Sex Influence on the Efficacy and Safety of Sacubitril/Valsartan.

Abstract:

BACKGROUND:Women are underrepresented in sacubitril/valsartan (SV) clinical trials. The aim of this study was to assess sex-specific differences in efficacy, tolerability, and safety of SV in real-world heart failure with reduced ejection fraction (HFrEF) patients. METHODS:A prospective registry in 10 centers including all patients who started SV during the last 6 months was analyzed in this study. RESULTS:A total of 427 patients were included, 126 (29.5%) were women. There were no substantial differences in HFrEF treatment before SV initiation, although fewer women than men carried an implantable cardioverter defibrillator (57 [45.2%] vs. 173 [58.1%], p = 0.02). SV starting dose was 24/26 mg b.i.d. in 206 patients (48.2%), 49/51 mg b.i.d. in 184 (43.1%), and 97/103 mg b.i.d. in 34 (8.2%), without relevant differences associated to sex. There were no losses during a mean follow-up of 7.0 ± 0.1 months. The proportion of patients who discontinued the drug (16 [12.7%] women vs. 33 [11.0%] men, p = 0.66) or presented SV-related adverse effects (31 [24.6%] women vs. 79 [26.5%] men, p = 0.72) was also similar in both sexes. However, female sex was an independent predictor of functional class improvement in the multivariate analysis (odds ratio 2.33, 95% confidence interval: 1.24-4.38, p = 0.04). CONCLUSIONS:SV in women with HFrEF has a similar tolerability as in men. Females seem to have a more frequent functional class improvement than males.

journal_name

Cardiology

journal_title

Cardiology

authors

Vicent L,Ayesta A,Esteban-Fernández A,Gómez-Bueno M,De-Juan J,Díez-Villanueva P,Iniesta ÁM,Rojas-González A,Bover-Freire R,Iglesias D,García-Aguado M,Perea-Egido JA,Martínez-Sellés M

doi

10.1159/000498984

subject

Has Abstract

pub_date

2019-01-01 00:00:00

pages

73-78

issue

2

eissn

0008-6312

issn

1421-9751

pii

000498984

journal_volume

142

pub_type

杂志文章,多中心研究
  • Cardiopulmonary Exercise Testing in Patients with Asymptomatic or Equivocal Symptomatic Aortic Stenosis: Feasibility, Reproducibility, Safety and Information Obtained on Exercise Physiology.

    abstract:OBJECTIVE:The aim of this study was to determine the feasibility, reproducibility, safety and information obtained on exercise physiology from cardiopulmonary exercise testing (CPX) in patients with aortic stenosis. METHODS:Patients with an aortic valve area (AVA) <1.3 cm2 who were judged asymptomatic or equivocal sym...

    journal_title:Cardiology

    pub_type: 杂志文章

    doi:10.1159/000441292

    authors: van Le D,Jensen GV,Carstensen S,Kjøller-Hansen L

    更新日期:2016-01-01 00:00:00

  • Pre-clinical myocardial metabolic alterations in chronic kidney disease.

    abstract:UNLABELLED:The risk for cardiovascular events conferred by decreased renal function is curvilinear with exponentially greater increases in risk as estimated glomerular filtration rate (eGFR) declines. In 13 non-diabetic pre-dialysis chronic kidney disease (CKD) patients, we employed quantitative F-18 fluorodeoxyglucose...

    journal_title:Cardiology

    pub_type: 杂志文章

    doi:10.1159/000318227

    authors: Fink JC,Lodge MA,Smith MF,Hinduja A,Brown J,Dinits-Pensy MY,Dilsizian V

    更新日期:2010-01-01 00:00:00

  • Acute Coronary Stent Thrombosis in Modern Era: Etiology, Treatment, and Prognosis.

    abstract::Acute stent thrombosis (AST) is a rare but life-threatening complication of coronary artery stenting. AST remains a challenging task for cardiologists, despite the application of modern procedural techniques and dual-antiplatelet therapy strategies as well as improved understanding of the underlying pathophysiology. T...

    journal_title:Cardiology

    pub_type: 杂志文章,评审

    doi:10.1159/000464404

    authors: Ge J,Yu H,Li J

    更新日期:2017-01-01 00:00:00

  • Exercise testing in patients with valve replacement.

