The relationship of plasminogen activator inhibitor-1 levels to the ST deviation pattern of acute myocardial infarction.

Abstract:

OBJECTIVES:Myocardial infarction (MI) may be classified as ST elevation MI (STEMI) or non-ST elevation MI (NSTEMI). Procoagulants such as plasminogen activator inhibitor-1 (PAI-1) as well as markers of inflammation such as C-reactive protein (CRP), serum amyloid A (SAA) and interleukin-6 (IL-6) are elevated in acute coronary syndromes. However, no study has examined whether levels of these markers differ in patients with STEMI as opposed to NSTEMI. We sought to determine whether there are differences in plasma levels of PAI-1, CRP, SAA or IL-6 in patients with STEMI compared to patients with NSTEMI. METHODS:Seventy-six consecutive patients presenting with acute MI (37 with STEMI and 39 with NSTEMI) were prospectively enrolled. Blood samples were obtained from patients within 6 h from presentation and plasma PAI-1, CRP, IL-6 and SAA concentrations were measured. RESULTS:Plasma levels of PAI-1 were significantly higher in patients with STEMI compared to NSTEMI: 85.7 +/- 5 vs. 61.3 +/- 5 ng/ml (p < 0.001), while CRP, SAA and IL-6 levels were not significantly different between STEMI and NSTEMI patients. CONCLUSIONS:Higher plasma PAI-1 levels in STEMI patients may contribute to the predilection of these patients to occlusive thrombi and STEMI.

journal_name

Cardiology

journal_title

Cardiology

authors

Rott D,Leibowitz D,Finci-Yeheskel Z,Barak V,Chajek-Shaul T,Weiss T,Levin M,Urieli-Shoval S

doi

10.1159/000137700

subject

Has Abstract

pub_date

2009-01-01 00:00:00

pages

56-9

issue

1

eissn

0008-6312

issn

1421-9751

pii

000137700

journal_volume

112

pub_type

杂志文章
  • Mineralocorticoid and glucocorticoid receptors in circulating mononuclear leukocytes of patients with primary hyperaldosteronism.

    abstract::Mineralocorticoid and glucocorticoid receptors were measured in circulating mononuclear leukocytes in 5 patients affected by Conn's syndrome (3 cases of bilateral adrenal hyperplasia and 2 cases of adenoma plus unilateral hyperplasia). The number of the binding sites per cell resulted significantly lower (189 +/- 114,...

    journal_title:Cardiology

    pub_type: 杂志文章

    doi:10.1159/000173953

    authors: Armanini D,Witzgall H,Strasser T,Weber PC

    更新日期:1985-01-01 00:00:00

  • Specificity of cardiac troponin I and creatine kinase-MB isoenzyme in asymptomatic long-term hemodialysis patients and effect of hemodialysis on these cardiac markers.

    abstract:OBJECTIVES:The objectives of this study were: (1) to evaluate the specificity of cardiac troponin I and creatine kinase-MB isoenzyme in ambulatory asymptomatic chronic renal failure patients on long-term hemodialysis, and (2) to evaluate the effect of hemodialysis on the serum levels of cardiac troponin I and creatine ...

    journal_title:Cardiology

    pub_type: 杂志文章

    doi:10.1159/000006859

    authors: Tun A,Khan IA,Win MT,Hussain A,Hla TA,Wattanasuwan N,Vasavada BC,Sacchi TJ

    更新日期:1998-01-01 00:00:00

  • Differences in atrial septal activation with an intrasinoatrial nodal pacemaker and epicardial sinoatrial nodal pacing.

    abstract::Changes in Intra-SA nodal pacemaker localization were produced through stimulation of the decentralized cervical vagi and stellate ganglia in the anesthetized dog. Shifts in pacemaker to the rostral, middle, or caudal regions of the SA node produced a change in the timing as well as a change in the sequence of activat...

    journal_title:Cardiology

    pub_type: 杂志文章

    doi:10.1159/000170620

    authors: Goldberg JM

    更新日期:1979-01-01 00:00:00

  • Bromocriptine-induced coronary spasm caused acute coronary syndrome, which triggered its own clinical twin--Takotsubo syndrome.

    abstract::Bromocriptine-induced coronary spasm (BICS) causing myocardial infarction has been reported. Association between BICS and Takotsubo syndrome (TS) has not been described. We report on a 37-year-old woman presenting with a clinical picture of acute coronary syndrome 1 day after initiation of treatment with bromocriptine...

