Abstract:
:A number of cardiac metabolic intermediates, namely, adenosine triphosphate (ATP), H+, phosphocreatine (PCr), inorganic phosphate (Pi), adenosine diphosphate (ADP), and related functions of these intermediates, Gibbs' free energy of ATP hydrolysis (delta G) and phosphorylation ratio [ATP/(ADP.Pi)], are thought to adjust mitochondrial oxidative phosphorylation rates to conform to mechanical demand. The effects of hypothermia and altered perfusion pressure on these parameters were evaluated in 12 hearts from Sprague-Dawley rats perfused in the Langendorff mode. 31P-nuclear magnetic resonance (NMR) spectra were obtained at cardiac temperatures between 20 and 37 degrees C, and coronary perfusion pressures between 20 and 145 cm H2O. Coronary flow varied between 0.5 and 15 ml/min throughout this range of intervention. Heart rate (HR), left ventricular systolic pressure (LVSP), and specific volumetric coronary flow (SCF) were determined for each temperature and perfusion pressure. The product HR x LVSP directly correlated with perfusion pressure at all temperatures. The temperature dependence could be represented by an overall activation energy of 72.7 kJ/M. In the constant temperature experiment, SCF and HR x LVSP fell linearly with decreasing perfusion pressure. Quantitative evaluation of the relationship between cardiac function and the metabolic intermediates described above defined these intermediates as nonregulatory with the possible exception of H+.
journal_name
Cardiologyjournal_title
Cardiologyauthors
Blum H,Ivanics T,Zhang D,Wroblewski K,Osbakken MDdoi
10.1159/000175871subject
Has Abstractpub_date
1993-01-01 00:00:00pages
238-48issue
4eissn
0008-6312issn
1421-9751journal_volume
82pub_type
杂志文章相关文献
CARDIOLOGY文献大全abstract::Atherosclerosis is the most frequent cause of occlusion of aortocoronary saphenous vein grafts between 5 and 10 years after coronary artery bypass surgery. The typical atherosclerotic plaque appears between 1 and 3 years after operation and, at a mean of 5 years, histologic changes of atherosclerosis are present in 21...
journal_title:Cardiology
pub_type: 杂志文章,评审
doi:10.1159/000174019
更新日期:1986-01-01 00:00:00
abstract::The severe teratogenic side effects of thalidomide led to its well-publicized withdrawal in the 1970s, but as it is cautiously being reintroduced into clinical use, new adverse effects are being described. A 65-year-old male with multiple myeloma received chemotherapy which included cyclophosphamide, thalidomide and d...
journal_title:Cardiology
pub_type: 杂志文章
doi:10.1159/000348367
更新日期:2013-01-01 00:00:00
abstract:OBJECTIVES:The aim of this study was to define the phenotypic spectrum of apical hypertrophic cardiomyopathy (ApHCM) and clinical characteristics pertaining to identified subtypes. METHODS:In 182 consecutive ApHCM patients (58.9 +/- 11.2 years; 142 men) with left ventricular ejection fraction > or =50%, we measured en...
journal_title:Cardiology
pub_type: 杂志文章,多中心研究
doi:10.1159/000109407
更新日期:2008-01-01 00:00:00
abstract::Abnormal systolic anterior (SAM) motion of the mitral valve without asymmetric hypertrophy of the interventricular septum was observed in 16 patients (group 1). 5 of the 16 patients had no other evidence of heart disease and the remaining 11 had a variety of cardiac disorders. Left ventricular dimensions, septal and p...
journal_title:Cardiology
pub_type: 杂志文章
doi:10.1159/000170860
更新日期:1980-01-01 00:00:00
abstract::Studies of heart rate and blood pressure responses to 70 degrees head-up tilt and 30 degrees head-down tilt were conducted in normal subjects and in chronic cardiac chagasic patients without past or present cardiac decompensation. During steady state of tilt, heart rate alterations were less marked in the chagasic tha...
journal_title:Cardiology
pub_type: 杂志文章
doi:10.1159/000169734
更新日期:1975-01-01 00:00:00
abstract::Rosuvastatin (Crestor; licensed to AstraZeneca, Macclesfield, UK from Shionogi, Osaka, Japan) is a new statin with pharmacologic characteristics that translate into selectivity of effect in hepatic cells and enhanced potency in 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibition. It is approved for use at doses...
journal_title:Cardiology
pub_type: 杂志文章,评审
doi:10.1159/000070669
更新日期:2003-01-01 00:00:00
abstract:OBJECTIVES:To assess the relationship between nonalcoholic fatty liver disease (NAFLD) and arterial stiffness in nondiabetic, nonhypertensive individuals with and without metabolic syndrome (MetS). METHODS:Hepatic ultrasound and brachial-ankle pulse wave velocity (baPWV) were investigated in 4,467 individuals. The sub...
