Early social isolation augments alcohol consumption in rats.

abstract：:Sensorimotor gating disruptions are seen in various psychiatric illnesses with putatively different pathologies, including schizophrenia and bipolar disorder. Interestingly, mice lacking the dopamine (DA) transporter (DAT) gene display markedly increased levels of DA, deficits in sensorimotor gating, and hyperactivity...

journal_title：Behavioural pharmacology

authors： Powell SB,Young JW,Ong JC,Caron MG,Geyer MA

更新日期：2008-09-01 00:00:00

abstract：:The effects of the competitive NMDA antagonists, 2-amino-4,5-(1,2-cyclohexyl)-7-phosphonoheptanoic acid (NPC 12626) and 3-(2-carboxypiperazin-4-yl) propyl-l-phosphonic acid (CPP), were compared to those of the noncompetitive NMDA antagonists, phencyclidine (PCP) and (+)-5-methyl-10, 11-dihydro-5H-dibenzo (a,d) cyclohe...

journal_title：Behavioural pharmacology

authors： Willetts J,Rice A,Balster RL

更新日期：1990-01-01 00:00:00

abstract：:Rats in one group were trained to discriminate alprazolam (1.0mg/kg, i.p.) and in another group diazepam (3.0mg/kg, i.p.) from saline in a two-lever drug discrimination procedure. Food presentation occurred after 10 consecutive responses on the lever associated either with the training drug or with saline. Alprazolam,...

journal_title：Behavioural pharmacology

authors： Wettstein JG,Gauthier B

更新日期：1992-06-01 00:00:00

abstract：:The purpose of the present experiments was to develop and validate pharmacologically an automated, relatively rapid, and reproducible behavioral model of learning and memory using an autoshaping procedure in mice. Nose-poke responses into a recessed area were differentiated by response-dependent reinforcement during t...

journal_title：Behavioural pharmacology

authors： Vanover KE,Barrett JE

更新日期：1998-05-01 00:00:00

abstract：:The effects on memory of drugs of abuse from several pharmacological classes were examined in four adult male squirrel monkeys responding under a delayed matching-to-sample schedule of food presentation. Subjects were required to emit 20 responses on a sample key transilluminated by either a constant white or a flashi...

journal_title：Behavioural pharmacology

authors： Baron SP,Wenger GR

更新日期：2001-07-01 00:00:00

abstract：:Cannabinoid receptor (CBR) agonists produce antinociception in conventional preclinical assays of pain-stimulated behavior but are not effective in preclinical assays of pain-depressed behavior. Fatty acid amide hydrolase (FAAH) inhibitors increase physiological levels of the endocannabinoid anandamide, which may conf...

journal_title：Behavioural pharmacology

authors： Kwilasz AJ,Abdullah RA,Poklis JL,Lichtman AH,Negus SS

更新日期：2014-04-01 00:00:00

abstract：:Over the last 15 years, genetically modified mice have added important data to our knowledge on psychiatric diseases including anxiety. This has produced many behavioural publications, partially by non-behaviourists, in which differences between mutants and normal wild-type animals were described. The popularity of th...

journal_title：Behavioural pharmacology

authors： Bouwknecht JA,Paylor R

更新日期：2008-09-01 00:00:00

abstract：:Changes in extracellular concentrations of dopamine (DA) were measured in vivo in the nucleus accumbens of the rat during intravenous self-administration of either cocaine (0.25, 0.5, 1.0mg/infusion) or d-amphetamine (0.05, 0.1, 0.2mg/infusion). Drug intake was limited to 12 self-administered infusions per session for...

journal_title：Behavioural pharmacology

authors： Di Ciano P,Coury A,Depoortere RY,Egilmez Y,Lane JD,Emmett-Oglesby MW,Lepiane FG,Phillips AG,Blaha CD

更新日期：1995-06-01 00:00:00

abstract：:The purpose of the present experiment was to assess the degree of tolerance and cross-tolerance to the response rate-decreasing effects of opioids with different degrees of intrinsic efficacy at the mu receptor. The mu opioids included buprenorphine, etorphine, l-methadone, morphine, and sufentanil. Lever pressing of ...

journal_title：Behavioural pharmacology

authors： Hughes CE,Picker MJ,Dykstra LA

更新日期：1995-12-01 00:00:00

abstract：:The prototypic cannabinoid CB1 antagonist SR 141716A is one important pharmacologic tool for examining CB1 receptors that mediate the behavioral and physiologic effects of delta9-tetrahydrocannabinol (delta9-THC). This study examined the effects of SR 141716A on the rate-decreasing, hypothermic and discriminative stim...