    journal_title:Cardiology

    pub_type: 杂志文章

    doi:10.1159/000329349

    authors: Y-Hassan S,Jernberg T

    更新日期:2011-01-01 00:00:00

  • Renal function in borderline hypertensive first-degree relatives of essential hypertensives. Effects of sodium load.

    abstract::Renal function in the basal state and after sodium load has been investigated in 21 borderline, hypertensive, first-degree relatives of established hypertensives and in 21 age- and sex-matched, normal subjects with no family history of hypertension. During intravenous infusion of inulin and p-aminohippurate in saline,...

    journal_title:Cardiology

    pub_type: 杂志文章

    doi:10.1159/000173517

    authors: Trimarco B,De Simone A,Volpe M,Ricciardelli B,Ungaro B,Sacca L,Rengo F,Condorelli M

    更新日期:1982-01-01 00:00:00

  • Grade III ischemia on presentation with acute myocardial infarction predicts rapid progression of necrosis and less myocardial salvage with thrombolysis.

    abstract::We assessed the relation between baseline electrocardiographic ischemia grades and initial myocardial area at risk (AR) and final infarct size (IS) in 49 patients who had undergone (99m)Tc sestamibi single-photon emission computed tomography before and 6 +/- 1 days after thrombolysis. Patients were classed as having g...

    journal_title:Cardiology

    pub_type: 临床试验,杂志文章

    doi:10.1159/000063334

    authors: Birnbaum Y,Mahaffey KW,Criger DA,Gates KB,Barbash GI,Barbagelata A,Clemmensen P,Sgarbossa EB,Gibbons RJ,Rahman MA,Califf RM,Granger CB,Wagner GS,AMISTAD (Acute Myocardial Infarction Study of Adenosine) Investigators.

    更新日期:2002-01-01 00:00:00

  • Evaluation of the exercise test in patients with angiographically documented coronary artery disease.

    abstract::100 male patients with at least 75% obstruction of one or more coronary arteries were subjected to submaximal exercise tests. Among the 73 subjects who had positive tests, 92% of those with one-vessel obstruction had an ST depression of 1 mm, none having more than 2 mm; by contrast, 44% of those with three-vessel dise...

    journal_title:Cardiology

    pub_type: 杂志文章

    doi:10.1159/000169871

    authors: Friedmann J,Agmon J,Cherbakoff A,Aygen M,Wurzel M

    更新日期:1977-01-01 00:00:00

  • Postmarketing surveillance versus clinical trials: which benefits the patient?

    abstract::Both randomized controlled clinical trials and observational postmarketing surveillance studies have a place in providing information to physicians and patients on effectiveness and safety of new medicines. Prelicensing is the realm of the basic scientist producing a medicine which is available for investigation by cl...

    journal_title:Cardiology

    pub_type: 杂志文章

    doi:

    authors: Lawson DH

    更新日期:1994-01-01 00:00:00

  • Myocardial angiogenesis resulting in functional communications with the left cavity induced by intramyocardial high-frequency ablation: histomorphology of immediate and long-term effects in pigs.

    abstract::A previous study in rabbit hearts demonstrated the feasibility of creating transmyocardial channels by application of temperature-regulated high-frequency (HF) energy. Feasibility of creating non-transmural channels using a transvascular approach was tested in 14 pigs which were followed for 1 h, and 3 and 9 weeks (gr...

    journal_title:Cardiology

    pub_type: 杂志文章

    doi:10.1159/000068450

    authors: Dietz U,Horstick G,Manke T,Otto M,Eick O,Kirkpatrick CJ,Meyer J,Darius H

    更新日期:2003-01-01 00:00:00

  • MicroRNAs miR-1, miR-133a, miR-133b and miR-208 are dysregulated in human myocardial infarction.

    abstract:OBJECTIVES:MicroRNAs (miRNAs) are noncoding single-stranded RNA molecules that regulate gene expression in physiological functions, development and disease. In recent studies, three miRNAs have been described as muscle or cardiac specific: miR-1, miR-133, and miR-208, being involved in heart development and disease; bu...

    journal_title:Cardiology

    pub_type: 杂志文章

    doi:10.1159/000268088

    authors: Bostjancic E,Zidar N,Stajer D,Glavac D

    更新日期:2010-01-01 00:00:00

  • Apolipoprotein A1 Inhibits the TGF-β1-Induced Endothelial-to-Mesenchymal Transition of Human Coronary Artery Endothelial Cells.

