Co-inspired hydroxyapatite-based scaffolds for vascularized bone regeneration.

abstract：:The present work is an amalgamation of computation and experimental approach to gain an insight into composition-structure-bioactivity relationships of alkali-free bioactive glasses in the CaO-MgO-SiO2-P2O5 system. The glasses have been designed in the diopside (CaO·MgO·2SiO2; Di)-tricalcium phosphate (3CaO·P2O5; TCP)...

journal_title：Acta biomaterialia

authors： Kapoor S,Semitela Â,Goel A,Xiang Y,Du J,Lourenço AH,Sousa DM,Granja PL,Ferreira JM

更新日期：2015-03-01 00:00:00

abstract：:In the present report, a degradable gene delivery system (PAMS/DNA/10NLS) containing nucleus location signal peptide (NLS) was prepared. The agarose gel electrophoresis, particle size and zeta potential of PAMS/DNA/10NLS were similar to those of PAMS/DNA, which proved that NLS did not affect the interaction between PA...

journal_title：Acta biomaterialia

authors： Chen K,Guo L,Zhang J,Chen Q,Wang K,Li C,Li W,Qiao M,Zhao X,Hu H,Chen D

更新日期：2017-01-15 00:00:00

abstract：:β-Cyclodextrin can form inclusion complex with a series of guest molecules including phenyl moieties, and has gained considerable popularity in the study of supramolecular nanostructure. In this study, a biodegradable nanocomplex (HA(CD)-4Phe4 nanocomplex) was developed from β-cyclodextrin grafted hyaluronic acid (HA)...

journal_title：Acta biomaterialia

authors： Ji Y,Shan S,He M,Chu CC

更新日期：2017-10-15 00:00:00

abstract：:Currently there is no material that can be used as a long-term vitreous substitute, and this remains an unmet clinical need in ophthalmology. In this study, we developed an injectable, in situ chemically crosslinked hydrogel system and evaluated it in a rabbit model. The system consisted of two components, both based ...

journal_title：Acta biomaterialia

authors： Tao Y,Tong X,Zhang Y,Lai J,Huang Y,Jiang YR,Guo BH

更新日期：2013-02-01 00:00:00

abstract：:The use of hybrid pH-sensitive micelles based mainly on the (PEO)(129)(P2VP)(43)(PCL)(17) ABC miktoarm star copolymer as potential triggered drug delivery systems was investigated. Co-micellization of this star copolymer with a second copolymer labeled by a targeting ligand, i.e. biotin, on the pH sensitive block (pol...

journal_title：Acta biomaterialia

authors： Cajot S,Van Butsele K,Paillard A,Passirani C,Garcion E,Benoit JP,Varshney SK,Jérôme C

更新日期：2012-12-01 00:00:00

abstract：:Biphasic calcium phosphates (BCPs) are bioceramics composed of hydroxyapatite (HAp, Ca10(PO4)6(OH)2) and beta-Tricalcium Phosphate (β-TCP, Ca3(PO4)2). Because their chemical and mineral composition closely resembles that of the mineral component of bone, they are potentially interesting candidates for bone repair surg...

journal_title：Acta biomaterialia

authors： Gomes S,Kaur A,Grenèche JM,Nedelec JM,Renaudin G

更新日期：2017-03-01 00:00:00

abstract：:It is important to understand the effects of mechanical stimulation on cell behaviors for homeostasis. Many studies have been performed on cell responses to mechanical stimuli, but the mechanosensing mechanism is still under debate. In the present study, experiments employing molecular dynamics (MD) simulations concer...

journal_title：Acta biomaterialia

authors： Deguchi S,Kato A,Wu P,Hakamada M,Mabuchi M

更新日期：2021-02-01 00:00:00

abstract：:There is an unmet need for improved, effective tissue engineering strategies to replace or repair bone damaged through disease or injury. Recent research has focused on developing biomaterial scaffolds capable of spatially and temporally releasing combinations of bioactive growth factors, rather than individual molecu...

