Abstract:
:Valsartan is a specific angiotensin II receptor antagonist with high selectivity for the AT(1) receptor subtype. After oral administration of single or repeated once-daily doses, valsartan 40-80 mg inhibits the pressor response to angiotensin II for 24 hours. In patients with mild-to-moderate hypertension, efficacy of valsartan appears to be independent of age, sex, and race, and is at least equivalent to that of calcium antagonists, ACE inhibitors, or thiazide diuretics. Response rate to valsartan 160 mg o.d. is significantly greater than after receiving losartan 100 mg o.d. Valsartan has additive effects with other antihypertensive drugs and combination therapy is effective in severe hypertension and in hypertension with renal insufficiency, where renal function is well maintained. Valsartan has good tolerability with a side-effect profile indistinguishable from placebo and superior to that of comparable drugs. Valsartan does not cause cough or adverse metabolic effects; first dose hypotension and rebound hypertension on abrupt withdrawal have not been encountered. Valsartan has clear clinical advantage in the management of hypertension. Its impact on prognosis in patients with a high risk of cardiovascular morbidity and mortality is under evaluation.
journal_name
Cardiologyjournal_title
Cardiologyauthors
McInnes GTdoi
10.1159/000047283subject
Has Abstractpub_date
1999-01-01 00:00:00pages
14-8eissn
0008-6312issn
1421-9751pii
47283journal_volume
91 Suppl 1pub_type
杂志文章,评审相关文献
CARDIOLOGY文献大全abstract::A 65-year-old female patient suffering from hypertension and myxedema due to chronic thyroiditis developed anginal attacks under trichlormethiazide therapy. The ECG revealed a SA block with reciprocal beats and aberrant ventricular conduction in a form of bigeminy. Upon substitution of desiccated thyroid for the antih...
journal_title:Cardiology
pub_type: 杂志文章
doi:10.1159/000169716
更新日期:1975-01-01 00:00:00
abstract::We report on a 47-year-old woman who experienced an Eisenmenger reaction (mean pulmonary artery pressure: 86 mm Hg) induced by atrial septal defect. Radionuclide myocardial scans with 99mTc-MIBI and 123I-BMIPP showed increased uptake to the right ventricular myocardium, whereas the 123I-MIBG scan disclosed no uptake t...
journal_title:Cardiology
pub_type: 杂志文章
doi:10.1159/000177435
更新日期:1997-11-01 00:00:00
abstract::Renin is a key component of the renin-angiotensin system (RAS), which plays an important role in the maintenance of blood pressure and electrolyte-volume homeostasis. RAS also plays a role in cardiovascular (CV) disease as a result of effects on inflammation and oxidative stress. There is growing evidence that plasma ...
journal_title:Cardiology
pub_type: 杂志文章,评审
doi:10.1159/000348365
更新日期:2013-01-01 00:00:00
abstract::We investigated the effect of mannan-binding lectin (MBL) deficiency on the susceptibility to bypass graft occlusion in 62 patients with coronary heart disease. MBL deficiency appeared to be associated with occlusion (p = 0.0099). A high level of anti-cardiolipin IgG as well as the number of venous bypass grafts were ...
journal_title:Cardiology
pub_type: 杂志文章
doi:10.1159/000066313
更新日期:2002-01-01 00:00:00
abstract::Lipid-lowering agents are used with the purpose of ameliorating hyperlipoproteinemias, in order to prevent arterial disease. Lipid-lowering drugs can be classified into absorbable agents and into nonabsorbable compounds, acting within the gastrointestinal lumen. Absorbable drugs (fibric acids, nicotinic acid, probucol...
journal_title:Cardiology
pub_type: 杂志文章,评审
doi:10.1159/000174789
更新日期:1991-01-01 00:00:00
abstract::The impact of the duration of atrioventricular (AV) delay on obstruction in hypertrophic cardiomyopathy was evaluated in 12 patients by cardiac catheterization, and in 8 of them also by Doppler echocardiography. The AV delay was programmed in random order at 125, 100 and 75 ms in the invasive study and at 120, 100 and...
journal_title:Cardiology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1159/000006736
更新日期:1998-01-01 00:00:00
abstract::The prognostic significance of finding vegetations by M-mode echocardiography in patients with infective endocarditis remains controversial because many such patients are referred for early surgery. We detected vegetations in 7 of 25 consecutive subjects with active infective endocarditis (28.1%) studied by M-mode ech...
journal_title:Cardiology
pub_type: 杂志文章
doi:10.1159/000173593
更新日期:1983-01-01 00:00:00
abstract:BACKGROUND:The pathogenesis of chronic thromboembolic pulmonary hypertension (CTEPH) is largely unknown. Proteomics offers an approach to overview the molecular activities and signal transduction pathways involved in specific disease processes. OBJECTIVES:In this study, the expression of proteins in endarterectomized ...
