Drug-eluting stent, but not bare metal stent, accentuates the systematic inflammatory response in patients.

Abstract:

OBJECTIVE:The systematic pro-inflammatory responses after percutaneous coronary intervention with drug-eluting stents (DES) remain poorly defined. Therefore, we compared the systematic pro-inflammatory state of circulating mononuclear cells (MNCs) between DES and bare metal stent (BMS) implantation. METHODS:Patients with indications for treatment with stents were randomized in a 1:1 ratio to placement of DES or BMS. The primary endpoint was a change of pro-inflammatory state at 12 weeks post-procedure. RESULTS:Thirty-six consecutive patients received DES or BMS. At 12 weeks after stent implantation, the lipid profile and high-sensitivity C-reactive protein (hs-CRP) improved significantly in both groups. The mRNA levels and plasma concentrations of interleukin-6, tumor necrosis factor-α and matrix metalloproteinase-9 were significantly elevated in the DES group, which was not observed in the BMS group. An increase in NF-κB binding activity and a decrease in PPAR-γ expression in MNCs were observed in the DES group, along with increases in IκB phosphorylation and p50 expression. However, similar changes were not observed in the BMS group. CONCLUSIONS:Systematic inflammatory responses were accentuated after the patients were treated percutaneously with DES, despite their improved lipid profile and hs-CRP. These data may provide fundamental information for optimizing therapeutic strategy in the era of DES.

journal_name

Cardiology

journal_title

Cardiology

authors

Liu J,Zhuo XZ,Liu W,Wan Z,Wang X,Zhang W,Gao S,Yuan Z,Wu Y

doi

10.1159/000358508

subject

Has Abstract

pub_date

2014-01-01 00:00:00

pages

259-65

issue

3

eissn

0008-6312

issn

1421-9751

pii

000358508

journal_volume

128

pub_type

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    pub_type: 临床试验,杂志文章,随机对照试验

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    pub_type:

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    pub_type: 杂志文章

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    更新日期:1993-01-01 00:00:00

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