Effect of intravenous glibornuride and tolbutamide on myocardial contractility.

Abstract:

:The acute effects of therapeutic doses of intravenous tolbutamide and glibornuride on the systolic time intervals (QS2c, LVETc, PEPc and PEP/LVET) were examined in 5 healthy volunteers. Blood sugar was maintained constant throughout the study. No significant changes of these intervals as well as of heart rate and blood pressure were observed. Therefore, it is concluded that tolbutamide and glibornuride have no acute positive inotropic action.

journal_name

Cardiology

journal_title

Cardiology

authors

Dubach UC,Burckhardt D,Raeder EA,Forgo I,Amrein R,Bückert A

doi

10.1159/000170617

subject

Has Abstract

pub_date

1979-01-01 00:00:00

pages

208-14

issue

4

eissn

0008-6312

issn

1421-9751

journal_volume

64

pub_type

临床试验,杂志文章,随机对照试验
  • Mechanism of vasodilation by nitrates: role of cyclic GMP.

    abstract::Nitrovasodilators relax vascular smooth muscle by stimulating soluble guanylate cyclase (GC). The resulting rise in cGMP probably initiates Ca extrusion from the smooth muscle cell which causes relaxation. Since repeated administration of organic nitrates, particularly nitroglycerin, leads to tolerance, i.e. a decreas...

    journal_title:Cardiology

    pub_type: 杂志文章

    doi:10.1159/000174258

    authors: Kukovetz WR,Holzmann S,Romanin C

    更新日期:1987-01-01 00:00:00

  • Persistent thallium-201 defect: can clinical, electrocardiographic and exercise hemodynamic variables predict defect normalization with reinjection?

    abstract::This study was designed to assess the contribution of clinical, electrocardiographic and exercise hemodynamic variables to the prediction of normalization on resting reinjection scintigraphy of persistent thallium-201 (201Tl) myocardial perfusion defects seen with exercise and 2- to 4-hour delayed (redistribution) ima...

    journal_title:Cardiology

    pub_type: 杂志文章

    doi:10.1159/000177093

    authors: Shammas NW,Schwartz RG,Pomerantz RM,Murphy GW,Hall WJ

    更新日期:1996-05-01 00:00:00

  • Postmarketing surveillance versus clinical trials: which benefits the patient?

    abstract::Both randomized controlled clinical trials and observational postmarketing surveillance studies have a place in providing information to physicians and patients on effectiveness and safety of new medicines. Prelicensing is the realm of the basic scientist producing a medicine which is available for investigation by cl...

    journal_title:Cardiology

    pub_type: 杂志文章

    doi:

    authors: Lawson DH

    更新日期:1994-01-01 00:00:00

  • QT prolongation and torsade de pointes induced by fluoroquinolones: infrequent side effects from commonly used medications.

    abstract::Although very useful agents, fluoroquinolones are associated with a number of adverse events, some with considerable clinical significance. Prolongation of the QT interval, for example, is an adverse effect associated with the use of fluoroquinolones. Fluoroquinolones prolong the QT interval by blocking voltage-gated ...

    journal_title:Cardiology

    pub_type: 杂志文章,评审

    doi:10.1159/000334441

    authors: Briasoulis A,Agarwal V,Pierce WJ

    更新日期:2011-01-01 00:00:00

  • Selective alpha-1 inhibitors: first- or second-line antihypertensive agents?

    abstract::It is well documented that in the treatment of mild or moderate hypertension selective alpha 1-inhibitors such as doxazosin and prazosin lower blood pressure to approximately the same extent as beta-blockers, diuretics, ACE inhibitors and calcium antagonists. However, treatment with selective alpha 1-inhibitors is als...

    journal_title:Cardiology

    pub_type: 杂志文章,评审

    doi:10.1159/000175963

    authors: Lund-Johansen P,Hjermann I,Iversen BM,Thaulow E

    更新日期:1993-01-01 00:00:00

  • A pilot study exploring the mechanisms involved in the longitudinal propagation of acute aortic dissection through computational fluid dynamic analysis.

    abstract:OBJECTIVE:This study sought to elucidate the underlying hemodynamic mechanisms involved in the longitudinal propagation of acute, type-B aortic dissections. METHODS:Three-dimensional patient-specific aortic geometry was reconstructed from computed tomography images of 3 cases, followed by computational fluid dynamic a...

