Hemodynamics of a stenosis in a complaint artery.

Abstract:

:The effects of arterial compliance on stenotic hemodynamics were examined in an in vitro arterial preparation. Carotid arteries, obtained from anesthetized mongrel dogs (11.3-15.4 kg), were attached to a perfusion apparatus consisting of a constant pressure reservoir and a fixed distal resistance. To create an intraluminal stenosis a balloon catheter was partially inflated within the artery. Pressures proximal and distal to the arterial segment and flow through the arterial segment were measured. Stenotic resistance was calculated as the pressure gradient across the stenosis divided by the flow. Using this preparation, stenotic resistance was shown to be dependent on perfusion pressure and peripheral resistance. Decreasing the perfusion pressure from 141 +/- 1.4 to 78 +/- 0.3 caused stenotic resistance to increase from 0.72 +/- 0.10 to 9.10 +/- 1.18 mm Hg . ml-1. min (p greater than 0.01). Reducing the peripheral resistance caused stenotic resistance to increase from 1.16 +/- 0.22 to 2.37 +/- 0.29 (p greater than 0.05). Further, these arterial stenoses present in the compliant artery were unstable. In striking contrast, fixed stenoses, obtained by replacing the artery with a glass rod, were stable and not affected by perfusion pressure or peripheral resistance. Dynamic stenoses respond differently than fixed stenoses to the same interventions.

journal_name

Cardiology

journal_title

Cardiology

authors

Santamore WP,Bove AA,Carey RA

doi

10.1159/000173478

subject

Has Abstract

pub_date

1982-01-01 00:00:00

pages

1-10

issue

1

eissn

0008-6312

issn

1421-9751

journal_volume

69

pub_type

杂志文章
  • Persistent thallium-201 defect: can clinical, electrocardiographic and exercise hemodynamic variables predict defect normalization with reinjection?

    abstract::This study was designed to assess the contribution of clinical, electrocardiographic and exercise hemodynamic variables to the prediction of normalization on resting reinjection scintigraphy of persistent thallium-201 (201Tl) myocardial perfusion defects seen with exercise and 2- to 4-hour delayed (redistribution) ima...

    journal_title:Cardiology

    pub_type: 杂志文章

    doi:10.1159/000177093

    authors: Shammas NW,Schwartz RG,Pomerantz RM,Murphy GW,Hall WJ

    更新日期:1996-05-01 00:00:00

  • Fixed subaortic stenosis revisited. congenital abnormalities in 72 new cases and review of the literature.

    abstract::Seventy-two patients aged 2-65 years (mean 20.2) with fixed subaortic stenosis (FSS) are reported. All patients underwent echocardiography and angiography prior to surgical intervention. Sixty-four (89%) had discrete subaortic stenosis (DSS) and 8 (11%) tunnel type stenosis (TSS). Patients with DSS aged 2-65 years (me...

    journal_title:Cardiology

    pub_type: 杂志文章,评审

    doi:10.1159/000006939

    authors: Tentolouris K,Kontozoglou T,Trikas A,Brilli S,Chlapoutakis E,Exadactylos N,Pitsavos C,Toutouzas P

    更新日期:1999-01-01 00:00:00

  • The value of combining CYP2C19*2 polymorphism with classic risk factors in prediction of clinical prognosis in acute coronary syndrome patients.

    abstract:OBJECTIVES:To assess the impact of different CYP2C19*2 polymorphisms on clinical outcomes and the effects of CYP2C19*2 polymorphism on predicting clinical outcomes in association with classic risk factors in patients with acute coronary syndromes (ACS). METHODS:Between July 2008 and September 2009, 497 consecutive pat...

    journal_title:Cardiology

    pub_type: 杂志文章

    doi:10.1159/000329048

    authors: Yan SD,Chen M,Li Q,Liu XJ,Peng Y,Chai H,Xu YN,Wei JF,Huang DJ

    更新日期:2011-01-01 00:00:00

  • Clinical value of the pitch of the third heart sound in ischemic heart disease.

    abstract::The study investigates the genesis of the third heart sound (S3) in ischemic heart disease based on a mass-spring model. In such a system, the natural frequency of vibration, Fn, depends on the elastic constant, k, and the mass, m, according to the following relationship: Fn = 1/2 pi square root of k/m. To identify th...

