Meta-analysis of trials comparing oral anticoagulation and aspirin versus dual antiplatelet therapy after coronary stenting. Clues for the management of patients with an indication for long-term anticoagulation undergoing coronary stenting.

Abstract:

:The combination of oral anticoagulation (OAC) and aspirin was the antithrombotic treatment initially adopted after coronary stenting (PCI-S). Although dual antiplatelet therapy with aspirin and a thienopyridine subsequently proved safer and more effective, OAC and aspirin combination is still used in patients with an indication for long-term OAC undergoing PCI-S. The absolute (AR) and relative (RR) risk of cardiac events and hemorrhagic/vascular complications of OAC and aspirin versus antiplatelet therapy were evaluated in a meta-analysis of four historical clinical trials. In 2,436 patients, the RR of a 30-day primary composite endpoint of death, myocardial infarction and the need for revascularization was significantly reduced by antiplatelet therapy (RR 0.41; 95% CI 0.25-0.69), whereas the RR of stent thrombosis (RR 0.26; 95% CI 0.06-1.14) and major bleeding (RR 0.36; 95% CI 0.14-1.02) was not statistically different. The 30-day AR of death, myocardial infarction, need for revascularization, major bleedings and vascular complications with OAC and aspirin were 0.65, 3.8, 4.2, 6.4 and 6.6%, respectively. In conclusion, due to the low AR of adverse events, the combination of OAC and aspirin appears an acceptable treatment after PCI-S in patients in whom long-term OAC is deemed mandatory.

journal_name

Cardiology

journal_title

Cardiology

authors

Rubboli A,Milandri M,Castelvetri C,Cosmi B

doi

10.1159/000086918

subject

Has Abstract

pub_date

2005-01-01 00:00:00

pages

101-6

issue

2

eissn

0008-6312

issn

1421-9751

pii

86918

journal_volume

104

pub_type

杂志文章,meta分析
  • Pericardial effusion after streptokinase for acute myocardial infarction: an echocardiographic 1-year follow-up study.

    abstract::Since the reported incidence of pericardial effusion following thrombolysis is highly variable, we have evaluated 80 consecutive patients with first acute myocardial infarction treated with streptokinase. Two-dimensional echocardiographic studies were performed on days 1, 2, 3, and 7, at 3 and 6 weeks, and 3, 6, and 1...

    journal_title:Cardiology

    pub_type: 杂志文章

    doi:10.1159/000177417

    authors: Otasević P,Nesković AN,Bojić M,Popović AD

    更新日期:1997-11-01 00:00:00

  • OPG/RANK/RANKL axis in stabilization of spontaneously restored sinus rhythm in permanent atrial fibrillation patients after mitral valve surgery.

    abstract:OBJECTIVE:To investigate the expression of the osteoprotegerin (OPG)/receptor activator of nuclear factor-ĸB (RANK)/RANK ligand (RANKL) axis in the stabilization of spontaneously restored sinus rhythm (SR) in permanent atrial fibrillation (AF) patients after mitral valve (MV) surgery and study its clinical significance...

    journal_title:Cardiology

    pub_type: 杂志文章

    doi:10.1159/000342784

    authors: Xi L,Cao H,Zhu J,Røe OD,Li M,Wu Y,Wang D,Chen Y

    更新日期:2013-01-01 00:00:00

  • Fibrinolytic therapy and n-acetylocysteine in the treatment of patients with acute myocardial infarction: its influence on authentic plasma hydroperoxide levels and polymorphonuclear neutrophil oxygen metabolism.

    abstract::Recently it has been demonstrated that the administration of n-acetylocysteine (NAC), in combination with streptokinase, significantly diminished oxidative stress in patients with myocardial infarction. The aim of our study was to assess the influence of NAC treatment, as adjunct therapy in an evolving myocardial infa...

    journal_title:Cardiology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1159/000006878

    authors: Sajkowska A,Wykretowicz A,Szczepanik A,Kempa M,Minczykowski A,Wysocki H

    更新日期:1999-01-01 00:00:00

  • Aging does not affect radial viscoelastic behavior of the left ventricle.

