Abstract:
INTRODUCTION:There is no consensus regarding the natural history of rheumatic mitral stenosis (MS) among adults presenting with nonsevere disease. This study aims to describe the progression of stenosis among adult rheumatic MS patients, to identify predictive factors for progression, and to assess the incidence of complications. METHODS:A retrospective cohort analysis was performed among patients with rheumatic MS treated at a single center. Eighty-five patients were included with mild to moderate MS, ≥30 years old on initial echocardiography. Demographics, medical history, echocardiographic reports over at least 10 years, and related complications were obtained from a computerized database. RESULTS:Over a period of 13.1 ± 2.38 years, 75 patients (88%) had no significant progression in stenosis severity. The final echocardiographic assessment demonstrated 2 groups with a significant difference between them regarding the mitral valve area (1.58 ± 0.44 vs. 1.1 ± 0.26 cm2, p = 0.001) and mean valvular pressure gradient (6.27 ± 2.52 vs. 8.5 ± 2.69 mm Hg, p = 0.01). Patients with indolent MS (group A) were compared to patients with progressive disease (group B), and a higher percent of Bedouin patients were found in group B (OR 8.036, p = 0.015). No significant differences were found in other parameters. Complications including atrial fibrillation, cerebral ischemic events, and impaired right ventricle function, although frequent, were not statistically different between the groups. CONCLUSIONS:An indolent natural progression of rheumatic MS was observed in our study. Despite this finding, it still has potentially deleterious effects. Bedouin patients have a higher risk for progressive disease.
journal_name
Cardiologyjournal_title
Cardiologyauthors
Bitan A,Mazor-Dray E,Weinstein JM,Carmel S,Ilia Rdoi
10.1159/000505481subject
Has Abstractpub_date
2020-01-01 00:00:00pages
155-160issue
3eissn
0008-6312issn
1421-9751pii
000505481journal_volume
145pub_type
杂志文章相关文献
CARDIOLOGY文献大全abstract:OBJECTIVE:Niacin is underutilized due to flushing, which occurs in over 90% of niacin-treated patients. Laropiprant (LRPT) reduces flushing associated with niacin. This study compared flushing with a combination tablet of extended-release (ER) niacin (ERN)/LRPT to niacin ER (N-ER; without LRPT) during the first week of...
journal_title:Cardiology
pub_type: 杂志文章,随机对照试验
doi:10.1159/000228585
更新日期:2009-01-01 00:00:00
abstract::Heart failure (HF) with reduced ejection fraction (HFrEF) has a well-known epidemic relevance in western countries. It affects up to 1-2% of patients > 60 years and reaches a prevalence of 12% in octogenarian patients. The role of N-terminal pro-B-type natriuretic peptide (NT-proBNP) and high-sensitive troponin I (hsT...
journal_title:Cardiology
pub_type: 杂志文章
doi:10.1159/000488640
更新日期:2019-01-01 00:00:00
abstract::Patients with Marfan syndrome are at risk for ascending aortic dilation and dissection at the level of the aortic sinuses, making aortic root and valve replacement common. Patients undergoing an aortic root replacement with concomitant replacement of the aortic valve with a bioprosthesis (Bio-Bentall) are predisposed ...
journal_title:Cardiology
pub_type: 杂志文章
doi:10.1159/000357265
更新日期:2014-01-01 00:00:00
abstract::Acute renal infarction due to emboli represents a very rare but significant threat for kidney loss, and the clinical presentation is challenging. The differential diagnosis of massive renal thrombi includes all other causes of abdominal pain, and they can be easily misdiagnosed as renal colic due to nephrolithiasis. A...
journal_title:Cardiology
pub_type: 杂志文章
doi:10.1159/000322510
更新日期:2010-01-01 00:00:00
abstract::The acute effects of therapeutic doses of intravenous tolbutamide and glibornuride on the systolic time intervals (QS2c, LVETc, PEPc and PEP/LVET) were examined in 5 healthy volunteers. Blood sugar was maintained constant throughout the study. No significant changes of these intervals as well as of heart rate and bloo...
journal_title:Cardiology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1159/000170617
更新日期:1979-01-01 00:00:00
abstract::In a prospective randomized short-term study, the efficacy and safety of xipamide and a combination of spironolactone and furosemide were compared in the treatment of hepatic cirrhotic ascites. Twenty-two patients were randomized to either xipamide, 20 mg/day (group I), or spironolactone, 200 mg/day, combined with fur...
journal_title:Cardiology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1159/000176461
更新日期:1994-01-01 00:00:00
abstract::Ventricular late potentials are obtained by signal averaging of surface electrocardiograms. Late potentials have been reported to be affected by body size or left ventricular mass. However, the effect of subadipose tissue, which is known to influence QRS amplitudes of surface ECG, on the variables of late potentials h...