journal_title：Behavioural pharmacology

authors： McMahon LR,Amin MR,France CP

更新日期：2005-09-01 00:00:00

abstract：:Previous exposure to a variety of drugs of abuse has been shown to cause long-term impairments in reversal learning and reinforcer devaluation tasks. However, there is mixed evidence in the literature for a long-term effect of ketamine exposure on reversal learning and the long-term effect of ketamine exposure on deva...

journal_title：Behavioural pharmacology

authors： Pickens CL,Aurand L,Hunt J,Fisher H

更新日期：2017-06-01 00:00:00

abstract：:Neuropsychiatric disorders, such as addiction, are associated with cognitive impairment, including learning and memory deficits. Previous research has demonstrated that the chronic use of methamphetamine (METH) induces long-term cognitive impairment and cannabidiol (CBD), as a neuroprotectant, can reverse spatial memo...

journal_title：Behavioural pharmacology

authors： Razavi Y,Shabani R,Mehdizadeh M,Haghparast A

更新日期：2020-06-01 00:00:00

abstract：:Current concepts of basal ganglia function have evolved from the essentially motoric, to include a range of extramotoric functions that involve not only dopaminergic but also cholinergic, γ-aminobutyric acid (GABA)ergic and glutamatergic mechanisms. We consider these mechanisms and their efferent systems, including sp...

journal_title：Behavioural pharmacology

authors： Ikeda H,Adachi K,Fujita S,Tomiyama K,Saigusa T,Kobayashi M,Koshikawa N,Waddington JL

更新日期：2015-02-01 00:00:00

abstract：:Rats were trained on one of two multiple random-interval schedules of reinforcement, which contained both ascending and descending reinforcement density sequences. The design of the schedules made it possible to determine whether performance changes in a particular component depended on the reinforcement density in th...

journal_title：Behavioural pharmacology

authors： Willner P,Phillips G,Sampson D,Muscat R

更新日期：1989-01-01 00:00:00

abstract：:We studied the anxiolytic-like activity of alnespirone and buspirone, two 5-HT(1A) receptor agonists, in a modified Geller-Seifter conflict model, and examined the role of 5-HT(1A) receptors by studying whether WAY-100635, a selective antagonist at these receptors, blocked their effects. Administered s.c. 30 minutes b...

journal_title：Behavioural pharmacology

authors： Cervo L,Munoz C,Bertaglia A,Samanin R

更新日期：2000-04-01 00:00:00

abstract：:This study assessed whether access to a sweet solution in the home cage could change sensitivity to cocaine, using a drug discrimination procedure. Rats were trained to discriminate 10 mg/kg cocaine from saline. After acquisition, rats were tested with a cumulative dose-response procedure (0-18 mg/kg) for 12 consecuti...

journal_title：Behavioural pharmacology

authors： Kohut SJ,Riley AL

更新日期：2010-05-01 00:00:00

abstract：:Nicotine, a cognition enhancer and a drug of abuse, exerts its central actions through neuronal nicotinic acetylcholine receptors which show sexual dimorphism. This study tested the effects of nicotine on active avoidance learning in male and female rats. Three month-old Sprague-Dawley rats received varying doses of n...

journal_title：Behavioural pharmacology

authors： Yilmaz O,Kanit L,Okur BE,Pöğün S

更新日期：1997-06-01 00:00:00

abstract：:The therapeutic potential of S1RA (E-52862), a selective sigma-1 receptor (σ1R) antagonist, has been explored in experimental neuropathic pain, but not in inflammatory pain models. The present study investigated the effect of the intraperitoneal administration of S1RA on the hind paw withdrawal response to thermal and...

journal_title：Behavioural pharmacology

authors： Gris G,Merlos M,Vela JM,Zamanillo D,Portillo-Salido E

更新日期：2014-06-01 00:00:00

abstract：:Rats were given fixed-time, 1-min food-pellet delivery sessions, for 3 h every day, which resulted in over drinking (schedule-induced polydipsia). In previous research, groups of animals came to prefer solutions of cocaine or lidocaine to concurrently presented water, if the drugs were first offered in a glucose/sacch...

journal_title：Behavioural pharmacology

authors： Falk JL,Yosef E,Schwartz A,Lau CE

更新日期：1999-02-01 00:00:00

abstract：:Fragile X syndrome is an X-linked form of mental retardation including, among others, symptoms such as stereotypic behaviour, hyperactivity, hyperarousal, and cognitive deficits. We hypothesized that hyperactivity and/or compromised attentional, cognitive functions may lead to impaired performance in cognitive tasks i...

