Abstract:
:In 6 patients with healthy hearts (controls), 17 with coronary artery disease (CAD) and 6 with left ventricular hypertrophy due to aortic valvular disease, aortic pressure, coronary sinus blood flow (CSF) and lactate extraction were determined before and after the sudden onset of a paced ventricular tachycardia of 170 bpm (VT 170 = simulated paroxysmal ventricular tachycardia). Comparison to parameter changes during dipyridamol vasodilation revealed reduced coronary vascular reserve for CAD and hypertrophy. While VT induced a reduction of aortic pressure (stabilized by an average of 22%, and most excessively for CAD; p less than 0.05) and CSF remained at/or slightly above control levels (by an average of 31%; p greater than 0.05) equally for all groups (p greater than 0.05), lactate production in the groups with CAD and hypertrophy indicated myocardial impairment by ischemia. Excessively greater increases of CSF during dipyridamol vasodilation (vs. VT) for all groups suggested VTs extravascular resistance increase to have limited the extent of the potential of coronary vascular decrease. With one variable being kept constant (i.e. 'clamping' the vascular component of coronary resistance at its limit by dipyridamol), tachycardia during dipyridamol (D) vasodilation (VT 170+D and VT 140+D) in the controls and in the CAD group resulted in a linear decrease of CSF, allowing quantification of impaired coronary reserve for CAD. We concluded from the observations that: (1) paroxysmal VT demands fast therapeutic action foremost in the impaired myocardium, and (2) tachycardia per se acts as limiting factor for coronary blood flow via increase in extravascular resistance (aside from a shortened diastole).
journal_name
Cardiologyjournal_title
Cardiologyauthors
Thormann J,Schlepper M,Neuss Hdoi
10.1159/000173524subject
Has Abstractpub_date
1982-01-01 00:00:00pages
326-42issue
6eissn
0008-6312issn
1421-9751journal_volume
69pub_type
杂志文章相关文献
CARDIOLOGY文献大全abstract::The effects of arterial compliance on stenotic hemodynamics were examined in an in vitro arterial preparation. Carotid arteries, obtained from anesthetized mongrel dogs (11.3-15.4 kg), were attached to a perfusion apparatus consisting of a constant pressure reservoir and a fixed distal resistance. To create an intralu...
journal_title:Cardiology
pub_type: 杂志文章
doi:10.1159/000173478
更新日期:1982-01-01 00:00:00
abstract::Three generations of a family with the Romano-Ward syndrome are described. Of all the affected members, only 1 was symptomatic, experiencing episodes of syncope proven to be due to polymorphous ventricular tachycardia (PMVT) induced by chlorimipramine treatment for depression. During treatment of an episode of PMVT wi...
journal_title:Cardiology
pub_type: 杂志文章
doi:10.1159/000173500
更新日期:1982-01-01 00:00:00
abstract::We describe the 2- and 5-year prognoses following coronary artery bypass grafting (CABG) in relation to smoking habits among consecutive patients being operated on in western Sweden during a 3-year period. Among the 2,121 patients, 10.2% admitted smoking at coronary angiography as compared with 7.5% 2 years after CABG...
journal_title:Cardiology
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1159/000177397
更新日期:1997-11-01 00:00:00
abstract:OBJECTIVE:Transforming growth factor β1 (TGF-β1) is the major cytokine for stimulating endothelial cells (ECs) to transdifferentiate to mesenchymal cells (MCs) in the process known as endothelial-to-mesenchymal transition (EndMT). Recently, TGF-β1-induced EndMT has been implicated in the pathogenesis of atherosclerosis...
journal_title:Cardiology
pub_type: 杂志文章
doi:10.1159/000464321
更新日期:2017-01-01 00:00:00
abstract::Single-drug therapy is often not sufficient to lower total and low-density lipoprotein (LDL) cholesterol levels in patients with familial hypercholesterolemia to desirable or target levels. Therefore, combination drug therapy is often necessary. The most potent therapy to achieve this goal is a combination of a 3-hydr...
journal_title:Cardiology
pub_type: 杂志文章
doi:10.1159/000174681
更新日期:1990-01-01 00:00:00
abstract::We studied the relation between the plasma concentration of brain natriuretic peptide (BNP) and echocardiographic findings to determine the sensitivity of BNP as an indicator of left-ventricular dysfunction in elderly patients with various cardiovascular diseases. The plasma concentration of BNP was positively correla...
journal_title:Cardiology
pub_type: 杂志文章
doi:10.1159/000177368
更新日期:1997-09-01 00:00:00
abstract::This study was carried out in order to investigate the relationship between endogenous sex steroid hormones and coronary artery disease (CAD). Three hundred and thirty-seven men undergoing coronary angiography were enrolled in the study. Total testosterone, estradiol, free testosterone levels in men with CAD (n = 213)...