    abstract:OBJECTIVE:Transforming growth factor β1 (TGF-β1) is the major cytokine for stimulating endothelial cells (ECs) to transdifferentiate to mesenchymal cells (MCs) in the process known as endothelial-to-mesenchymal transition (EndMT). Recently, TGF-β1-induced EndMT has been implicated in the pathogenesis of atherosclerosis...

    journal_title:Cardiology

    pub_type: 杂志文章

    doi:10.1159/000464321

    authors: Feng J,Zhang J,Jackson AO,Zhu X,Chen H,Chen W,Gui Q,Yin K

    更新日期:2017-01-01 00:00:00

  • Rheumatic Mitral Stenosis: Long-Term Follow-Up of Adult Patients with Nonsevere Initial Disease.

    abstract:INTRODUCTION:There is no consensus regarding the natural history of rheumatic mitral stenosis (MS) among adults presenting with nonsevere disease. This study aims to describe the progression of stenosis among adult rheumatic MS patients, to identify predictive factors for progression, and to assess the incidence of com...

    journal_title:Cardiology

    pub_type: 杂志文章

    doi:10.1159/000505481

    authors: Bitan A,Mazor-Dray E,Weinstein JM,Carmel S,Ilia R

    更新日期:2020-01-01 00:00:00

  • NT-ProBNP and hsTnI: A Multistate Survival Analysis in Outpatients with Reduced Left-Ventricular Ejection Fraction.

    abstract::Heart failure (HF) with reduced ejection fraction (HFrEF) has a well-known epidemic relevance in western countries. It affects up to 1-2% of patients > 60 years and reaches a prevalence of 12% in octogenarian patients. The role of N-terminal pro-B-type natriuretic peptide (NT-proBNP) and high-sensitive troponin I (hsT...

    journal_title:Cardiology

    pub_type: 杂志文章

    doi:10.1159/000488640

    authors: Di Gesaro G,Caccamo G,Bellavia D,Falletta C,Minà C,Romano G,Agnese V,Tuzzolino F,Clemenza F

    更新日期:2019-01-01 00:00:00

  • Comparative hemodynamic effects of intravenous digoxin and enoximone in severe chronic heart failure.

    abstract::In order to compare the acute hemodynamic effects of digoxin (0.01 mg/kg) and enoximone (1 mg/kg), a phosphodiesterase inhibitor inotropic agent, in severe chronic congestive heart failure, 8 patients (male, mean age 56.7 years, sinus rhythm) were investigated with a randomized cross-over study. Peak effect of enoximo...

    journal_title:Cardiology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1159/000176702

    authors: Casella G,Cantelli I,Pavesi PC,Barbato G,Bracchetti D

    更新日期:1994-01-01 00:00:00

  • Prognostic Role of Hyponatremia in Heart Failure Patients Depending on Renal Disease: Clinical Evidence.

    abstract:AIM:Hyponatremia is very often associated with renal disease in patients with heart failure (HF) and, when present, determines a poor outcome. We investigated the role of hyponatremia in HF patients in whom the presence or absence renal insufficiency was accurately predefined. METHODS:This was a cohort study based on ...

    journal_title:Cardiology

    pub_type: 杂志文章,多中心研究

    doi:10.1159/000502566

    authors: Arévalo-Lorido JC,Carretero-Gómez J,Robles NR,Llácer P,Carrera M,Suárez-Pedreira I,Álvarez-Rocha P,Manzano-Espinosa L,Cepeda-Rodrigo JM,Montero-Pérez-Barquero M,on behalf of the RICA Investigators Group.

    更新日期:2019-01-01 00:00:00

  • Heart disease indicators in patients with aortocoronary bypass operation.

    abstract::The incidence of cardiovascular disease risk factors and other indicators of cardiac impairment were studied in 478 patients prior to their aortocoronary vein bypass operation and 194 patients who had angiographic examination but did not undergo the operation because the clinical and coronary angiographic findings wer...

    journal_title:Cardiology

    pub_type: 杂志文章

    doi:10.1159/000169758

    authors: Barboriak JJ,Rimm AA,Anderson AJ,Tristani FE,Walker JA,Flemma RJ

    更新日期:1976-01-01 00:00:00

  • Role of adrenal androgens in the development of arteriosclerosis as judged by pulse wave velocity and calcification of the aorta.

