Association of apolipoprotein J polymorphism 1598delT with coronary artery disease and lipoprotein levels.

Abstract:

OBJECTIVES:To investigate a polymorphism of the apolipoprotein J (APOJ) gene in relation to coronary artery disease (CAD) and lipid variables in a Chinese male population of genetically unrelated individuals. METHODS:In this study, we recruited 126 control male subjects and 237 CAD male patients. CAD was defined as a fixed stenotic lesion with luminal narrowing ≥50% in at least one of the major or minor coronary arteries. In cases with documented myocardial infarction, only those rated as fully recovered for more than 3 months were enrolled. Patients with acute or chronic infectious diseases and those with malignancies were excluded. All subjects with a fasting serum triglyceride level higher than 300 mg/dl were likewise excluded. RESULTS:We identified a single nucleotide polymorphism, 1598delT, and showed its association with CAD. Subjects with the I/I genotype showed a significantly higher CAD risk compared to those with the D/D genotype (OR 2.34, 95% CI 1.11-4.94, p = 0.026). Patients with the I/I genotype also had abnormal levels of high-density lipoprotein-cholesterol and low-density lipoprotein-cholesterol associated with CAD. CONCLUSIONS:Our data indicated that the APOJ single nucleotide polymorphism (1598delT) is associated with risk factors for CAD in a Chinese population.

journal_name

Cardiology

journal_title

Cardiology

authors

Pan JP,Wei SL,Chiang SC,Lee-Chen GJ

doi

10.1159/000326852

subject

Has Abstract

pub_date

2011-01-01 00:00:00

pages

83-92

issue

2

eissn

0008-6312

issn

1421-9751

pii

000326852

journal_volume

118

pub_type

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