Multi-layer imager design for mega-voltage spectral imaging.

Abstract:

:The architecture of multi-layer imagers (MLIs) can be exploited to provide megavoltage spectral imaging (MVSPI) for specific imaging tasks. In the current work, we investigated bone suppression and gold fiducial contrast enhancement as two clinical tasks which could be improved with spectral imaging. A method based on analytical calculations that enables rapid investigation of MLI component materials and thicknesses was developed and validated against Monte Carlo computations. The figure of merit for task-specific imaging performance was the contrast-to-noise ratio (CNR) of the gold fiducial when the CNR of bone was equal to zero after a weighted subtraction of the signals obtained from each MLI layer. Results demonstrated a sharp increase in the CNR of gold when the build-up component or scintillation materials and thicknesses were modified. The potential for low-cost, prompt implementation of specific modifications (e.g. composition of the build-up component) could accelerate clinical translation of MVSPI.

journal_name

Phys Med Biol

authors

Myronakis M,Hu YH,Fueglistaller R,Wang A,Baturin P,Huber P,Morf D,Star-Lack J,Berbeco R

doi

10.1088/1361-6560/aabe21

subject

Has Abstract

pub_date

2018-05-10 00:00:00

pages

105002

issue

10

eissn

0031-9155

issn

1361-6560

journal_volume

63

pub_type

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