Abstract:
INTRODUCTION:the carcinogenesis may be initiated and promoted by the oxidative DNA damage. The compounds of chrome (Cr [VI]) cause oxidative stress (EOx) and are recognized as carcinogens in humans. In this sense, it is proposed that drinks with a high antioxidative potential, such as red wine, may have protective or modulatory effects on the oxidative DNA damage. OBJECTIVE:to study the effects of the administration in vivo of undiluted, diluted (75%) and alcohol-free red wine on the genotoxic damage induced by carcinogenic metals (Cr [VI]), by evaluating the micronucleus (MN) in polychromatic erythrocytes (EPC) in mice (CD-1). MATERIAL AND METHOD:it was randomly organized the follow groups: (i) control, (ii) undiluted, diluted and alcohol-free red wine (free access), (iii) CrO3 (20 mg/kg by intraperitoneal route) and (iv) CrO3-red wine. The evaluations were made in blood samples obtained from the caudal vein, in which it was identified the MN and EPC before, during and after treatments. RESULTS AND DISCUSSION:the red wine (diluted and alcohol-free) was capable of decreasing the averages of MN induced by CrO3, demonstrating its modular capacity in vivo in the oxidative DNA damage caused by EOx-induced carcinogens. The administration of only undiluted red wine presented toxic effects. CONCLUSIONS:our results raises expectations on the use of substances like the red wine for the protection or modulation of genotoxic damage, encouraging its application in the carcinogenic and mutagenic processes. :Introducción: la carcinogénesis puede ser iniciada y promovida por el daño oxidativo al ADN. Los compuestos de cromo (Cr) [VI] generan estrés oxidativo (EOx) y son reconocidos como cancerígenos en humanos. En este sentido, se plantea que bebidas que presentan un alto potencial antioxidante, como el vino tinto, pudieran tener efectos protectores o moduladores del daño oxidativo al ADN. Objetivo: estudiar los efectos de la administración in vivo de vino tinto sin diluir, diluido (75%) y sin alcohol, sobre el daño genotóxico inducido por metales cancerígenos (Cr [VI]), mediante la evaluación de micronúcleos (MN) en eritrocitos policromáticos (EPC) de ratones (CD-1). Material y método: se conformaron aleatoriamente los siguientes grupos: (i) testigo, (ii) vino tinto sin diluir, diluido o sin alcohol (libre acceso), (iii) CrO3 (20 mg/kg por vía intraperitoneal) y (iv) vino tinto-CrO3. Las evaluaciones se realizaron en muestras de sangre obtenidas de la vena caudal, en las que se identificaron los MN en EPC antes, durante y después de los tratamientos. Resultados y discusión: el vino tinto (diluido y sin alcohol) fue capaz de disminuir los promedios de MN inducidos por el CrO3, lo que muestra su capacidad para modular in vivo el daño oxidativo al ADN causado por cancerígenos inductores de EOx. La administración únicamente de vino tinto sin diluir presentó efectos tóxicos. Conclusiones: nuestros resultados generan expectativas sobre el empleo de sustancias como el vino tinto en la protección o modulación del daño genotóxico, lo que podría conducir a su aplicación en los procesos de carcinogénesis y mutagénesis.
journal_name
Nutr Hospjournal_title
Nutricion hospitalariaauthors
García Rodríguez Mdel C,Mateos Nava RA,Altamirano Lozano Mdoi
10.3305/nh.2015.32.4.9520subject
Has Abstractpub_date
2015-10-01 00:00:00pages
1645-52issue
4eissn
0212-1611issn
1699-5198journal_volume
32pub_type
杂志文章abstract:INTRODUCTION:Gestational diabetes has been associated with obesity later in life. However, reported results have not been consistent and the methods used have shown weakness. OBJECTIVE:To analize prospective and retrospective cohort studies that assess the gestational diabetes effects on adiposity indicators in the of...
journal_title:Nutricion hospitalaria
pub_type: 杂志文章,meta分析,评审
doi:10.3305/nh.2014.29.2.7042
更新日期:2014-02-01 00:00:00
abstract:BACKGROUND:the prognostic value of maximal inspiratory and expiratory pressures on functional capacity and mortality of hospitalized patients are not well established. AIM:to evaluate the prognostic value of respiratory pressures in hospitalized patients. METHODS:patients admitted to a general hospital in Santiago-Ch...