    abstract::To determine whether detection of pathologic exercise hemodynamics can be based on assessment of noninvasive parameters, pulmonary artery pressure and cardiac output were measured during graded bicycle ergometry in 33 patients with mitral valve replacement and 42 patients with aortic valve replacement. No relationship...

    journal_title:Cardiology

    pub_type: 杂志文章

    doi:10.1159/000173323

    authors: Kraus F,Rudolph W

    更新日期:1981-01-01 00:00:00

  • Tiapamil in the treatment of lidocaine-resistant ventricular arrhythmias complicating acute myocardial infarction.

    abstract::The antiarrhythmic effects of tiapamil were investigated in 48 patients, mean age 54, with acute myocardial infarction and ventricular arrhythmias. 9 had ventricular tachycardia, 6 ventricular fibrillation, and 33 multifocal premature ventricular contractions. Before and after therapy, ECG parameters, left ventricular...

    journal_title:Cardiology

    pub_type: 杂志文章

    doi:10.1159/000173556

    authors: Lessem J

    更新日期:1982-01-01 00:00:00

  • Rheumatic Mitral Stenosis: Long-Term Follow-Up of Adult Patients with Nonsevere Initial Disease.

    abstract:INTRODUCTION:There is no consensus regarding the natural history of rheumatic mitral stenosis (MS) among adults presenting with nonsevere disease. This study aims to describe the progression of stenosis among adult rheumatic MS patients, to identify predictive factors for progression, and to assess the incidence of com...

    journal_title:Cardiology

    pub_type: 杂志文章

    doi:10.1159/000505481

    authors: Bitan A,Mazor-Dray E,Weinstein JM,Carmel S,Ilia R

    更新日期:2020-01-01 00:00:00

  • Ibopamine as a valuable adjunct and substitute for dopamine in bridging therapy before heart transplantation.

    abstract::Ibopamine is an active dopamine analogue leading to improved renal perfusion and afterload reduction in heart failure. This report describes casuistic experiences in patients with severe heart failure awaiting heart transplantation. All patients could be stabilized, intravenous catecholamines be discontinued, and diur...

    journal_title:Cardiology

    pub_type: 杂志文章

    doi:10.1159/000175786

    authors: Kleber FX,Sabin GV,Thyroff-Friesinger U,Cabell B,Glogar D

    更新日期:1992-01-01 00:00:00

  • Does chronic ST segment elevation following Q wave myocardial infarction exclude tissue viability?

    abstract:PURPOSE:Electrocardiographic (ECG) ST segment elevation lasting 2 or more weeks following Q wave myocardial infarction has been associated with 'ventricular aneurysm' and absence of tissue viability. Regional systolic dysfunction may reflect either viable myocardium or scar. Positron emission-tomographic (PET) imaging ...

    journal_title:Cardiology

    pub_type: 杂志文章

    doi:10.1159/000072386

    authors: Saber W,Nishime EO,Brunken RC,Apperson-Hansen C,Mills RM

    更新日期:2003-01-01 00:00:00

  • Persistent thallium-201 defect: can clinical, electrocardiographic and exercise hemodynamic variables predict defect normalization with reinjection?

    abstract::This study was designed to assess the contribution of clinical, electrocardiographic and exercise hemodynamic variables to the prediction of normalization on resting reinjection scintigraphy of persistent thallium-201 (201Tl) myocardial perfusion defects seen with exercise and 2- to 4-hour delayed (redistribution) ima...

    journal_title:Cardiology

    pub_type: 杂志文章

    doi:10.1159/000177093

    authors: Shammas NW,Schwartz RG,Pomerantz RM,Murphy GW,Hall WJ

    更新日期:1996-05-01 00:00:00

  • Biventricular Rupture with Extracardiac Left-to-Right Shunt Complicating Acute Myocardial Infarction.

    abstract:BACKGROUND:Simultaneous rupture of the left and right ventricles is an extremely rare mechanical complication of acute myocardial infarction (MI). When associated with the formation of a false aneurysm, an extracardiac left-to-right shunt may occur. METHODS:We summarized all published data describing this unique condi...