    journal_title:Cardiology

    pub_type: 杂志文章

    doi:10.1159/000358041

    authors: Zhang Y,Lu Q,Feng J,Yu P,Zhang S,Teng Z,Gillard JH,Song R,Jing Z

    更新日期:2014-01-01 00:00:00

  • Low lymphocyte ratio as a novel prognostic factor in acute heart failure: results from the Pre-RELAX-AHF study.

    abstract:BACKGROUND:Previous studies have suggested that a lower lymphocyte ratio (Ly%) in the white blood cell (WBC) differential count is related to worse outcomes in patients with acute heart failure (AHF) and other cardiovascular disorders. METHODS:In the Pre-RELAX-AHF study, 234 patients with AHF, systolic blood pressure ...

    journal_title:Cardiology

    pub_type: 杂志文章,随机对照试验

    doi:10.1159/000321416

    authors: Milo-Cotter O,Teerlink JR,Metra M,Felker GM,Ponikowski P,Voors AA,Edwards C,Weatherley BD,Greenberg B,Filippatos G,Unemori E,Teichman SL,Cotter G

    更新日期:2010-01-01 00:00:00

  • Height Is Associated with Dyslipidemia in Korean Premenopausal Women: Data from the Korea National Health and Nutrition Examination Survey.

    abstract:BACKGROUND:The association between height and cardiovascular disease (CVD) has been reported in epidemiological studies for decades; however, the mechanism for this relationship is still unclear. We previously reported that dyslipidemia was associated with adult height in Korean men without CVD. OBJECTIVES:This study ...

    journal_title:Cardiology

    pub_type: 新闻

    doi:10.1159/000509631

    authors: Hwang IC,Park YM,Kang WC,Moon J

    更新日期:2020-01-01 00:00:00

  • Cardiovascular Comorbidities Are the Main Predictors of Cardiac Reverse Remodeling following Kidney Transplantation.

    abstract:BACKGROUND:End-stage renal disease is associated with cardiac remodeling, which is partly reversible after kidney transplantation (KT). We aimed to determine the association of cardiovascular comorbidities or kidney-related factors with cardiac reverse remodeling after KT. METHODS:We performed echocardiography in 56 p...

    journal_title:Cardiology

    pub_type: 杂志文章

    doi:10.1159/000504381

    authors: Kobayashi M,Huttin O,Schikowski J,Bozec E,Zohra L,Frimat L,Girerd N,Girerd S

    更新日期:2020-01-01 00:00:00

  • Surgical closure of the left atrial appendage - a beneficial procedure?

    abstract:BACKGROUND:Closure of the fibrillating left atrial appendage (LAA) has been recommended during valve surgery to decrease the risk of arterial embolism. However, patients undergoing surgical LAA closure have not systematically been reevaluated for complete LAA obliteration. METHODS AND RESULTS:During a 12-month period,...

    journal_title:Cardiology

    pub_type: 临床试验,杂志文章

    doi:10.1159/000087632

    authors: Schneider B,Stollberger C,Sievers HH

    更新日期:2005-01-01 00:00:00

  • Valvular heart disease by transthoracic echocardiography is associated with focal brain injury and central neuropsychiatric systemic lupus erythematosus.

    abstract:BACKGROUND:Previous studies using transesophageal echocardiography (TEE) report an association of valvular heart disease (VHD) with cerebral infarcts and central neuropsychiatric systemic lupus erythematosus (NPSLE). However, TEE cannot be routinely used. AIM:To determine if VHD detected by transthoracic echocardiogra...

    journal_title:Cardiology

    pub_type: 杂志文章

    doi:10.1159/000099104

    authors: Roldan CA,Gelgand EA,Qualls CR,Sibbitt WL Jr

    更新日期:2007-01-01 00:00:00

  • Sex Influence on the Efficacy and Safety of Sacubitril/Valsartan.

    abstract:BACKGROUND:Women are underrepresented in sacubitril/valsartan (SV) clinical trials. The aim of this study was to assess sex-specific differences in efficacy, tolerability, and safety of SV in real-world heart failure with reduced ejection fraction (HFrEF) patients. METHODS:A prospective registry in 10 centers includin...

