Abstract:
:Cell membrane phospholipids, including platelet-activating factor (PAF), participate in the pathogenesis of acute myocardial infarction (AMI). The plasma level of PAF acetylhydrolase (AH) was determined in 18 patients at presentation with AMI before thrombolysis, and the administration of adjunctive therapy, and compared with 13 healthy controls. Plasma levels of PAF-AH were significantly lower in the AMI patients (23.15 +/- 1.75 nmol/min/ml) than in the controls (30.43 +/- 2.13 nmol/min/ml; p = 0.027). Considering normal plasma levels of PAF and lyso-PAF, and lack of evidence that anti-PAF antibodies are really beneficial in myocardial ischemia-reperfusion, it is reasonable to speculate that an inability of systemic PAF to 'turn on' PAF-AH enzymatic activity could contribute substantially to the observed events. Decreased PAF-AH activity in AMI patients may represent not a consequence, but rather, a risk factor for the development of acute coronary syndromes.
journal_name
Cardiologyjournal_title
Cardiologyauthors
Serebruany VL,Gurbel PA,Murugesan SR,Lowry DR,Sturm E,Svetlov SIdoi
10.1159/000006831subject
Has Abstractpub_date
1998-10-01 00:00:00pages
127-30issue
2eissn
0008-6312issn
1421-9751pii
crd90127journal_volume
90pub_type
临床试验,杂志文章,随机对照试验相关文献
CARDIOLOGY文献大全abstract:OBJECTIVE:Recent studies have shown that high-sensitivity C-reactive protein (hs-CRP) measured before cardioversion (CV) plays a significant role in predicting atrial fibrillation (AF) relapse. The time course of changes in hs-CRP after successful electrical CV remains controversial. The aim of the present study was to...
journal_title:Cardiology
pub_type: 杂志文章
doi:10.1159/000327998
更新日期:2011-01-01 00:00:00
abstract::Three generations of a family with the Romano-Ward syndrome are described. Of all the affected members, only 1 was symptomatic, experiencing episodes of syncope proven to be due to polymorphous ventricular tachycardia (PMVT) induced by chlorimipramine treatment for depression. During treatment of an episode of PMVT wi...
journal_title:Cardiology
pub_type: 杂志文章
doi:10.1159/000173500
更新日期:1982-01-01 00:00:00
abstract::Renal function in the basal state and after sodium load has been investigated in 21 borderline, hypertensive, first-degree relatives of established hypertensives and in 21 age- and sex-matched, normal subjects with no family history of hypertension. During intravenous infusion of inulin and p-aminohippurate in saline,...
journal_title:Cardiology
pub_type: 杂志文章
doi:10.1159/000173517
更新日期:1982-01-01 00:00:00
abstract::Ventricular late potentials are obtained by signal-averaged surface electrocardiography. Late potentials in normal subjects may be influenced by physiological elements such as gender, height and body mass index. Considering that growth hormone (GH) hypersecretion is able to markedly alter different anthropometric vari...
journal_title:Cardiology
pub_type: 杂志文章
doi:10.1159/000176852
更新日期:1995-01-01 00:00:00
abstract::The renin-angiotensin-aldosterone system plays an important role in the development of congestive heart failure (CHF). In patients with chronic heart failure, angiotensin-converting enzyme (ACE) inhibitors, such as captopril, enalapril, and quinapril, have been shown to improve hemodynamics, reduce symptoms of fatigue...
journal_title:Cardiology
pub_type: 临床试验,杂志文章,随机对照试验,评审
doi:10.1159/000174558
更新日期:1989-01-01 00:00:00
abstract::A bicuspid aortic valve (BAV) is one of the most common congenital heart anomalies. Although each annuloaortic ectasia (AAE) and malformation of the left coronary artery has been described as a complication of BAV, no case associated with both abnormalities has been reported previously. We present here a very rare cas...
journal_title:Cardiology
pub_type: 杂志文章
doi:10.1159/000176329
更新日期:1994-01-01 00:00:00
abstract::The multivariate analysis approach in 30 normal subjects and 84 patients significantly improved the sensitivity and correct classification rate when compared to the stress test (ST) response (p less than 0.05). Although the probability of disease could separate normal from diseased subjects, it could not separate sing...
journal_title:Cardiology
pub_type: 杂志文章
doi:10.1159/000173314
更新日期:1981-01-01 00:00:00
abstract:OBJECTIVE:The objective was to evaluate the effect of hormone replacement therapy (HRT) on plasma homocysteine levels in postmenopausal women with coronary artery disease (CAD) and to investigate associations of homocysteine to other cardiovascular risk factors. METHODS:The women in this single-center, controlled, and...
