Congenital prolongation of Q-T interval: a family study of three generations.

Abstract:

:Three generations of a family with the Romano-Ward syndrome are described. Of all the affected members, only 1 was symptomatic, experiencing episodes of syncope proven to be due to polymorphous ventricular tachycardia (PMVT) induced by chlorimipramine treatment for depression. During treatment of an episode of PMVT with lidocaine, the patient developed the 'torsade de pointes' variant of ventricular tachycardia, which progressed to ventricular fibrillation and was successfully treated with electroversion. The hazards of treating these patients with commonly used drugs, the possible etiologies for the Romano-Ward syndrome and its mode of inheritance are discussed.

journal_name

Cardiology

journal_title

Cardiology

authors

Flugelman MY,Pollack S,Hammerman H,Riss E,Barzilai D

doi

10.1159/000173500

subject

Has Abstract

pub_date

1982-01-01 00:00:00

pages

170-4

issue

3

eissn

0008-6312

issn

1421-9751

journal_volume

69

pub_type

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