journal_title:Cardiology
pub_type: 临床试验,杂志文章
doi:10.1159/000006977
更新日期:1999-01-01 00:00:00
abstract::A 50-year-old man with intermittent ventricular parasystolic bigeminy is reported in whom the parasystolic focus was protected from late intervening sinus impulses. This is the first report to suggest the presence of protection due to interference in parasystolic bigeminy. The findings in this case suggest that when a...
journal_title:Cardiology
pub_type: 杂志文章
doi:10.1159/000174583
更新日期:1990-01-01 00:00:00
abstract::Limited prospective data are available regarding the influence of pacemaker leads on tricuspid valve function. To examine the true incidence of these complications, 35 patients were prospectively examined by two-dimensional and Doppler echocardiography before and after implantation of either a permanent pacemaker or a...
journal_title:Cardiology
pub_type: 杂志文章
doi:10.1159/000007005
更新日期:2000-01-01 00:00:00
abstract:OBJECTIVE:To assess improvement in predictive performance of Global Registry of Acute Coronary Events risk score (GRS) by addition of a glucose matrix. METHODS:1,056 acute coronary syndrome (ACS) survivors without known diabetes had pre-discharge fasting (FPG) and 2-h post-load plasma glucose (2h-PG) measured. GRS was...
journal_title:Cardiology
pub_type: 杂志文章
doi:10.1159/000509180
更新日期:2020-01-01 00:00:00
abstract::We report on a 47-year-old woman who experienced an Eisenmenger reaction (mean pulmonary artery pressure: 86 mm Hg) induced by atrial septal defect. Radionuclide myocardial scans with 99mTc-MIBI and 123I-BMIPP showed increased uptake to the right ventricular myocardium, whereas the 123I-MIBG scan disclosed no uptake t...
journal_title:Cardiology
pub_type: 杂志文章
doi:10.1159/000177435
更新日期:1997-11-01 00:00:00
abstract::Both coronary artery disease and aging produce a similar pattern of left ventricular diastolic dysfunction with increased left atrial (LA) activity. We studied the Doppler left ventricular filling pattern in 75 patients (age 40-91 years) with coronary artery disease. A linear correlation with age was found for isovolu...
journal_title:Cardiology
pub_type: 杂志文章
doi:10.1159/000176639
更新日期:1994-01-01 00:00:00
abstract::A laminar color Doppler flow was discovered in the pericardial space in a 35-year-old man with postpericardiotomy effusive constrictive pericarditis. The flow was detected by transesophageal color Doppler echocardiography. A further pulsed Doppler study revealed a to-and-fro flow, which was synchronized with the cardi...
journal_title:Cardiology
pub_type: 杂志文章
doi:10.1159/000175960
更新日期:1993-01-01 00:00:00
abstract::Lower extremity atherosclerosis results in significant morbidity in women, particularly in women following the menopause. Up to 25% of women aged 55 to 74 years are affected by this disease. When noninvasive testing is used to determine the prevalence of lower extremity atherosclerosis, and men in this age group are e...
journal_title:Cardiology
pub_type: 杂志文章,评审
doi:10.1159/000176899
更新日期:1995-01-01 00:00:00
abstract:BACKGROUND:C-reactive protein (CRP) is a well-established inflammation marker associated with cardiovascular risk. However, its relationship with chitotriosidase activity, a novel marker of activated macrophages highly expressed in human atherosclerotic plaques, is unknown. Therefore, we sought to determine if serum ch...
journal_title:Cardiology
pub_type: 杂志文章
doi:10.1159/000099099
更新日期:2007-01-01 00:00:00
abstract::A smooth muscle layer exists in the parietal endocardium. Notwithstanding previous pioneer work, little has been known on the phenotypes of these smooth muscles. In humans as in animals, smooth muscles show two distinct phenotypes, the 'synthetic' and 'contractile' states, which can be differentiated on the basis of t...
journal_title:Cardiology
pub_type: 杂志文章
doi:10.1159/000177055
更新日期:1996-01-01 00:00:00
abstract::Although very useful agents, fluoroquinolones are associated with a number of adverse events, some with considerable clinical significance. Prolongation of the QT interval, for example, is an adverse effect associated with the use of fluoroquinolones. Fluoroquinolones prolong the QT interval by blocking voltage-gated ...
journal_title:Cardiology
pub_type: 杂志文章,评审
doi:10.1159/000334441
更新日期:2011-01-01 00:00:00
abstract:OBJECTIVE:Left atrial (LA) mechanical function is thought to be virtually inexistent in patients with permanent atrial fibrillation (AF). Due to recent advances in multidetector computed tomography (MDCT) technology, it is now possible to acquire images of the entire heart in a single heartbeat. The objective of this s...
journal_title:Cardiology
pub_type: 杂志文章
doi:10.1159/000365915
更新日期:2014-01-01 00:00:00
abstract:OBJECTIVES:The aim of this study was to assess the recovery of regional myocardial function of the left-ventricular septal wall and the septal site of the mitral valve (MV) annulus by tissue Doppler imaging (TDI). METHODS:In 63 (32 diabetic and 31 control) patients having off-pump coronary artery bypass grafting (OPCA...
