Abstract:
OBJECTIVE:To investigate the expression of the osteoprotegerin (OPG)/receptor activator of nuclear factor-ĸB (RANK)/RANK ligand (RANKL) axis in the stabilization of spontaneously restored sinus rhythm (SR) in permanent atrial fibrillation (AF) patients after mitral valve (MV) surgery and study its clinical significance. METHODS:Clinical data, biopsies of right atrial appendages were collected from 135 permanent AF patients who spontaneously restored SR after conventional isolated MV replacement. A comparison was made between patients who had recurrence of AF within 7 days and patients with persistent SR for more than 7 days. RESULTS:AF patients had an increased expression of RANK, RANKL, and the RANKL/OPG ratio compared to SR patients, and the degree of fibrosis was lower in SR compared to AF in the atria. Moreover, the expressions of RANK, RANKL, and the RANKL/OPG ratio were positively correlated with the degree of fibrosis. CONCLUSION:These findings suggest that the OPG/RANK/RANKL axis plays important roles in the stabilization of restored SR after MV surgery by stimulating AF-related atrial remodeling in AF patients.
journal_name
Cardiologyjournal_title
Cardiologyauthors
Xi L,Cao H,Zhu J,Røe OD,Li M,Wu Y,Wang D,Chen Ydoi
10.1159/000342784subject
Has Abstractpub_date
2013-01-01 00:00:00pages
18-24issue
1eissn
0008-6312issn
1421-9751pii
000342784journal_volume
124pub_type
杂志文章相关文献
CARDIOLOGY文献大全abstract:OBJECTIVES:Recent research has indicated that red blood cell distribution width (RDW) is associated with the prognosis of cardiovascular diseases such as chronic heart failure and coronary heart disease. We aimed to study the predictive value of RDW for bleeding events in patients with nonvalvular atrial fibrillation (...
journal_title:Cardiology
pub_type: 杂志文章
doi:10.1159/000449461
更新日期:2017-01-01 00:00:00
abstract::Cardiovascular adaptation to the sudden inflation of a balloon in the descending aorta was investigated in intact awake, standing dogs. The balloon inflation raised pressure in the arterial bed proximal from the balloon. Initially, it lowered heart rate and cardiac output. After 4 sec, heart rate and cardiac output be...
journal_title:Cardiology
pub_type: 杂志文章
doi:10.1159/000169905
更新日期:1978-01-01 00:00:00
abstract::Ulcers in extracranial carotid arteries are a known source of cerebral embolism. However, there are no data available on the prevalence of ulcerations located at the origin of these vessels in the aortic arch. Therefore, in this pathological study the topographic distribution of ulcerated lesions were determined in th...
journal_title:Cardiology
pub_type: 杂志文章
doi:10.1159/000006793
更新日期:1998-03-01 00:00:00
abstract::The long-term patency of the left internal mammary artery (IMA) has made it the preferred conduit for myocardial revascularization. The proximal segment of the subclavian artery becomes functionally connected to the coronary circulation as a result of IMA implantation during coronary artery bypass surgery. The subclav...
journal_title:Cardiology
pub_type: 杂志文章
doi:10.1159/000063116
更新日期:2002-01-01 00:00:00
abstract::Lipid-lowering agents are used with the purpose of ameliorating hyperlipoproteinemias, in order to prevent arterial disease. Lipid-lowering drugs can be classified into absorbable agents and into nonabsorbable compounds, acting within the gastrointestinal lumen. Absorbable drugs (fibric acids, nicotinic acid, probucol...
journal_title:Cardiology
pub_type: 杂志文章,评审
doi:10.1159/000174789
更新日期:1991-01-01 00:00:00
abstract::Coronary artery disease (CAD) remains a disease of major public health importance among women. In light of this fact, attention has focused recently on the differential expression of the disease in women as compared to men. This review will attempt to describe the characteristics of CAD among women from a population-b...
journal_title:Cardiology
pub_type: 杂志文章,评审
doi:10.1159/000176889
更新日期:1995-01-01 00:00:00
abstract:OBJECTIVE:The objective was to evaluate the effect of hormone replacement therapy (HRT) on plasma homocysteine levels in postmenopausal women with coronary artery disease (CAD) and to investigate associations of homocysteine to other cardiovascular risk factors. METHODS:The women in this single-center, controlled, and...
journal_title:Cardiology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1159/000064667
更新日期:2002-01-01 00:00:00
abstract:BACKGROUND:Left-ventricular pseudohypertrophy reflecting left-ventricular compression was reported in a selected group of patients with cardiac tamponade. HYPOTHESIS:Criteria for the presence of pseudohypertrophy can be established to guide its use as a sign of left-ventricular compression in patients with cardiac tam...
