Induction of overdrive excitation in the sinoatrial node in the presence of caffeine.

Abstract:

:The induction of spontaneous repetitive activity by a drive ('overdrive excitation') was studied in the sinoatrial node of the guinea pig by recording electrical and mechanical activity in sinoatrial preparations made quiescent by exposure to 20 mM caffeine of caffeine plus high [Ca]0. Electrical drive induced action potentials that were followed by oscillatory potentials and simultaneous aftercontractions. The oscillatory potentials (and the associated aftercontractions) increased in magnitude with successive action potentials, thereby initiating spontaneous beats during slow drives or after fast drives. The repetitive activity eventually slowed and ceased abruptly as the oscillatory potential failed to attain the threshold. Overdrive induced oscillatory potential and aftercontractions even when it did not initiate spontaneous activity. These results suggest that in the presence of caffeine calcium overload can occur in the sinoatrial node and result in oscillatory potentials and abnormal automaticity.

journal_name

Cardiology

journal_title

Cardiology

authors

Vassalle M,Carbonin P,Iacono G,Di Gennaro M

doi

10.1159/000174372

subject

Has Abstract

pub_date

1988-01-01 00:00:00

pages

206-13

issue

3

eissn

0008-6312

issn

1421-9751

journal_volume

75

pub_type

杂志文章
  • Acute effects of biventricular pacing in heart failure patients with a normal ejection fraction and mechanical dyssynchrony.

    abstract:OBJECTIVES:We tested the acute effects of resynchronization in heart failure patients with a normal (>50%) left ventricular (LV) ejection fraction (HFNEF) and mechanical dyssynchrony. METHODS:Twenty-four HFNEF patients (72 ± 6 years, 5 male) with mechanical dyssynchrony (standard deviation of electromechanical time de...

    journal_title:Cardiology

    pub_type: 杂志文章

    doi:10.1159/000368795

    authors: Wang YC,Yu CC,Chiu FC,Splett V,Klepfer R,Hilpisch K,Tsai CT,Lai LP,Hwang JJ,Lin JL

    更新日期:2015-01-01 00:00:00

  • Hemodynamics and prognosis of patients with angina pectoris without coronary heart disease (syndrome X).

    abstract::A history of exercise-induced chest pain or even typical angina pectoris combined with normal coronary arteries is usually described with terms like small vessel disease or syndrome X [2, 5]. The aim of this paper is to study the hemodynamics at rest, and with exercise, and the outcome of patients with this syndrome. ...

    journal_title:Cardiology

    pub_type: 杂志文章

    doi:10.1159/000173325

    authors: Gleichmann U,Ohlmeier H,Mannebach H,Fassbender D

    更新日期:1981-01-01 00:00:00

  • Value of three-dimensional echocardiography as an adjunct to conventional transesophageal echocardiography.

    abstract::Three-dimensional imaging of cardiac structures could enhance the functional understanding and the interpretation of pathologies. Limited processing capabilities, relocation problems and inadequate two-dimensional image quality have previously limited its applicability. Recently, an integrated echocardiographic comput...

    journal_title:Cardiology

    pub_type: 杂志文章

    doi:10.1159/000177116

    authors: Binder T,Globits S,Zangeneh M,Gabriel H,Röthy W,Glogar D,Maurer G,Baumgartner H

    更新日期:1996-07-01 00:00:00

  • Detection of the earliest ventricular contraction site in patients with Wolff-Parkinson-White syndrome using two-dimensional guided M-mode tissue Doppler echocardiography.

    abstract:OBJECTIVE:The purpose of this study was to examine the feasibility of M-mode tissue Doppler imaging for localizing the accessory pathway in patients with Wolff-Parkinson-White (WPW) syndrome. METHODS:Two-dimensional guided tissue Doppler M-mode was recorded at the mitral and tricuspid annular levels in 13 WPW patients...

    journal_title:Cardiology

    pub_type: 杂志文章

    doi:10.1159/000006970

    authors: Nagai H,Takata S,Sakagami S,Furusho H,Takamura M,Yuasa T,Kobayashi K

    更新日期:1999-01-01 00:00:00

  • Brain natriuretic peptide is a sensitive indicator of impaired left-ventricular function in elderly patients with cardiovascular disease.