    journal_title:Cardiology

    pub_type: 杂志文章,评审

    doi:10.1159/000444579

    authors: Yalonetsky S,Aronson D

    更新日期:2016-01-01 00:00:00

  • Effect of subadipose tissue on the variables of signal-averaged electrocardiograms in healthy subjects.

    abstract::Ventricular late potentials are obtained by signal averaging of surface electrocardiograms. Late potentials have been reported to be affected by body size or left ventricular mass. However, the effect of subadipose tissue, which is known to influence QRS amplitudes of surface ECG, on the variables of late potentials h...

    journal_title:Cardiology

    pub_type: 杂志文章

    doi:10.1159/000175854

    authors: Masui A,Tsuji H,Tamura K,Sugiura T,Matsui Y,Iwasaka T,Inada M

    更新日期:1993-01-01 00:00:00

  • Hemodynamics of a stenosis in a complaint artery.

    abstract::The effects of arterial compliance on stenotic hemodynamics were examined in an in vitro arterial preparation. Carotid arteries, obtained from anesthetized mongrel dogs (11.3-15.4 kg), were attached to a perfusion apparatus consisting of a constant pressure reservoir and a fixed distal resistance. To create an intralu...

    journal_title:Cardiology

    pub_type: 杂志文章

    doi:10.1159/000173478

    authors: Santamore WP,Bove AA,Carey RA

    更新日期:1982-01-01 00:00:00

  • Common form of Lyme borreliosis carditis--complete heart block with syncope: report on 3 cases.

    abstract::Third degree atrioventricular (AV) heart block with severe Adams-Stokes attacks in 3 patients with Lyme borreliosis is described. All patients had similar clinical manifestations: previously healthy, they experience syncope as an abrupt onset of the disease. Data on skin changes--erythema migrans--was subsequently obt...

    journal_title:Cardiology

    pub_type: 杂志文章

    doi:10.1159/000177064

    authors: Vasiljević Z,Dmitrović R,Naumović Z,Ostojić M,Radosavljević M,Karadzić A,Prostran M,Colić M

    更新日期:1996-01-01 00:00:00

  • A pilot study exploring the mechanisms involved in the longitudinal propagation of acute aortic dissection through computational fluid dynamic analysis.

    abstract:OBJECTIVE:This study sought to elucidate the underlying hemodynamic mechanisms involved in the longitudinal propagation of acute, type-B aortic dissections. METHODS:Three-dimensional patient-specific aortic geometry was reconstructed from computed tomography images of 3 cases, followed by computational fluid dynamic a...

    journal_title:Cardiology

    pub_type: 杂志文章

    doi:10.1159/000358041

    authors: Zhang Y,Lu Q,Feng J,Yu P,Zhang S,Teng Z,Gillard JH,Song R,Jing Z

    更新日期:2014-01-01 00:00:00

  • Aortic stiffness is an independent predictor of left ventricular function in patients with coronary heart disease.

    abstract::Although aortic stiffness plays an important role in patients with coronary artery disease (CAD), the influence of aortic stiffness on left ventricular systolic function has not yet been fully evaluated. In the present study, we measured brachial-ankle pulse wave velocity (baPWV), which is a new index of aortic stiffn...

    journal_title:Cardiology

    pub_type: 杂志文章

    doi:10.1159/000082472

    authors: Sakuragi S,Iwasaki J,Tokunaga N,Hiramatsu S,Ohe T

    更新日期:2005-01-01 00:00:00

  • Use of programmed stimulation in identifying patients at high risk for sudden cardiac death.

    abstract::Sudden cardiac death accounts for 60% of the total cardiovascular mortality in the United States. Individuals after myocardial infarction or with chronic left ventricular dysfunction are known to be at increased risk. Noninvasive studies have been applied to these populations, but the predictive accuracy of these test...

    journal_title:Cardiology

    pub_type: 杂志文章

    doi:10.1159/000174604

    authors: Hessen SE,Nydegger CC,Kutalek SP

    更新日期:1990-01-01 00:00:00

  • Depressed plasma platelet-activating factor acetylhydrolase in patients presenting with acute myocardial infarction.

    abstract::Cell membrane phospholipids, including platelet-activating factor (PAF), participate in the pathogenesis of acute myocardial infarction (AMI). The plasma level of PAF acetylhydrolase (AH) was determined in 18 patients at presentation with AMI before thrombolysis, and the administration of adjunctive therapy, and compa...

