Role of adrenal androgens in the development of arteriosclerosis as judged by pulse wave velocity and calcification of the aorta.

Abstract:

:To evaluate the role of adrenal androgens in the development of arteriosclerosis, serum dehydroepiandrosterone sulfate (DHEAS), dehydroepiandrosterone (DHEA), aortic calcification and pulse wave velocity (PWV) were measured in 69 males and 119 females without overt cardiovascular disease. The steroids decreased with age in both sexes, and the reduction was significantly steeper in younger (< or = 40 years) than in older (> 40 years) subjects only in females. When adjusted for age, the steroids were significantly lower in subjects with aortic calcification than in those without it, and the PWV was significantly slower in the latter. Adrenal androgens appear to retard the development and/or progression of arteriosclerosis.

journal_name

Cardiology

journal_title

Cardiology

authors

Ishihara F,Hiramatsu K,Shigematsu S,Aizawa T,Niwa A,Takasu N,Yamada T,Matsuo K

doi

10.1159/000175022

subject

Has Abstract

pub_date

1992-01-01 00:00:00

pages

332-8

issue

5-6

eissn

0008-6312

issn

1421-9751

journal_volume

80

pub_type

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