Abstract:
:The combination of oral anticoagulation (OAC) and aspirin was the antithrombotic treatment initially adopted after coronary stenting (PCI-S). Although dual antiplatelet therapy with aspirin and a thienopyridine subsequently proved safer and more effective, OAC and aspirin combination is still used in patients with an indication for long-term OAC undergoing PCI-S. The absolute (AR) and relative (RR) risk of cardiac events and hemorrhagic/vascular complications of OAC and aspirin versus antiplatelet therapy were evaluated in a meta-analysis of four historical clinical trials. In 2,436 patients, the RR of a 30-day primary composite endpoint of death, myocardial infarction and the need for revascularization was significantly reduced by antiplatelet therapy (RR 0.41; 95% CI 0.25-0.69), whereas the RR of stent thrombosis (RR 0.26; 95% CI 0.06-1.14) and major bleeding (RR 0.36; 95% CI 0.14-1.02) was not statistically different. The 30-day AR of death, myocardial infarction, need for revascularization, major bleedings and vascular complications with OAC and aspirin were 0.65, 3.8, 4.2, 6.4 and 6.6%, respectively. In conclusion, due to the low AR of adverse events, the combination of OAC and aspirin appears an acceptable treatment after PCI-S in patients in whom long-term OAC is deemed mandatory.
journal_name
Cardiologyjournal_title
Cardiologyauthors
Rubboli A,Milandri M,Castelvetri C,Cosmi Bdoi
10.1159/000086918subject
Has Abstractpub_date
2005-01-01 00:00:00pages
101-6issue
2eissn
0008-6312issn
1421-9751pii
86918journal_volume
104pub_type
杂志文章,meta分析相关文献
CARDIOLOGY文献大全abstract::Since the reported incidence of pericardial effusion following thrombolysis is highly variable, we have evaluated 80 consecutive patients with first acute myocardial infarction treated with streptokinase. Two-dimensional echocardiographic studies were performed on days 1, 2, 3, and 7, at 3 and 6 weeks, and 3, 6, and 1...
journal_title:Cardiology
pub_type: 杂志文章
doi:10.1159/000177417
更新日期:1997-11-01 00:00:00
abstract:OBJECTIVE:To investigate the expression of the osteoprotegerin (OPG)/receptor activator of nuclear factor-ĸB (RANK)/RANK ligand (RANKL) axis in the stabilization of spontaneously restored sinus rhythm (SR) in permanent atrial fibrillation (AF) patients after mitral valve (MV) surgery and study its clinical significance...
journal_title:Cardiology
pub_type: 杂志文章
doi:10.1159/000342784
更新日期:2013-01-01 00:00:00
abstract::Recently it has been demonstrated that the administration of n-acetylocysteine (NAC), in combination with streptokinase, significantly diminished oxidative stress in patients with myocardial infarction. The aim of our study was to assess the influence of NAC treatment, as adjunct therapy in an evolving myocardial infa...
journal_title:Cardiology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1159/000006878
更新日期:1999-01-01 00:00:00
abstract:OBJECTIVES:This study investigates the effect of aging on the radial viscoelastic behavior of the left ventricle (LV) based on a previously validated model that uses myocardial tissue phase mapping (TPM) of cine phase-contrast MRI. METHODS:Previous studies suggest that aging remarkably influences regional myocardial m...
journal_title:Cardiology
pub_type: 杂志文章
doi:10.1159/000348871
更新日期:2013-01-01 00:00:00
abstract:BACKGROUND:The purpose of the present study was to examine physician's attitudes and practices toward the use of different lipid-lowering management strategies in patients at increased risk for coronary heart disease (CHD). AIMS/METHODS:An internet-based questionnaire was completed by 78 general internists and family ...
journal_title:Cardiology
pub_type: 杂志文章
doi:10.1159/000099066
更新日期:2007-01-01 00:00:00
abstract::Accessory mitral valve tissue is a rare anomaly of embryologic development of the endocardial cushion and may cause substantial and progressive obstruction of the left ventricular outflow tract. Subaortic obstruction resulting from accessory mitral tissue is most likely due to systolic ballooning of the tissue into th...
journal_title:Cardiology
pub_type: 杂志文章
doi:10.1159/000091290
更新日期:2006-01-01 00:00:00
abstract::To determine predictors of acute coronary dissection after coronary angioplasty, we studied 170 consecutive patients who underwent arterial dilatations of 234 arteries. Coronary dissection occurred in 103 (44%) arteries. More dissections occurred in women [40/73 (55%) versus 63/161 (39%), p < 0.03] and in patients wit...
journal_title:Cardiology
pub_type: 杂志文章
doi:10.1159/000176680
更新日期:1994-01-01 00:00:00
abstract::In a 79-year-old female with shortness of breath, catheterization via the femoral vein encountered difficulty entering the right heart; venography revealed anomalous drainage of the inferior vena cava via a dilated azygos vein permitting subsequent catheterization. Similar difficulties during catheterization merit con...
