The effect of positive inotropes on the failing human myocardium.

Abstract:

:Heart failure is associated with pathobiochemical changes that can reduce the responsiveness of the myocardium to positive inotropic agents. We studied the contractile effects of a range of inotropic agents on papillary muscle strips from healthy and failing human hearts. Specimens were obtained from patients with different grades of heart failure. These included individuals undergoing mitral valve replacement (New York Heart Association Class II-III) or receiving heart transplantation (New York Heart Association Class IV). Heart failure was associated with attenuation of myocardial contractile responses to dobutamine, histamine, 3-isobutyl-1-methylxanthine, and the phosphodiesterase inhibitors, milrinone and pimobendan. However, pretreatment of the papillary muscle with isoprenaline augmented the positive inotropic effect observed with the phosphodiesterase inhibitors. The contractile response to ouabain was not influenced by the presence of heart failure. We conclude that, unlike beta-adrenoceptors, cardiac glycoside receptors in the myocardium are not down regulated in the presence of heart failure.

journal_name

Cardiology

journal_title

Cardiology

authors

Erdmann E

doi

10.1159/000177478

subject

Has Abstract

pub_date

1997-01-01 00:00:00

pages

7-11

eissn

0008-6312

issn

1421-9751

journal_volume

88 Suppl 2

pub_type

杂志文章
  • Evaluation of the exercise test in patients with angiographically documented coronary artery disease.

    abstract::100 male patients with at least 75% obstruction of one or more coronary arteries were subjected to submaximal exercise tests. Among the 73 subjects who had positive tests, 92% of those with one-vessel obstruction had an ST depression of 1 mm, none having more than 2 mm; by contrast, 44% of those with three-vessel dise...

    journal_title:Cardiology

    pub_type: 杂志文章

    doi:10.1159/000169871

    authors: Friedmann J,Agmon J,Cherbakoff A,Aygen M,Wurzel M

    更新日期:1977-01-01 00:00:00

  • Effect of right atrial stimulation on both atrial pressure and atrial natriuretic peptide release in essential hypertension.

    abstract:UNLABELLED:Several reports indicated a direct relationship between atrial pacing and atrial natriuretic peptide (ANP) blood levels, but few controlled hemodynamic studies have been reported. In particular, the relationship between increase in heart rate, release of ANP and increase in right atrial pressure (RAP) are st...

    journal_title:Cardiology

    pub_type: 杂志文章

    doi:10.1159/000174809

    authors: Michelucci A,Padeletti L,Monopoli A,Fabbri G,Tostiguerra C,Giovannini T,Franchi F

    更新日期:1991-01-01 00:00:00

  • Induction of overdrive excitation in the sinoatrial node in the presence of caffeine.

    abstract::The induction of spontaneous repetitive activity by a drive ('overdrive excitation') was studied in the sinoatrial node of the guinea pig by recording electrical and mechanical activity in sinoatrial preparations made quiescent by exposure to 20 mM caffeine of caffeine plus high [Ca]0. Electrical drive induced action ...

    journal_title:Cardiology

    pub_type: 杂志文章

    doi:10.1159/000174372

    authors: Vassalle M,Carbonin P,Iacono G,Di Gennaro M

    更新日期:1988-01-01 00:00:00

  • Measuring cardiac output in critically Ill patients: disagreement between thermodilution-, calculated-, expired gas-, and oxygen consumption-based methods.

    abstract::Calculated values of oxygen consumption have been used to calculate a Fick cardiac output when thermodilution measurements are unreliable and when oxygen consumption measurements are unavailable. To determine the accuracy of these calculations, we measured cardiac output in 20 patients by four methods: (1) a reference...

    journal_title:Cardiology

    pub_type: 杂志文章

    doi:10.1159/000177304

    authors: Sherman MS,Kosinski R,Paz HL,Campbell D

    更新日期:1997-01-01 00:00:00

  • Venoarterial carbon dioxide tension gradient in acute heart failure.

    abstract::The venoarterial carbon dioxide tension gradient (P[v-a]CO2) was studied in patients with acute myocardial infarction. Seven patients with congestive heart failure (CHF group) and 10 patients without heart failure (control) were enrolled in this study. In all patients, hemodynamics were continuously monitored. Simulta...