journal_title:Cardiology
pub_type: 新闻
doi:10.1159/000502831
更新日期:2020-01-01 00:00:00
abstract::Investigations on orthostatic tolerance and physical fitness prior to and after 6-8 h immersion experiments surprisingly revealed that all untrained subjects endured pre- and postimmersion tilt table tests without subjective complaints, whereas after immersion all trained participants collapsed within the first minute...
journal_title:Cardiology
pub_type: 杂志文章
doi:10.1159/000169816
更新日期:1976-01-01 00:00:00
abstract::Clopidogrel, in combination with acetylsalicylic acid, has become a mainstay of the pharmacological therapy for patients with acute coronary syndromes, especially in those undergoing percutaneous coronary interventions (PCI). While a series of studies has shown that pre-treatment with a loading dose of clopidogrel 300...
journal_title:Cardiology
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1159/000096988
更新日期:2007-01-01 00:00:00
abstract:BACKGROUND:Acute pulmonary embolism (PE) may result in right ventricular (RV) pressure overload with a dilated RV which can be diagnosed by two-dimensional echocardiography. METHODS:A retrospective analysis was performed in 190 unselected patients who had acute PE documented by contrast-enhanced spiral computed tomogr...
journal_title:Cardiology
pub_type: 杂志文章
doi:10.1159/000084585
更新日期:2005-01-01 00:00:00
abstract:OBJECTIVES:Retropharyngeal lesions are often associated with Kawasaki disease (KD). A 4-year-old male first presented a peritonsillar and retropharyngeal abscess-like lesion. Surgical tonsillectomy was performed to avoid a risk of mediastinal abscess, but he fulfilled the diagnostic criteria of KD after the operation. ...
journal_title:Cardiology
pub_type: 杂志文章
doi:10.1159/000467388
更新日期:2017-01-01 00:00:00
abstract::The National Exercise and Heart Disease Project (NEHDP) was funded by the Rehabilitation Services Administration (RSA) of the Department of Health, Education and Welfare, to determine the effects of regular physical activity on the rehabilitation, morbidity and mortality of patients with healed myocardial infarctions....
journal_title:Cardiology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1159/000169916
更新日期:1978-01-01 00:00:00
abstract::Aortic dissection is accompanied by fever in about one third of the patients. However, fever of unknown origin as the predominant manifestation of aortic dissection seems to be extremely rare. A review of the English literature revealed only 3 patients characterized by fever as the principal sign of aortic dissection....
journal_title:Cardiology
pub_type: 杂志文章
doi:10.1159/000174770
更新日期:1991-01-01 00:00:00
abstract::Fractional flow reserve (FFR) may not be immune from hemodynamic perturbations caused by both vessel and lesion related factors. The aim of this study was to investigate the impact of plaque- and vessel wall-related features of vulnerability on the hemodynamic effect of intermediate coronary stenoses. Methods and Resu...
journal_title:Cardiology
pub_type: 杂志文章
doi:10.1159/000508885
更新日期:2021-01-01 00:00:00
abstract::The antiarrhythmic effects of tiapamil were investigated in 48 patients, mean age 54, with acute myocardial infarction and ventricular arrhythmias. 9 had ventricular tachycardia, 6 ventricular fibrillation, and 33 multifocal premature ventricular contractions. Before and after therapy, ECG parameters, left ventricular...
journal_title:Cardiology
pub_type: 杂志文章
doi:10.1159/000173556
更新日期:1982-01-01 00:00:00
abstract::Coronary artery disease (CAD) remains a disease of major public health importance among women. In light of this fact, attention has focused recently on the differential expression of the disease in women as compared to men. This review will attempt to describe the characteristics of CAD among women from a population-b...
journal_title:Cardiology
pub_type: 杂志文章,评审
doi:10.1159/000176889
更新日期:1995-01-01 00:00:00
abstract::A pulmonary artery aneurysm is defined as pulmonary artery dilatation >4 cm. Pulmonary artery aneurysms are rare findings and are usually not associated with chest pain. This is the first report of a case of pulmonary artery aneurysm causing chest pain in a patient with Noonan's syndrome. Chest X-ray showed cardiomega...
journal_title:Cardiology
pub_type: 杂志文章
doi:10.1159/000112408
更新日期:2008-01-01 00:00:00
abstract::A double-chambered right ventricle (DCRV) is an uncommon congenital anomaly: the right ventricle (RV) is divided into two chambers due to the presence of an abnormally located muscular band or anomalous muscle hypertrophy in the subinfundibular part of RV outflow tract, with a variable degree of obstruction. Generally...
