Abstract:
:Amiodarone, a highly effective medication for suppressing cardiac rhythm disturbances, may cause pulmonary injury, such as chronic interstitial lung diseases, in 5-15% of the patients who take it. We applied induced sputum (IS), a non-invasive technique, for diagnosing amiodarone-induced pulmonary toxicity. Four patients with interstitial lung disease who were treated by amiodarone for ischemic heart diseases were evaluated by a conventional clinical workup. All four patients showed marked interstitial pattern on computerized tomography and decreased diffusion capacity (DLCO-SB 51-76%). IS showed lymphocytosis, a high CD4 or CD8 count, eosinophilia and amiodarone in 3 of 4 patients. IS may be a useful tool for assessing amiodarone toxicity in patients with ischemic heart diseases and concomitant pulmonary side effects.
journal_name
Cardiologyjournal_title
Cardiologyauthors
Fireman E,Topilsky I,Viskin S,Priel IEdoi
10.1159/000096782subject
Has Abstractpub_date
2007-01-01 00:00:00pages
223-7issue
4eissn
0008-6312issn
1421-9751pii
96782journal_volume
108pub_type
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