journal_title：Acta biomaterialia

authors： Smith EL,Kanczler JM,Gothard D,Roberts CA,Wells JA,White LJ,Qutachi O,Sawkins MJ,Peto H,Rashidi H,Rojo L,Stevens MM,El Haj AJ,Rose FR,Shakesheff KM,Oreffo RO

更新日期：2014-10-01 00:00:00

abstract：:A biphasic layer with a Zn-containing beta-tricalcium phosphate (ZnTCP) phase and a fluoridated hydroxyapatite (FHA) phase on titanium alloy substrate was prepared by the sol-gel technique. Scanning electron microscopy and energy-dispersive X-ray analysis results showed the ZnTCP/FHA layer to have a heterogeneous surf...

journal_title：Acta biomaterialia

authors： Miao S,Cheng K,Weng W,Du P,Shen G,Han G,Yan W,Zhang S

更新日期：2008-03-01 00:00:00

abstract：:Seeking strategies to enhance the overall combinations of mechanical properties is of great significance for engineering materials, but still remains a key challenge because many of these properties are often mutually exclusive. Here we reveal from the perspective of materials science and mechanics that adaptive struc...

journal_title：Acta biomaterialia

authors： Liu Z,Zhang Y,Zhang M,Tan G,Zhu Y,Zhang Z,Ritchie RO

更新日期：2019-03-01 00:00:00

abstract：:Biocompatible polymer solutions that can crosslink in situ following injection to form stable hydrogels are of interest as depots for sustained delivery of therapeutic factors or cells, and as scaffolds for regenerative medicine. Here, injectable self-gelling alginate formulations obtained by mixing alginate microsphe...

journal_title：Acta biomaterialia

authors： Hori Y,Winans AM,Irvine DJ

更新日期：2009-05-01 00:00:00

abstract：:Several studies have reported the benefits of mesenchymal stem cells (MSCs) for bone tissue engineering. However, vascularization remains one of the main obstacles that must be overcome to reconstruct large bone defects. In vitro prevascularization of the three-dimensional (3-D) constructs using co-cultures of human p...

journal_title：Acta biomaterialia

authors： Guerrero J,Catros S,Derkaoui SM,Lalande C,Siadous R,Bareille R,Thébaud N,Bordenave L,Chassande O,Le Visage C,Letourneur D,Amédée J

更新日期：2013-09-01 00:00:00

abstract：UNLABELLED:Chondrocyte dedifferentiation presents a major barrier in engineering functional cartilage constructs. To mitigate the effects of dedifferentiation, this study employed a post-expansion aggregate culture step to enhance the chondrogenic phenotype of passaged articular chondrocytes (ACs) before their integrat...

journal_title：Acta biomaterialia

authors： Huang BJ,Hu JC,Athanasiou KA

更新日期：2016-10-01 00:00:00

abstract：:We have performed a comparative analysis of glutaraldehyde-preserved ostrich pericardium, as a novel biomaterial, with bovine pericardium. The biochemical characteristics (histology, water content, amino acid composition, and collagen and elastin contents), mechanical properties, and in vivo calcification in a subcuta...

journal_title：Acta biomaterialia

authors： Maestro MM,Turnay J,Olmo N,Fernández P,Suárez D,García Páez JM,Urillo S,Lizarbe MA,Jorge-Herrero E

更新日期：2006-03-01 00:00:00

abstract：:A pH-sensitive copolymer PAsp(DIP)-b-PAsp(MEA) (PDPM) was synthesized and self-assembled to micelle loading chemotherapeutic drug doxorubicin (DOX) and introducing a gold nanocage structure for photothermo-chemotherapy and photoacoustic imaging. After further surface modification with polyethylene glycol (PEG), the DO...

journal_title：Acta biomaterialia

authors： Zhou G,Xiao H,Li X,Huang Y,Song W,Song L,Chen M,Cheng D,Shuai X

更新日期：2017-12-01 00:00:00

abstract：UNLABELLED:Humans make high levels of antibody to carbohydrates with terminal galactose α 1,3 galactose (Gal) modifications. This Gal antigen is widely expressed in other mammals and is present on an array of current animal derived biomedical devices including bioprosthetic heart valves. There is growing interest in us...