journal_title：Behavioural pharmacology

authors： Ventura R,Pascucci T,Catania MV,Musumeci SA,Puglisi-Allegra S

更新日期：2004-09-01 00:00:00

abstract：:Adult male Wistar rats were bilaterally implanted with indwelling cannulae in the CA1 region of the dorsal hippocampus. Once recovered from surgery, animals were submitted to one session of step-down inhibitory avoidance training (3.0 s, 0.4 mA footshock). Animals received a 0.5-microl infusion of saline, or of LY2940...

journal_title：Behavioural pharmacology

authors： Barros DM,Mello e Souza T,de Souza MM,Choi H,DeDavid e Silva T,Lenz G,Medina JH,Izquierdo I

更新日期：2001-12-01 00:00:00

abstract：:The behavioural effects of six compounds with N-methyl-D-aspartate (NMDA) antagonist properties were compared on the responding of rats maintained by a differential reinforcement of low rate 15s (DRL-15s) schedule. This schedule requires that responses be temporally spaced in order to be reinforced (timing behaviour)....

journal_title：Behavioural pharmacology

authors： Sanger DJ

更新日期：1992-12-01 00:00:00

abstract：:We have observed that, after myocardial infarction (MI), rats display apoptosis in the limbic system that can be prevented by pentoxifylline (PTX), a proinflammatory cytokine inhibitor. We have hypothesized that reduction of apoptosis in the limbic system can attenuate the depressive behaviour occurring post-MI. The p...

journal_title：Behavioural pharmacology

authors： Bah TM,Kaloustian S,Rousseau G,Godbout R

更新日期：2011-12-01 00:00:00

abstract：:Both opioids and cannabinoids have inhibitory effects at micromolar doses, which are mediated by activated receptors coupling to Gi/o-proteins. Surprisingly, the analgesic effects of opioids are enhanced by ultra-low doses (nanomolar to picomolar) of the opioid antagonist, naltrexone. As opioid and cannabinoid systems...

journal_title：Behavioural pharmacology

authors： Paquette J,Olmstead MC

更新日期：2005-12-01 00:00:00

abstract：:A runway was used to measure locomotor responses to quinpirole (200µg/kg), in rats. The locomotor stimulant effect of quinpirole increased progressively over successive trials at 3-day intervals. Animals administered quinpirole in the home cage were also sensitized, but to a lesser degree than animals tested in the ru...

journal_title：Behavioural pharmacology

authors： Willner P,Papp M,Cheeta S,Muscat R

更新日期：1992-02-01 00:00:00

abstract：:Pigeons were trained to discriminate 5mg/kg pentobarbital from saline under several multiple fixed-ratio fixed-interval schedules of food presentation. The following schedules were studied: multiple fixed-ratio 40 fixed-interval 18s (mult FR40 FI18), mult FR10 FI18s, mult FR10 FI180s and mult FR90 FI10s. After respond...

journal_title：Behavioural pharmacology

authors： McMillan DE,Hardwick WC

更新日期：1996-05-01 00:00:00

abstract：:The development of Parkinson's disease (PD) involves the degeneration of dopaminergic neurons caused by oxidative stress. Accumulating clinical evidence indicates that high blood levels of uric acid (UA), an intrinsic antioxidative substance, are associated with reduced risk of PD. However, this hypothesis has not bee...

journal_title：Behavioural pharmacology

authors： Nakashima A,Yamauchi A,Matsumoto J,Dohgu S,Takata F,Koga M,Fukae J,Tsuboi Y,Kataoka Y

更新日期：2019-02-01 00:00:00

abstract：:Drug withdrawal is often conceptualized as an aversive state that motivates drug-seeking and drug-taking behaviors in humans. Stress is more difficult to define, but is also frequently associated with aversive states. Here we describe evidence for the simple theory that drug withdrawal is a stress-like state, on the b...

journal_title：Behavioural pharmacology

authors： Chartoff EH,Carlezon WA Jr

更新日期：2014-09-01 00:00:00

abstract：:The purpose of this study was to examine, in healthy volunteers without histories of extensive sedative use, the acute behavioral effects of doses of alprazolam used in clinical applications. Subjects participated in daily sessions over 12 study days. They consumed a standard breakfast, received an oral drug dose (0, ...

journal_title：Behavioural pharmacology

authors： Kelly TH,Foltin RW,Serpick E,Fischman MW

更新日期：1997-02-01 00:00:00

abstract：:The fentanyl derivative mirfentanil has a novel set of behavioral effects in non-humans including low-efficacy opioid actions and non-opioid antinociceptive actions. This study evaluated the rate-decreasing effects of mirfentanil, morphine, naltrexone and ketamine in pigeons both prior to and during a period of chroni...

journal_title：Behavioural pharmacology

authors： Gauthier CA,Bagley JR,Brockunier LL,France CP

更新日期：1999-09-01 00:00:00