    abstract::To evaluate the role of adrenal androgens in the development of arteriosclerosis, serum dehydroepiandrosterone sulfate (DHEAS), dehydroepiandrosterone (DHEA), aortic calcification and pulse wave velocity (PWV) were measured in 69 males and 119 females without overt cardiovascular disease. The steroids decreased with a...

    journal_title:Cardiology

    pub_type: 杂志文章

    doi:10.1159/000175022

    authors: Ishihara F,Hiramatsu K,Shigematsu S,Aizawa T,Niwa A,Takasu N,Yamada T,Matsuo K

    更新日期:1992-01-01 00:00:00

  • Optimal treatment of stable angina.

    abstract::Angina pectoris due to coronary artery disease is a common manifestation of myocardial ischemia. Reduction of oxygen demand (beta-blockers) and relief of coronary vasoconstriction (calcium blocker or nitrate) are additive approaches to controlling ischemia. Risk factor reduction may improve coronary vascular physiolog...

    journal_title:Cardiology

    pub_type: 杂志文章,评审

    doi:10.1159/000177503

    authors: Parmley WW

    更新日期:1997-01-01 00:00:00

  • Molecular genetic studies in atrial fibrillation.

    abstract::Atrial fibrillation is a complex disease. Its etiologies are diverse and genetic factors may also contribute to this disease. With the advent of modern molecular biology technology, it is now possible to explore the genetic components in the pathogenesis of atrial fibrillation. Past molecular genetic studies on atrial...

    journal_title:Cardiology

    pub_type: 杂志文章,评审

    doi:10.1159/000073910

    authors: Lai LP,Lin JL,Huang SK

    更新日期:2003-01-01 00:00:00

  • Atherosclerosis after coronary artery bypass surgery: results of recent studies and recommendations regarding prevention.

    abstract::Atherosclerosis is the most frequent cause of occlusion of aortocoronary saphenous vein grafts between 5 and 10 years after coronary artery bypass surgery. The typical atherosclerotic plaque appears between 1 and 3 years after operation and, at a mean of 5 years, histologic changes of atherosclerosis are present in 21...

    journal_title:Cardiology

    pub_type: 杂志文章,评审

    doi:10.1159/000174019

    authors: Bourassa MG,Campeau L,Lespérance J,Solymoss BC

    更新日期:1986-01-01 00:00:00

  • Hypothermic cardioplegic arrest is associated with increased myocardial adenosine.

    abstract::The current study examined the effects of temperature on myocardial pH, contractile function and adenosine triphosphate metabolism, particularly the production of adenosine. We matched intermittent delivery of blood cardioplegia in two groups (hypothermia 15 degrees C; normothermia 37 degrees C), for 2 h of cardiopleg...

    journal_title:Cardiology

    pub_type: 杂志文章

    doi:10.1159/000177148

    authors: Shortt KG,Stahl RF,Soller BR,Belle Isle JM,Auerbach AH,Hsi CC

    更新日期:1996-11-01 00:00:00

  • Changes of serum beta-endorphin by programmed exercise training are correlated with improvement of clinical symptoms and quality of life in female mitral valve prolapse syndrome.

    abstract:BACKGROUND:Mitral valve prolapse (MVP) is a common entity in female population. Although this is a minor disease, it may cause annoying symptoms that impair quality of life (QOL), and no established therapy for this problem. The aim of this study isto examine whether programmed exercise training by treadmill in female ...

    journal_title:Cardiology

    pub_type: 临床试验,杂志文章

    doi:10.1159/000096952

    authors: Hung HF,Kao PF,Lin YS,Chen FC,Chen FC,Tsai JC,Chan P

    更新日期:2007-01-01 00:00:00

  • Clinical value of the pitch of the third heart sound in ischemic heart disease.

    abstract::The study investigates the genesis of the third heart sound (S3) in ischemic heart disease based on a mass-spring model. In such a system, the natural frequency of vibration, Fn, depends on the elastic constant, k, and the mass, m, according to the following relationship: Fn = 1/2 pi square root of k/m. To identify th...

    journal_title:Cardiology

    pub_type: 杂志文章

    doi:10.1159/000174588

    authors: Aggio S,Baracca E,Brunazzi C,Sgobino P,Aubert AE,Longhini C

    更新日期:1990-01-01 00:00:00

  • Exercise capacity in patients with left ventricular dysfunction following acute myocardial infarction: relation to systolic and diastolic function and intervention with captopril.

