Early social isolation augments alcohol consumption in rats.


:There is a considerable degree of individual vulnerability for alcohol use disorder (AUD) as only a subpopulation of individuals who regularly consume alcohol develop AUD. It is therefore very important to understand the factors and mechanisms that contribute towards the individual risk for AUD. In this respect, social influences, in particular during development, may be relevant for AUD as disruptions in early social experiences are associated with an increased risk for AUD. Social play, the most prominent form of social behaviour shown by young mammals, is rewarding and considered to be important for social, emotional and cognitive development. Recent studies suggest that early social isolation, effectively depriving animals from social play, increases the risk for addictive behaviour. The aim of this study was therefore to explore the long-term consequences of early social isolation on alcohol consumption and motivation for alcohol. To this end, rats were socially isolated from postnatal days 21-42, followed by 4 weeks of social housing, and voluntary alcohol consumption and operant responding for alcohol were determined in adulthood. We observed enhanced levels of alcohol consumption in adulthood in previously isolated rats, whereas operant responding for alcohol was not altered. The impact of early social isolation was independent of the individual variation in alcohol consumption. These data indicate that social isolation, during a developmental period when social play is highly abundant, enhances the propensity to consume alcohol in adulthood. This implies that early social experience may be a protective factor against excessive alcohol use.


Behav Pharmacol


Behavioural pharmacology


Lesscher HM,Spoelder M,Rotte MD,Janssen MJ,Hesseling P,Lozeman-van't Klooster JG,Baars AM,Vanderschuren LJ




Has Abstract


2015-10-01 00:00:00




7 Spec No










  • Chronic intracerebroventricular infusion of lipopolysaccharide: effects of ibuprofen treatment and behavioural and histopathological correlates.

    abstract::Twenty male Wistar rats were trained under an alternating-lever cyclic-ratio (ALCR) schedule of food reinforcement. When responding showed no trends, each subject was subcutaneously implanted with an Alzet osmotic mini-pump, connected to a chronic indwelling cannula extending into the lateral ventricle of the brain. T...

    journal_title:Behavioural pharmacology

    pub_type: 杂志文章


    authors: Richardson RL,Kim EM,Gardiner T,O'Hare E

    更新日期:2005-11-01 00:00:00

  • Pitfalls in the interpretation of genetic and pharmacological effects on anxiety-like behaviour in rodents.

    abstract::Over the last 15 years, genetically modified mice have added important data to our knowledge on psychiatric diseases including anxiety. This has produced many behavioural publications, partially by non-behaviourists, in which differences between mutants and normal wild-type animals were described. The popularity of th...

    journal_title:Behavioural pharmacology

    pub_type: 杂志文章,评审


    authors: Bouwknecht JA,Paylor R

    更新日期:2008-09-01 00:00:00

  • Role of orexin-2 and CB1 receptors within the periaqueductal gray matter in lateral hypothalamic-induced antinociception in rats.

    abstract::Orexin plays an important role in pain modulation. Orexin-1 and orexin-2 receptors (Ox1r and Ox2r) are found at high density in the ventrolateral periaqueductal gray matter (vlPAG). Our previous study showed that chemical stimulation of the lateral hypothalamus with carbachol induces antinociception in the tail-flick ...

    journal_title:Behavioural pharmacology

    pub_type: 杂志文章


    authors: Esmaeili MH,Reisi Z,Ezzatpanah S,Haghparast A

    更新日期:2017-02-01 00:00:00

  • A comparison of the predictive therapeutic and undesired side-effects of the NMDA receptor antagonist, memantine, in mice.

    abstract::Memantine (1-amino-3,5-dimethyl-adamantane) is the only clinically used NMDA (N-methyl-D-aspartate) glutamate receptor antagonist. The present experiments were carried out to compare the dose-response for memantine's predictive therapeutic and side-effects in a variety of tests in C57BL/6J/Han mice, and to elucidate i...

