Abstract:
:Earlier studies have shown that spinal cord stimulation (SCS) has antianginal and anti-ischemic effects in severe coronary artery disease. In the present study, 14 patients were subjected to right-sided atrial catheterization and atrial pacing. The patients were paced to angina during a control session and during spinal cord stimulation. Myocardial extraction of beta-endorphin (BE) during control pacing (8 +/- 22%) changed to release at the maximum pacing rate during treatment (-21 +/- 47%, a negative value representing release). Furthermore, the results indicate local myocardial turnover of leuenkephalin, BE and calcitonin-gene-related peptide. In addition, it is implied that SCS may induce myocardial release of BE which could explain the beneficial effects in myocardial ischemia.
journal_name
Cardiologyjournal_title
Cardiologyauthors
Eliasson T,Mannheimer C,Waagstein F,Andersson B,Bergh CH,Augustinsson LE,Hedner T,Larson Gdoi
10.1159/000006783subject
Has Abstractpub_date
1998-03-01 00:00:00pages
170-7issue
3eissn
0008-6312issn
1421-9751pii
crd89170journal_volume
89pub_type
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