Abstract:
OBJECTIVE:To test the hypothesis that pioglitazone, a peroxisome proliferator-activated receptor-gamma agonist, will improve endothelial function in non-diabetic subjects with coronary artery disease, we conducted a prospective study to evaluate the effect of this medication on the brachial artery vasomotor function and circulating markers of endothelial activation. METHODS:Baseline characteristics were collected. After initial endothelial function assessment, patients were treated with pioglitazone hydrochloride 30 mg daily. The medication was continued for 12 weeks and endothelial function was reassessed as well as the inflammatory markers. The study medication then was stopped, and all the tests were repeated 12 weeks later. RESULTS:Seventeen subjects completed all three-study phases. Mean age was 58 (range: 36-77 years). Compared with the baseline, the endothelium-dependent vasodilation improved significantly with the treatment (p < 0.001) from 4.4 +/- 3.9 to 8.4 +/- 4.1%, a relative increase of 91%. After withdrawal of treatment, the endothelium-dependent vasodilation returned towards baseline values. There was no change in endothelium-independent vasodilatation (12.27 +/- 6.35 to 13.9 +/- 9.23%, to 12.42 +/- 5.35%, p = 0.177). The urine asymmetric dimethlyarginine levels decreased significantly with the treatment, but also returned to the initial values after the wash-out period (1.27 +/- 0.5 micromol/ml to 0.97 +/- 0.3 micromol/ml to 1.34 +/- 0.5 micromol/ml, p = 0.017). No difference in the lipid profile, C-reactive protein, erythrocyte sedimentation rate, or fibrinogen levels was seen. CONCLUSION:Pioglitazone rapidly improves endothelial function in non-diabetic patients with coronary artery disease. This improvement is associated with a change in mean urinary asymmetric dimethylarginine levels, although a cause and effect cannot be determined from this investigation.
journal_name
Cardiologyjournal_title
Cardiologyauthors
Staniloae C,Mandadi V,Kurian D,Coppola J,Bernaski E,El-Khally Z,Morlote M,Pinassi E,Ambrose Jdoi
10.1159/000096601subject
Has Abstractpub_date
2007-01-01 00:00:00pages
164-9issue
3eissn
0008-6312issn
1421-9751pii
96601journal_volume
108pub_type
临床试验,杂志文章相关文献
CARDIOLOGY文献大全abstract::Accessory mitral valve tissue is a rare anomaly of embryologic development of the endocardial cushion and may cause substantial and progressive obstruction of the left ventricular outflow tract. Subaortic obstruction resulting from accessory mitral tissue is most likely due to systolic ballooning of the tissue into th...
journal_title:Cardiology
pub_type: 杂志文章
doi:10.1159/000091290
更新日期:2006-01-01 00:00:00
abstract::In view of the favourable results of the short-term therapy of acute myocardial infarction (AMI) with glyceryl-trinitrate (GTN) infusion, we undertook a randomized study to test the hypothesis whether the administration of a single dose of isosorbide 5-mononitrate (IS 5-MN) given orally would have the same favourable ...
journal_title:Cardiology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1159/000174272
更新日期:1987-01-01 00:00:00
abstract::HMG-CoA (3-hydroxy-3-methylglutaryl coenzyme A) reductase inhibitors, or 'statins', have revolutionized the management of patients with atherosclerotic vascular disease. Following 2 large acute coronary syndrome trials, additional clinical benefit outside their effect of low-density lipoprotein (LDL) lowering was prop...
journal_title:Cardiology
pub_type: 杂志文章,评审
doi:10.1159/000137692
更新日期:2009-01-01 00:00:00
abstract::This report describes the effect of age and gender on the results of balloon angioplasty using current technique and indications. A consecutive group of 2,067 patients who underwent angioplasty at a single institution after 1990 is described. Angioplastic success was 92.2% and similar among men and women and the vario...
journal_title:Cardiology
pub_type: 杂志文章
doi:10.1159/000177127
更新日期:1996-09-01 00:00:00
abstract:OBJECTIVES:During the past decade, the most common causes of mortality and morbidity were cardiovascular diseases and malignancies. The aim of the current study was to describe the incidence, course of admission, and short-term (30-day) prognosis of patients with and without malignancy, admitted to a tertiary center in...
journal_title:Cardiology
pub_type: 杂志文章
doi:10.1159/000477840
更新日期:2017-01-01 00:00:00
abstract:BACKGROUND:Atrial fibrosis plays a critical role in the occurrence and maintenance of atrial fibrillation. The role of TGF-β1 in mediating atrial fibrosis is well documented. The β-galactoside-binding lectin galectin-3 (Gal-3) is mainly produced by macrophages in biological events such as inflammation and angiogenesis....
journal_title:Cardiology
pub_type: 杂志文章
doi:10.1159/000506072
更新日期:2020-01-01 00:00:00
abstract:OBJECTIVE:This study sought to elucidate the underlying hemodynamic mechanisms involved in the longitudinal propagation of acute, type-B aortic dissections. METHODS:Three-dimensional patient-specific aortic geometry was reconstructed from computed tomography images of 3 cases, followed by computational fluid dynamic a...