journal_title:Cardiology
pub_type: 杂志文章
doi:10.1159/000047319
更新日期:2000-01-01 00:00:00
abstract:BACKGROUND:The association between height and cardiovascular disease (CVD) has been reported in epidemiological studies for decades; however, the mechanism for this relationship is still unclear. We previously reported that dyslipidemia was associated with adult height in Korean men without CVD. OBJECTIVES:This study ...
journal_title:Cardiology
pub_type: 新闻
doi:10.1159/000509631
更新日期:2020-01-01 00:00:00
abstract:OBJECTIVES:β-Thalassemias are inherited hemolytic anemias with a broad phenotype and an increased rate of vascular complications despite a near absence of coronary artery disease. METHODS:We investigated the presence of endothelial dysfunction and subclinical atherosclerosis in non-transfusion-dependent patients with ...
journal_title:Cardiology
pub_type: 杂志文章
doi:10.1159/000327997
更新日期:2011-01-01 00:00:00
abstract::Lower extremity atherosclerosis results in significant morbidity in women, particularly in women following the menopause. Up to 25% of women aged 55 to 74 years are affected by this disease. When noninvasive testing is used to determine the prevalence of lower extremity atherosclerosis, and men in this age group are e...
journal_title:Cardiology
pub_type: 杂志文章,评审
doi:10.1159/000176899
更新日期:1995-01-01 00:00:00
abstract::The early administration of nitrates in acute myocardial infarction (AMI) may lower myocardial oxygen demand and increase blood supply to the ischemic myocardium. Actually, nitrates are the drugs most largely used in AMI patients, but no definite proof of their clinical benefits had been reported before GISSI 3 and IS...
journal_title:Cardiology
pub_type: 杂志文章,meta分析
doi:10.1159/000176441
更新日期:1994-01-01 00:00:00
abstract::The subcutaneous implantable cardioverter defibrillator (S-ICD) registry included very few patients with a body mass index (BMI) greater than 40. We present a case of a 40-year-old male with a BMI of 44 and ejection fraction of 25% who underwent S-ICD implantation for primary prevention of sudden cardiac death in the ...
journal_title:Cardiology
pub_type: 杂志文章
doi:10.1159/000447484
更新日期:2017-01-01 00:00:00
abstract::Renal hemodynamics in essential hypertensives is characterized by an increase in renal vascular resistance (RVR) and a decrease in renal plasma flow (RPF), while glomerular filtration rate (GFR) is either normal or slightly decreased. Filtration fraction (FF) is increased, indicating that vasoconstriction predominantl...
journal_title:Cardiology
pub_type: 杂志文章,评审
doi:10.1159/000176006
更新日期:1993-01-01 00:00:00
abstract::Spontaneous coronary artery dissection (SCAD) is a rare pathology, principally affecting young women free of atheroma risk factors. Its physiopathology remains little understood, and the prognosis for such acute coronary syndromes is poor, as they occur suddenly. Management is often difficult, and no guidelines exist....
journal_title:Cardiology
pub_type: 杂志文章,评审
doi:10.1159/000244608
更新日期:2010-01-01 00:00:00
abstract::Previous studies have compared the outcome between patients with and without a confirmed acute myocardial infarction (AMI) mainly during the first few years after its onset. Our aim was to compare the prognosis between patients with and without a confirmed AMI during 10 years of follow-up. Patients participating in an...
journal_title:Cardiology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1159/000176529
更新日期:1994-01-01 00:00:00
abstract::Coronary arteries in diabetic patients appear to be narrower than in normal subjects, but this has not been examined systematically. To investigate this hypothesis we reviewed the data of 711 consecutive patients with angiographically 'normal coronary arteries'. Excluded were patients with valvular, myocardial or peri...
journal_title:Cardiology
pub_type: 杂志文章
doi:10.1159/000006764
更新日期:1998-01-01 00:00:00
abstract::The purpose of this study was to elucidate the mechanism that induces an improvement in exercise capacity by nitrates in patients with stable effort angina pectoris. The study population was composed of 19 patients: group A, 10 patients with chronic stable effort angina who had a well-developed coronary collateral cir...
journal_title:Cardiology
pub_type: 杂志文章
doi:10.1159/000174812
更新日期:1991-01-01 00:00:00
abstract::Bromocriptine-induced coronary spasm (BICS) causing myocardial infarction has been reported. Association between BICS and Takotsubo syndrome (TS) has not been described. We report on a 37-year-old woman presenting with a clinical picture of acute coronary syndrome 1 day after initiation of treatment with bromocriptine...