    journal_title:Cardiology

    pub_type: 杂志文章

    doi:10.1159/000174588

    authors: Aggio S,Baracca E,Brunazzi C,Sgobino P,Aubert AE,Longhini C

    更新日期:1990-01-01 00:00:00

  • Advanced atrioventricular block and complete left bundle branch block in a case of Takayasu's aortitis.

    abstract::A 56-year-old woman, who had received an aortic valve replacement suffered from complete left bundle branch block and advanced atrioventricular block. On the basis of marked systemic inflammatory findings on admission and histopathological findings on previous cardiac surgery, this patient was considered to have condu...

    journal_title:Cardiology

    pub_type: 杂志文章

    doi:10.1159/000174579

    authors: Naitoh M,Chino M,Sakai T,Saitoh S,Ohkura M,Nishikawa K

    更新日期:1990-01-01 00:00:00

  • Ten-year mortality among patients with suspected acute myocardial infarction in relation to early diagnosis.

    abstract::Previous studies have compared the outcome between patients with and without a confirmed acute myocardial infarction (AMI) mainly during the first few years after its onset. Our aim was to compare the prognosis between patients with and without a confirmed AMI during 10 years of follow-up. Patients participating in an...

    journal_title:Cardiology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1159/000176529

    authors: Herlitz J,Karlson BW,Hjalmarson A

    更新日期:1994-01-01 00:00:00

  • Relationship of baseline major risk factors to coronary and all-cause mortality, and to longevity: findings from long-term follow-up of Chicago cohorts.

    abstract::The focus here is on relationships between major risk factors and long-term mortality from coronary heart disease (CHD) and all causes, and on longevity, in Chicago cohorts: 25-year follow-up for Peoples Gas (PG) men aged 25-39 (n = 1,119), 30-year follow-up for PG men aged 40-59 (n = 1,235), 24-year follow-up for Wes...

    journal_title:Cardiology

    pub_type: 杂志文章

    doi:10.1159/000175868

    authors: Stamler J,Dyer AR,Shekelle RB,Neaton J,Stamler R

    更新日期:1993-01-01 00:00:00

  • Stress testing and working capacity in Chagas' cardiomyopathy.

    abstract::The EKG response to exercise and the working capacity in a group of 70 patients with positive serology for Chagas' disease has been determined by stress testing on a bicycle-ergometer, in order to establish the usefulness of such a test in the early diagnosis of Chagas' cardiomyopathy. The exercise EKG provides inform...

    journal_title:Cardiology

    pub_type: 杂志文章

    doi:10.1159/000169915

    authors: Hirschhaut E,Aparicio JM

    更新日期:1978-01-01 00:00:00

  • Sleep quality and quality of life in patients with hypertrophic cardiomyopathy.

    abstract:OBJECTIVES:To evaluate clinical predictors of poor sleep quality and quality of life (QOL) in patients with hypertrophic cardiomyopathy (HCM). METHODS:Consecutive stable patients with HCM were evaluated for the risk of obstructive sleep apnea (OSA) by the Berlin Questionnaire, daytime sleepiness by the Epworth Sleepin...

    journal_title:Cardiology

    pub_type: 杂志文章

    doi:10.1159/000321718

    authors: Pedrosa RP,Lima SG,Drager LF,Genta PR,Amaro AC,Antunes MO,Arteaga E,Mady C,Lorenzi-Filho G

    更新日期:2010-01-01 00:00:00

  • Abnormal left ventricular filling pattern in patients with single vessel coronary artery disease: effect of angioplasty.

    abstract::To study the effect of coronary angioplasty (PTCA) on left ventricular (LV) diastolic filling, mitral Doppler flow tracings of 15 patients with isolated stenosis of the left anterior descending coronary artery (LAD) and normal systolic LV function were recorded before PTCA as well as 24 h and 3 months after successful...

    journal_title:Cardiology

    pub_type: 杂志文章

    doi:10.1159/000175007

    authors: Ricou F,Lerch R,Meier B,Rutishauser W

    更新日期:1992-01-01 00:00:00

  • Early-onset familial dilatation of the ascending aorta.