    abstract:OBJECTIVES:This study investigates the effect of aging on the radial viscoelastic behavior of the left ventricle (LV) based on a previously validated model that uses myocardial tissue phase mapping (TPM) of cine phase-contrast MRI. METHODS:Previous studies suggest that aging remarkably influences regional myocardial m...

    journal_title:Cardiology

    pub_type: 杂志文章

    doi:10.1159/000348871

    authors: Mangual JO,Föll D,Jung B,Pedrizzetti G,Kheradvar A

    更新日期:2013-01-01 00:00:00

  • Survey of physician's attitudes and practices toward lipid-lowering management strategies.

    abstract:BACKGROUND:The purpose of the present study was to examine physician's attitudes and practices toward the use of different lipid-lowering management strategies in patients at increased risk for coronary heart disease (CHD). AIMS/METHODS:An internet-based questionnaire was completed by 78 general internists and family ...

    journal_title:Cardiology

    pub_type: 杂志文章

    doi:10.1159/000099066

    authors: Goldberg RJ,Rosen J,Roselli A,Lewis B

    更新日期:2007-01-01 00:00:00

  • Accessory mitral valve tissue: report of two asymptomatic cases.

    abstract::Accessory mitral valve tissue is a rare anomaly of embryologic development of the endocardial cushion and may cause substantial and progressive obstruction of the left ventricular outflow tract. Subaortic obstruction resulting from accessory mitral tissue is most likely due to systolic ballooning of the tissue into th...

    journal_title:Cardiology

    pub_type: 杂志文章

    doi:10.1159/000091290

    authors: Uslu N,Gorgulu S,Yildirim A,Eren M

    更新日期:2006-01-01 00:00:00

  • Predictors of coronary dissection following percutaneous transluminal coronary balloon angioplasty.

    abstract::To determine predictors of acute coronary dissection after coronary angioplasty, we studied 170 consecutive patients who underwent arterial dilatations of 234 arteries. Coronary dissection occurred in 103 (44%) arteries. More dissections occurred in women [40/73 (55%) versus 63/161 (39%), p < 0.03] and in patients wit...

    journal_title:Cardiology

    pub_type: 杂志文章

    doi:10.1159/000176680

    authors: Ilia R,Bigham H,Brennan J,Cabin H,Cleman M,Remetz M

    更新日期:1994-01-01 00:00:00

  • Isolated anomalous inferior vena cava with azygos drainage.

    abstract::In a 79-year-old female with shortness of breath, catheterization via the femoral vein encountered difficulty entering the right heart; venography revealed anomalous drainage of the inferior vena cava via a dilated azygos vein permitting subsequent catheterization. Similar difficulties during catheterization merit con...

    journal_title:Cardiology

    pub_type: 杂志文章

    doi:10.1159/000176884

    authors: Ramsaran EK,Filiberti AW,Spodick DH

    更新日期:1995-01-01 00:00:00

  • Exploring the ticagrelor-statin interplay in the PLATO trial.

    abstract:CONTEXT:Much emphasis has been placed on a ticagrelor-aspirin (ASA) interaction in the Platelet Inhibition and Patient Outcomes (PLATO) trial, despite this particular interaction being inconclusive. However, a potential ticagrelor-statin interplay occurred and may be important in PLATO, especially considering the remar...

    journal_title:Cardiology

    pub_type: 社论

    doi:10.1159/000346151

    authors: Dinicolantonio JJ,Serebruany VL

    更新日期:2013-01-01 00:00:00

  • Seven-year experience of noninvasive preoperative diagnostics in children with congenital heart defects: comprehensive analysis of 2,788 consecutive patients.

    abstract::The spectrum of patients operated on without preoperative catheterization and angiography, the accuracy of echocardiographic diagnosis and its impact on the results of surgical treatment were prospectively assessed in 2,788 children consecutively operated for congenital heart defects (CHD) between 1986 and 1992. The o...

    journal_title:Cardiology

    pub_type: 杂志文章

    doi:10.1159/000176928

    authors: Marek J,Skovránek J,Hucín B,Chaloupecký V,Tax P,Reich O,Samánek M

    更新日期:1995-01-01 00:00:00

  • Postoperative hemodynamic and electrophysiological evaluation of the Senning procedure.