    journal_title:Cardiology

    pub_type: 杂志文章

    doi:10.1159/000175891

    authors: Inoue T,Sakai Y,Morooka S,Hayashi T,Takayanagi K,Yamaguchi H,Takabatake Y

    更新日期:1993-01-01 00:00:00

  • Brain natriuretic peptide is a sensitive indicator of impaired left-ventricular function in elderly patients with cardiovascular disease.

    abstract::We studied the relation between the plasma concentration of brain natriuretic peptide (BNP) and echocardiographic findings to determine the sensitivity of BNP as an indicator of left-ventricular dysfunction in elderly patients with various cardiovascular diseases. The plasma concentration of BNP was positively correla...

    journal_title:Cardiology

    pub_type: 杂志文章

    doi:10.1159/000177368

    authors: Yamada Y,Goto J,Yokota M

    更新日期:1997-09-01 00:00:00

  • Blood pressure and sleep apnea: results of long-term nasal continuous positive airway pressure therapy.

    abstract::Arterial blood pressure patterns in 12 men with sleep apnea and arterial hypertension were studied at baseline and after 6 months' therapy with nasal continuous positive airway pressure (nCPAP). Preexisting antihypertensive medication was discontinued 1 week before baseline measurements. Weight did not change during t...

    journal_title:Cardiology

    pub_type: 杂志文章

    doi:10.1159/000174864

    authors: Mayer J,Becker H,Brandenburg U,Penzel T,Peter JH,von Wichert P

    更新日期:1991-01-01 00:00:00

  • Transvenous pacemaker leads do not worsen tricuspid regurgitation: a prospective echocardiographic study.

    abstract::Limited prospective data are available regarding the influence of pacemaker leads on tricuspid valve function. To examine the true incidence of these complications, 35 patients were prospectively examined by two-dimensional and Doppler echocardiography before and after implantation of either a permanent pacemaker or a...

    journal_title:Cardiology

    pub_type: 杂志文章

    doi:10.1159/000007005

    authors: Leibowitz DW,Rosenheck S,Pollak A,Geist M,Gilon D

    更新日期:2000-01-01 00:00:00

  • Increased urinary cortisol and androgen metabolites in a young female with hypertension: partial glucocorticoid resistance syndrome.

    abstract::A 21-year-old woman with hypertension confirmed on ambulatory blood pressure monitoring and unresponsive to beta-blockers, diltiazem and amiloride was found to have serum potassium, renin and aldosterone levels at or just below the lower end of normal. Urinary glucocorticoid metabolite analysis revealed high excretion...

    journal_title:Cardiology

    pub_type: 杂志文章

    doi:10.1159/000007015

    authors: Shamim W,Bakhai A,Yousufuddin M,Coats AJ

    更新日期:2000-01-01 00:00:00

  • Systolic time intervals in chronic obstructive pulmonary disease.

    abstract::The systolic time intervals (STI) were used to study the left ventricular performance in 51 patients with chronic obstructive pulmonary disease (COPD), in 24 normal subjects and in 13 patients with both COPD and coronary heart disease (CHD). Our study shows that resting spine STI are abnormal in patients with COPD and...

    journal_title:Cardiology

    pub_type: 杂志文章

    doi:10.1159/000173261

    authors: Louridas G,Patakas D,Christaki R,Stavropoulos C

    更新日期:1981-01-01 00:00:00

  • Soluble VCAM-1 and E-selectin, but not ICAM-1 discriminate endothelial injury in patients with documented coronary artery disease.

    abstract::It has been shown that endothelial cell adhesion molecules play an important role in the development of coronary atherosclerosis and inflammatory disease. We sought to test whether soluble vascular cell adhesion molecule-1 (VCAM-1), intercellular adhesion molecule-1 (ICAM-1) and E-selectin are increased in patients wi...

    journal_title:Cardiology

    pub_type: 杂志文章

    doi:10.1159/000006995

    authors: Semaan HB,Gurbel PA,Anderson JL,Muhlestein JB,Carlquist JF,Horne BD,Serebruany VL