journal_title:Cardiology
pub_type: 杂志文章
doi:10.1159/000358041
更新日期:2014-01-01 00:00:00
abstract::An abundance of clinical trial data indicates that lipid-regulating therapy reduces coronary artery disease morbidity and mortality. In patients with established coronary artery disease, lipid regulation has been shown to attenuate progression of atherosclerosis and extend survival. In primary prevention, a clear bene...
journal_title:Cardiology
pub_type: 杂志文章,评审
doi:10.1159/000177138
更新日期:1996-11-01 00:00:00
abstract::The focus here is on relationships between major risk factors and long-term mortality from coronary heart disease (CHD) and all causes, and on longevity, in Chicago cohorts: 25-year follow-up for Peoples Gas (PG) men aged 25-39 (n = 1,119), 30-year follow-up for PG men aged 40-59 (n = 1,235), 24-year follow-up for Wes...
journal_title:Cardiology
pub_type: 杂志文章
doi:10.1159/000175868
更新日期:1993-01-01 00:00:00
abstract::A new method is presented for decomposition of 99mTc-DTPA renal transfer functions (TF) into their capillary and tubular parts. Amplitudes and mean transit times of both parts were calculated and used for quantitative evaluation of renal perfusion, extraction and transport in 21 patients with renal artery stenosis. Th...
journal_title:Cardiology
pub_type: 杂志文章
doi:10.1159/000173943
更新日期:1985-01-01 00:00:00
abstract::Atherosclerosis is the most frequent cause of occlusion of aortocoronary saphenous vein grafts between 5 and 10 years after coronary artery bypass surgery. The typical atherosclerotic plaque appears between 1 and 3 years after operation and, at a mean of 5 years, histologic changes of atherosclerosis are present in 21...
journal_title:Cardiology
pub_type: 杂志文章,评审
doi:10.1159/000174019
更新日期:1986-01-01 00:00:00
abstract:OBJECTIVES:To assess the impact of different CYP2C19*2 polymorphisms on clinical outcomes and the effects of CYP2C19*2 polymorphism on predicting clinical outcomes in association with classic risk factors in patients with acute coronary syndromes (ACS). METHODS:Between July 2008 and September 2009, 497 consecutive pat...
journal_title:Cardiology
pub_type: 杂志文章
doi:10.1159/000329048
更新日期:2011-01-01 00:00:00
abstract:OBJECTIVES:Increased homocysteine (HCY) levels are associated with an increased risk of cardiovascular disease. Plasma HCY is increased in chronic heart failure (CHF) patients, and previous studies suggest that hyperhomocysteinemia causes adverse cardiac remodeling and affects pump function. We aimed to evaluate the HC...
journal_title:Cardiology
pub_type: 杂志文章
doi:10.1159/000320106
更新日期:2010-01-01 00:00:00
abstract::During a 21-month period, the prognosis in all patients admitted to a hospital ward from the emergency room with suspected acute myocardial infarction (AMI) was prospectively recorded and related to the time between onset of symptoms and arrival in hospital. They were classified as early arrivers (less than or equal t...
journal_title:Cardiology
pub_type: 杂志文章
doi:10.1159/000174777
更新日期:1991-01-01 00:00:00
abstract::Thromboembolism is a major complication of long-term central venous catheter, usually associated with catheter or venous occlusion. Intracavitary right atrial thrombosis is currently considered to result from line-tip thrombosis extension. We report three adult patients in whom repeated mechanical trauma to the right ...
journal_title:Cardiology
pub_type: 杂志文章
doi:10.1159/000006905
更新日期:1999-01-01 00:00:00
abstract::Malignant hypertension is associated with high mortality and morbidity usually caused by cardiovascular events. The course and prognosis of malignant hypertension patients treated with renal replacement therapy has not been thoroughly investigated. In the present work, we compared the clinical evolution and survival o...
journal_title:Cardiology
pub_type: 杂志文章
doi:10.1159/000006954
更新日期:1999-01-01 00:00:00
abstract::This is the case of a 43-year-old Caucasian man with frequent episodes of paroxysmal atrial fibrillation (AF) and normal resting electrocardiogram (ECG), who fulfilled two minor diagnostic criteria for arrhythmogenic right ventricular cardiomyopathy (ARVC): late potentials by signal-averaged ECG and regional right ven...
journal_title:Cardiology
pub_type: 杂志文章
doi:10.1159/000342274
更新日期:2012-01-01 00:00:00
abstract:OBJECTIVES:We tested the acute effects of resynchronization in heart failure patients with a normal (>50%) left ventricular (LV) ejection fraction (HFNEF) and mechanical dyssynchrony. METHODS:Twenty-four HFNEF patients (72 ± 6 years, 5 male) with mechanical dyssynchrony (standard deviation of electromechanical time de...
journal_title:Cardiology
pub_type: 杂志文章
doi:10.1159/000368795
更新日期:2015-01-01 00:00:00
abstract::The aim of our study was to examine the pathophysiology of ST depression (STD) in leads V1-V3 in the setting of inferior ST elevation myocardial infarction (iSTEMI) through the perspective of cardiac magnetic resonance (CMR). METHODS:Differences in myocardial area at risk (MaR), infarct size, ejection fraction and my...