    abstract::We studied the relation between the plasma concentration of brain natriuretic peptide (BNP) and echocardiographic findings to determine the sensitivity of BNP as an indicator of left-ventricular dysfunction in elderly patients with various cardiovascular diseases. The plasma concentration of BNP was positively correla...

    journal_title:Cardiology

    pub_type: 杂志文章

    doi:10.1159/000177368

    authors: Yamada Y,Goto J,Yokota M

    更新日期:1997-09-01 00:00:00

  • Prediction of left ventricular functional recovery by dobutamine echocardiography, F-18 deoxyglucose or 99mTc sestamibi nuclear imaging in patients with chronic myocardial infarction.

    abstract:BACKGROUND:Currently, several modalities are available to predict viability, however, studies comparing various modalities validated by functional recovery after revascularization are scarce. This study analyzed the relative merits of low-dose dobutamine echocardiography, F-18 deoxyglucose (FDG) positron emission tomog...

    journal_title:Cardiology

    pub_type: 杂志文章

    doi:10.1159/000067311

    authors: Lund GK,Freyhoff J,Schwaiger M,Lübeck M,Lund CH,Buchert R,Sheehan FH,Meinertz T,Nienaber CA

    更新日期:2002-01-01 00:00:00

  • Accessory mitral valve tissue: report of two asymptomatic cases.

    abstract::Accessory mitral valve tissue is a rare anomaly of embryologic development of the endocardial cushion and may cause substantial and progressive obstruction of the left ventricular outflow tract. Subaortic obstruction resulting from accessory mitral tissue is most likely due to systolic ballooning of the tissue into th...

    journal_title:Cardiology

    pub_type: 杂志文章

    doi:10.1159/000091290

    authors: Uslu N,Gorgulu S,Yildirim A,Eren M

    更新日期:2006-01-01 00:00:00

  • Relationship of baseline major risk factors to coronary and all-cause mortality, and to longevity: findings from long-term follow-up of Chicago cohorts.

    abstract::The focus here is on relationships between major risk factors and long-term mortality from coronary heart disease (CHD) and all causes, and on longevity, in Chicago cohorts: 25-year follow-up for Peoples Gas (PG) men aged 25-39 (n = 1,119), 30-year follow-up for PG men aged 40-59 (n = 1,235), 24-year follow-up for Wes...

    journal_title:Cardiology

    pub_type: 杂志文章

    doi:10.1159/000175868

    authors: Stamler J,Dyer AR,Shekelle RB,Neaton J,Stamler R

    更新日期:1993-01-01 00:00:00

  • Differential effects of antihypertensive drugs on hypertension: associated risk factors.

    abstract::The primary aim of the management of hypertension should be to prevent coronary heart disease. Antihypertensive treatment should have a beneficial effect on the risk factors associated with coronary heart disease, particularly hypertension, dyslipidemia, hyperinsulinemia, and/or glucose intolerance. Other important ri...

    journal_title:Cardiology

    pub_type: 杂志文章

    doi:10.1159/000176764

    authors: Weidmann P

    更新日期:1994-01-01 00:00:00

  • Persistent thallium-201 defect: can clinical, electrocardiographic and exercise hemodynamic variables predict defect normalization with reinjection?

    abstract::This study was designed to assess the contribution of clinical, electrocardiographic and exercise hemodynamic variables to the prediction of normalization on resting reinjection scintigraphy of persistent thallium-201 (201Tl) myocardial perfusion defects seen with exercise and 2- to 4-hour delayed (redistribution) ima...

    journal_title:Cardiology

    pub_type: 杂志文章

    doi:10.1159/000177093

    authors: Shammas NW,Schwartz RG,Pomerantz RM,Murphy GW,Hall WJ

    更新日期:1996-05-01 00:00:00

  • Venoarterial carbon dioxide tension gradient in acute heart failure.

    abstract::The venoarterial carbon dioxide tension gradient (P[v-a]CO2) was studied in patients with acute myocardial infarction. Seven patients with congestive heart failure (CHF group) and 10 patients without heart failure (control) were enrolled in this study. In all patients, hemodynamics were continuously monitored. Simulta...

    journal_title:Cardiology

    pub_type: 杂志文章

    doi:10.1159/000175891

    authors: Inoue T,Sakai Y,Morooka S,Hayashi T,Takayanagi K,Yamaguchi H,Takabatake Y

