Decreased levels of beta-endorphin in circulating mononuclear leukocytes from patients with acute myocardial infarction.

Abstract:

:Lymphocytes can be activated to produce and release opioid peptides. We investigated the levels of immunoreactive beta-endorphin in peripheral blood mononuclear cells from 11 patients with acute myocardial infarction. The concentrations of beta-endorphin in mononuclear leukocytes of 30.2 +/- 6.9 pg/10(6) cells on admission were in the normal range of 20-40 pg/10(6) cells and decreased significantly to 6.9 +/- 1.9 pg/10(6) cells after 48 h (p < 0.05). Decreased levels of mononuclear leukocyte-associated beta-endorphin in acute myocardial infarction may be due to the release of endogenous opioid after stimulation by stress and acute-phase reactants and play a role in inflammation and pain.

journal_name

Cardiology

journal_title

Cardiology

authors

Buratti T,Schratzberger P,Dunzendorfer S,Manfreda SE,Pechlaner C,Joannidis M,Sacerdote P,Panerai AE,Wiedermann CJ

doi

10.1159/000006815

subject

Has Abstract

pub_date

1998-07-01 00:00:00

pages

43-7

issue

1

eissn

0008-6312

issn

1421-9751

pii

crd90043

journal_volume

90

pub_type

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