    journal_title:Behavioural pharmacology

    pub_type: 杂志文章


    authors: Kos T,Popik P

    更新日期:2005-05-01 00:00:00

  • Infralimbic cortex activation and motivated arousal induce histamine release.

    abstract::Appetitive behaviours occur in a state of behavioural and physiological activation that allows the optimal performance of these goal-directed behaviours. Here, we tested the hypothesis that histamine neurons under the command of the infralimbic cortex are important to provide behavioural activation. Extracellular hist...

    journal_title:Behavioural pharmacology

    pub_type: 杂志文章


    authors: Riveros ME,Forray MI,Torrealba F

    更新日期:2015-06-01 00:00:00

  • Blockade of CB1 receptors prevents retention of extinction but does not increase low preincubated conditioned fear in the fear incubation procedure.

    abstract::We recently developed a procedure to study fear incubation, in which rats given 100 tone-shock pairings over 10 days show low fear 2 days after conditioned fear training and high fear after 30 days. Notably, fear 2 days after 10 sessions of fear conditioning is lower than fear seen 2 days after a single session of fea...

    journal_title:Behavioural pharmacology

    pub_type: 杂志文章


    authors: Pickens CL,Theberge FR

    更新日期:2014-02-01 00:00:00

  • Spatial and associative learning deficits induced by neonatal excitotoxic hippocampal damage in rats: further evaluation of an animal model of schizophrenia.

    abstract::Neonatal ventral hippocampal lesions in the rat result in post-pubertal onset of behavioural abnormalities, modelling some aspects of schizophrenia. We further assessed the behavioural effects of neonatal lesions in rats in a variety of cognitive tasks and in the prepulse inhibition (PPI) of startle response paradigm....

    journal_title:Behavioural pharmacology

    pub_type: 杂志文章


    authors: Le Pen G,Grottick AJ,Higgins GA,Martin JR,Jenck F,Moreau JL

    更新日期:2000-06-01 00:00:00

  • Ontogenetic difference in ethanol reinforcing properties: the role of the opioid system.

    abstract::Previous data indicate that ethanol intoxication (3 g/kg, intragastric) on postnatal day (PD) 7 and 8 increases ethanol acceptance, but on PD 10 and 11 generates an aversion in infant rats. We investigated the participation of the opioid system in these effects. Subcutaneous administration of naloxone (1 or 10 mg/kg) ...

    journal_title:Behavioural pharmacology

    pub_type: 杂志文章


    authors: Gabriela Chotro M,Arias C

    更新日期:2007-11-01 00:00:00

  • Facilitation and disruption of memory for the passive avoidance task in the day-old chick using dopamine D1 receptor compounds.

    abstract::This series of studies provides a behavioural account of dopamine D1-receptor-dependent facilitation and disruption of memory for the single-trial passive avoidance task in the day-old chick. The D1 antagonist, SCH23390, induced memory disruption in a dose-dependent manner from 60 min after training with a strong (100...

    journal_title:Behavioural pharmacology

    pub_type: 杂志文章


    authors: Hale MW,Crowe SF

    更新日期:2003-11-01 00:00:00

  • Affective communication in rodents: serotonin and its modulating role in ultrasonic vocalizations.

    abstract::Serotonin (5-hydroxytryptamine, 5-HT) is an important modulatory neurotransmitter and functions as a key neurodevelopmental signal in the mammalian brain. 5-HT plays a prominent role in regulating various types of psychological processes and functions, including mood and emotion, particularly anxiety, but also in regu...

    journal_title:Behavioural pharmacology

    pub_type: 杂志文章,评审


    authors: Wöhr M,van Gaalen MM,Schwarting RK

    更新日期:2015-09-01 00:00:00

  • The discriminative stimulus and reinforcing effects of nicotine in humans following nicotine pretreatment.

    abstract::Smokers often report that the first cigarette of the day is the most rewarding, and subsequent smoking is less rewarding. Reduction in smoking enjoyment later in the day may be related to acute tolerance to the discriminative stimulus effects of nicotine. We examined changes in nicotine discrimination behaviour in hum...