    abstract::To determine efficacy of the Senning procedure for correction of transposition of the great arteries we performed detailed hemodynamic and electrophysiological studies in 6 consecutive children operated upon at 5-18 months of age. Cardiac catheterizations were performed 10-19 months following surgery. All patients wer...

    journal_title:Cardiology

    pub_type: 杂志文章

    doi:10.1159/000173601

    authors: Epstein ML,Riemenschneider TA,Mathewson JW,Hurley EJ

    更新日期:1983-01-01 00:00:00

  • Transcatheter electrical shock ablation of a concealed accessory pathway.

    abstract::Transcatheter electrical shock ablation of a concealed posteroseptal accessory pathway was performed on a 57-year-old man with drug-refractory paroxysmal supraventricular tachycardia. A single 300-joules shock delivered at the ostium of the coronary sinus abolished conduction in the accessory pathway and resulted in l...

    journal_title:Cardiology

    pub_type: 杂志文章

    doi:10.1159/000174387

    authors: Belhassen B,Shapira I,Miller H,Geller E,Laniado S

    更新日期:1988-01-01 00:00:00

  • Differences in atrial septal activation with an intrasinoatrial nodal pacemaker and epicardial sinoatrial nodal pacing.

    abstract::Changes in Intra-SA nodal pacemaker localization were produced through stimulation of the decentralized cervical vagi and stellate ganglia in the anesthetized dog. Shifts in pacemaker to the rostral, middle, or caudal regions of the SA node produced a change in the timing as well as a change in the sequence of activat...

    journal_title:Cardiology

    pub_type: 杂志文章

    doi:10.1159/000170620

    authors: Goldberg JM

    更新日期:1979-01-01 00:00:00

  • Physical rehabilitation in coronary patients who have suffered from episodes of cardiac failure.

    abstract::The effects of bicycle training for 5 weeks were evaluated in 12 patients after myocardial infarction with left ventricular dysfunction (left ventricular ejection fraction < 40%) and at least one episode of cardiac failure in the past. The patients were divided into two groups of six according to the Weber classificat...

    journal_title:Cardiology

    pub_type: 杂志文章

    doi:10.1159/000175034

    authors: Scalvini S,Marangoni S,Volterrani M,Schena M,Quadri A,Levi GF

    更新日期:1992-01-01 00:00:00

  • Changes of serum beta-endorphin by programmed exercise training are correlated with improvement of clinical symptoms and quality of life in female mitral valve prolapse syndrome.

    abstract:BACKGROUND:Mitral valve prolapse (MVP) is a common entity in female population. Although this is a minor disease, it may cause annoying symptoms that impair quality of life (QOL), and no established therapy for this problem. The aim of this study isto examine whether programmed exercise training by treadmill in female ...

    journal_title:Cardiology

    pub_type: 临床试验,杂志文章

    doi:10.1159/000096952

    authors: Hung HF,Kao PF,Lin YS,Chen FC,Chen FC,Tsai JC,Chan P

    更新日期:2007-01-01 00:00:00

  • Trans-Fatty Acids and Cardiovascular Disease: Urgent Need for Legislation.

    abstract::Hydrogenated oils containing trans-fatty acids (TFA) are used to produce margarine and various processed foods. TFA affect serum lipid levels, fatty acid metabolism, and endothelial function. High TFA intake is linked to increased all-cause mortality, coronary heart disease mortality, and cardiovascular disease (CVD) ...

    journal_title:Cardiology

    pub_type: 杂志文章,评审

    doi:10.1159/000479956

    authors: Wilczek MM,Olszewski R,Krupienicz A

    更新日期:2017-01-01 00:00:00

  • The effect of sinus rhythm restoration on high-sensitivity C-reactive protein levels and their association with long-term atrial fibrillation recurrence after electrical cardioversion.

    abstract:OBJECTIVE:Recent studies have shown that high-sensitivity C-reactive protein (hs-CRP) measured before cardioversion (CV) plays a significant role in predicting atrial fibrillation (AF) relapse. The time course of changes in hs-CRP after successful electrical CV remains controversial. The aim of the present study was to...

