Prognosis of a normal positron emission tomography 82Rb myocardial perfusion imaging study in women with no history of coronary disease.

Abstract:

OBJECTIVES:Myocardial perfusion imaging (MPI) with positron emission tomography (PET) has advantages over single-photon emission computerized tomography, particularly for women. This investigation was undertaken to define the prognosis of a normal stress PET MPI study in women. METHODS:The cohort comprised 457 women evaluated for suspected coronary artery disease (CAD) who had normal pharmacologic stress (82)Rb PET MPI. No patient had clinically evident CAD. Kaplan-Meier estimates were used to determine death and initial nonfatal cardiac event rates over 7 years. Log rank tests were used to assess the relationship between baseline cardiac risk and events during follow-up, and to contrast survival in the cohort with age- and gender-matched US census comparators. RESULTS:During follow-up, there were 11 deaths (all nonischemic), 3 nonfatal myocardial infarctions, 3 percutaneous coronary interventions and 1 coronary artery bypass operation. Average risks of death and initial nonfatal cardiac events were 0.72 and 0.47% per year, respectively. Cardiac events were associated with a history of diabetes (p < 0.0003) and a family history of CAD (p < 0.05). CONCLUSION:A normal cardiac PET study is associated with a very low rate of future cardiac events. Women with diabetes and a strong family history of CAD are more likely to sustain events and require close surveillance for the development of coronary disease.

journal_name

Cardiology

journal_title

Cardiology

authors

Van Tosh A,Supino PG,Nichols KJ,Garza D,Horowitz SF,Reichek N

doi

10.1159/000323841

subject

Has Abstract

pub_date

2010-01-01 00:00:00

pages

301-6

issue

4

eissn

0008-6312

issn

1421-9751

pii

000323841

journal_volume

117

pub_type

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