journal_title:Nutricion hospitalaria
pub_type: 杂志文章
doi:10.20960/nh.1478
更新日期:2018-05-17 00:00:00
abstract:OBJECTIVE:To evaluate the prevalence of anaemia and the risk of haemoconcentration and its risk factors during all 3 trimesters of pregnancy in women in a Mediterranean area in the south of Europe. MATERIAL AND METHODS:Longitudinal study of 11,259 women whose pregnancies were monitored at primary care centres between ...
journal_title:Nutricion hospitalaria
pub_type: 杂志文章
doi:10.20960/nh.1045
更新日期:2018-01-10 00:00:00
abstract:BACKGROUND:fat-soluble vitamin deficiency may be a health problem not recognized in children and adolescents. OBJECTIVE:to estimate the prevalence and factors associated with the deficiency of vitamins A, D and E among adolescent students from Northeastern Brazil. METHODS:transversal study with adolescents aged 12 to...
journal_title:Nutricion hospitalaria
pub_type: 杂志文章
doi:10.20960/nh.1785
更新日期:2018-10-05 00:00:00
abstract:UNLABELLED:Meal replacement (MR) has been frequently used to substitute one or more meals during the day. However, few randomized long-term studies have assessed its efficacy. OBJECTIVE:To asses meal replacement use and its effectiveness on long-term weight loss (> 1 year) in overweight and obese people with or withou...
journal_title:Nutricion hospitalaria
pub_type: 杂志文章,meta分析,评审
doi:10.1590/S0212-16112011000600011
更新日期:2011-11-01 00:00:00
abstract:BACKGROUND:Although changes in eating patterns may occur during gestation, predictors of these changes have not been explored. This study aimed to identify predictors of adherence to the Mediterranean diet (MD) from the first to second trimester of pregnancy. METHODS:A prospective study was conducted with 102 pregnant...
journal_title:Nutricion hospitalaria
pub_type: 杂志文章
doi:10.3305/nh.2015.31.3.8158
更新日期:2014-10-04 00:00:00
abstract:INTRODUCTION:in the last few years, as the rate of childhood obesity has been rising, there has been a parallel increase in the incidence of dislipemia in the pediatric population, in which blood triglycerids might play an important role. Plant sterols have been shown to be useful in the tratment of hypercholesterolemi...
journal_title:Nutricion hospitalaria
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.3305/nh.2015.32.3.9319
更新日期:2015-09-01 00:00:00
abstract::Dual-energy X ray absorptiometry (DEXA) is primarily used in the assessment of bone mineral. However, the transmissions of the two different energy beams in nonbone areas can be processed to calculate the amount of fat and free-fat mass of the soft tissues. We have compared the estimation of body fat mass (FM) by DEXA...
journal_title:Nutricion hospitalaria
pub_type: 杂志文章
doi:
更新日期:1994-01-01 00:00:00
abstract:INTRODUCTION:Dietary questionnaires usually only assess the intake of drinks that provide calories, but do not accurately evaluate total fluid or water intake. The evaluation of the fluid consumption pattern of a population has been the main objective of only a very few studies. OBJECTIVE:To evaluate the total fluid i...
journal_title:Nutricion hospitalaria
pub_type: 杂志文章
doi:10.3305/nh.2014.29.5.7421
更新日期:2014-05-01 00:00:00
abstract::Given the high numbers of nutritional supplements and enteral diets which are supplied for patients suffering from cystic fibrosis, by the departments of hospital pharmacy, the present study aims to review which are the characteristics of this disease which determine the appearance of malnutrition in these patients. A...
journal_title:Nutricion hospitalaria
pub_type: 杂志文章,评审
doi:
更新日期:1997-03-01 00:00:00
abstract:OBJECTIVE:To update the system for nutritional screening. The high prevalence of nutritional unstability that causes the Clinical Undernutrition (CU), especially within the hospitals and assisted residencies, makes it necessary to use screening tools for the constant control of undernutrition to combat it during its de...