journal_title:Cardiology
pub_type: 杂志文章
doi:10.1159/000176884
更新日期:1995-01-01 00:00:00
abstract:CONTEXT:Much emphasis has been placed on a ticagrelor-aspirin (ASA) interaction in the Platelet Inhibition and Patient Outcomes (PLATO) trial, despite this particular interaction being inconclusive. However, a potential ticagrelor-statin interplay occurred and may be important in PLATO, especially considering the remar...
journal_title:Cardiology
pub_type: 社论
doi:10.1159/000346151
更新日期:2013-01-01 00:00:00
abstract::The spectrum of patients operated on without preoperative catheterization and angiography, the accuracy of echocardiographic diagnosis and its impact on the results of surgical treatment were prospectively assessed in 2,788 children consecutively operated for congenital heart defects (CHD) between 1986 and 1992. The o...
journal_title:Cardiology
pub_type: 杂志文章
doi:10.1159/000176928
更新日期:1995-01-01 00:00:00
abstract::To determine efficacy of the Senning procedure for correction of transposition of the great arteries we performed detailed hemodynamic and electrophysiological studies in 6 consecutive children operated upon at 5-18 months of age. Cardiac catheterizations were performed 10-19 months following surgery. All patients wer...
journal_title:Cardiology
pub_type: 杂志文章
doi:10.1159/000173601
更新日期:1983-01-01 00:00:00
abstract::Transcatheter electrical shock ablation of a concealed posteroseptal accessory pathway was performed on a 57-year-old man with drug-refractory paroxysmal supraventricular tachycardia. A single 300-joules shock delivered at the ostium of the coronary sinus abolished conduction in the accessory pathway and resulted in l...
journal_title:Cardiology
pub_type: 杂志文章
doi:10.1159/000174387
更新日期:1988-01-01 00:00:00
abstract::Changes in Intra-SA nodal pacemaker localization were produced through stimulation of the decentralized cervical vagi and stellate ganglia in the anesthetized dog. Shifts in pacemaker to the rostral, middle, or caudal regions of the SA node produced a change in the timing as well as a change in the sequence of activat...
journal_title:Cardiology
pub_type: 杂志文章
doi:10.1159/000170620
更新日期:1979-01-01 00:00:00
abstract::The effects of bicycle training for 5 weeks were evaluated in 12 patients after myocardial infarction with left ventricular dysfunction (left ventricular ejection fraction < 40%) and at least one episode of cardiac failure in the past. The patients were divided into two groups of six according to the Weber classificat...
journal_title:Cardiology
pub_type: 杂志文章
doi:10.1159/000175034
更新日期:1992-01-01 00:00:00
abstract:BACKGROUND:Mitral valve prolapse (MVP) is a common entity in female population. Although this is a minor disease, it may cause annoying symptoms that impair quality of life (QOL), and no established therapy for this problem. The aim of this study isto examine whether programmed exercise training by treadmill in female ...
journal_title:Cardiology
pub_type: 临床试验,杂志文章
doi:10.1159/000096952
更新日期:2007-01-01 00:00:00
abstract::Hydrogenated oils containing trans-fatty acids (TFA) are used to produce margarine and various processed foods. TFA affect serum lipid levels, fatty acid metabolism, and endothelial function. High TFA intake is linked to increased all-cause mortality, coronary heart disease mortality, and cardiovascular disease (CVD) ...
journal_title:Cardiology
pub_type: 杂志文章,评审
doi:10.1159/000479956
更新日期:2017-01-01 00:00:00
abstract:OBJECTIVE:Recent studies have shown that high-sensitivity C-reactive protein (hs-CRP) measured before cardioversion (CV) plays a significant role in predicting atrial fibrillation (AF) relapse. The time course of changes in hs-CRP after successful electrical CV remains controversial. The aim of the present study was to...
journal_title:Cardiology
pub_type: 杂志文章
doi:10.1159/000327998
更新日期:2011-01-01 00:00:00
abstract:OBJECTIVES:Increased homocysteine (HCY) levels are associated with an increased risk of cardiovascular disease. Plasma HCY is increased in chronic heart failure (CHF) patients, and previous studies suggest that hyperhomocysteinemia causes adverse cardiac remodeling and affects pump function. We aimed to evaluate the HC...
journal_title:Cardiology
pub_type: 杂志文章
doi:10.1159/000320106
更新日期:2010-01-01 00:00:00
abstract::In 50 patients undergoing percutaneous transluminal coronary angioplasty because of chronic angina pectoris, a collateral flow index (CFI) was determined at the start and the end of two 1-min coronary occlusions, randomly accompanied by a resting state or a 3-min dynamic handgrip exercise (DHE). CFI expressing collate...