    journal_title:Cardiology

    pub_type: 杂志文章,多中心研究

    doi:10.1159/000498984

    authors: Vicent L,Ayesta A,Esteban-Fernández A,Gómez-Bueno M,De-Juan J,Díez-Villanueva P,Iniesta ÁM,Rojas-González A,Bover-Freire R,Iglesias D,García-Aguado M,Perea-Egido JA,Martínez-Sellés M

    更新日期:2019-01-01 00:00:00

  • Estimating mortality in survivors of the acute coronary syndrome by the 4-drug score.

    abstract:OBJECTIVE:Four drug classes, platelet inhibitors, β-blockers, statins, and angiotensin-converting enzyme inhibitors (or angiotensin receptor blockers), have been shown to reduce mortality in clinical trials. We sought to evaluate whether the simple number of secondary prevention drugs at discharge is independently asso...

    journal_title:Cardiology

    pub_type: 杂志文章

    doi:10.1159/000355160

    authors: Kopel E,Klempfner R,Goldenberg I,Schwammenthal E

    更新日期:2014-01-01 00:00:00

  • Left ventricular function during asynchronous ventricular pacing: a radionuclide study.

    abstract::This study was undertaken to assess ventricular volumes and function by radionuclide angiography during asynchronous ventricular pacing in a group of 22 patients who needed an artificial pacemaker. 14 had ischaemic heart disease and 8 had primary disturbances of conduction of the impulse-forming system. The transition...

    journal_title:Cardiology

    pub_type: 杂志文章

    doi:10.1159/000173685

    authors: Weiss AT,Gotsman MS,Lewis BS,Rein AJ,Atlan H

    更新日期:1984-01-01 00:00:00

  • Pulse pressure and left ventricular diastolic dysfunction in hypertensive patients.

    abstract:BACKGROUND:Impaired left ventricular diastolic function is a common finding in essential hypertension. METHODS:In order to investigate possible relationships between flow velocity through the mitral valve (E/A; index of left ventricular diastolic function) and 24-hour blood pressure and heart rate variations, 198 pati...

    journal_title:Cardiology

    pub_type: 杂志文章

    doi:10.1159/000078149

    authors: Trika CO,Zakopoulos N,Toumanidis ST,Stamatelopoulos SF,Moulopoulos SD

    更新日期:2004-01-01 00:00:00

  • Accessory mitral valve tissue: report of two asymptomatic cases.

    abstract::Accessory mitral valve tissue is a rare anomaly of embryologic development of the endocardial cushion and may cause substantial and progressive obstruction of the left ventricular outflow tract. Subaortic obstruction resulting from accessory mitral tissue is most likely due to systolic ballooning of the tissue into th...

    journal_title:Cardiology

    pub_type: 杂志文章

    doi:10.1159/000091290

    authors: Uslu N,Gorgulu S,Yildirim A,Eren M

    更新日期:2006-01-01 00:00:00

  • Comparative hemodynamic effects of intravenous digoxin and enoximone in severe chronic heart failure.

    abstract::In order to compare the acute hemodynamic effects of digoxin (0.01 mg/kg) and enoximone (1 mg/kg), a phosphodiesterase inhibitor inotropic agent, in severe chronic congestive heart failure, 8 patients (male, mean age 56.7 years, sinus rhythm) were investigated with a randomized cross-over study. Peak effect of enoximo...

    journal_title:Cardiology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1159/000176702

    authors: Casella G,Cantelli I,Pavesi PC,Barbato G,Bracchetti D

    更新日期:1994-01-01 00:00:00

  • Efficacy and Safety of Adjunctive Trimetazidine Therapy for Acute Myocardial Infarction: A Systematic Review and Meta-Analysis.

    abstract:BACKGROUND:Several lines of evidence support the clinical use of trimetazidine as an adjunctive therapy in cardioischemic patients. Therefore, we assessed here the efficacy and safety of adjunctive trimetazidine therapy in acute myocardial infarction (MI) patients by a systematic review and meta-analysis of the current...