    journal_title:Behavioural pharmacology

    pub_type: 临床试验,杂志文章


    authors: Perkins KA,Fonte C,Meeker J,White W,Wilson A

    更新日期:2001-02-01 00:00:00

  • Clonidine and yohimbine in opioid-dependent humans responding under a naloxone novel-response discrimination procedure.

    abstract::Opioid-maintained volunteers were trained to distinguish between a low dose of the opioid antagonist naloxone (0.15 mg/70 kg, i.m.; i.e. Drug A) and placebo (i.e. Drug B), under an instructed novel-response drug discrimination procedure in which subjects identify the drug condition as 'A', 'B', or 'N' (neither A nor B...

    journal_title:Behavioural pharmacology

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Oliveto A,Sevarino K,McCance-Katz E,Benios T,Poling J,Feingold A

    更新日期:2003-03-01 00:00:00

  • Interaction of N-methyl-D-aspartate and group 5 metabotropic glutamate receptors on behavioral flexibility using a novel operant set-shift paradigm.

    abstract::Behavioral flexibility or 'set-shifting' refers to the ability to modify ongoing behavior in response to changing goals or environmental contingencies. Impaired behavioral flexibility is associated with disorders such as schizophrenia and addiction. Hypofunction of N-methyl-D-aspartate (NMDA) receptors has been implic...

    journal_title:Behavioural pharmacology

    pub_type: 杂志文章


    authors: Darrah JM,Stefani MR,Moghaddam B

    更新日期:2008-05-01 00:00:00

  • A-68930, a novel, potent dopamine D1 receptor agonist: a microstructural analysis of its effects on feeding and other behaviour in the rat.

    abstract::A-68930 [1R, 3S)-1-aminomethyl-5,6-dihydroxy-3-phenylisochroman HCI] is a novel, potent and selective dopamine D1 receptor agonist. Previous reports have shown that the selective D1 partial agonist, SK & F 38393, reduced food consumption in rats and mice. The aim of this study was to undertake a microstructural analys...

    journal_title:Behavioural pharmacology

    pub_type: 杂志文章


    authors: AI-Naser HA,Cooper SJ

    更新日期:1994-04-01 00:00:00

  • Chronic treatment with Delta(9)-tetrahydrocannabinol impairs spatial memory and reduces zif268 expression in the mouse forebrain.

    abstract::Few studies have investigated the effects of chronic cannabinoid exposure on memory performance and whether tolerance occurs to cannabinoid-induced memory impairment. Here, we studied the effects of repeated exposure to Delta-tetrahydrocannabinol (THC: 1 mg/kg) on spatial memory and zif268 expression in mice. One grou...

    journal_title:Behavioural pharmacology

    pub_type: 杂志文章


    authors: Boucher AA,Vivier L,Metna-Laurent M,Brayda-Bruno L,Mons N,Arnold JC,Micheau J

    更新日期:2009-02-01 00:00:00

  • Gamma-hydroxybutyric acid affects the acquisition and reinstatement of cocaine-induced conditioned place preference in mice.

    abstract::Cocaine addicts very often use different combinations of cocaine and other drugs of abuse such as gamma-hydroxybutyric acid. The objective of the present work was to evaluate the impact of gamma-hydroxybutyric acid administration on the rewarding actions of cocaine, using the conditioned place preference procedure. Co...

    journal_title:Behavioural pharmacology

    pub_type: 杂志文章


    authors: Maldonado C,Rodríguez-Arias M,Castillo A,Aguilar MA,Miñarro J

    更新日期:2006-03-01 00:00:00

  • 5-HT mediation of the antiaversive effect of isamoltane injected into the dorsal periaqueductal grey.

    abstract::A previous study from this laboratory reported an antiaversive effect of the beta-adrenoceptor blocker propranolol microinjected into the dorsal periaqueductal grey (DPAG) of the rat, that was antagonized by the 5-HT(2) receptor blocker ritanserin. The present results show that microinjection into the DPAG of isamolta...