journal_title:Cardiology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1159/000064667
更新日期:2002-01-01 00:00:00
abstract:BACKGROUND:The association between height and cardiovascular disease (CVD) has been reported in epidemiological studies for decades; however, the mechanism for this relationship is still unclear. We previously reported that dyslipidemia was associated with adult height in Korean men without CVD. OBJECTIVES:This study ...
journal_title:Cardiology
pub_type: 新闻
doi:10.1159/000509631
更新日期:2020-01-01 00:00:00
abstract:OBJECTIVES:The aims of this study were to clarify the influence of cardiac diastolic and peripheral vascular function on the exercise capacity of patients with coronary bypass surgery (CABG) and diabetes mellitus (DM) by tissue Doppler imaging (TDI) and flow-mediated vasodilatation (FMD), and to investigate interrelati...
journal_title:Cardiology
pub_type: 杂志文章
doi:10.1159/000111929
更新日期:2008-01-01 00:00:00
abstract:OBJECTIVES:Atrial fibrillation (AF) is one of the most frequent heart rhythm disorders. It potentially influences cardiac function and its measurement. Cardiac magnetic resonance imaging (CMR) has become the new gold standard for non-invasive assessment of cardiac output (CO). A novel inert gas rebreathing (IGR) device...
journal_title:Cardiology
pub_type: 杂志文章
doi:10.1159/000288712
更新日期:2010-01-01 00:00:00
abstract::In this 12-week, double-blind, parallel-group, comparative trial, 57 adult patients with mild-to-moderate hypertension were randomly allocated to receive imidapril or captopril, initially at a dose of 5 mg once a day and 25 mg twice daily, respectively. After 4 weeks of therapy, the dose of each drug was increased twi...
journal_title:Cardiology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1159/000047361
更新日期:2001-01-01 00:00:00
abstract::The systolic time intervals (STI) were used to study the left ventricular performance in 51 patients with chronic obstructive pulmonary disease (COPD), in 24 normal subjects and in 13 patients with both COPD and coronary heart disease (CHD). Our study shows that resting spine STI are abnormal in patients with COPD and...
journal_title:Cardiology
pub_type: 杂志文章
doi:10.1159/000173261
更新日期:1981-01-01 00:00:00
abstract::Heart failure is a huge healthcare issue not only for clinicians but for healthcare managers also, with increasing pressure to demonstrate the cost-effectiveness of therapies especially for common chronic conditions. The cost-effectiveness of heart failure treatments relate to their effects on the progression of the d...
journal_title:Cardiology
pub_type: 杂志文章,评审
doi:10.1159/000177166
更新日期:1996-01-01 00:00:00
abstract::Mineralocorticoid and glucocorticoid receptors were measured in circulating mononuclear leukocytes in 5 patients affected by Conn's syndrome (3 cases of bilateral adrenal hyperplasia and 2 cases of adenoma plus unilateral hyperplasia). The number of the binding sites per cell resulted significantly lower (189 +/- 114,...
journal_title:Cardiology
pub_type: 杂志文章
doi:10.1159/000173953
更新日期:1985-01-01 00:00:00
abstract::Renal hemodynamics in essential hypertensives is characterized by an increase in renal vascular resistance (RVR) and a decrease in renal plasma flow (RPF), while glomerular filtration rate (GFR) is either normal or slightly decreased. Filtration fraction (FF) is increased, indicating that vasoconstriction predominantl...
journal_title:Cardiology
pub_type: 杂志文章,评审
doi:10.1159/000176006
更新日期:1993-01-01 00:00:00
abstract::Treatment of congestive heart failure has changed dramatically during the past 20 years, but diuretic drugs remain an essential component. Diuretics are essential despite the fact that these drugs stimulate the renin-angiotensin-aldosterone (RAA) axis and lead to adaptive responses that may be counterproductive. In th...
journal_title:Cardiology
pub_type: 杂志文章
doi:10.1159/000047397
更新日期:2001-01-01 00:00:00
abstract::To study the effect of coronary angioplasty (PTCA) on left ventricular (LV) diastolic filling, mitral Doppler flow tracings of 15 patients with isolated stenosis of the left anterior descending coronary artery (LAD) and normal systolic LV function were recorded before PTCA as well as 24 h and 3 months after successful...
journal_title:Cardiology
pub_type: 杂志文章
doi:10.1159/000175007
更新日期:1992-01-01 00:00:00
abstract::Carvedilol is a multiple-action cardiovascular agent that is a nonselective beta-adrenoceptor antagonist and a vasodilator. beta-Adrenoceptor antagonists reduce myocardial work, secondary to reductions in heart rate and contractility, both in animals and in humans. For these reasons, carvedilol may improve survival of...
