinical Manifestation of the Known SCN5A D1790G Mutation.

    abstract::The D1790G mutation was found in all 24 patients of an extended long QT family but not in 200 chromosomes carried by healthy individuals. We describe a 37-year-old man presenting with a typical spontaneous type 1 Brugada pattern who in electrophysiological testing had easily inducible ventricular fibrillation. At the ...

    journal_title:Cardiology

    pub_type: 杂志文章

    doi:10.1159/000437089

    authors: Blich M,Efrati E,Marai I,Suleiman M,Gepstein L,Boulous M

    更新日期:2015-01-01 00:00:00

  • Aortic Valve Gradient and Clinical Outcome in Patients Undergoing Transcatheter Aortic Valve Implantation for Severe Aortic Stenosis.

    abstract:OBJECTIVES:To explore the relation between the baseline aortic valve gradient (AVG) as a continuous variable and clinical outcomes following transcatheter aortic valve implantation (TAVI) in general and specifically in patients with high-gradient aortic stenosis (AS). METHODS:We reviewed 317 consecutive patients who u...

    journal_title:Cardiology

    pub_type: 杂志文章

    doi:10.1159/000444007

    authors: Witberg G,Barsheshet A,Assali A,Vaknin-Assa H,Shaul AA,Orvin K,Vaturi M,Schwartzenberg S,Shapira Y,Sagie A,Kornowski R

    更新日期:2016-01-01 00:00:00

  • Exercise-induced improvement in atrial depolarization abnormality in a patient after treatment with beta-adrenergic blockers.

    abstract::Abnormal atrial depolarization, characterized by P waves >or=110 ms on the electrocardiogram, can manifest as partial or advanced interatrial conduction delay or interatrial block (IAB). Progression from partial to advanced IAB has been shown to be altered by the use of angiotensin-converting enzyme inhibitors and bet...

    journal_title:Cardiology

    pub_type: 杂志文章

    doi:10.1159/000113425

    authors: Ariyarajah V,Shaikh N,Spodick DH

    更新日期:2008-01-01 00:00:00

  • Clinical Application of Biomarkers in Heart Failure with a Preserved Ejection Fraction: A Review.

    abstract::Heart failure with a preserved ejection fraction (HFpEF) is increasingly prevalent and a leading cause of morbidity and mortality worldwide. HFpEF has a complex pathophysiology, with recent evidence suggesting that an interaction of cardiovascular and noncardiovascular comorbidities (e.g. obesity, hypertension, diabet...

    journal_title:Cardiology

    pub_type: 杂志文章,评审

    doi:10.1159/000450573

    authors: Garg A,Virmani D,Agrawal S,Agarwal C,Sharma A,Stefanini G,Kostis JB

    更新日期:2017-01-01 00:00:00

  • Prognostic implication of detecting vegetations by M-mode echocardiography.

    abstract::The prognostic significance of finding vegetations by M-mode echocardiography in patients with infective endocarditis remains controversial because many such patients are referred for early surgery. We detected vegetations in 7 of 25 consecutive subjects with active infective endocarditis (28.1%) studied by M-mode ech...

    journal_title:Cardiology

    pub_type: 杂志文章

    doi:10.1159/000173593

    authors: Markiewicz W,Moscovitz M,Edoute Y,Finkelstein R,Raz R

    更新日期:1983-01-01 00:00:00