    更新日期:2000-01-01 00:00:00

  • Ventricular assist devices as a bridge to transplant or recovery.

    abstract::Ventricular assist devices have emerged as the standard of care in treating end-stage heart failure. Their success in bridging patients to transplantation is well documented. The data supporting their ability to bridge patients to recovery is sparser. However, as technology continues to advance, these devices will off...

    journal_title:Cardiology

    pub_type: 杂志文章,评审

    doi:10.1159/000075989

    authors: Kherani AR,Maybaum S,Oz MC

    更新日期:2004-01-01 00:00:00

  • Asymptomatic Pulmonary Embolism after Ablation.

    abstract:BACKGROUND:Pulmonary embolism (PE) is a life-threatening event with a broad presentation spectrum ranging from asymptomatic cases to sudden cardiac arrest. It is unclear if right atrial emboli cause PE in patients with atrial fibrillation (AF) or if mild PE itself increases right cardiac pressure provoking AF. OBJECTI...

    journal_title:Cardiology

    pub_type: 杂志文章

    doi:10.1159/000444440

    authors: Guler GB,Can MM,Guler E,Akinci T,Sogukpinar O,Hatipoglu S,Kilicaslan F,Serebruany VL

    更新日期:2016-01-01 00:00:00

  • Liver cirrhosis with ascites: pathogenesis of resistance to diuretics and long-term efficacy and safety of torasemide.

    abstract::In a prospective randomized short-term study, the efficacy and safety of xipamide and a combination of spironolactone and furosemide were compared in the treatment of hepatic cirrhotic ascites. Twenty-two patients were randomized to either xipamide, 20 mg/day (group I), or spironolactone, 200 mg/day, combined with fur...

    journal_title:Cardiology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1159/000176461

    authors: Knauf H,Mutschler E

    更新日期:1994-01-01 00:00:00

  • Central venous catheter mechanical irritation of the right atrial free Wall:A cause for thrombus formation.

    abstract::Thromboembolism is a major complication of long-term central venous catheter, usually associated with catheter or venous occlusion. Intracavitary right atrial thrombosis is currently considered to result from line-tip thrombosis extension. We report three adult patients in whom repeated mechanical trauma to the right ...

    journal_title:Cardiology

    pub_type: 杂志文章

    doi:10.1159/000006905

    authors: Fuchs S,Pollak A,Gilon D

    更新日期:1999-01-01 00:00:00

  • Detection of Björk-Shiley convexo-concave heart valve outlet strut single leg separations: consensus image acquisition and interpretation using two different cineradiographic imaging technologies.

    abstract:BACKGROUND:Conventional cineradiology has been used clinically to detect partially broken outlet struts (single leg separations, SLSs) in normally functioning Björk-Shiley convexo-concave (C/C) heart valves. The value of radiographic screening has, however, been debated in the medical literature. This study uses the sa...

    journal_title:Cardiology

    pub_type: 杂志文章

    doi:10.1159/000006887

    authors: Hopper KD,Gilchrist IC,Landis JR,Localio AR,Wilson RP,Pae WE Jr,Kunselman AR,Griffith JW,Pierce WS,Potok PS,TenHave TR

    更新日期:1999-01-01 00:00:00

  • Heart disease indicators in patients with aortocoronary bypass operation.

    abstract::The incidence of cardiovascular disease risk factors and other indicators of cardiac impairment were studied in 478 patients prior to their aortocoronary vein bypass operation and 194 patients who had angiographic examination but did not undergo the operation because the clinical and coronary angiographic findings wer...

    journal_title:Cardiology

    pub_type: 杂志文章

    doi:10.1159/000169758

    authors: Barboriak JJ,Rimm AA,Anderson AJ,Tristani FE,Walker JA,Flemma RJ

    更新日期:1976-01-01 00:00:00

  • Association of mannan-binding lectin deficiency with venous bypass graft occlusions in patients with coronary heart disease.

    abstract::We investigated the effect of mannan-binding lectin (MBL) deficiency on the susceptibility to bypass graft occlusion in 62 patients with coronary heart disease. MBL deficiency appeared to be associated with occlusion (p = 0.0099). A high level of anti-cardiolipin IgG as well as the number of venous bypass grafts were ...