    更新日期:1993-01-01 00:00:00

  • Heart failure as a risk factor for diabetes mellitus.

    abstract:BACKGROUND:Diabetes mellitus (DM) is a well-recognized risk factor for heart failure (HF). We hypothesized that HF also increases the risk for DM. OBJECTIVE:We explored the hypothesis that HF is a risk factor for DM. METHODS:The Cardiovascular Health Study was a prospective cohort study of cardiovascular risk in ambu...

    journal_title:Cardiology

    pub_type: 杂志文章

    doi:10.1159/000363282

    authors: Guglin M,Lynch K,Krischer J

    更新日期:2014-01-01 00:00:00

  • Endothelin concentrations in coronary sinus during atrial pacing-induced myocardial ischemia.

    abstract::To investigate the possible role of endothelin in coronary vasoconstriction contributing to the development of myocardial ischemia, plasma endothelin concentrations at rest and during atrial pacing-induced myocardial ischemia have been measured in blood samples drawn from the aorta and coronary sinus in 12 patients wi...

    journal_title:Cardiology

    pub_type: 杂志文章

    doi:10.1159/000176670

    authors: Vojácek J,Rohác J,Jindra A Jr,Jáchymová M,Savlíková J,Kmonicek P,Simek S,Horký K

    更新日期:1994-01-01 00:00:00

  • The Utility of Flow Rate Compared with Left Ventricular Stroke Volume Index in the Hemodynamic Classification of Severe Aortic Stenosis with Preserved Ejection Fraction.

    abstract:OBJECTIVES:To substitute the stroke volume index (SVi) with flow rate (FR) in the hemodynamic classification of severe aortic stenosis (AS) with preserved ejection fraction (EF), in order to evaluate its prognostic value. METHODS:A total of 529 patients (78.8 ± 9.8 years old, 44.1% males) with isolated severe AS (aort...

    journal_title:Cardiology

    pub_type: 杂志文章

    doi:10.1159/000493165

    authors: Alexandru D,Pollack S,Petillo F,Cao JJ,Barasch E

    更新日期:2018-01-01 00:00:00

  • Isolated anomalous inferior vena cava with azygos drainage.

    abstract::In a 79-year-old female with shortness of breath, catheterization via the femoral vein encountered difficulty entering the right heart; venography revealed anomalous drainage of the inferior vena cava via a dilated azygos vein permitting subsequent catheterization. Similar difficulties during catheterization merit con...

    journal_title:Cardiology

    pub_type: 杂志文章

    doi:10.1159/000176884

    authors: Ramsaran EK,Filiberti AW,Spodick DH

    更新日期:1995-01-01 00:00:00

  • Height Is Associated with Dyslipidemia in Korean Premenopausal Women: Data from the Korea National Health and Nutrition Examination Survey.

    abstract:BACKGROUND:The association between height and cardiovascular disease (CVD) has been reported in epidemiological studies for decades; however, the mechanism for this relationship is still unclear. We previously reported that dyslipidemia was associated with adult height in Korean men without CVD. OBJECTIVES:This study ...

    journal_title:Cardiology

    pub_type: 新闻

    doi:10.1159/000509631

    authors: Hwang IC,Park YM,Kang WC,Moon J

    更新日期:2020-01-01 00:00:00

  • A case of pulmonary alveolar microlithiasis with cardiac constriction secondary to severe adjacent pleural involvement.

    abstract::Pulmonary alveolar microlithiasis (PAM) is a rare disorder of uncertain etiology and pathogenesis that is characterized by tiny calcium phosphate depositions in lung alveoli. Ectopic organ involvement has been reported infrequently. We hereby present a patient with PAM complicated by severe pleural calcification that ...

    journal_title:Cardiology

    pub_type: 杂志文章

    doi:10.1159/000095420

    authors: Kacmaz F,Alyan O,Celenk M,Ozdemir O,Turkvatan A,Dogan M,Ilkay E

    更新日期:2007-01-01 00:00:00

  • Coronary artery disease in women: a population-based perspective.

    abstract::Coronary artery disease (CAD) remains a disease of major public health importance among women. In light of this fact, attention has focused recently on the differential expression of the disease in women as compared to men. This review will attempt to describe the characteristics of CAD among women from a population-b...