    journal_title:Cardiology

    pub_type: 杂志文章

    doi:10.1159/000327998

    authors: Celebi OO,Celebi S,Canbay A,Ergun G,Aydogdu S,Diker E

    更新日期:2011-01-01 00:00:00

  • Homocysteine levels in patients with heart failure with preserved ejection fraction.

    abstract:OBJECTIVES:Increased homocysteine (HCY) levels are associated with an increased risk of cardiovascular disease. Plasma HCY is increased in chronic heart failure (CHF) patients, and previous studies suggest that hyperhomocysteinemia causes adverse cardiac remodeling and affects pump function. We aimed to evaluate the HC...

    journal_title:Cardiology

    pub_type: 杂志文章

    doi:10.1159/000320106

    authors: Okuyan E,Uslu A,Cakar MA,Sahin I,Onür I,Enhos A,Biter HI,Cetin S,Dinçkal MH

    更新日期:2010-01-01 00:00:00

  • Exercise-induced human coronary collateral function: quantitative assessment during acute coronary occlusions.

    abstract::In 50 patients undergoing percutaneous transluminal coronary angioplasty because of chronic angina pectoris, a collateral flow index (CFI) was determined at the start and the end of two 1-min coronary occlusions, randomly accompanied by a resting state or a 3-min dynamic handgrip exercise (DHE). CFI expressing collate...

    journal_title:Cardiology

    pub_type: 杂志文章

    doi:10.1159/000073039

    authors: Pohl T,Wustmann K,Zbinden S,Windecker S,Mehta H,Meier B,Seiler C

    更新日期:2003-01-01 00:00:00

  • Mechanisms of lipid-lowering agents.

    abstract::Lipid-lowering agents are used with the purpose of ameliorating hyperlipoproteinemias, in order to prevent arterial disease. Lipid-lowering drugs can be classified into absorbable agents and into nonabsorbable compounds, acting within the gastrointestinal lumen. Absorbable drugs (fibric acids, nicotinic acid, probucol...

    journal_title:Cardiology

    pub_type: 杂志文章,评审

    doi:10.1159/000174789

    authors: Sirtori CR,Manzoni C,Lovati MR

    更新日期:1991-01-01 00:00:00

  • Noninvasive diagnosis of coronary heart disease in women.

    abstract::Coronary heart disease (CHD) is the leading cause of death in the United States accounting for over 600,000 deaths and 1 million hospital admissions each year. Although the overall prevalence of disease is lower in women than in men, one quarter of all deaths in women is caused by CHD. Observations in clinical practic...

    journal_title:Cardiology

    pub_type: 杂志文章,评审

    doi:10.1159/000174657

    authors: Taylor P,Becker RC

    更新日期:1990-01-01 00:00:00

  • Acute kidney infarction secondary to intracardiac thrombus embolization in a patient with ischemic dilated cardiomyopathy.

    abstract::Acute renal infarction due to emboli represents a very rare but significant threat for kidney loss, and the clinical presentation is challenging. The differential diagnosis of massive renal thrombi includes all other causes of abdominal pain, and they can be easily misdiagnosed as renal colic due to nephrolithiasis. A...

    journal_title:Cardiology

    pub_type: 杂志文章

    doi:10.1159/000322510

    authors: Can MM,Tanboğa IH,Demircan HC,Ozkan A,Koca F,Keleş N,Sönmez K,Kaymaz C,Serebruany V

    更新日期:2010-01-01 00:00:00

  • Combined carotid and coronary artery surgery: early and late results.

    abstract::Patients with coronary artery disease can exhibit substantial vascular involvement; and vascular patients have a high incidence of coronary disease. Combined coronary artery bypass grafting (CABG) and treatment of extracranial cerebrovascular disease was performed in 52 patients, presenting strong indications for surg...

    journal_title:Cardiology

    pub_type: 杂志文章

    doi:10.1159/000174989

    authors: Carrel T,Stillhard G,Turina M

    更新日期:1992-01-01 00:00:00

  • Pulse pressure and left ventricular diastolic dysfunction in hypertensive patients.

    abstract:BACKGROUND:Impaired left ventricular diastolic function is a common finding in essential hypertension. METHODS:In order to investigate possible relationships between flow velocity through the mitral valve (E/A; index of left ventricular diastolic function) and 24-hour blood pressure and heart rate variations, 198 pati...