journal_title:Nutricion hospitalaria
pub_type: 杂志文章,评审
doi:10.3305/nh.2014.29.4.7275
更新日期:2014-01-13 00:00:00
abstract:Introduction:Introduction: currently, it is important to determine whether food frequency questionnaires (FFQ) are valid tools to collect information on usual diet in children. Objective: we evaluated the reproducibility and validity of the semi-quantitative FFQ used in a Spanish cohort of children aged 4-7 years. Meth...
journal_title:Nutricion hospitalaria
pub_type: 杂志文章
doi:10.20960/nh.03003
更新日期:2020-08-27 00:00:00
abstract:Introduction:Introduction: child excess weight has been associated with obesity in adulthood and, as a consequence, increased risk of death due to cardiometabolic factors. Objective: to identify whether BMI reflects changes in the content and distribution of fat/adipose tissue and the cardiometabolic risk in children b...
journal_title:Nutricion hospitalaria
pub_type: 杂志文章
doi:10.20960/nh.2071
更新日期:2019-04-10 00:00:00
abstract:INTRODUCTION:The multi-behavioral Transtheoretical Model (TTM) addresses multiple behaviors and it is a promising strategy to control multifactorial morbidities, such as chronic diseases. The results obtained using the TTM are positive, but are not consistently methodical. OBJECTIVES:The aim of this study was to syste...
journal_title:Nutricion hospitalaria
pub_type: 杂志文章,meta分析,评审
doi:10.20960/nh.586
更新日期:2016-09-20 00:00:00
abstract:BACKGROUND:Parenteral nutrition (PN) is a costly therapy that can also be associated with serious complications. Therefore, efforts are focusing on reducing rate of complications, and costs related to PN. OBJECTIVE:The aim was to analyze the effect of the implementation of PN standardization on costs and quality crite...
journal_title:Nutricion hospitalaria
pub_type: 杂志文章
doi:10.3305/nh.2014.30.2.7575
更新日期:2014-08-01 00:00:00
abstract:BACKGROUND:many endocrine-metabolic changes are involved in smoking. OBJECTIVES:to evaluate serum concentrations of inflammatory adipokines in smokers at baseline and after four months of treatment for smoking cessation. METHODS:the serum concentrations of inflammatory cytokines were evaluated in smokers and abstinen...
journal_title:Nutricion hospitalaria
pub_type: 杂志文章
doi:10.20960/nh.1548
更新日期:2018-02-27 00:00:00
abstract:BACKGROUND:overweight and obesity have been increasing, and university students are an important target for prevention programs. Previous studies have reported differences in the diagnosis between different anthropometric methods, so some students can be misclassified depending on the method used. OBJECTIVE:to evaluat...
journal_title:Nutricion hospitalaria
pub_type: 杂志文章
doi:10.20960/nh.1189
更新日期:2018-03-01 00:00:00
abstract:OBJECTIVE:the aim was to establish reference standards for waist/hip ratio among Colombia children and adolescent aged 9 to 17.9 years who participated in "The FUPRECOL Study". METHODS:cross-sectional study. A sample of 3 005 children and 2 916 adolescents healthy Colombian youth (boys n = 2 542 and girls n = 3 384) p...
journal_title:Nutricion hospitalaria
pub_type: 杂志文章
doi:10.3305/nh.2015.32.5.9633
更新日期:2015-11-01 00:00:00
abstract:OBJECTIVE:To evaluate the effect of the glycemic index (GI) on food intake, anthropometric measurements and body composition in subjects with excess body weight. METHODS:Crossover study, in which 17 subjects participated in two study sessions (high GI or low GI). Two daily meals were consumed in laboratory for 30 cons...
journal_title:Nutricion hospitalaria
pub_type: 临床试验,杂志文章
doi:10.3305/nh.2012.27.4.5845
更新日期:2012-07-01 00:00:00
abstract::The term "conditionally essential" (or semi-essential), initially applied to amino acids, has been generalized to other nutrients. A conditionally essential nutrient is a compound usually produced in adequate amounts by endogenous synthesis but that is exogenously required under certain circumstances. Thus, arginine, ...
journal_title:Nutricion hospitalaria
pub_type: 杂志文章,评审
doi:
更新日期:2006-05-01 00:00:00
abstract::Irritable bowel syndrome (IBS) is characterized by symptoms of abdominal pain and altered bowel habits. This common disorder is managed by varying clinical styles as no dominant therapeutic strategy has emerged. The pathophysiology of IBS remains unknown, but several lines of evidence link this disorder with the gut m...
