Depressed plasma platelet-activating factor acetylhydrolase in patients presenting with acute myocardial infarction.

Abstract:

:Cell membrane phospholipids, including platelet-activating factor (PAF), participate in the pathogenesis of acute myocardial infarction (AMI). The plasma level of PAF acetylhydrolase (AH) was determined in 18 patients at presentation with AMI before thrombolysis, and the administration of adjunctive therapy, and compared with 13 healthy controls. Plasma levels of PAF-AH were significantly lower in the AMI patients (23.15 +/- 1.75 nmol/min/ml) than in the controls (30.43 +/- 2.13 nmol/min/ml; p = 0.027). Considering normal plasma levels of PAF and lyso-PAF, and lack of evidence that anti-PAF antibodies are really beneficial in myocardial ischemia-reperfusion, it is reasonable to speculate that an inability of systemic PAF to 'turn on' PAF-AH enzymatic activity could contribute substantially to the observed events. Decreased PAF-AH activity in AMI patients may represent not a consequence, but rather, a risk factor for the development of acute coronary syndromes.

journal_name

Cardiology

journal_title

Cardiology

authors

Serebruany VL,Gurbel PA,Murugesan SR,Lowry DR,Sturm E,Svetlov SI

doi

10.1159/000006831

subject

Has Abstract

pub_date

1998-10-01 00:00:00

pages

127-30

issue

2

eissn

0008-6312

issn

1421-9751

pii

crd90127

journal_volume

90

pub_type

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