journal_title:Cardiology
pub_type: 杂志文章
doi:10.1159/000341248
更新日期:2012-01-01 00:00:00
abstract:BACKGROUND:A number of innovative approaches have been investigated for their value in the early detection of acute ischemia or infarction in patients presenting to the emergency department (ED) with chest pain suggestive of a cardiac origin. Prior investigations have demonstrated the utility of adding right precordial...
journal_title:Cardiology
pub_type: 杂志文章
doi:10.1159/000077912
更新日期:2004-01-01 00:00:00
abstract::The antiarrhythmic effects of tiapamil were investigated in 48 patients, mean age 54, with acute myocardial infarction and ventricular arrhythmias. 9 had ventricular tachycardia, 6 ventricular fibrillation, and 33 multifocal premature ventricular contractions. Before and after therapy, ECG parameters, left ventricular...
journal_title:Cardiology
pub_type: 杂志文章
doi:10.1159/000173556
更新日期:1982-01-01 00:00:00
abstract::Thirty patients who had undergone coronary artery bypass grafting and who required vasodilator therapy for control of arterial hypertension were allocated to receive either low-dose or high-dose enoximone or placebo infusions. A closed-loop arterial pressure control system was used to assess cardiovascular stability a...
journal_title:Cardiology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1159/000174671
更新日期:1990-01-01 00:00:00
abstract:BACKGROUND:The purpose of the present study was to examine physician's attitudes and practices toward the use of different lipid-lowering management strategies in patients at increased risk for coronary heart disease (CHD). AIMS/METHODS:An internet-based questionnaire was completed by 78 general internists and family ...
journal_title:Cardiology
pub_type: 杂志文章
doi:10.1159/000099066
更新日期:2007-01-01 00:00:00
abstract:OBJECTIVES:Myocardial perfusion imaging (MPI) with positron emission tomography (PET) has advantages over single-photon emission computerized tomography, particularly for women. This investigation was undertaken to define the prognosis of a normal stress PET MPI study in women. METHODS:The cohort comprised 457 women e...
journal_title:Cardiology
pub_type: 杂志文章
doi:10.1159/000323841
更新日期:2010-01-01 00:00:00
abstract::Several lines of evidence have shown that viral infections are capable of causing coronary spasm and precipitating or mimicking clinical myocardial infarction. Here we report the case of a 41-year-old woman with recurrent angina who was admitted to our hospital because of ventricular tachycardia. Laboratory examinatio...
journal_title:Cardiology
pub_type: 杂志文章
doi:10.1159/000006987
更新日期:1999-01-01 00:00:00
abstract:OBJECTIVES:It is known that the expression, activity and alternative splicing of Ca2+/calmodulin-dependent protein kinase IIδ (CaMKIIδ) are dysregulated in the cardiac remodeling process. Recently, we found a further signaling pathway, by which dual-specificity tyrosine phosphorylation-regulated kinase 1A (Dyrk1A) regu...
journal_title:Cardiology
pub_type: 杂志文章
doi:10.1159/000441695
更新日期:2016-01-01 00:00:00
abstract:BACKGROUND:Multiple studies have quantified the relationship between aortic size and risk of dissection. However, these studies estimated the risk of dissection without accounting for any increase in aortic size from the dissection process itself. OBJECTIVES:This study aims to compare aortic size before and after diss...
journal_title:Cardiology
pub_type: 杂志文章
doi:10.1159/000481930
更新日期:2018-01-01 00:00:00
abstract::In an attempt to determine factors that are related to atrial natriuretic factor (ANF) release in normal subjects, 10 male volunteers were studied at rest supine, sitting and during treadmill exercise. Echocardiography was used to measure atrial volumes, and a Swan-Ganz catheter was used to measure right atrial pressu...
journal_title:Cardiology
pub_type: 杂志文章
doi:10.1159/000174635
更新日期:1990-01-01 00:00:00
abstract::Amiodarone is a potent antiarrhythmic drug with a prolonged half life. The administration of amiodarone for 6 weeks in rabbits caused a significant elevation of serum lipids. We measured serum lipoproteins in 24 patients before, 30 and 90 days after treatment with amiodarone. Serum triglycerides decreased for all pati...
journal_title:Cardiology
pub_type: 杂志文章
doi:10.1159/000173998
更新日期:1986-01-01 00:00:00
abstract::This study shows significant changes occurring in systolic time intervals in an experimental animal model of aortic outflow obstruction with cardiac hypertrophy. The left ventricular ejection time is markedly prolonged and the preejection period/left ventricular ejection time ratio shortened. These changes are in the ...
journal_title:Cardiology
pub_type: 杂志文章
doi:10.1159/000173260
更新日期:1981-01-01 00:00:00
abstract:OBJECTIVES:Myocardial infarction (MI) may be classified as ST elevation MI (STEMI) or non-ST elevation MI (NSTEMI). Procoagulants such as plasminogen activator inhibitor-1 (PAI-1) as well as markers of inflammation such as C-reactive protein (CRP), serum amyloid A (SAA) and interleukin-6 (IL-6) are elevated in acute co...
