Abstract:
:Implant-associated infections is one of the most challenging post-operative complications in bone-related implantations. To tackle this clinical issue, we developed a low-cost and durable surface coating for medical grade titanium implants that uses positively charged silane molecules. The in vitro antimicrobial tests revealed that the titanium surface coated with (3-aminopropyl) triethoxysilane, which has the appropriate length of hydrophobic alkyl chain and positive charged amino group, suppressed more than 90% of the initial bacterial adhesion of S. aureus, P. aeruginosa, and E. coli after 30 min of incubation. In terms of growth inhibitory rate, the treated surface was able to reduce 75.7% ± 11.9% of bacterial growth after a 24-hour culturing, thereby exhibiting superior anti-biofilm formation in the late stage. When implanted into the rat model infected by S. aureus, the treated surface eliminated the implant-associated infection through the mechanism of inhibition of bacterial adhesion on the implant surface. Additionally, the treated surface was highly compatible with mammalian cells. In general, our design demonstrated its potential for human clinical trials as a low-cost and effective antibacterial strategy to minimize post-operative implant-related bacterial infection.
journal_name
Acta Biomaterjournal_title
Acta biomaterialiaauthors
Shen J,Gao P,Han S,Kao RYT,Wu S,Liu X,Qian S,Chu PK,Cheung KMC,Yeung KWKdoi
10.1016/j.actbio.2020.07.040subject
Has Abstractpub_date
2020-09-15 00:00:00pages
421-430eissn
1742-7061issn
1878-7568pii
S1742-7061(20)30426-8journal_volume
114pub_type
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