    abstract::Patients with acute or chronic heart disease may have limited exercise capacity if they have reduced left ventricular function. Indexes of reduced left ventricular function during exercise are a predictor of subsequent survival although left ventricular ejection fraction is a poor predictor of physical endurance. We e...

    journal_title:Cardiology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1159/000176419

    authors: Søgaard P,Gøtzsche CO,Ravkilde J,Nørgaard A,Thygesen K

    更新日期:1994-01-01 00:00:00

  • Comparison of Quality of Life Perceived by Patients with Bioprosthetic versus Mechanical Valves after Composite Aortic Root Replacement.

    abstract:OBJECTIVE:To assess whether postoperative quality of life (QOL) for composite aortic root replacement patients differs according to whether it is based on the use of mechanical valves or bioprosthetic valves. METHODS:The study included 146 consecutive patients who underwent composite aortic root replacement at our ins...

    journal_title:Cardiology

    pub_type: 杂志文章

    doi:10.1159/000438783

    authors: Repack A,Ziganshin BA,Elefteriades JA,Mukherjee SK

    更新日期:2016-01-01 00:00:00

  • Effect of alpha-allocryptopine on transient outward potassium current in rabbit ventricular myocytes.

    abstract:OBJECTIVE:To investigate the mechanism of alpha-allocryptopine-induced inhibition of the transient outward potassium current (I(to)) in rabbit left-ventricular myocytes. METHODS:We used the whole-cell patch-clamp technique to record the I(to) in the myocytes, which were isolated from the rabbit left ventricle by a Lan...

    journal_title:Cardiology

    pub_type: 杂志文章

    doi:10.1159/000127443

    authors: Li Y,Wang S,Liu Y,Li Z,Yang X,Wang H,Wen Y,Chen Y

    更新日期:2008-01-01 00:00:00

  • Blood pressure and sleep apnea: results of long-term nasal continuous positive airway pressure therapy.

    abstract::Arterial blood pressure patterns in 12 men with sleep apnea and arterial hypertension were studied at baseline and after 6 months' therapy with nasal continuous positive airway pressure (nCPAP). Preexisting antihypertensive medication was discontinued 1 week before baseline measurements. Weight did not change during t...

    journal_title:Cardiology

    pub_type: 杂志文章

    doi:10.1159/000174864

    authors: Mayer J,Becker H,Brandenburg U,Penzel T,Peter JH,von Wichert P

    更新日期:1991-01-01 00:00:00

  • Right precordial and posterior electrocardiographic leads do not increase detection of ischemia in low-risk patients presenting with chest pain.

    abstract:BACKGROUND:A number of innovative approaches have been investigated for their value in the early detection of acute ischemia or infarction in patients presenting to the emergency department (ED) with chest pain suggestive of a cardiac origin. Prior investigations have demonstrated the utility of adding right precordial...

    journal_title:Cardiology

    pub_type: 杂志文章

    doi:10.1159/000077912

    authors: Ganim RP,Lewis WR,Diercks DB,Kirk D,Sabapathy R,Baker L,Amsterdam EA

    更新日期:2004-01-01 00:00:00

  • Prognostic Value of Red Blood Cell Distribution Width on Bleeding Events in Nonvalvular Atrial Fibrillation Patients Taking Dabigatran (110 mg b.i.d.) after Catheter Ablation.

    abstract:OBJECTIVES:Recent research has indicated that red blood cell distribution width (RDW) is associated with the prognosis of cardiovascular diseases such as chronic heart failure and coronary heart disease. We aimed to study the predictive value of RDW for bleeding events in patients with nonvalvular atrial fibrillation (...

    journal_title:Cardiology

    pub_type: 杂志文章

    doi:10.1159/000449461

    authors: Zhang Q,Qin Y,Zhao DS,Zhao HP,Zhou L

    更新日期:2017-01-01 00:00:00

  • Application of tissue Doppler imaging in cardiology.

    abstract::Tissue Doppler imaging (TDI) is a new echocardiographic technique employing the Doppler principle to measure the velocity of myocardial segments and other cardiac structures. It is well suited for the measurement of long-axis ventricular function. Impairment of longitudinal myocardial fiber motion is a sensitive marke...

    journal_title:Cardiology

    pub_type: 杂志文章,评审

    doi:10.1159/000076694

    authors: Nikitin NP,Witte KK

    更新日期:2004-01-01 00:00:00