journal_title:Cardiology
pub_type: 杂志文章
doi:10.1159/000329349
更新日期:2011-01-01 00:00:00
abstract::We evaluated the efficacy and safety of daily administration of gallopamil 150 mg/day and its effects on myocardial perfusion in a medium-term, randomized, double-blind, cross-over, placebo-controlled trial. We studied 19 patients (17 males and 2 females; mean age 57 +/- 6.8 years) with stable effort angina, angiograp...
journal_title:Cardiology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1159/000177359
更新日期:1997-07-01 00:00:00
abstract::Aortic valve myxoma is an extremely rare cardiac tumour. We describe a 60-year-old woman found to have an aortic valve myxoma and a patent foramen ovale (PFO) presenting as a stroke. In view of the recurrent cerebral ischaemic events, the aortic valve myxoma was surgically removed and the PFO was closed. To the best o...
journal_title:Cardiology
pub_type: 杂志文章
doi:10.1159/000327081
更新日期:2011-01-01 00:00:00
abstract:OBJECTIVES:Systemic or local inflammation causes cardiac nerve sprouting and consequent arrhythmia. Metoprolol can prevent sympathetic nerve remodeling after myocardial infarction (MI), but the underlying mechanism is unclear. In this study, we evaluated the role of metoprolol in ameliorating sympathetic sprouting. ME...
journal_title:Cardiology
pub_type: 杂志文章
doi:10.1159/000351074
更新日期:2013-01-01 00:00:00
abstract:OBJECTIVE:To assess improvement in predictive performance of Global Registry of Acute Coronary Events risk score (GRS) by addition of a glucose matrix. METHODS:1,056 acute coronary syndrome (ACS) survivors without known diabetes had pre-discharge fasting (FPG) and 2-h post-load plasma glucose (2h-PG) measured. GRS was...
journal_title:Cardiology
pub_type: 杂志文章
doi:10.1159/000509180
更新日期:2020-01-01 00:00:00
abstract::Of 1,125 patients catheterized over a period of 8 years, 68 (6%) had coronary ectasia. Twenty-five of them were catheterized at least twice and constituted the study group. The time between the first and last catheterization ranged from 2 to 8 years (mean +/- SD = 4.2 +/- 1.6). Coronary ectasia was more frequent in ma...
journal_title:Cardiology
pub_type: 杂志文章
doi:10.1159/000176907
更新日期:1995-01-01 00:00:00
abstract::In a group of eight patients with ventricular premature beats, ventriculoatrial conduction, with retrograde activation of the His bundle and the atria could be demonstrated by His bundle electrograms in four subjects. All had early ventricular premature beats with coupling indices between 210 and 350 msec. In the othe...
journal_title:Cardiology
pub_type: 杂志文章
doi:10.1159/000169687
更新日期:1974-01-01 00:00:00
abstract::Fifteen congestive heart failure patients (NYHA: class III or IV) were enrolled in the study and were classified into two groups. Six patients (group I) received combined therapy by nitroglycerin tape (5 mg) and ibopamine (100 mg), while the remaining 9 patients (group II) were given nitroglycerin tape (5 mg) and nife...
journal_title:Cardiology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1159/000174696
更新日期:1990-01-01 00:00:00
abstract::Protruding aortic plaques--especially those with mobile properties--on transesophageal echocardiography (TEE) are a potential source of stroke and systemic embolism in the elderly. Whether the various morphologies of atheromas with mobile components represent potential differences in the risk for embolic events has no...
journal_title:Cardiology
pub_type: 杂志文章
doi:10.1159/000006795
更新日期:1998-05-01 00:00:00
abstract::The National Exercise and Heart Disease Project (NEHDP) was funded by the Rehabilitation Services Administration (RSA) of the Department of Health, Education and Welfare, to determine the effects of regular physical activity on the rehabilitation, morbidity and mortality of patients with healed myocardial infarctions....
journal_title:Cardiology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1159/000169916
更新日期:1978-01-01 00:00:00
abstract:BACKGROUND:We compared the effect of arterial remodeling on intimal hyperplasia (IH) after the implantation of a sirolimus-eluting stent (SES) and a paclitaxel-eluting stent (PES). METHODS:The study population consisted of patients with positive or intermediate remodeling and negative remodeling. RESULTS:Sixty-nine p...
journal_title:Cardiology
pub_type: 杂志文章
doi:10.1159/000317071
更新日期:2010-01-01 00:00:00
abstract::In this first clinical report of an idiopathic familial persistently short QT interval (QTI), we describe three members of one family (a 17-year-old female, her 21-year-old brother, and their 51-year-old mother) demonstrating this ECG phenomenon, associated in the 17-year-old with several episodes of paroxysmal atrial...
journal_title:Cardiology
pub_type: 杂志文章
doi:10.1159/000047299
更新日期:2000-01-01 00:00:00