journal_title:Cardiology
pub_type: 杂志文章
doi:10.1159/000491745
更新日期:2018-01-01 00:00:00
abstract:BACKGROUND:Diabetes mellitus (DM) is a well-recognized risk factor for heart failure (HF). We hypothesized that HF also increases the risk for DM. OBJECTIVE:We explored the hypothesis that HF is a risk factor for DM. METHODS:The Cardiovascular Health Study was a prospective cohort study of cardiovascular risk in ambu...
journal_title:Cardiology
pub_type: 杂志文章
doi:10.1159/000363282
更新日期:2014-01-01 00:00:00
abstract::Both randomized controlled clinical trials and observational postmarketing surveillance studies have a place in providing information to physicians and patients on effectiveness and safety of new medicines. Prelicensing is the realm of the basic scientist producing a medicine which is available for investigation by cl...
journal_title:Cardiology
pub_type: 杂志文章
doi:
更新日期:1994-01-01 00:00:00
abstract::The aim of this study was to determine whether defibrillation waveform duration adjustment with single-coil defibrillation leads can be used to increase the proportion of patients with satisfactory defibrillation thresholds (DFTs). A retrospective analysis of the DFT levels for 105 patients with implantable cardiovert...
journal_title:Cardiology
pub_type: 杂志文章
doi:10.1159/000345776
更新日期:2013-01-01 00:00:00
abstract::Heart failure is associated with pathobiochemical changes that can reduce the responsiveness of the myocardium to positive inotropic agents. We studied the contractile effects of a range of inotropic agents on papillary muscle strips from healthy and failing human hearts. Specimens were obtained from patients with dif...
journal_title:Cardiology
pub_type: 杂志文章
doi:10.1159/000177478
更新日期:1997-01-01 00:00:00
abstract:OBJECTIVES:Retropharyngeal lesions are often associated with Kawasaki disease (KD). A 4-year-old male first presented a peritonsillar and retropharyngeal abscess-like lesion. Surgical tonsillectomy was performed to avoid a risk of mediastinal abscess, but he fulfilled the diagnostic criteria of KD after the operation. ...
journal_title:Cardiology
pub_type: 杂志文章
doi:10.1159/000467388
更新日期:2017-01-01 00:00:00
abstract::Changes in Intra-SA nodal pacemaker localization were produced through stimulation of the decentralized cervical vagi and stellate ganglia in the anesthetized dog. Shifts in pacemaker to the rostral, middle, or caudal regions of the SA node produced a change in the timing as well as a change in the sequence of activat...
journal_title:Cardiology
pub_type: 杂志文章
doi:10.1159/000170620
更新日期:1979-01-01 00:00:00
abstract::The current study examined the effects of temperature on myocardial pH, contractile function and adenosine triphosphate metabolism, particularly the production of adenosine. We matched intermittent delivery of blood cardioplegia in two groups (hypothermia 15 degrees C; normothermia 37 degrees C), for 2 h of cardiopleg...
journal_title:Cardiology
pub_type: 杂志文章
doi:10.1159/000177148
更新日期:1996-11-01 00:00:00
abstract:BACKGROUND AND AIMS:Most cases of infective endocarditis are caused by nonenterococcal streptococci. The emergence of strains resistant to penicillin is increasingly recognized worldwide. This study sought to assess the effect of penicillin resistance on presentation and outcome of streptococcal endocarditis. METHODS:...
journal_title:Cardiology
pub_type: 杂志文章
doi:10.1159/000091821
更新日期:2006-01-01 00:00:00
abstract:OBJECTIVE:Transforming growth factor β1 (TGF-β1) is the major cytokine for stimulating endothelial cells (ECs) to transdifferentiate to mesenchymal cells (MCs) in the process known as endothelial-to-mesenchymal transition (EndMT). Recently, TGF-β1-induced EndMT has been implicated in the pathogenesis of atherosclerosis...
journal_title:Cardiology
pub_type: 杂志文章
doi:10.1159/000464321
更新日期:2017-01-01 00:00:00
abstract::Lipid-lowering agents are used with the purpose of ameliorating hyperlipoproteinemias, in order to prevent arterial disease. Lipid-lowering drugs can be classified into absorbable agents and into nonabsorbable compounds, acting within the gastrointestinal lumen. Absorbable drugs (fibric acids, nicotinic acid, probucol...
journal_title:Cardiology
pub_type: 杂志文章,评审
doi:10.1159/000174789
更新日期:1991-01-01 00:00:00
abstract::Since the introduction of fenofibrate to European clinical practice in 1975, some 6.5 million patient-years of experience in the treatment of hyperlipidemia have been accumulated. A review of results of clinical trials shows fenofibrate to have a broad spectrum of lipid-lowering activity, reducing the total cholestero...
journal_title:Cardiology
pub_type: 临床试验,杂志文章,评审
doi:10.1159/000174541
更新日期:1989-01-01 00:00:00