journal_title:Cardiology
pub_type: 杂志文章,评审
doi:10.1159/000444743
更新日期:2016-01-01 00:00:00
abstract::The venoarterial carbon dioxide tension gradient (P[v-a]CO2) was studied in patients with acute myocardial infarction. Seven patients with congestive heart failure (CHF group) and 10 patients without heart failure (control) were enrolled in this study. In all patients, hemodynamics were continuously monitored. Simulta...
journal_title:Cardiology
pub_type: 杂志文章
doi:10.1159/000175891
更新日期:1993-01-01 00:00:00
abstract:OBJECTIVE:To assess improvement in predictive performance of Global Registry of Acute Coronary Events risk score (GRS) by addition of a glucose matrix. METHODS:1,056 acute coronary syndrome (ACS) survivors without known diabetes had pre-discharge fasting (FPG) and 2-h post-load plasma glucose (2h-PG) measured. GRS was...
journal_title:Cardiology
pub_type: 杂志文章
doi:10.1159/000509180
更新日期:2020-01-01 00:00:00
abstract::Coronary calcification is a hard challenge for the interventional cardiologist, as it is associated with incomplete stent expansion and frequently stent failure. In recent years, innovative techniques, such as rotational atherectomy, have been developed to treat coronary calcification. However, these are burdened with...
journal_title:Cardiology
pub_type: 杂志文章
doi:10.1159/000495177
更新日期:2018-01-01 00:00:00
abstract::Fourteen hypertensive patients and 14 normotensive control subjects were submitted to the oral glucose test and their plasma potassium, glucose and insulin levels were measured. Cardiovascular responses were evaluated by blood pressure and pulse rate measurements. Five of 14 hypertensive patients were hyperinsulinemic...
journal_title:Cardiology
pub_type: 杂志文章
doi:10.1159/000174852
更新日期:1991-01-01 00:00:00
abstract:OBJECTIVE:To investigate the mechanism of alpha-allocryptopine-induced inhibition of the transient outward potassium current (I(to)) in rabbit left-ventricular myocytes. METHODS:We used the whole-cell patch-clamp technique to record the I(to) in the myocytes, which were isolated from the rabbit left ventricle by a Lan...
journal_title:Cardiology
pub_type: 杂志文章
doi:10.1159/000127443
更新日期:2008-01-01 00:00:00
abstract:BACKGROUND:End-stage renal disease is associated with cardiac remodeling, which is partly reversible after kidney transplantation (KT). We aimed to determine the association of cardiovascular comorbidities or kidney-related factors with cardiac reverse remodeling after KT. METHODS:We performed echocardiography in 56 p...
journal_title:Cardiology
pub_type: 杂志文章
doi:10.1159/000504381
更新日期:2020-01-01 00:00:00
abstract::Mass screening for heart disease in children can be accomplished by automatic analysis of phonocardiograms (PCG) obtained from five routine auscultation points. An ECG signal serves as reference. PCG signals exceeding 20% of the amplitude of the first heart sound S1 in the diastolic interval and 40% of S1 in the systo...
journal_title:Cardiology
pub_type: 杂志文章
doi:10.1159/000169876
更新日期:1978-01-01 00:00:00
abstract:BACKGROUND:Currently, several modalities are available to predict viability, however, studies comparing various modalities validated by functional recovery after revascularization are scarce. This study analyzed the relative merits of low-dose dobutamine echocardiography, F-18 deoxyglucose (FDG) positron emission tomog...
journal_title:Cardiology
pub_type: 杂志文章
doi:10.1159/000067311
更新日期:2002-01-01 00:00:00
abstract::This study shows significant changes occurring in systolic time intervals in an experimental animal model of aortic outflow obstruction with cardiac hypertrophy. The left ventricular ejection time is markedly prolonged and the preejection period/left ventricular ejection time ratio shortened. These changes are in the ...
journal_title:Cardiology
pub_type: 杂志文章
doi:10.1159/000173260
更新日期:1981-01-01 00:00:00
abstract::Three generations of a family with the Romano-Ward syndrome are described. Of all the affected members, only 1 was symptomatic, experiencing episodes of syncope proven to be due to polymorphous ventricular tachycardia (PMVT) induced by chlorimipramine treatment for depression. During treatment of an episode of PMVT wi...
journal_title:Cardiology
pub_type: 杂志文章
doi:10.1159/000173500
更新日期:1982-01-01 00:00:00
abstract:BACKGROUND:A number of innovative approaches have been investigated for their value in the early detection of acute ischemia or infarction in patients presenting to the emergency department (ED) with chest pain suggestive of a cardiac origin. Prior investigations have demonstrated the utility of adding right precordial...
journal_title:Cardiology
pub_type: 杂志文章
doi:10.1159/000077912
更新日期:2004-01-01 00:00:00