    journal_title:Cardiology

    pub_type: 杂志文章,meta分析,评审

    doi:10.1159/000446640

    authors: Li Y,Wang D,Hu C,Zhang P,Zhang D,Qin S

    更新日期:2016-01-01 00:00:00

  • Long-Term Outcome of Patients with Perimembranous Ventricular Septal Defect: Results from the Belgian Registry on Adult Congenital Heart Disease.

    abstract:OBJECTIVES:Studies evaluating the long-term outcome of adults with ventricular septal defect (VSD) are important to inform patients about prognosis. This study investigated the long-term outcome of patients with perimembranous VSD (pmVSD) followed in the Belgian Registry on Adult Congenital Heart Disease. METHODS:All ...

    journal_title:Cardiology

    pub_type: 杂志文章

    doi:10.1159/000448513

    authors: Gabriels C,De Backer J,Pasquet A,Paelinck BP,Morissens M,Helsen F,Van De Bruaene A,Budts W

    更新日期:2017-01-01 00:00:00

  • Sudden cardiac death in athletes.

    abstract::Sudden cardiac death in athletes, although relatively uncommon, is a well-recognized condition generally associated with some congenital abnormalities. It, however, continues to be of vast interest to the public as athletes are seen as a distinct group of individuals who are especially able to tolerate more intense ph...

    journal_title:Cardiology

    pub_type: 杂志文章,评审

    doi:10.1159/000074812

    authors: Lorvidhaya P,Stephen Huang SK

    更新日期:2003-01-01 00:00:00

  • Aging does not affect radial viscoelastic behavior of the left ventricle.

    abstract:OBJECTIVES:This study investigates the effect of aging on the radial viscoelastic behavior of the left ventricle (LV) based on a previously validated model that uses myocardial tissue phase mapping (TPM) of cine phase-contrast MRI. METHODS:Previous studies suggest that aging remarkably influences regional myocardial m...

    journal_title:Cardiology

    pub_type: 杂志文章

    doi:10.1159/000348871

    authors: Mangual JO,Föll D,Jung B,Pedrizzetti G,Kheradvar A

    更新日期:2013-01-01 00:00:00

  • Systolic anterior motion of the mitral valve with and without asymmetric septal hypertrophy. Role of left ventricular posterior wall motion.

    abstract::Abnormal systolic anterior (SAM) motion of the mitral valve without asymmetric hypertrophy of the interventricular septum was observed in 16 patients (group 1). 5 of the 16 patients had no other evidence of heart disease and the remaining 11 had a variety of cardiac disorders. Left ventricular dimensions, septal and p...

    journal_title:Cardiology

    pub_type: 杂志文章

    doi:10.1159/000170860

    authors: Udoshi M,Shah A,Fisher VJ,Dolgin M

    更新日期:1980-01-01 00:00:00

  • Sirolimus- versus paclitaxel-eluting stent implantation for unprotected left main coronary artery stenosis.

    abstract::We performed this study in order to compare the immediate and mid-term outcomes of sirolimus-eluting stents (SES) and paclitaxel-eluting stents (PES) in lesions of the unprotected left main coronary artery (LMCA). We assessed 54 patients from 5 centers who had undergone unprotected LMCA stenting (35 SES and 19 PES). T...

    journal_title:Cardiology

    pub_type: 杂志文章,多中心研究

    doi:10.1159/000088106

    authors: Lee SH,Ko YG,Jang Y,Kwon HM,Lee SH,Yoon JH,Park SH,Kim BO,Jeon DW,Yang JY,Ryu SK,Korean Multicenter Angioplasty Team (KOMATE) Investigators.

    更新日期:2005-01-01 00:00:00

  • Acute effects of biventricular pacing in heart failure patients with a normal ejection fraction and mechanical dyssynchrony.

    abstract:OBJECTIVES:We tested the acute effects of resynchronization in heart failure patients with a normal (>50%) left ventricular (LV) ejection fraction (HFNEF) and mechanical dyssynchrony. METHODS:Twenty-four HFNEF patients (72 ± 6 years, 5 male) with mechanical dyssynchrony (standard deviation of electromechanical time de...

    journal_title:Cardiology

    pub_type: 杂志文章

    doi:10.1159/000368795

    authors: Wang YC,Yu CC,Chiu FC,Splett V,Klepfer R,Hilpisch K,Tsai CT,Lai LP,Hwang JJ,Lin JL

