Abstract:
:Type 2 diabetes mellitus (T2DM) and heart failure (HF) have a tremendous impact worldwide, markedly reducing life-expectancy and quality of life. It is now known that each disease represents a risk factor for the other. Moreover, when they are combined, the prognosis is significantly worse. Until recently, these pathologies have been managed independently. However, their treatment paradigm is rapidly changing, with recent cardiovascular outcome trials showing that sodium-glucose cotransporter-2 inhibitors (SGLT-2i) are effective in the management of both diseases. This article explores the interactions between T2DM and HF and the concept of diabetic cardiomyopathy and summarizes recent data regarding the effects of SGLT-2i on HF hospitalization and the proposed pathophysiological mechanisms involved.
journal_name
Cardiologyjournal_title
Cardiologyauthors
Santos-Ferreira D,Gonçalves-Teixeira P,Fontes-Carvalho Rdoi
10.1159/000504694subject
Has Abstractpub_date
2020-01-01 00:00:00pages
311-320issue
5eissn
0008-6312issn
1421-9751pii
000504694journal_volume
145pub_type
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