Abstract:
OBJECTIVES:The aim of this study was to define the phenotypic spectrum of apical hypertrophic cardiomyopathy (ApHCM) and clinical characteristics pertaining to identified subtypes. METHODS:In 182 consecutive ApHCM patients (58.9 +/- 11.2 years; 142 men) with left ventricular ejection fraction > or =50%, we measured end-diastolic wall thickness of all 16 left ventricular segments to determine patterns of hypertrophy. Echo-Doppler parameters, electrocardiography patterns, and clinical findings were analyzed. RESULTS:ApHCM was classified into three types as pure focal (n = 81), pure diffuse (n = 70) and mixed type (n = 31) according to patterns of hypertrophy. Incidence of atrial fibrillation (5% for pure focal vs. 11% for pure diffuse vs. 23% for mixed type, p < 0.05) and left atrial volume index (30.9 +/- 11.8, 35.7 +/- 14.8, and 41.3 +/- 15.9 ml/m(2), respectively, p < 0.001) were significantly different among subtypes. Peak systolic (6.6 +/- 1.0 vs. 6.3 +/- 1.2 vs. 5.9 +/- 1.1 cm/s, respectively, p < 0.05), diastolic (5.1 +/- 1.8 vs. 5.0 +/- 1.2 vs. 4.1 +/- 1.3 cm/s, respectively, p < 0.05) mitral annular velocity, E/E' (13.3 +/- 4.2 vs. 13.7 +/- 5.4 vs. 16.1 +/- 6.1, respectively, p < 0.05) were also significantly different. CONCLUSIONS:ApHCM contains three morphologically distinct phenotypes and detailed subtyping is important in the prediction of development of atrial fibrillation, left atrial volume index and left ventricular longitudinal function.
journal_name
Cardiologyjournal_title
Cardiologyauthors
Choi EY,Rim SJ,Ha JW,Kim YJ,Lee SC,Kang DH,Park SW,Song JK,Sohn DW,Chung Ndoi
10.1159/000109407subject
Has Abstractpub_date
2008-01-01 00:00:00pages
53-61issue
1eissn
0008-6312issn
1421-9751pii
000109407journal_volume
110pub_type
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