    journal_title:Behavioural pharmacology

    pub_type: 杂志文章


    authors: Nogueira RL,Graeff FG

    更新日期:1991-02-01 00:00:00

  • Separate and combined effects of gabapentin and [INCREMENT]9-tetrahydrocannabinol in humans discriminating [INCREMENT]9-tetrahydrocannabinol.

    abstract::The aim of the present study was to examine a potential mechanism of action of gabapentin to manage cannabis-use disorders by determining the interoceptive effects of gabapentin in cannabis users discriminating [INCREMENT]-tetrahydrocannabinol ([INCREMENT]-THC) using a pharmacologically selective drug-discrimination p...

    journal_title:Behavioural pharmacology

    pub_type: 杂志文章


    authors: Lile JA,Wesley MJ,Kelly TH,Hays LR

    更新日期:2016-04-01 00:00:00

  • Effects of NMDA antagonists on memory processes in a novel two-trial swimming test.

    abstract::Rats were placed in a circular swimming pool for two 3-min swims separated by 3 days. In the first swim control rats swam initially around the perimeter of the pool and later spent more time in the central region and swam more slowly. The time spent in the centre during min 1 was much higher in the second swim than in...

    journal_title:Behavioural pharmacology

    pub_type: 杂志文章


    authors: Venable N,Kelly PH

    更新日期:1991-04-01 00:00:00

  • Addictive and nonaddictive smoking as related to responsivity to neurotransmitter systems.

    abstract::In a double-blind crossover design on 36 male smokers, differences in hormone responses to a serotonergic (citalopram) and dopaminergic (bromocriptine) challenge were tested, to compare transmitter responsivities in addicted and pleasure-motivated smokers with respective controls. A general score of smoking addiction,...

    journal_title:Behavioural pharmacology

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Netter P,Toll C,Lujic C,Reuter M,Hennig J

    更新日期:2002-09-01 00:00:00

  • Effects of chronic caffeine pre-exposure on conditioned and unconditioned psychomotor activity induced by nicotine and amphetamine in rats.

    abstract::Three experiments examined the effects of chronic pre-exposure to caffeine on the subsequent conditioned and unconditioned locomotor activating effects of nicotine or amphetamine in rats. Rats were given daily intraperitoneal injections of caffeine anhydrous (0, 10 or 30 mg/kg base) for 30 days. Conditioning (environm...

    journal_title:Behavioural pharmacology

    pub_type: 杂志文章


    authors: Palmatier MI,Fung EY,Bevins RA

    更新日期:2003-05-01 00:00:00

  • Environment modifies the expression of behavioral sensitization produced by methamphetamine: behavioral and neurochemical studies.

    abstract::Effects of environmental modulation of methamphetamine (MA)-induced behavior on the establishment and mode of expression of behavioral sensitization were examined. Rats received daily injection of MA for 10 days (1mg/kg, s.c.). Half of them were immediately returned to the home cage (home cage group) and the other hal...

    journal_title:Behavioural pharmacology

    pub_type: 杂志文章


    authors: Ohmori T,Abekawa T,Koyama T

    更新日期:1995-03-01 00:00:00

  • Assessment of executive function using the Tinkertoy test.

    abstract::The Tinkertoy test (TTT) has often been used to assess executive function. Despite its clinical importance, there are few published normative data for it. Thus, the primary aim of this study was to fill this gap. Moreover, as there exists a sex difference in many cognitive abilities and neuropsychological tests, a sec...

    journal_title:Behavioural pharmacology

    pub_type: 杂志文章


    authors: Lambert M,Stenger J,Bielajew C

    更新日期:2018-12-01 00:00:00

  • Latent learning in a radial arm maze following neonatal dopamine depletion.

    abstract::Animals neonatally depleted of dopamine show decreases in exploratory behaviour. As latent learning may depend on exploratory behaviour the present study was undertaken to examine the effects of neonatal dopamine depletion on latent learning. In two experiments dopamine was depleted neonatally, using 6-hydroxydopamine...