    journal_title:Cardiology

    pub_type: 杂志文章

    doi:10.1159/000066313

    authors: Limnell V,Aittoniemi J,Vaarala O,Lehtimäki T,Laine S,Virtanen V,Palosuo T,Miettinen A

    更新日期:2002-01-01 00:00:00

  • Pericardial effusion after streptokinase for acute myocardial infarction: an echocardiographic 1-year follow-up study.

    abstract::Since the reported incidence of pericardial effusion following thrombolysis is highly variable, we have evaluated 80 consecutive patients with first acute myocardial infarction treated with streptokinase. Two-dimensional echocardiographic studies were performed on days 1, 2, 3, and 7, at 3 and 6 weeks, and 3, 6, and 1...

    journal_title:Cardiology

    pub_type: 杂志文章

    doi:10.1159/000177417

    authors: Otasević P,Nesković AN,Bojić M,Popović AD

    更新日期:1997-11-01 00:00:00

  • Age- and gender-related differences in success, major and minor complication rates and the duration of hospitalization after percutaneous transluminal coronary angioplasty.

    abstract::This report describes the effect of age and gender on the results of balloon angioplasty using current technique and indications. A consecutive group of 2,067 patients who underwent angioplasty at a single institution after 1990 is described. Angioplastic success was 92.2% and similar among men and women and the vario...

    journal_title:Cardiology

    pub_type: 杂志文章

    doi:10.1159/000177127

    authors: Rozenman Y,Gilon D,Zelingher J,Sapoznikov D,Lotan C,Mosseri M,Weiss AT,Hasin Y,Gotsman MS

    更新日期:1996-09-01 00:00:00

  • Prognostic value of ischemia monitoring with on-line vectorcardiography in patients with unstable coronary artery disease.

    abstract:AIM:The aim of this study was to determine whether on-line vectorcardiography (VCG) gives independent prognostic information, regarding death, myocardial infarction (MI), and revascularization in patients with unstable coronary artery disease, i.e. unstable angina or non-Q-wave MI. METHODS AND RESULTS:One hundred and ...

    journal_title:Cardiology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1159/000007024

    authors: Lundin P,Jensen J,Lindahl B,Wallentin L,Eriksson SV

    更新日期:2000-01-01 00:00:00

  • Mycotic aneurysms of aortic root and aorta-to-left atrial fistula complicating bicuspid aortic valve endocarditis.

    abstract::Unlike root abscess, fistula formation is quite uncommon in aortic valve endocarditis. In this report, we describe a patient with subacute bicuspid aortic valve endocarditis complicated by aortic insufficiency, mycotic aneurysms of the aortic root and fistulous communication between the aorta and the left atrium and h...

    journal_title:Cardiology

    pub_type: 杂志文章

    doi:10.1159/000090203

    authors: Ozerkan F,Duygu H,Nalbantgil S,Cinar CS

    更新日期:2006-01-01 00:00:00

  • Cold pressure test producing coronary spasm, coronary thrombosis and myocardial infarction in a patient with IgM antibodies against Coxsackie B virus.

    abstract::Several lines of evidence have shown that viral infections are capable of causing coronary spasm and precipitating or mimicking clinical myocardial infarction. Here we report the case of a 41-year-old woman with recurrent angina who was admitted to our hospital because of ventricular tachycardia. Laboratory examinatio...

    journal_title:Cardiology

    pub_type: 杂志文章

    doi:10.1159/000006987

    authors: Haberbosch W,Roerich N,Neuzner J

    更新日期:1999-01-01 00:00:00

  • Grade III ischemia on presentation with acute myocardial infarction predicts rapid progression of necrosis and less myocardial salvage with thrombolysis.

    abstract::We assessed the relation between baseline electrocardiographic ischemia grades and initial myocardial area at risk (AR) and final infarct size (IS) in 49 patients who had undergone (99m)Tc sestamibi single-photon emission computed tomography before and 6 +/- 1 days after thrombolysis. Patients were classed as having g...

    journal_title:Cardiology

    pub_type: 临床试验,杂志文章

    doi:10.1159/000063334

    authors: Birnbaum Y,Mahaffey KW,Criger DA,Gates KB,Barbash GI,Barbagelata A,Clemmensen P,Sgarbossa EB,Gibbons RJ,Rahman MA,Califf RM,Granger CB,Wagner GS,AMISTAD (Acute Myocardial Infarction Study of Adenosine) Investigators.

