A comparison of selected antihypertensives and the use of conventional vs ambulatory blood pressure in the detection and treatment of hypertension.

Abstract:

:This multicenter, randomized, double-blind, parallel group study was undertaken to determine the effectiveness of selected antihypertensives (doxazosin, amlodipine, enalapril, and bendrofluazide) in maintaining 24-hour control of blood pressure (BP). The predictive value of ambulatory (A)BP versus clinic (C)BP measurements as a method for detecting patients with hypertension was also evaluated. A total of 204 patients were screened and of these 110 were diagnosed as mild to moderately hypertensive with clinic diastolic BP 100-110 mm Hg (> or =95 mm Hg in patients with coronary heart disease risk factors). The 4 antihypertensives were all equally effective at controlling BP over 24 h, as shown by 24-hour ABP measurements. The incidence of adverse events was similar for all 4 treatment groups; headache was the most common event, being reported by 22 patients (20%). There was a clinically relevant reduction in total cholesterol for the doxazosin (-15.4 mg/dl) and amlodipine (-11.6 mg/dl) treatment groups in comparison with enalapril and bendrofluazide. Our results from ABP measurements suggest that the antihypertensives studied are effective first-line therapy in the regulation of hypertension and that ABP is a reproducible measure. ABP may also be useful in identifying patients with various types of high BP, for instance those with 'white coat' hypertension, enabling more accurate screening and diagnosis.

journal_name

Cardiology

journal_title

Cardiology

authors

Ebbs D

doi

10.1159/000049095

subject

Has Abstract

pub_date

2001-01-01 00:00:00

pages

3-9

eissn

0008-6312

issn

1421-9751

pii

49095

journal_volume

96 Suppl 1

pub_type

临床试验,杂志文章,多中心研究,随机对照试验
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    更新日期:2014-01-01 00:00:00

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    更新日期:1990-01-01 00:00:00

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    pub_type: 杂志文章,多中心研究

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    pub_type: 临床试验,杂志文章

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    更新日期:2002-01-01 00:00:00

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    更新日期:1991-01-01 00:00:00

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    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1159/000170635

    authors: Rossi P,Giordano A,Tamiz A,Schiavo B,Minuco G

    更新日期:1979-01-01 00:00:00

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    doi:10.1159/000176928

    authors: Marek J,Skovránek J,Hucín B,Chaloupecký V,Tax P,Reich O,Samánek M

    更新日期:1995-01-01 00:00:00

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    pub_type: 杂志文章

    doi:10.1159/000176832

    authors: Lundin P,Eriksson SV,Fredrikson M,Rehnqvist N

    更新日期:1995-01-01 00:00:00

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    pub_type: 杂志文章

    doi:10.1159/000175000

    authors: Erbas T,Erbas B,Usman A,Bekdik CF

    更新日期:1992-01-01 00:00:00

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    更新日期:2020-01-01 00:00:00

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    更新日期:1994-01-01 00:00:00

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    pub_type:

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    pub_type: 临床试验,杂志文章,随机对照试验

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    更新日期:1994-01-01 00:00:00

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    pub_type: 杂志文章,评审

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    pub_type: 杂志文章

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    authors: Witberg G,Barsheshet A,Assali A,Vaknin-Assa H,Shaul AA,Orvin K,Vaturi M,Schwartzenberg S,Shapira Y,Sagie A,Kornowski R

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    pub_type: 杂志文章

    doi:10.1159/000092743

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    更新日期:2006-01-01 00:00:00

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    pub_type: 临床试验,杂志文章

    doi:10.1159/000096782

    authors: Fireman E,Topilsky I,Viskin S,Priel IE

    更新日期:2007-01-01 00:00:00

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    pub_type: 临床试验,杂志文章,随机对照试验

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    pub_type: 杂志文章

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    authors: Weidmann P

    更新日期:1994-01-01 00:00:00

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    pub_type: 杂志文章

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    pub_type: 杂志文章

    doi:10.1159/000176873

    authors: Martens P,Calle P,Hubloue I,Van den Poel B,Lewi P

    更新日期:1995-01-01 00:00:00