    journal_title:Cardiology

    pub_type: 杂志文章,评审

    doi:10.1159/000176889

    authors: Pagley PR,Goldberg RJ

    更新日期:1995-01-01 00:00:00

  • [Physiology of orthostatic regulation].

    abstract::The arterial blood pressure is integrated into a feedback control system and practically depends on three parameters, i. e. blood volume, heart dynamics, and peripheral resistance. When circulation is disturbed in the orthostatic, the correcting elements heart and vessels have to adapt themselves according to this dem...

    journal_title:Cardiology

    pub_type: 杂志文章

    doi:10.1159/000169794

    authors: Rieckert H

    更新日期:1976-01-01 00:00:00

  • The kinetocardiogram during the isoproterenol test for the assessment of coronary heart disease.

    abstract::50 patients, 20 without heart disease and 30 with coronary heart disease (CHD), were studied by kinetocardiography (KCG), before and after administration of isoproterenol (initial dose 2 microgram/min, maximum dose 6 microgram/min). In the control subjects the KCG was unaffected by the drug. In contrast, in most of th...

    journal_title:Cardiology

    pub_type: 杂志文章

    doi:10.1159/000169861

    authors: Strozzi C,Cocco G

    更新日期:1977-01-01 00:00:00

  • Hemodynamics of a stenosis in a complaint artery.

    abstract::The effects of arterial compliance on stenotic hemodynamics were examined in an in vitro arterial preparation. Carotid arteries, obtained from anesthetized mongrel dogs (11.3-15.4 kg), were attached to a perfusion apparatus consisting of a constant pressure reservoir and a fixed distal resistance. To create an intralu...

    journal_title:Cardiology

    pub_type: 杂志文章

    doi:10.1159/000173478

    authors: Santamore WP,Bove AA,Carey RA

    更新日期:1982-01-01 00:00:00

  • Long-term prognostic value of creatine kinase-myocardial band mass after cardiac surgery in low-risk patients with stable angina.

    abstract:OBJECTIVES:The long-term prognostic value (>5 years) of elevated cardiac biomarkers after elective cardiac surgery is not clear. Most previous studies have included high-risk, unstable patients. The aim of this study was to determine the prognostic value of creatine kinase-myocardial band (CK-MB) mass after elective ca...

    journal_title:Cardiology

    pub_type: 杂志文章

    doi:10.1159/000177949

    authors: Vikenes K,Andersen KS,Melberg T,Farstad M,Nordrehaug JE

    更新日期:2009-01-01 00:00:00

  • Specificity of cardiac troponin I and creatine kinase-MB isoenzyme in asymptomatic long-term hemodialysis patients and effect of hemodialysis on these cardiac markers.

    abstract:OBJECTIVES:The objectives of this study were: (1) to evaluate the specificity of cardiac troponin I and creatine kinase-MB isoenzyme in ambulatory asymptomatic chronic renal failure patients on long-term hemodialysis, and (2) to evaluate the effect of hemodialysis on the serum levels of cardiac troponin I and creatine ...

    journal_title:Cardiology

    pub_type: 杂志文章

    doi:10.1159/000006859

    authors: Tun A,Khan IA,Win MT,Hussain A,Hla TA,Wattanasuwan N,Vasavada BC,Sacchi TJ

    更新日期:1998-01-01 00:00:00

  • Myocardial turnover of endogenous opioids and calcitonin-gene-related peptide in the human heart and the effects of spinal cord stimulation on pacing-induced angina pectoris.

    abstract::Earlier studies have shown that spinal cord stimulation (SCS) has antianginal and anti-ischemic effects in severe coronary artery disease. In the present study, 14 patients were subjected to right-sided atrial catheterization and atrial pacing. The patients were paced to angina during a control session and during spin...

    journal_title:Cardiology

    pub_type: 杂志文章

    doi:10.1159/000006783

    authors: Eliasson T,Mannheimer C,Waagstein F,Andersson B,Bergh CH,Augustinsson LE,Hedner T,Larson G

    更新日期:1998-03-01 00:00:00

  • Automated phonocardiographic screening for heart disease in children.