    journal_title:Behavioural pharmacology

    pub_type: 杂志文章


    authors: Archer T,Beninger RJ,Järbe TU,Seiden LS

    更新日期:1989-01-01 00:00:00

  • Effects of chronic scopolamine administration on spatial working memory and hippocampal receptors related to learning.

    abstract::Scopolamine has been used in neuropsychopharmacology as a standard drug that leads to symptoms mimicking cognitive deficits seen during the aging process in healthy humans and animals. Scopolamine is known to be a nonselective muscarinic receptor blocker, but its chronic effect on the expression of certain hippocampal...

    journal_title:Behavioural pharmacology

    pub_type: 杂志文章


    authors: Doguc DK,Delibas N,Vural H,Altuntas I,Sutcu R,Sonmez Y

    更新日期:2012-12-01 00:00:00

  • Adenosine receptor antagonists improve short-term object-recognition ability of spontaneously hypertensive rats: a rodent model of attention-deficit hyperactivity disorder.

    abstract::The strain of spontaneously hypertensive rats (SHR) is considered a genetic model for the study of attention-deficit hyperactivity disorder (ADHD), as it displays hyperactivity, impulsivity and poorly sustained attention. Recently, we have shown the involvement of adenosinergic neuromodulation in the SHR's short-term ...

    journal_title:Behavioural pharmacology

    pub_type: 杂志文章


    authors: Pires VA,Pamplona FA,Pandolfo P,Fernandes D,Prediger RD,Takahashi RN

    更新日期:2009-03-01 00:00:00

  • Pharmacological characterization of the discriminative stimulus properties of the dopamine D1 agonist, SKF 81297.

    abstract::A range of selective dopamine D1 and D2 receptor agonists and antagonists was used to characterize to the discriminative stimuli produced by d-amphetamine (0.5mg/kg) and the D1 agonists SKF 81297 (0.1mg/kg). In rats trained to discriminate d-amphetamine (0.5mg/kg) from saline, d-amphetamine produced a dose-related inc...

    journal_title:Behavioural pharmacology

    pub_type: 杂志文章


    authors: Reavill C,B Bond,Overend P,Hunter AJ

    更新日期:1993-04-01 00:00:00

  • Alterations of acoustic features of 50 kHz vocalizations by nicotine and phencyclidine in rats.

    abstract::Ultrasonic vocalizations are widely used to examine affective states in rats, yet relatively few studies explore the acoustic features of vocalizations, especially in relation to drug exposure, and no studies have explored alterations in acoustic features over time. The goal of this study was to examine nicotine- and ...

    journal_title:Behavioural pharmacology

    pub_type: 杂志文章


    authors: Swalve N,Mulholland MM,Li M

    更新日期:2019-08-01 00:00:00

  • Yawning and locomotor behavior induced by dopamine receptor agonists in mice and rats.

    abstract::Dopaminergic (DA) agonist-induced yawning in rats seems to be mediated by DA D3 receptors, and low doses of several DA agonists decrease locomotor activity, an effect attributed to presynaptic D2 receptors. Effects of several DA agonists on yawning and locomotor activity were examined in rats and mice. Yawning was rel...

    journal_title:Behavioural pharmacology

    pub_type: 杂志文章


    authors: Li SM,Collins GT,Paul NM,Grundt P,Newman AH,Xu M,Grandy DK,Woods JH,Katz JL

    更新日期:2010-05-01 00:00:00

  • Diphenyl diselenide improves scopolamine-induced memory impairment in mice.

    abstract::This study was conducted to evaluate the effects of exposure to diphenyl diselenide (PhSe)2 on cognitive impairment induced by scopolamine, a muscarinic antagonist, using the Y-maze and Morris water maze tests in mice. One hour before the tests, mice were treated with (PhSe)2 (50 mg/kg, oral) and 30 min later memory i...

    journal_title:Behavioural pharmacology

    pub_type: 杂志文章


    authors: Souza AC,Brüning CA,Leite MR,Zeni G,Nogueira CW

    更新日期:2010-09-01 00:00:00