    abstract::A mother and her two children with idiopathic ascending aortic dilatation are reported. This provides further evidence that genetic factors are involved in the etiology of aortic aneurysms and calls for screening first-degree family members, including children, of young adult patients diagnosed with this condition. ...

    journal_title:Cardiology

    pub_type: 杂志文章

    doi:10.1159/000006949

    authors: Beghetti M,Steinmann B,Didier D,Kalangos A,Bottani A

    更新日期:1999-01-01 00:00:00

  • Peripheral arterial-vascular disease in women: prevalence, prognosis, and treatment.

    abstract::Lower extremity atherosclerosis results in significant morbidity in women, particularly in women following the menopause. Up to 25% of women aged 55 to 74 years are affected by this disease. When noninvasive testing is used to determine the prevalence of lower extremity atherosclerosis, and men in this age group are e...

    journal_title:Cardiology

    pub_type: 杂志文章,评审

    doi:10.1159/000176899

    authors: Gerhard M,Baum P,Raby KE

    更新日期:1995-01-01 00:00:00

  • Does chronic ST segment elevation following Q wave myocardial infarction exclude tissue viability?

    abstract:PURPOSE:Electrocardiographic (ECG) ST segment elevation lasting 2 or more weeks following Q wave myocardial infarction has been associated with 'ventricular aneurysm' and absence of tissue viability. Regional systolic dysfunction may reflect either viable myocardium or scar. Positron emission-tomographic (PET) imaging ...

    journal_title:Cardiology

    pub_type: 杂志文章

    doi:10.1159/000072386

    authors: Saber W,Nishime EO,Brunken RC,Apperson-Hansen C,Mills RM

    更新日期:2003-01-01 00:00:00

  • A pilot study exploring the mechanisms involved in the longitudinal propagation of acute aortic dissection through computational fluid dynamic analysis.

    abstract:OBJECTIVE:This study sought to elucidate the underlying hemodynamic mechanisms involved in the longitudinal propagation of acute, type-B aortic dissections. METHODS:Three-dimensional patient-specific aortic geometry was reconstructed from computed tomography images of 3 cases, followed by computational fluid dynamic a...

    journal_title:Cardiology

    pub_type: 杂志文章

    doi:10.1159/000358041

    authors: Zhang Y,Lu Q,Feng J,Yu P,Zhang S,Teng Z,Gillard JH,Song R,Jing Z

    更新日期:2014-01-01 00:00:00

  • Seven-year experience of noninvasive preoperative diagnostics in children with congenital heart defects: comprehensive analysis of 2,788 consecutive patients.

    abstract::The spectrum of patients operated on without preoperative catheterization and angiography, the accuracy of echocardiographic diagnosis and its impact on the results of surgical treatment were prospectively assessed in 2,788 children consecutively operated for congenital heart defects (CHD) between 1986 and 1992. The o...

    journal_title:Cardiology

    pub_type: 杂志文章

    doi:10.1159/000176928

    authors: Marek J,Skovránek J,Hucín B,Chaloupecký V,Tax P,Reich O,Samánek M

    更新日期:1995-01-01 00:00:00

  • [Physiology of orthostatic regulation].

    abstract::The arterial blood pressure is integrated into a feedback control system and practically depends on three parameters, i. e. blood volume, heart dynamics, and peripheral resistance. When circulation is disturbed in the orthostatic, the correcting elements heart and vessels have to adapt themselves according to this dem...

    journal_title:Cardiology

    pub_type: 杂志文章

    doi:10.1159/000169794

    authors: Rieckert H

    更新日期:1976-01-01 00:00:00

  • Protease-Activated Receptor 1 Contributes to Angiotensin II-Induced Cardiovascular Remodeling and Inflammation.

    abstract:BACKGROUND:Angiotensin II (Ang II) plays an important role in cardiovascular disease. It also leads to the activation of coagulation. The coagulation protease thrombin induces cellular responses by activating protease-activated receptor 1 (PAR-1). We investigated whether PAR-1 contributes to Ang II-induced cardiovascul...