journal_title:Cardiology
pub_type: 杂志文章
doi:10.1159/000073039
更新日期:2003-01-01 00:00:00
abstract::Lipid-lowering agents are used with the purpose of ameliorating hyperlipoproteinemias, in order to prevent arterial disease. Lipid-lowering drugs can be classified into absorbable agents and into nonabsorbable compounds, acting within the gastrointestinal lumen. Absorbable drugs (fibric acids, nicotinic acid, probucol...
journal_title:Cardiology
pub_type: 杂志文章,评审
doi:10.1159/000174789
更新日期:1991-01-01 00:00:00
abstract::Coronary heart disease (CHD) is the leading cause of death in the United States accounting for over 600,000 deaths and 1 million hospital admissions each year. Although the overall prevalence of disease is lower in women than in men, one quarter of all deaths in women is caused by CHD. Observations in clinical practic...
journal_title:Cardiology
pub_type: 杂志文章,评审
doi:10.1159/000174657
更新日期:1990-01-01 00:00:00
abstract::Acute renal infarction due to emboli represents a very rare but significant threat for kidney loss, and the clinical presentation is challenging. The differential diagnosis of massive renal thrombi includes all other causes of abdominal pain, and they can be easily misdiagnosed as renal colic due to nephrolithiasis. A...
journal_title:Cardiology
pub_type: 杂志文章
doi:10.1159/000322510
更新日期:2010-01-01 00:00:00
abstract::Patients with coronary artery disease can exhibit substantial vascular involvement; and vascular patients have a high incidence of coronary disease. Combined coronary artery bypass grafting (CABG) and treatment of extracranial cerebrovascular disease was performed in 52 patients, presenting strong indications for surg...
journal_title:Cardiology
pub_type: 杂志文章
doi:10.1159/000174989
更新日期:1992-01-01 00:00:00
abstract:BACKGROUND:Impaired left ventricular diastolic function is a common finding in essential hypertension. METHODS:In order to investigate possible relationships between flow velocity through the mitral valve (E/A; index of left ventricular diastolic function) and 24-hour blood pressure and heart rate variations, 198 pati...
journal_title:Cardiology
pub_type: 杂志文章
doi:10.1159/000078149
更新日期:2004-01-01 00:00:00
abstract:OBJECTIVES:MicroRNAs (miRNAs) are noncoding single-stranded RNA molecules that regulate gene expression in physiological functions, development and disease. In recent studies, three miRNAs have been described as muscle or cardiac specific: miR-1, miR-133, and miR-208, being involved in heart development and disease; bu...
journal_title:Cardiology
pub_type: 杂志文章
doi:10.1159/000268088
更新日期:2010-01-01 00:00:00
abstract::Three-dimensional imaging of cardiac structures could enhance the functional understanding and the interpretation of pathologies. Limited processing capabilities, relocation problems and inadequate two-dimensional image quality have previously limited its applicability. Recently, an integrated echocardiographic comput...
journal_title:Cardiology
pub_type: 杂志文章
doi:10.1159/000177116
更新日期:1996-07-01 00:00:00
abstract::In this first clinical report of an idiopathic familial persistently short QT interval (QTI), we describe three members of one family (a 17-year-old female, her 21-year-old brother, and their 51-year-old mother) demonstrating this ECG phenomenon, associated in the 17-year-old with several episodes of paroxysmal atrial...
journal_title:Cardiology
pub_type: 杂志文章
doi:10.1159/000047299
更新日期:2000-01-01 00:00:00
abstract::Low cardiac output in acute heart failure can result in a functional impairment of organs, when tissue hypoxia occurs and cardiogenic shock develops. To restore cardiac output, various forms of therapy can be considered. Fluid replacement is sometimes beneficial in acute situations where oedema can reduce effective pl...
journal_title:Cardiology
pub_type: 临床试验,杂志文章
doi:10.1159/000174667
更新日期:1990-01-01 00:00:00
abstract::In earlier studies by our group it was shown that the urinary tetrahydroaldosterone excretion is a more reliable test for the diagnosis of primary aldosteronism than aldosterone-18-glucuronide ('urinary aldosterone'). However, in several patients with primary aldosteronism even the tetrahydroaldosterone values remaine...
journal_title:Cardiology
pub_type: 杂志文章
doi:10.1159/000173954
更新日期:1985-01-01 00:00:00
abstract::The efficacy of the transfemoral left-ventricular assist device Hemopump (HP; 21 Fr outer diameter) was examined in experiments with adult sheep in two different models of cardiogenic shock (tachycardia shock; ischemia shock), and during ventricular fibrillation. During tachycardia (high frequency pacing-induced; n = ...
journal_title:Cardiology
pub_type: 杂志文章
doi:10.1159/000176399
更新日期:1994-01-01 00:00:00