    journal_title:Cardiology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1159/000006831

    authors: Serebruany VL,Gurbel PA,Murugesan SR,Lowry DR,Sturm E,Svetlov SI

    更新日期:1998-10-01 00:00:00

  • Syncope in dilated cardiomyopathy is a predictor of sudden cardiac death.

    abstract::Fifty percent of patients with dilated cardiomyopathy die within 5 years of diagnosis. Syncope is known to be a predictor of poor outcome in patients with advanced heart failure. To assess the risk of patients with dilated cardiomyopathy with a history of syncope during standard medical treatment we compared this grou...

    journal_title:Cardiology

    pub_type: 杂志文章

    doi:10.1159/000177083

    authors: Fruhwald FM,Eber B,Schumacher M,Zweiker R,Watzinger N,Klein WW

    更新日期:1996-05-01 00:00:00

  • Proteomic Analyses of Endarterectomized Tissues from Patients with Chronic Thromboembolic Pulmonary Hypertension.

    abstract:BACKGROUND:The pathogenesis of chronic thromboembolic pulmonary hypertension (CTEPH) is largely unknown. Proteomics offers an approach to overview the molecular activities and signal transduction pathways involved in specific disease processes. OBJECTIVES:In this study, the expression of proteins in endarterectomized ...

    journal_title:Cardiology

    pub_type: 新闻

    doi:10.1159/000502831

    authors: Xi Q,Liu Z,Song Y,Gan H,Huang Z,Luo Q,Zhao Z

    更新日期:2020-01-01 00:00:00

  • Idiopathic short QT interval: a new clinical syndrome?

    abstract::In this first clinical report of an idiopathic familial persistently short QT interval (QTI), we describe three members of one family (a 17-year-old female, her 21-year-old brother, and their 51-year-old mother) demonstrating this ECG phenomenon, associated in the 17-year-old with several episodes of paroxysmal atrial...

    journal_title:Cardiology

    pub_type: 杂志文章

    doi:10.1159/000047299

    authors: Gussak I,Brugada P,Brugada J,Wright RS,Kopecky SL,Chaitman BR,Bjerregaard P

    更新日期:2000-01-01 00:00:00

  • Survey of physician's attitudes and practices toward lipid-lowering management strategies.

    abstract:BACKGROUND:The purpose of the present study was to examine physician's attitudes and practices toward the use of different lipid-lowering management strategies in patients at increased risk for coronary heart disease (CHD). AIMS/METHODS:An internet-based questionnaire was completed by 78 general internists and family ...

    journal_title:Cardiology

    pub_type: 杂志文章

    doi:10.1159/000099066

    authors: Goldberg RJ,Rosen J,Roselli A,Lewis B

    更新日期:2007-01-01 00:00:00

  • Selective alpha-1 inhibitors: first- or second-line antihypertensive agents?

    abstract::It is well documented that in the treatment of mild or moderate hypertension selective alpha 1-inhibitors such as doxazosin and prazosin lower blood pressure to approximately the same extent as beta-blockers, diuretics, ACE inhibitors and calcium antagonists. However, treatment with selective alpha 1-inhibitors is als...

    journal_title:Cardiology

    pub_type: 杂志文章,评审

    doi:10.1159/000175963

    authors: Lund-Johansen P,Hjermann I,Iversen BM,Thaulow E

    更新日期:1993-01-01 00:00:00

  • Efficacy and safety of imidapril in patients with essential hypertension: a double-blind comparison with captopril.

    abstract::In this 12-week, double-blind, parallel-group, comparative trial, 57 adult patients with mild-to-moderate hypertension were randomly allocated to receive imidapril or captopril, initially at a dose of 5 mg once a day and 25 mg twice daily, respectively. After 4 weeks of therapy, the dose of each drug was increased twi...

    journal_title:Cardiology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1159/000047361

    authors: Huang PJ,Chien KL,Chen MF,Lai LP,Chiang FT

    更新日期:2001-01-01 00:00:00

  • Percutaneous transluminal coronary angioplasty in unstable and stable angina pectoris: a comparison of immediate success and complications.