    journal_title:Cardiology

    pub_type: 杂志文章

    doi:10.1159/000452269

    authors: Antoniak S,Cardenas JC,Buczek LJ,Church FC,Mackman N,Pawlinski R

    更新日期:2017-01-01 00:00:00

  • Postinfarction unstable angina. Pathophysiologic basis for current treatment modalities.

    abstract::Unstable angina is an acute coronary syndrome characterized by the rapid progression of clinical symptoms which may culminate in acute myocardial infarction, infarct extension or sudden death. The pathologic substrate involves atherosclerotic plaque rupture with platelet deposition, thrombus formation and coronary art...

    journal_title:Cardiology

    pub_type: 杂志文章,评审

    doi:10.1159/000174485

    authors: Becker RC,Gore JM,Alpert JS

    更新日期:1989-01-01 00:00:00

  • Randomized, double-blind, placebo-controlled, multicenter study of sibutramine in obese hypertensive patients.

    abstract:OBJECTIVES:To compare weight loss efficacy, safety and tolerability of sibutramine and placebo in mildly to moderately obese hypertensive subjects; to assess the effect of weight loss on blood pressure. DESIGN:Randomized, double-blind, parallel-group; 3-week placebo run-in and 12-week treatment phase. SETTING:Nine ho...

    journal_title:Cardiology

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:10.1159/000047310

    authors: Hazenberg BP

    更新日期:2000-01-01 00:00:00

  • Burden of late repeat hospitalization in patients undergoing angioplasty or bypass surgery. A long-term (13 years) report from the Lady Davis Carmel Medical Center registry.

    abstract::We investigated the incidence and determinants of early and late repeat hospitalization for cardiac causes in 378 patients following myocardial revascularization [199 coronary balloon angioplasty (PTCA), 179 coronary bypass surgery (CABG)] in a single cardiovascular center and followed for a median period of 13 years....

    journal_title:Cardiology

    pub_type: 杂志文章

    doi:10.1159/000064681

    authors: Halon DA,Rennert HS,Flugelman MY,Jaffe R,Lewis BS

    更新日期:2002-01-01 00:00:00

  • Optimal treatment of stable angina.

    abstract::Angina pectoris due to coronary artery disease is a common manifestation of myocardial ischemia. Reduction of oxygen demand (beta-blockers) and relief of coronary vasoconstriction (calcium blocker or nitrate) are additive approaches to controlling ischemia. Risk factor reduction may improve coronary vascular physiolog...

    journal_title:Cardiology

    pub_type: 杂志文章,评审

    doi:10.1159/000177503

    authors: Parmley WW

    更新日期:1997-01-01 00:00:00

  • Rheumatic Mitral Stenosis: Long-Term Follow-Up of Adult Patients with Nonsevere Initial Disease.

    abstract:INTRODUCTION:There is no consensus regarding the natural history of rheumatic mitral stenosis (MS) among adults presenting with nonsevere disease. This study aims to describe the progression of stenosis among adult rheumatic MS patients, to identify predictive factors for progression, and to assess the incidence of com...

    journal_title:Cardiology

    pub_type: 杂志文章

    doi:10.1159/000505481

    authors: Bitan A,Mazor-Dray E,Weinstein JM,Carmel S,Ilia R

    更新日期:2020-01-01 00:00:00

  • Measurement of coronary blood flow and flow reserve using magnetic resonance imaging.

    abstract:PURPOSE:It was the purpose of this study to demonstrate the feasibility of performing coronary artery flow and coronary flow reserve (CFR) measurements in normal human volunteers using a magnetic resonance (MR) phase contrast technique. MATERIALS AND METHODS:Coronary flow rate, flow velocity, peak flow and CFR were de...

    journal_title:Cardiology

    pub_type: 杂志文章

    doi:10.1159/000177314

    authors: Grist TM,Polzin JA,Bianco JA,Foo TK,Bernstein MA,Mistretta CM

    更新日期:1997-01-01 00:00:00

  • Surgical closure of the left atrial appendage - a beneficial procedure?