journal_title:Cardiology
pub_type: 杂志文章
doi:10.1159/000175854
更新日期:1993-01-01 00:00:00
abstract::CD18 integrins mediate leucocyte adhesion to vascular endothelium. This represents the initial step in inflammatory cell infiltration following myocardial necrosis. The current study assessed whether the expression of these rapidly activated and readily measured adhesion receptors on circulating neutrophils would refl...
journal_title:Cardiology
pub_type: 杂志文章
doi:10.1159/000047341
更新日期:2001-01-01 00:00:00
abstract::The EKG response to exercise and the working capacity in a group of 70 patients with positive serology for Chagas' disease has been determined by stress testing on a bicycle-ergometer, in order to establish the usefulness of such a test in the early diagnosis of Chagas' cardiomyopathy. The exercise EKG provides inform...
journal_title:Cardiology
pub_type: 杂志文章
doi:10.1159/000169915
更新日期:1978-01-01 00:00:00
abstract::Ticagrelor has been shown to be superior to clopidogrel in patients presenting with acute myocardial infarction who undergo early invasive treatment. We discuss a hitherto unreported use of ticagrelor in the management of a patient resistant to multiple thienopyridines at high risk of stent thrombosis. ...
journal_title:Cardiology
pub_type: 杂志文章
doi:10.1159/000329916
更新日期:2011-01-01 00:00:00
abstract::We performed this study in order to compare the immediate and mid-term outcomes of sirolimus-eluting stents (SES) and paclitaxel-eluting stents (PES) in lesions of the unprotected left main coronary artery (LMCA). We assessed 54 patients from 5 centers who had undergone unprotected LMCA stenting (35 SES and 19 PES). T...
journal_title:Cardiology
pub_type: 杂志文章,多中心研究
doi:10.1159/000088106
更新日期:2005-01-01 00:00:00
abstract::A mother and her two children with idiopathic ascending aortic dilatation are reported. This provides further evidence that genetic factors are involved in the etiology of aortic aneurysms and calls for screening first-degree family members, including children, of young adult patients diagnosed with this condition. ...
journal_title:Cardiology
pub_type: 杂志文章
doi:10.1159/000006949
更新日期:1999-01-01 00:00:00
abstract:OBJECTIVE:Left atrial (LA) mechanical function is thought to be virtually inexistent in patients with permanent atrial fibrillation (AF). Due to recent advances in multidetector computed tomography (MDCT) technology, it is now possible to acquire images of the entire heart in a single heartbeat. The objective of this s...
journal_title:Cardiology
pub_type: 杂志文章
doi:10.1159/000365915
更新日期:2014-01-01 00:00:00
abstract::Normal subjects and cardiac chagasic patients without previous history of congestive failure or actual evidences of cardiac decompensation were exercised on a treadmill or a bicycle ergometer. Patients with less than the expected increase in heart rate during exercise were found to exhibit also an abnormal heart rate ...
journal_title:Cardiology
pub_type: 杂志文章
doi:10.1159/000169713
更新日期:1975-01-01 00:00:00
abstract::Protruding aortic plaques--especially those with mobile properties--on transesophageal echocardiography (TEE) are a potential source of stroke and systemic embolism in the elderly. Whether the various morphologies of atheromas with mobile components represent potential differences in the risk for embolic events has no...
journal_title:Cardiology
pub_type: 杂志文章
doi:10.1159/000006795
更新日期:1998-05-01 00:00:00
abstract::The multivariate analysis approach in 30 normal subjects and 84 patients significantly improved the sensitivity and correct classification rate when compared to the stress test (ST) response (p less than 0.05). Although the probability of disease could separate normal from diseased subjects, it could not separate sing...
journal_title:Cardiology
pub_type: 杂志文章
doi:10.1159/000173314
更新日期:1981-01-01 00:00:00
abstract:INTRODUCTION:COVID-19 is a rapidly growing infectious disease that represents an immediate threat for the health of millions of people around the world, both in direct and indirect ways. CASE PRESENTATION:In the present report we describe the development of stress cardiomyopathy in a patient who was overwhelmingly str...
journal_title:Cardiology
pub_type:
doi:10.1159/000511450
更新日期:2020-01-01 00:00:00
abstract::Spontaneous coronary artery dissection (SCAD) is a rare pathology, principally affecting young women free of atheroma risk factors. Its physiopathology remains little understood, and the prognosis for such acute coronary syndromes is poor, as they occur suddenly. Management is often difficult, and no guidelines exist....
journal_title:Cardiology
pub_type: 杂志文章,评审
doi:10.1159/000244608
更新日期:2010-01-01 00:00:00
abstract::The diagnostic values of adenosine, dobutamine, and exercise radionuclide ventriculography (RNVG) in the detection of coronary artery disease (CAD), and the characteristics of those patients who showed myocardial ischemia during the infusion of adenosine or dobutamine were assessed in 41 patients with suspected CAD. S...
