ACP1 genetic polymorphism and coronary artery disease: an association study.

Abstract:

OBJECTIVES:Assuming an immune component in the pathogenesis of atherosclerosis, we have investigated a possible association between coronary artery disease (CAD) and the acid phosphatase locus 1 (ACP1) genetic polymorphism, which has previously been found to be associated with immune disorders. METHODS:226 subjects admitted to the hospital for CAD, 358 consecutive newborn infants, 279 adult subjects with type 2 diabetes without CAD and 137 adults without diabetes and without CAD from the Caucasian population of Rome were studied. The ACP1 genotype was determined by DNA analysis. Statistical analyses were performed using the SPSS package. RESULTS:CAD females showed an excess of ACP1 *A/*C and *B/*C genotypes and a deficiency of ACP1 *B/*B genotype compared to controls, while CAD males did not show significant differences. Among diabetic women the proportion of *C allele carriers was much greater in those with CAD than in those without CAD. This difference was much less evident in nondiabetic women. CONCLUSION:ACP1 may be involved in susceptibility to CAD. Since ACP1 has been found to be associated with immunological diseases, our observation reinforces the notion of an immune component in the pathogenesis of atherosclerosis.

journal_name

Cardiology

journal_title

Cardiology

authors

Banci M,Saccucci P,D'Annibale F,Dofcaci A,Trionfera G,Magrini A,Bottini N,Bottini E,Gloria-Bottini F

doi

10.1159/000203405

subject

Has Abstract

pub_date

2009-01-01 00:00:00

pages

236-42

issue

4

eissn

0008-6312

issn

1421-9751

pii

000203405

journal_volume

113

pub_type

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