journal_title:Cardiology
pub_type: 杂志文章
doi:10.1159/000380811
更新日期:2015-01-01 00:00:00
abstract:OBJECTIVES:To evaluate clinical predictors of poor sleep quality and quality of life (QOL) in patients with hypertrophic cardiomyopathy (HCM). METHODS:Consecutive stable patients with HCM were evaluated for the risk of obstructive sleep apnea (OSA) by the Berlin Questionnaire, daytime sleepiness by the Epworth Sleepin...
journal_title:Cardiology
pub_type: 杂志文章
doi:10.1159/000321718
更新日期:2010-01-01 00:00:00
abstract:BACKGROUND:The landmark Dual Antiplatelet Therapy (DAPT) trial revealed an impressive reduction of stent thrombosis and myocardial infarction after prolonged 30-month DAPT compared to the conventional 12-month regimen. However, aside from the expected extra bleeding risks, more cancers and noncardiovascular deaths (NCV...
journal_title:Cardiology
pub_type: 杂志文章
doi:10.1159/000431356
更新日期:2015-01-01 00:00:00
abstract:OBJECTIVES:Mutations in genes encoding desmosomal proteins have been linked to arrhythmogenic right ventricular cardiomyopathy/dysplasia (ARVC/D). We hypothesized that a Scandinavian ARVC/D population would have a different spectrum of plakophilin-2 (PKP2) mutations and that some of the reported missense mutations may ...
journal_title:Cardiology
pub_type: 评论,杂志文章
doi:10.1159/000263456
更新日期:2010-01-01 00:00:00
abstract:OBJECTIVE:Recently, we reported that low-dose landiolol (1.5 µg·kg(-1)·min(-1)), an ultra-short-acting β-blocker, safely decreased the heart rate (HR) in patients with acute decompensated heart failure (ADHF) and sinus tachycardia, thereby improving cardiac function. We investigated whether low-dose landiolol effective...
journal_title:Cardiology
pub_type: 杂志文章
doi:10.1159/000355312
更新日期:2014-01-01 00:00:00
abstract:BACKGROUND:Mitral valve prolapse (MVP) is a common entity in female population. Although this is a minor disease, it may cause annoying symptoms that impair quality of life (QOL), and no established therapy for this problem. The aim of this study isto examine whether programmed exercise training by treadmill in female ...
journal_title:Cardiology
pub_type: 临床试验,杂志文章
doi:10.1159/000096952
更新日期:2007-01-01 00:00:00
abstract::The primary aim of the management of hypertension should be to prevent coronary heart disease. Antihypertensive treatment should have a beneficial effect on the risk factors associated with coronary heart disease, particularly hypertension, dyslipidemia, hyperinsulinemia, and/or glucose intolerance. Other important ri...
journal_title:Cardiology
pub_type: 杂志文章
doi:10.1159/000176764
更新日期:1994-01-01 00:00:00
abstract::Clopidogrel, in combination with acetylsalicylic acid, has become a mainstay of the pharmacological therapy for patients with acute coronary syndromes, especially in those undergoing percutaneous coronary interventions (PCI). While a series of studies has shown that pre-treatment with a loading dose of clopidogrel 300...
journal_title:Cardiology
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1159/000096988
更新日期:2007-01-01 00:00:00
abstract::We report the case of a man whose high-density lipoprotein cholesterol (HDL-C) and the ratios of total cholesterol to HDL-C and low-density lipoprotein cholesterol to HDL-C worsened dramatically during pravastatin treatment. After 3 years, pravastatin was replaced by fenofibrate. The result was spectacular. The HDL-C ...
journal_title:Cardiology
pub_type: 杂志文章
doi:10.1159/000063114
更新日期:2002-01-01 00:00:00
abstract::Amiodarone is a potent antiarrhythmic drug with a prolonged half life. The administration of amiodarone for 6 weeks in rabbits caused a significant elevation of serum lipids. We measured serum lipoproteins in 24 patients before, 30 and 90 days after treatment with amiodarone. Serum triglycerides decreased for all pati...
journal_title:Cardiology
pub_type: 杂志文章
doi:10.1159/000173998
更新日期:1986-01-01 00:00:00
abstract::Low cardiac output in acute heart failure can result in a functional impairment of organs, when tissue hypoxia occurs and cardiogenic shock develops. To restore cardiac output, various forms of therapy can be considered. Fluid replacement is sometimes beneficial in acute situations where oedema can reduce effective pl...
journal_title:Cardiology
pub_type: 临床试验,杂志文章
doi:10.1159/000174667
更新日期:1990-01-01 00:00:00
abstract:OBJECTIVES:The aim of the study was to determine whether the release by macrophages of matrix metalloproteinase (MMP)-12 and vascular endothelial growth factor (VEGF) - leading to inflammation, matrix degradation and neoangiogenesis - represents an effective pathway that underlies aortic wall remodeling in Stanford typ...
journal_title:Cardiology
pub_type: 杂志文章
doi:10.1159/000355253
更新日期:2014-01-01 00:00:00