Systolic time intervals in the experimental animal with aortic outflow obstruction. Effect of digoxin.

Abstract:

:This study shows significant changes occurring in systolic time intervals in an experimental animal model of aortic outflow obstruction with cardiac hypertrophy. The left ventricular ejection time is markedly prolonged and the preejection period/left ventricular ejection time ratio shortened. These changes are in the opposite direction of those usually observed with left ventricular dysfunction in man but similar to those described in man with aortic stenosis. Furthermore, the changes observed in systolic time intervals after digoxin in this experimental model are not comparable to those reported in man with normal or abnormal left ventricular function. Hence, the use of systolic time intervals, including digitalis effect, to evaluate the functional state of the left ventricle in aortic outflow obstruction are probably unreliable.

journal_name

Cardiology

journal_title

Cardiology

authors

Murphy ML,Doherty JE,de Soyza N,Kane JJ,Straub KD

doi

10.1159/000173260

subject

Has Abstract

pub_date

1981-01-01 00:00:00

pages

19-29

issue

1

eissn

0008-6312

issn

1421-9751

journal_volume

68

pub_type

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