    abstract:BACKGROUND:Closure of the fibrillating left atrial appendage (LAA) has been recommended during valve surgery to decrease the risk of arterial embolism. However, patients undergoing surgical LAA closure have not systematically been reevaluated for complete LAA obliteration. METHODS AND RESULTS:During a 12-month period,...

    journal_title:Cardiology

    pub_type: 临床试验,杂志文章

    doi:10.1159/000087632

    authors: Schneider B,Stollberger C,Sievers HH

    更新日期:2005-01-01 00:00:00

  • Automated phonocardiographic screening for heart disease in children.

    abstract::Mass screening for heart disease in children can be accomplished by automatic analysis of phonocardiograms (PCG) obtained from five routine auscultation points. An ECG signal serves as reference. PCG signals exceeding 20% of the amplitude of the first heart sound S1 in the diastolic interval and 40% of S1 in the systo...

    journal_title:Cardiology

    pub_type: 杂志文章

    doi:10.1159/000169876

    authors: Ninova PP,Dascalov IK,Dimitrova MI

    更新日期:1978-01-01 00:00:00

  • Systolic anterior motion of the mitral valve with and without asymmetric septal hypertrophy. Role of left ventricular posterior wall motion.

    abstract::Abnormal systolic anterior (SAM) motion of the mitral valve without asymmetric hypertrophy of the interventricular septum was observed in 16 patients (group 1). 5 of the 16 patients had no other evidence of heart disease and the remaining 11 had a variety of cardiac disorders. Left ventricular dimensions, septal and p...

    journal_title:Cardiology

    pub_type: 杂志文章

    doi:10.1159/000170860

    authors: Udoshi M,Shah A,Fisher VJ,Dolgin M

    更新日期:1980-01-01 00:00:00

  • The relationship of plasminogen activator inhibitor-1 levels to the ST deviation pattern of acute myocardial infarction.

    abstract:OBJECTIVES:Myocardial infarction (MI) may be classified as ST elevation MI (STEMI) or non-ST elevation MI (NSTEMI). Procoagulants such as plasminogen activator inhibitor-1 (PAI-1) as well as markers of inflammation such as C-reactive protein (CRP), serum amyloid A (SAA) and interleukin-6 (IL-6) are elevated in acute co...

    journal_title:Cardiology

    pub_type: 杂志文章

    doi:10.1159/000137700

    authors: Rott D,Leibowitz D,Finci-Yeheskel Z,Barak V,Chajek-Shaul T,Weiss T,Levin M,Urieli-Shoval S

    更新日期:2009-01-01 00:00:00

  • Mechanism of vasodilation by nitrates: role of cyclic GMP.

    abstract::Nitrovasodilators relax vascular smooth muscle by stimulating soluble guanylate cyclase (GC). The resulting rise in cGMP probably initiates Ca extrusion from the smooth muscle cell which causes relaxation. Since repeated administration of organic nitrates, particularly nitroglycerin, leads to tolerance, i.e. a decreas...

    journal_title:Cardiology

    pub_type: 杂志文章

    doi:10.1159/000174258

    authors: Kukovetz WR,Holzmann S,Romanin C

    更新日期:1987-01-01 00:00:00

  • Topographic pattern of advanced atherosclerotic lesions in carotid arteries.

    abstract::Ulcers in extracranial carotid arteries are a known source of cerebral embolism. However, there are no data available on the prevalence of ulcerations located at the origin of these vessels in the aortic arch. Therefore, in this pathological study the topographic distribution of ulcerated lesions were determined in th...

    journal_title:Cardiology

    pub_type: 杂志文章

    doi:10.1159/000006793

    authors: Khatibzadeh M,Sheikhzadeh A,Gromoll B,Stierle U

    更新日期:1998-03-01 00:00:00

  • When an MI is not an MI: a case of varicella zoster myocarditis.

    abstract::A sixteen-year-old male presented with symptoms and investigations suggestive of acute myocardial infarction. The patient had suffered from a varicella zoster infection 5 days prior to presentation. Varicella myocarditis was suspected and diagnosed following treatment and positive varicella serology. This case highlig...

    journal_title:Cardiology

    pub_type: 杂志文章

    doi:10.1159/000106682

    authors: Kelly E,Cullen G,McGurk C

    更新日期:2008-01-01 00:00:00