    更新日期:2015-01-01 00:00:00

  • The Role of Platelet-Derived Growth Factor-B/Platelet-Derived Growth Factor Receptor-β Signaling in Chronic Atrial Fibrillation.

    abstract:OBJECTIVE:To explore the role of platelet-derived growth factor-B (PDGF-B)/platelet-derived growth factor receptor-β (PDGFR-β) signaling in chronic atrial fibrillation (AF). METHODS:Thirty-nine AF patients and 33 patients with sinus rhythm (SR) were enrolled. Twenty canines were randomized into 5 groups: control, sham...

    journal_title:Cardiology

    pub_type: 杂志文章

    doi:10.1159/000442940

    authors: Jiang Z,Zhong G,Wen L,Hong Y,Fang S,Sun P,Li S,Li S,Feng G

    更新日期:2016-01-01 00:00:00

  • Percutaneous transluminal coronary angioplasty in unstable and stable angina pectoris: a comparison of immediate success and complications.

    abstract::To determine the success rate and the safety of percutaneous transluminal coronary angioplasty in patients with unstable angina pectoris (group 1) versus stable angina (group 2), we studied 299 consecutive patients who underwent coronary angioplasty of 373 consecutive lesions. Of these patients, 149 had unstable angin...

    journal_title:Cardiology

    pub_type: 杂志文章

    doi:10.1159/000175811

    authors: Ilia R,Kolansky D,Setaro J,Brennan J,Cabin H,Cleman M,Remetz M

    更新日期:1992-01-01 00:00:00

  • Cardiovascular changes in awake dogs caused by suddenly induced aortic hypertension.

    abstract::Cardiovascular adaptation to the sudden inflation of a balloon in the descending aorta was investigated in intact awake, standing dogs. The balloon inflation raised pressure in the arterial bed proximal from the balloon. Initially, it lowered heart rate and cardiac output. After 4 sec, heart rate and cardiac output be...

    journal_title:Cardiology

    pub_type: 杂志文章

    doi:10.1159/000169905

    authors: Ehrlich W,Rodriguez-Lopez E

    更新日期:1978-01-01 00:00:00

  • Role of adrenal androgens in the development of arteriosclerosis as judged by pulse wave velocity and calcification of the aorta.

    abstract::To evaluate the role of adrenal androgens in the development of arteriosclerosis, serum dehydroepiandrosterone sulfate (DHEAS), dehydroepiandrosterone (DHEA), aortic calcification and pulse wave velocity (PWV) were measured in 69 males and 119 females without overt cardiovascular disease. The steroids decreased with a...

    journal_title:Cardiology

    pub_type: 杂志文章

    doi:10.1159/000175022

    authors: Ishihara F,Hiramatsu K,Shigematsu S,Aizawa T,Niwa A,Takasu N,Yamada T,Matsuo K

    更新日期:1992-01-01 00:00:00

  • Prognostic information from on-line vectorcardiography in unstable angina pectoris.

    abstract::The prognostic information from 24-hour monitoring with on-line vectorcardiography (VCG) was assessed in 100 patients with a clinical diagnosis of unstable angina pectoris. ST change vector magnitude, ST vector magnitude and QRS vector difference were monitored. During a follow-up period of 343 +/- 77 days, 7 patients...

    journal_title:Cardiology

    pub_type: 杂志文章

    doi:10.1159/000176832

    authors: Lundin P,Eriksson SV,Fredrikson M,Rehnqvist N

    更新日期:1995-01-01 00:00:00

  • Congenital prolongation of Q-T interval: a family study of three generations.

    abstract::Three generations of a family with the Romano-Ward syndrome are described. Of all the affected members, only 1 was symptomatic, experiencing episodes of syncope proven to be due to polymorphous ventricular tachycardia (PMVT) induced by chlorimipramine treatment for depression. During treatment of an episode of PMVT wi...

    journal_title:Cardiology

    pub_type: 杂志文章

    doi:10.1159/000173500

    authors: Flugelman MY,Pollack S,Hammerman H,Riss E,Barzilai D

    更新日期:1982-01-01 00:00:00