    journal_title:Cardiology

    pub_type: 杂志文章

    doi:10.1159/000078149

    authors: Trika CO,Zakopoulos N,Toumanidis ST,Stamatelopoulos SF,Moulopoulos SD

    更新日期:2004-01-01 00:00:00

  • MicroRNAs miR-1, miR-133a, miR-133b and miR-208 are dysregulated in human myocardial infarction.

    abstract:OBJECTIVES:MicroRNAs (miRNAs) are noncoding single-stranded RNA molecules that regulate gene expression in physiological functions, development and disease. In recent studies, three miRNAs have been described as muscle or cardiac specific: miR-1, miR-133, and miR-208, being involved in heart development and disease; bu...

    journal_title:Cardiology

    pub_type: 杂志文章

    doi:10.1159/000268088

    authors: Bostjancic E,Zidar N,Stajer D,Glavac D

    更新日期:2010-01-01 00:00:00

  • Value of three-dimensional echocardiography as an adjunct to conventional transesophageal echocardiography.

    abstract::Three-dimensional imaging of cardiac structures could enhance the functional understanding and the interpretation of pathologies. Limited processing capabilities, relocation problems and inadequate two-dimensional image quality have previously limited its applicability. Recently, an integrated echocardiographic comput...

    journal_title:Cardiology

    pub_type: 杂志文章

    doi:10.1159/000177116

    authors: Binder T,Globits S,Zangeneh M,Gabriel H,Röthy W,Glogar D,Maurer G,Baumgartner H

    更新日期:1996-07-01 00:00:00

  • Idiopathic short QT interval: a new clinical syndrome?

    abstract::In this first clinical report of an idiopathic familial persistently short QT interval (QTI), we describe three members of one family (a 17-year-old female, her 21-year-old brother, and their 51-year-old mother) demonstrating this ECG phenomenon, associated in the 17-year-old with several episodes of paroxysmal atrial...

    journal_title:Cardiology

    pub_type: 杂志文章

    doi:10.1159/000047299

    authors: Gussak I,Brugada P,Brugada J,Wright RS,Kopecky SL,Chaitman BR,Bjerregaard P

    更新日期:2000-01-01 00:00:00

  • The role of enoximone in the treatment of cardiogenic shock.

    abstract::Low cardiac output in acute heart failure can result in a functional impairment of organs, when tissue hypoxia occurs and cardiogenic shock develops. To restore cardiac output, various forms of therapy can be considered. Fluid replacement is sometimes beneficial in acute situations where oedema can reduce effective pl...

    journal_title:Cardiology

    pub_type: 临床试验,杂志文章

    doi:10.1159/000174667

    authors: Vincent JL,Léon M,Berré J

    更新日期:1990-01-01 00:00:00

  • 21-Deoxytetrahydroaldosterone excretion in primary hyperaldosteronism.

    abstract::In earlier studies by our group it was shown that the urinary tetrahydroaldosterone excretion is a more reliable test for the diagnosis of primary aldosteronism than aldosterone-18-glucuronide ('urinary aldosterone'). However, in several patients with primary aldosteronism even the tetrahydroaldosterone values remaine...

    journal_title:Cardiology

    pub_type: 杂志文章

    doi:10.1159/000173954

    authors: Abdelhamid S,Lewicka S,Vecsei P,Winter J

    更新日期:1985-01-01 00:00:00

  • Left-ventricular unloading by transvalvular axial flow pumping in experimental cardiogenic shock and during regional myocardial ischemia.

    abstract::The efficacy of the transfemoral left-ventricular assist device Hemopump (HP; 21 Fr outer diameter) was examined in experiments with adult sheep in two different models of cardiogenic shock (tachycardia shock; ischemia shock), and during ventricular fibrillation. During tachycardia (high frequency pacing-induced; n = ...

    journal_title:Cardiology

    pub_type: 杂志文章

    doi:10.1159/000176399

    authors: Scholz KH,Hering JP,Schröder T,Uhlig P,Kreuzer H,Hellige G

    更新日期:1994-01-01 00:00:00