Myocardial angiogenesis resulting in functional communications with the left cavity induced by intramyocardial high-frequency ablation: histomorphology of immediate and long-term effects in pigs.

Abstract:

:A previous study in rabbit hearts demonstrated the feasibility of creating transmyocardial channels by application of temperature-regulated high-frequency (HF) energy. Feasibility of creating non-transmural channels using a transvascular approach was tested in 14 pigs which were followed for 1 h, and 3 and 9 weeks (group A, B and C). Myocardial channels were found to be highly reproducible and patent in more than two thirds in group A. Channels were replaced by connective tissue during follow-up which contained newly formed small vessels. A functional communication between the left ventricular cavum and newly formed vessels of the channel remnants could be demonstrated in one heart of group C. Thus, intramyocardial HF ablation can be performed with high reproducibility to induce local angiogenesis.

journal_name

Cardiology

journal_title

Cardiology

authors

Dietz U,Horstick G,Manke T,Otto M,Eick O,Kirkpatrick CJ,Meyer J,Darius H

doi

10.1159/000068450

subject

Has Abstract

pub_date

2003-01-01 00:00:00

pages

32-8

issue

1

eissn

0008-6312

issn

1421-9751

pii

68450

journal_volume

99

pub_type

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