journal_title:Cardiology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1159/000177327
更新日期:1997-03-01 00:00:00
abstract:OBJECTIVE:The systematic pro-inflammatory responses after percutaneous coronary intervention with drug-eluting stents (DES) remain poorly defined. Therefore, we compared the systematic pro-inflammatory state of circulating mononuclear cells (MNCs) between DES and bare metal stent (BMS) implantation. METHODS:Patients w...
journal_title:Cardiology
pub_type: 杂志文章,随机对照试验
doi:10.1159/000358508
更新日期:2014-01-01 00:00:00
abstract:OBJECTIVES:Red blood cell microparticles (RBCm) have potential adverse vascular effects and they have been shown to be elevated in ST elevation myocardial infarction (STEMI). The purpose of this study is to investigate their relationship with biochemical infarct size. METHODS:RBCm were quantified with flow cytometry i...
journal_title:Cardiology
pub_type: 杂志文章
doi:10.1159/000447625
更新日期:2017-01-01 00:00:00
abstract::The current study examined the effects of temperature on myocardial pH, contractile function and adenosine triphosphate metabolism, particularly the production of adenosine. We matched intermittent delivery of blood cardioplegia in two groups (hypothermia 15 degrees C; normothermia 37 degrees C), for 2 h of cardiopleg...
journal_title:Cardiology
pub_type: 杂志文章
doi:10.1159/000177148
更新日期:1996-11-01 00:00:00
abstract::A previous study in rabbit hearts demonstrated the feasibility of creating transmyocardial channels by application of temperature-regulated high-frequency (HF) energy. Feasibility of creating non-transmural channels using a transvascular approach was tested in 14 pigs which were followed for 1 h, and 3 and 9 weeks (gr...
journal_title:Cardiology
pub_type: 杂志文章
doi:10.1159/000068450
更新日期:2003-01-01 00:00:00
abstract::The combination of oral anticoagulation (OAC) and aspirin was the antithrombotic treatment initially adopted after coronary stenting (PCI-S). Although dual antiplatelet therapy with aspirin and a thienopyridine subsequently proved safer and more effective, OAC and aspirin combination is still used in patients with an ...
journal_title:Cardiology
pub_type: 杂志文章,meta分析
doi:10.1159/000086918
更新日期:2005-01-01 00:00:00
abstract::Seventy-two patients aged 2-65 years (mean 20.2) with fixed subaortic stenosis (FSS) are reported. All patients underwent echocardiography and angiography prior to surgical intervention. Sixty-four (89%) had discrete subaortic stenosis (DSS) and 8 (11%) tunnel type stenosis (TSS). Patients with DSS aged 2-65 years (me...
journal_title:Cardiology
pub_type: 杂志文章,评审
doi:10.1159/000006939
更新日期:1999-01-01 00:00:00
abstract::Although very useful agents, fluoroquinolones are associated with a number of adverse events, some with considerable clinical significance. Prolongation of the QT interval, for example, is an adverse effect associated with the use of fluoroquinolones. Fluoroquinolones prolong the QT interval by blocking voltage-gated ...
journal_title:Cardiology
pub_type: 杂志文章,评审
doi:10.1159/000334441
更新日期:2011-01-01 00:00:00
abstract::A 50-year-old man with intermittent ventricular parasystolic bigeminy is reported in whom the parasystolic focus was protected from late intervening sinus impulses. This is the first report to suggest the presence of protection due to interference in parasystolic bigeminy. The findings in this case suggest that when a...
journal_title:Cardiology
pub_type: 杂志文章
doi:10.1159/000174583
更新日期:1990-01-01 00:00:00
abstract::We investigated in 306 patients, mean age 57 +/- 10 years, with diabetes mellitus (202 patients) or hypertension (179 patients) whether microalbuminuria was a significant independent risk factor for the development of new stroke or new myocardial infarction (MI) or death. At 39-month follow-up, new stroke or new MI or...
journal_title:Cardiology
pub_type: 杂志文章
doi:10.1159/000105327
更新日期:2008-01-01 00:00:00
abstract:OBJECTIVE:To investigate the effect of nicotine on cardiomyocyte apoptosis in vitro and explore the potential mechanisms involved. METHODS:The MTT assay was used to detect the viability of cultured cardiomyocytes exposed to different concentrations of nicotine (0.1-100 microM). Laser confocal microscopy, TUNEL assay a...
journal_title:Cardiology
pub_type: 杂志文章
doi:10.1159/000301278
更新日期:2010-01-01 00:00:00
abstract:BACKGROUND:C-reactive protein (CRP) is a well-established inflammation marker associated with cardiovascular risk. However, its relationship with chitotriosidase activity, a novel marker of activated macrophages highly expressed in human atherosclerotic plaques, is unknown. Therefore, we sought to determine if serum ch...
journal_title:Cardiology
pub_type: 杂志文章
doi:10.1159/000099099
更新日期:2007-01-01 00:00:00