    更新日期:2002-01-01 00:00:00

  • Combination drug therapy with HMG CoA reductase inhibitors and bile acid sequestrants for hypercholesterolemia.

    abstract::Single-drug therapy is often not sufficient to lower total and low-density lipoprotein (LDL) cholesterol levels in patients with familial hypercholesterolemia to desirable or target levels. Therefore, combination drug therapy is often necessary. The most potent therapy to achieve this goal is a combination of a 3-hydr...

    journal_title:Cardiology

    pub_type: 杂志文章

    doi:10.1159/000174681

    authors: Erkelens DW

    更新日期:1990-01-01 00:00:00

  • Ibopamine as a valuable adjunct and substitute for dopamine in bridging therapy before heart transplantation.

    abstract::Ibopamine is an active dopamine analogue leading to improved renal perfusion and afterload reduction in heart failure. This report describes casuistic experiences in patients with severe heart failure awaiting heart transplantation. All patients could be stabilized, intravenous catecholamines be discontinued, and diur...

    journal_title:Cardiology

    pub_type: 杂志文章

    doi:10.1159/000175786

    authors: Kleber FX,Sabin GV,Thyroff-Friesinger U,Cabell B,Glogar D

    更新日期:1992-01-01 00:00:00

  • Left ventricular function during asynchronous ventricular pacing: a radionuclide study.

    abstract::This study was undertaken to assess ventricular volumes and function by radionuclide angiography during asynchronous ventricular pacing in a group of 22 patients who needed an artificial pacemaker. 14 had ischaemic heart disease and 8 had primary disturbances of conduction of the impulse-forming system. The transition...

    journal_title:Cardiology

    pub_type: 杂志文章

    doi:10.1159/000173685

    authors: Weiss AT,Gotsman MS,Lewis BS,Rein AJ,Atlan H

    更新日期:1984-01-01 00:00:00

  • Valvular heart disease by transthoracic echocardiography is associated with focal brain injury and central neuropsychiatric systemic lupus erythematosus.

    abstract:BACKGROUND:Previous studies using transesophageal echocardiography (TEE) report an association of valvular heart disease (VHD) with cerebral infarcts and central neuropsychiatric systemic lupus erythematosus (NPSLE). However, TEE cannot be routinely used. AIM:To determine if VHD detected by transthoracic echocardiogra...

    journal_title:Cardiology

    pub_type: 杂志文章

    doi:10.1159/000099104

    authors: Roldan CA,Gelgand EA,Qualls CR,Sibbitt WL Jr

    更新日期:2007-01-01 00:00:00

  • Ergometry in the assessment of arterial hypertension.

    abstract::The blood pressure behavior during and after ergometric exercise was investigated in 552 males in order to clarify if this standardized procedure is suitable for differentiating between normotensive subjects and hypertensive patients. Patients suffering from mild hypertension showed significantly (p less than 0.001) h...

    journal_title:Cardiology

    pub_type: 杂志文章,评审

    doi:10.1159/000173856

    authors: Franz IW

    更新日期:1985-01-01 00:00:00

  • Single versus Dual Antiplatelet Therapy after Transcatheter Aortic Valve Implantation: A Systematic Review and Meta-Analysis.

    abstract:OBJECTIVES:Although dual antiplatelet therapy (DAPT) with aspirin and clopidogrel is currently recommended in patients after transcatheter aortic valve implantation (TAVI), this practice is not supported by sufficient evidence. This study was performed to compare DAPT to single antiplatelet therapy (SAPT). METHODS:An ...

    journal_title:Cardiology

    pub_type: 杂志文章,meta分析

    doi:10.1159/000490307

    authors: Hu X,Yang FY,Wang Y,Zhang Y,Chen M

    更新日期:2018-01-01 00:00:00