journal_title:Cardiology
pub_type: 杂志文章
doi:10.1159/000175930
更新日期:1993-01-01 00:00:00
abstract::The effects of bicycle training for 5 weeks were evaluated in 12 patients after myocardial infarction with left ventricular dysfunction (left ventricular ejection fraction < 40%) and at least one episode of cardiac failure in the past. The patients were divided into two groups of six according to the Weber classificat...
journal_title:Cardiology
pub_type: 杂志文章
doi:10.1159/000175034
更新日期:1992-01-01 00:00:00
abstract:OBJECTIVES:Endothelin-1 (ET-1) induces cardiac hypertrophy, whereas adiponectin may elicit protective effects in the vasculature and myocardium. We therefore evaluated the relationship between plasma ET-1 and adiponectin levels in heart failure (HF) patients, and the association between adiponectin expression and ET-1-...
journal_title:Cardiology
pub_type: 杂志文章
doi:10.1159/000328780
更新日期:2011-01-01 00:00:00
abstract::CD18 integrins mediate leucocyte adhesion to vascular endothelium. This represents the initial step in inflammatory cell infiltration following myocardial necrosis. The current study assessed whether the expression of these rapidly activated and readily measured adhesion receptors on circulating neutrophils would refl...
journal_title:Cardiology
pub_type: 杂志文章
doi:10.1159/000047341
更新日期:2001-01-01 00:00:00
abstract:OBJECTIVE:Recently, we reported that low-dose landiolol (1.5 µg·kg(-1)·min(-1)), an ultra-short-acting β-blocker, safely decreased the heart rate (HR) in patients with acute decompensated heart failure (ADHF) and sinus tachycardia, thereby improving cardiac function. We investigated whether low-dose landiolol effective...
journal_title:Cardiology
pub_type: 杂志文章
doi:10.1159/000355312
更新日期:2014-01-01 00:00:00
abstract::To investigate the possible role of endothelin in coronary vasoconstriction contributing to the development of myocardial ischemia, plasma endothelin concentrations at rest and during atrial pacing-induced myocardial ischemia have been measured in blood samples drawn from the aorta and coronary sinus in 12 patients wi...
journal_title:Cardiology
pub_type: 杂志文章
doi:10.1159/000176670
更新日期:1994-01-01 00:00:00
abstract::To study the effects of steroid elution on chronic pacing threshold and impedance, a 4-mm2 surface area lead with steroid (030-368, Telectronics; n = 9) was compared to the same lead without steroid (030-359, Telectronics; n = 9) 3 months after implantation. The pulse duration thresholds of the steroid lead were signi...
journal_title:Cardiology
pub_type: 杂志文章
doi:10.1159/000175976
更新日期:1993-01-01 00:00:00
abstract::This is the case of a 43-year-old Caucasian man with frequent episodes of paroxysmal atrial fibrillation (AF) and normal resting electrocardiogram (ECG), who fulfilled two minor diagnostic criteria for arrhythmogenic right ventricular cardiomyopathy (ARVC): late potentials by signal-averaged ECG and regional right ven...
journal_title:Cardiology
pub_type: 杂志文章
doi:10.1159/000342274
更新日期:2012-01-01 00:00:00
abstract:BACKGROUND:The purpose of the present study was to examine physician's attitudes and practices toward the use of different lipid-lowering management strategies in patients at increased risk for coronary heart disease (CHD). AIMS/METHODS:An internet-based questionnaire was completed by 78 general internists and family ...
journal_title:Cardiology
pub_type: 杂志文章
doi:10.1159/000099066
更新日期:2007-01-01 00:00:00
abstract:OBJECTIVES:To evaluate the prognostic significance of early ultra-short-term heart rate variability (HRV) measurement in patients admitted for ST-elevation myocardial infarction (STEMI). METHODS:HRV was calculated retrospectively from the standard admission and discharge 10-second ECG of 196 consecutive patients with ...
journal_title:Cardiology
pub_type: 杂志文章
doi:10.1159/000235568
更新日期:2009-01-01 00:00:00
abstract::Electrocardiographic responses of body-builders and control subjects obtained during the performance of static and dynamic Valsalva maneuvers were studied to determine the causative stimulus for wandering pacemaker activity. The incidence of shifting or wandering pacemaker was nearly double in body-builders, suggestin...
journal_title:Cardiology
pub_type: 杂志文章
doi:10.1159/000173486
更新日期:1982-01-01 00:00:00
abstract::Renin is a key component of the renin-angiotensin system (RAS), which plays an important role in the maintenance of blood pressure and electrolyte-volume homeostasis. RAS also plays a role in cardiovascular (CV) disease as a result of effects on inflammation and oxidative stress. There is growing evidence that plasma ...
journal_title:Cardiology
pub_type: 杂志文章,评审
doi:10.1159/000348365
更新日期:2013-01-01 00:00:00