Abstract:
:Lymphocytes can be activated to produce and release opioid peptides. We investigated the levels of immunoreactive beta-endorphin in peripheral blood mononuclear cells from 11 patients with acute myocardial infarction. The concentrations of beta-endorphin in mononuclear leukocytes of 30.2 +/- 6.9 pg/10(6) cells on admission were in the normal range of 20-40 pg/10(6) cells and decreased significantly to 6.9 +/- 1.9 pg/10(6) cells after 48 h (p < 0.05). Decreased levels of mononuclear leukocyte-associated beta-endorphin in acute myocardial infarction may be due to the release of endogenous opioid after stimulation by stress and acute-phase reactants and play a role in inflammation and pain.
journal_name
Cardiologyjournal_title
Cardiologyauthors
Buratti T,Schratzberger P,Dunzendorfer S,Manfreda SE,Pechlaner C,Joannidis M,Sacerdote P,Panerai AE,Wiedermann CJdoi
10.1159/000006815subject
Has Abstractpub_date
1998-07-01 00:00:00pages
43-7issue
1eissn
0008-6312issn
1421-9751pii
crd90043journal_volume
90pub_type
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