journal_title:Cardiology
pub_type: 杂志文章
doi:10.1159/000137700
更新日期:2009-01-01 00:00:00
abstract::Acute renal infarction due to emboli represents a very rare but significant threat for kidney loss, and the clinical presentation is challenging. The differential diagnosis of massive renal thrombi includes all other causes of abdominal pain, and they can be easily misdiagnosed as renal colic due to nephrolithiasis. A...
journal_title:Cardiology
pub_type: 杂志文章
doi:10.1159/000322510
更新日期:2010-01-01 00:00:00
abstract::The combination of oral anticoagulation (OAC) and aspirin was the antithrombotic treatment initially adopted after coronary stenting (PCI-S). Although dual antiplatelet therapy with aspirin and a thienopyridine subsequently proved safer and more effective, OAC and aspirin combination is still used in patients with an ...
journal_title:Cardiology
pub_type: 杂志文章,meta分析
doi:10.1159/000086918
更新日期:2005-01-01 00:00:00
abstract::To investigate the possible role of endothelin in coronary vasoconstriction contributing to the development of myocardial ischemia, plasma endothelin concentrations at rest and during atrial pacing-induced myocardial ischemia have been measured in blood samples drawn from the aorta and coronary sinus in 12 patients wi...
journal_title:Cardiology
pub_type: 杂志文章
doi:10.1159/000176670
更新日期:1994-01-01 00:00:00
abstract:OBJECTIVE:Bisoprolol, carvedilol and nebivolol have been shown to be effective in the treatment of heart failure. However, the beta-blocking effects of these drugs have never been compared directly. METHODS:Therefore, we performed a randomized, double-blind, placebo-controlled, cross-over trial in 16 healthy males. Su...
journal_title:Cardiology
pub_type: 杂志文章,随机对照试验
doi:10.1159/000093060
更新日期:2006-01-01 00:00:00
abstract::Review of a longitudinal study of the effects of 40 mg of propranolol orally in 14 patients with coronary heart disease demonstrated a minor but not statistically significant change in the relationship of percentage of maximal oxygen uptake to percentage of maximal heart rate. In a cross-sectional comparison of severa...
journal_title:Cardiology
pub_type: 杂志文章
doi:10.1159/000170794
更新日期:1980-01-01 00:00:00
abstract::The induction of spontaneous repetitive activity by a drive ('overdrive excitation') was studied in the sinoatrial node of the guinea pig by recording electrical and mechanical activity in sinoatrial preparations made quiescent by exposure to 20 mM caffeine of caffeine plus high [Ca]0. Electrical drive induced action ...
journal_title:Cardiology
pub_type: 杂志文章
doi:10.1159/000174372
更新日期:1988-01-01 00:00:00
abstract::Physical training causes an increase of aerobic capacity in normal and cardiac patients. The influences of training plus placebo and training plus verapamil have been studied in a double-blind randomized trial on 40 patients recovering from actue myocardial infarction. The two groups were comparable as to clinical cha...
journal_title:Cardiology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1159/000170635
更新日期:1979-01-01 00:00:00
abstract::In a group of eight patients with ventricular premature beats, ventriculoatrial conduction, with retrograde activation of the His bundle and the atria could be demonstrated by His bundle electrograms in four subjects. All had early ventricular premature beats with coupling indices between 210 and 350 msec. In the othe...
journal_title:Cardiology
pub_type: 杂志文章
doi:10.1159/000169687
更新日期:1974-01-01 00:00:00
abstract::The systolic time intervals (STI) were used to study the left ventricular performance in 51 patients with chronic obstructive pulmonary disease (COPD), in 24 normal subjects and in 13 patients with both COPD and coronary heart disease (CHD). Our study shows that resting spine STI are abnormal in patients with COPD and...
journal_title:Cardiology
pub_type: 杂志文章
doi:10.1159/000173261
更新日期:1981-01-01 00:00:00
abstract:BACKGROUND:Digital health is rapidly entering clinical practice in cardiology. Estonia is one of the leading nations in implementing digital nationwide solutions. Recently, the European Society of Cardiology organized the 1st Summit on Digital Health in Tallinn, which provided the opportunity to discuss various aspects...
journal_title:Cardiology
pub_type: 杂志文章,评审
doi:10.1159/000504564
更新日期:2020-01-01 00:00:00
abstract::Three generations of a family with the Romano-Ward syndrome are described. Of all the affected members, only 1 was symptomatic, experiencing episodes of syncope proven to be due to polymorphous ventricular tachycardia (PMVT) induced by chlorimipramine treatment for depression. During treatment of an episode of PMVT wi...
journal_title:Cardiology
pub_type: 杂志文章
doi:10.1159/000173500
更新日期:1982-01-01 00:00:00