    abstract::To determine the success rate and the safety of percutaneous transluminal coronary angioplasty in patients with unstable angina pectoris (group 1) versus stable angina (group 2), we studied 299 consecutive patients who underwent coronary angioplasty of 373 consecutive lesions. Of these patients, 149 had unstable angin...

    journal_title:Cardiology

    pub_type: 杂志文章

    doi:10.1159/000175811

    authors: Ilia R,Kolansky D,Setaro J,Brennan J,Cabin H,Cleman M,Remetz M

    更新日期:1992-01-01 00:00:00

  • Physical rehabilitation in coronary patients who have suffered from episodes of cardiac failure.

    abstract::The effects of bicycle training for 5 weeks were evaluated in 12 patients after myocardial infarction with left ventricular dysfunction (left ventricular ejection fraction < 40%) and at least one episode of cardiac failure in the past. The patients were divided into two groups of six according to the Weber classificat...

    journal_title:Cardiology

    pub_type: 杂志文章

    doi:10.1159/000175034

    authors: Scalvini S,Marangoni S,Volterrani M,Schena M,Quadri A,Levi GF

    更新日期:1992-01-01 00:00:00

  • Ultra-short-term heart rate variability for early risk stratification following acute ST-elevation myocardial infarction.

    abstract:OBJECTIVES:To evaluate the prognostic significance of early ultra-short-term heart rate variability (HRV) measurement in patients admitted for ST-elevation myocardial infarction (STEMI). METHODS:HRV was calculated retrospectively from the standard admission and discharge 10-second ECG of 196 consecutive patients with ...

    journal_title:Cardiology

    pub_type: 杂志文章

    doi:10.1159/000235568

    authors: Karp E,Shiyovich A,Zahger D,Gilutz H,Grosbard A,Katz A

    更新日期:2009-01-01 00:00:00

  • Prognostic implication of detecting vegetations by M-mode echocardiography.

    abstract::The prognostic significance of finding vegetations by M-mode echocardiography in patients with infective endocarditis remains controversial because many such patients are referred for early surgery. We detected vegetations in 7 of 25 consecutive subjects with active infective endocarditis (28.1%) studied by M-mode ech...

    journal_title:Cardiology

    pub_type: 杂志文章

    doi:10.1159/000173593

    authors: Markiewicz W,Moscovitz M,Edoute Y,Finkelstein R,Raz R

    更新日期:1983-01-01 00:00:00

  • Soluble VCAM-1 and E-selectin, but not ICAM-1 discriminate endothelial injury in patients with documented coronary artery disease.

    abstract::It has been shown that endothelial cell adhesion molecules play an important role in the development of coronary atherosclerosis and inflammatory disease. We sought to test whether soluble vascular cell adhesion molecule-1 (VCAM-1), intercellular adhesion molecule-1 (ICAM-1) and E-selectin are increased in patients wi...

    journal_title:Cardiology

    pub_type: 杂志文章

    doi:10.1159/000006995

    authors: Semaan HB,Gurbel PA,Anderson JL,Muhlestein JB,Carlquist JF,Horne BD,Serebruany VL

    更新日期:2000-01-01 00:00:00

  • Cardioprotective potential of carvedilol.

    abstract::Carvedilol is a multiple-action cardiovascular agent that is a nonselective beta-adrenoceptor antagonist and a vasodilator. beta-Adrenoceptor antagonists reduce myocardial work, secondary to reductions in heart rate and contractility, both in animals and in humans. For these reasons, carvedilol may improve survival of...

    journal_title:Cardiology

    pub_type: 杂志文章

    doi:10.1159/000175930

    authors: Ruffolo RR Jr,Bril A,Feuerstein GZ

    更新日期:1993-01-01 00:00:00

  • Mycotic aneurysms of aortic root and aorta-to-left atrial fistula complicating bicuspid aortic valve endocarditis.

    abstract::Unlike root abscess, fistula formation is quite uncommon in aortic valve endocarditis. In this report, we describe a patient with subacute bicuspid aortic valve endocarditis complicated by aortic insufficiency, mycotic aneurysms of the aortic root and fistulous communication between the aorta and the left atrium and h...

    journal_title:Cardiology

    pub_type: 杂志文章

    doi:10.1159/000090203

    authors: Ozerkan F,Duygu H,Nalbantgil S,Cinar CS

    更新日期:2006-01-01 00:00:00