journal_title:Nutricion hospitalaria
pub_type: 杂志文章,评审
doi:10.3305/nh.2015.31.sup1.8713
更新日期:2015-02-07 00:00:00
abstract::Percutaneous endoscopic gastrostomy (PEG) is the first choice method for long-term enteral feeding when the digestive tube is undamaged and the patients' survival is longer than 2 months. There are increasing series and indications reported and although it is a safe technique we should take into account an appropriate...
journal_title:Nutricion hospitalaria
pub_type: 杂志文章
doi:10.1590/S0212-16112011000200023
更新日期:2011-03-01 00:00:00
abstract:INTRODUCTION:There are few studies assessing overall diet and food patterns of the oldest population. OBJECTIVES:To examine food groups consumption (grams and servings) and their compliance with the dietary guidelines in community-dwelling very old Spanish adults. The relationship with the risk of malnutrition was als...
journal_title:Nutricion hospitalaria
pub_type: 杂志文章
doi:10.20960/nh.263
更新日期:2016-06-30 00:00:00
abstract:OBJECTIVES/HYPOTHESIS:Presbycusis is the most prevalent cause of hearing-loss in the older, but pathogenesis is not well-know. The premise of this study is that hyperlipemia increase risk of age-related hearing-loss. PATIENTS AND METHODS:180 patient more than 65 years-old were studied. All patients had bilateral heari...
journal_title:Nutricion hospitalaria
pub_type: 杂志文章
doi:
更新日期:2005-01-01 00:00:00
abstract:UNLABELLED:The Hospital at Home (HAD) is a choice of care that enables own care in a hospital at home patient. Moreover, the nutritional support (NS) -enteral or parenteral nutrition- is usually indicated in patients with serious underlying disease, and/or frequently remain severely disabled. AIMS:To analyze the chara...
journal_title:Nutricion hospitalaria
pub_type: 杂志文章
doi:
更新日期:2009-01-01 00:00:00
abstract:INTRODUCTION:Epidemiological studies show that during the last two decades childhood obesity has increased dramatically to become, one of the major public health concerns. Dietary habits, lack of physical activity and the degree of obesity rates and worsen over the years making overweight children overweight adults. A...
journal_title:Nutricion hospitalaria
pub_type: 杂志文章
doi:10.3305/nh.2015.31.1.7785
更新日期:2015-01-01 00:00:00
abstract:INTRODUCTION:A sufficient intake of calcium enables correct bone mineralization. The bioavailability of calcium in water is similar to that in milk. OBJECTIVE:To determine the concentration of calcium in public drinking water and bottled mineral water. METHODS:We used ion chromatography to analyse the calcium concent...
journal_title:Nutricion hospitalaria
pub_type: 杂志文章
doi:10.3305/nh.2014.30.1.7491
更新日期:2014-07-01 00:00:00
abstract:INTRODUCTION:The aim of the study was to estimate if B12 deficiency is associated with the use of metformin in the elderly diabetics. METHODS:Case-control study in diabetic OP. Cases (n = 137) were defined as elderly with B12 < 221 pmol/L and controls (n = 279) elderly with B12 > 221 pmol/L. Four categories of metform...
journal_title:Nutricion hospitalaria
pub_type: 杂志文章
doi:10.3305/nh.2014.29.6.7405
更新日期:2014-06-01 00:00:00
abstract::Tube feeding is a widely used medical treatment for providing nutrition to terminally ill patients. Long term nutritional support in these patients or patients with irreversible neurological deterioration create a host of ethical and legal conflicts with difficult solutions. This work looks at the cultural and ethical...
journal_title:Nutricion hospitalaria
pub_type: 杂志文章
doi:
更新日期:2002-11-01 00:00:00
abstract:OBJECTIVE:To compare the accuracy of three BMI-forage references (World Health Organization reference, WHO; the updated International Obesity Task Force reference, IOTF; and Centers for Disease Control and Prevention (CDC) growth charts) to diagnose obesity in Mexican children. METHODS:A convenience sample of Mexican ...
journal_title:Nutricion hospitalaria
pub_type: 杂志文章
doi:10.3305/nh.2015.31.6.8639
更新日期:2015-06-01 00:00:00