SGLT-2 Inhibitors in Heart Failure and Type-2 Diabetes: Hitting Two Birds with One Stone?

Abstract:

:Type 2 diabetes mellitus (T2DM) and heart failure (HF) have a tremendous impact worldwide, markedly reducing life-expectancy and quality of life. It is now known that each disease represents a risk factor for the other. Moreover, when they are combined, the prognosis is significantly worse. Until recently, these pathologies have been managed independently. However, their treatment paradigm is rapidly changing, with recent cardiovascular outcome trials showing that sodium-glucose cotransporter-2 inhibitors (SGLT-2i) are effective in the management of both diseases. This article explores the interactions between T2DM and HF and the concept of diabetic cardiomyopathy and summarizes recent data regarding the effects of SGLT-2i on HF hospitalization and the proposed pathophysiological mechanisms involved.

journal_name

Cardiology

journal_title

Cardiology

authors

Santos-Ferreira D,Gonçalves-Teixeira P,Fontes-Carvalho R

doi

10.1159/000504694

subject

Has Abstract

pub_date

2020-01-01 00:00:00

pages

311-320

issue

5

eissn

0008-6312

issn

1421-9751

pii

000504694

journal_volume

145

pub_type

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