    abstract::Mass screening for heart disease in children can be accomplished by automatic analysis of phonocardiograms (PCG) obtained from five routine auscultation points. An ECG signal serves as reference. PCG signals exceeding 20% of the amplitude of the first heart sound S1 in the diastolic interval and 40% of S1 in the systo...

    journal_title:Cardiology

    pub_type: 杂志文章

    doi:10.1159/000169876

    authors: Ninova PP,Dascalov IK,Dimitrova MI

    更新日期:1978-01-01 00:00:00

  • Sirolimus- versus paclitaxel-eluting stent implantation for unprotected left main coronary artery stenosis.

    abstract::We performed this study in order to compare the immediate and mid-term outcomes of sirolimus-eluting stents (SES) and paclitaxel-eluting stents (PES) in lesions of the unprotected left main coronary artery (LMCA). We assessed 54 patients from 5 centers who had undergone unprotected LMCA stenting (35 SES and 19 PES). T...

    journal_title:Cardiology

    pub_type: 杂志文章,多中心研究

    doi:10.1159/000088106

    authors: Lee SH,Ko YG,Jang Y,Kwon HM,Lee SH,Yoon JH,Park SH,Kim BO,Jeon DW,Yang JY,Ryu SK,Korean Multicenter Angioplasty Team (KOMATE) Investigators.

    更新日期:2005-01-01 00:00:00

  • Dyrk1A-ASF-CaMKIIδ Signaling Is Involved in Valsartan Inhibition of Cardiac Hypertrophy in Renovascular Hypertensive Rats.

    abstract:OBJECTIVES:It is known that the expression, activity and alternative splicing of Ca2+/calmodulin-dependent protein kinase IIδ (CaMKIIδ) are dysregulated in the cardiac remodeling process. Recently, we found a further signaling pathway, by which dual-specificity tyrosine phosphorylation-regulated kinase 1A (Dyrk1A) regu...

    journal_title:Cardiology

    pub_type: 杂志文章

    doi:10.1159/000441695

    authors: Yao J,Qin X,Zhu J,Sheng H

    更新日期:2016-01-01 00:00:00

  • The Interplay between Features of Plaque Vulnerability and Hemodynamic Relevance of Coronary Artery Stenoses.

    abstract::Fractional flow reserve (FFR) may not be immune from hemodynamic perturbations caused by both vessel and lesion related factors. The aim of this study was to investigate the impact of plaque- and vessel wall-related features of vulnerability on the hemodynamic effect of intermediate coronary stenoses. Methods and Resu...

    journal_title:Cardiology

    pub_type: 杂志文章

    doi:10.1159/000508885

    authors: Sezer M,Aslanger E,Cakir O,Atici A,Sezer I,Ozcan A,Umman B,Bugra Z,Umman S

    更新日期:2021-01-01 00:00:00

  • The association between nonalcoholic fatty liver disease, metabolic syndrome and arterial stiffness in nondiabetic, nonhypertensive individuals.

    abstract:OBJECTIVES:To assess the relationship between nonalcoholic fatty liver disease (NAFLD) and arterial stiffness in nondiabetic, nonhypertensive individuals with and without metabolic syndrome (MetS). METHODS:Hepatic ultrasound and brachial-ankle pulse wave velocity (baPWV) were investigated in 4,467 individuals. The sub...

    journal_title:Cardiology

    pub_type: 杂志文章

    doi:10.1159/000341248

    authors: Kim BJ,Kim NH,Kim BS,Kang JH

    更新日期:2012-01-01 00:00:00

  • Long-Term Outcome of Patients with Perimembranous Ventricular Septal Defect: Results from the Belgian Registry on Adult Congenital Heart Disease.

    abstract:OBJECTIVES:Studies evaluating the long-term outcome of adults with ventricular septal defect (VSD) are important to inform patients about prognosis. This study investigated the long-term outcome of patients with perimembranous VSD (pmVSD) followed in the Belgian Registry on Adult Congenital Heart Disease. METHODS:All ...

    journal_title:Cardiology

    pub_type: 杂志文章

    doi:10.1159/000448513

    authors: Gabriels C,De Backer J,Pasquet A,Paelinck BP,Morissens M,Helsen F,Van De Bruaene A,Budts W

    更新日期:2017-01-01 00:00:00