journal_title：Acta biomaterialia

authors： McGregor C,Byrne G,Rahmani B,Chisari E,Kyriakopoulou K,Burriesci G

更新日期：2016-09-01 00:00:00

abstract：:Cell-instructive hydrogels are attractive for skin repair and regeneration, serving as interactive matrices to promote cell adhesion, cell-driven remodeling and de novo deposition of extracellular matrix components. This paper describes the synthesis and photocrosslinking of cell-instructive pectin hydrogels using cel...

journal_title：Acta biomaterialia

authors： Pereira RF,Barrias CC,Bártolo PJ,Granja PL

更新日期：2018-01-15 00:00:00

abstract：:The geometric features of bone graft substitutes, such as the pore and pore interconnection sizes, are of paramount importance for their biological performance. Such features are generally characterized by micro-computed tomography (μCT). Unfortunately, the resolution of μCT is often too limited. The aim of this study...

journal_title：Acta biomaterialia

authors： Bashoor-Zadeh M,Baroud G,Bohner M

更新日期：2011-11-01 00:00:00

abstract：:Tissue-derived extracellular matrix (ECM) biomaterials to regenerate the meniscus have gained increasing attention in treating meniscus injuries and diseases, particularly for aged persons and athletes. However, ECM scaffold has poor cell infiltration and can only be implanted using surgical procedures. To overcome th...

journal_title：Acta biomaterialia

authors： Wu J,Ding Q,Dutta A,Wang Y,Huang YH,Weng H,Tang L,Hong Y

更新日期：2015-04-01 00:00:00

abstract：:Large three-dimensional poly(glycerol sebacate) (PGS)/poly(l-lactic acid) (PLLA) scaffolds with similar bulk mechanical properties to native low and high stress adapted adipose tissue were fabricated via a freeze-drying and a subsequent curing process. PGS/PLLA scaffolds containing 73vol.% PGS were prepared using two ...

journal_title：Acta biomaterialia

authors： Frydrych M,Román S,MacNeil S,Chen B

更新日期：2015-05-01 00:00:00

abstract：UNLABELLED:Epithelial cellular heterogeneity has been observed in pathological tissues with abnormal matrix stiffness and cells cultured on rigid substrates. However, it remains unclear how matrix stiffness influences cellular heterogeneity formation in multi-cellular population. Here, we demonstrated that cellular het...

journal_title：Acta biomaterialia

authors： Wang B,Qin P,Zhao H,Xia T,Wang J,Liu L,Zhu L,Xu J,Huang C,Shi Y,Du Y

更新日期：2016-09-01 00:00:00

abstract：:Biomaterials made of biodegradable poly(α-hydroxyesters) such as poly(lactide-co-glycolide) (PLGA) are known to decrease the pH in the vicinity of the implants. Bioactive glass (BG) is being investigated as a counteracting agent buffering the acidic degradation products. However, in dentistry the question arises wheth...

journal_title：Acta biomaterialia

authors： Hild N,Tawakoli PN,Halter JG,Sauer B,Buchalla W,Stark WJ,Mohn D

更新日期：2013-11-01 00:00:00

abstract：:Silicon-doped hydroxyapatite has been functionalized with biotin molecules as a new methodology for the attachment of proteins, peptides or growth factors through the formation of avidin-biotin complex in this material. Bioceramic biotinylation has been performed by esterification reaction between the OH groups of hyd...

journal_title：Acta biomaterialia

authors： Baeza A,Izquierdo-Barba I,Vallet-Regí M

更新日期：2010-03-01 00:00:00

abstract：:Strombus gigas (conch) shells and Tridacna gigas (Giant clam) shells have dense, tailored structures that impart excellent mechanical properties to these shells. In this investigation, conch and clam seashells were converted to hydroxyapatite (HAP) by a hydrothermal method at different temperatures and for different c...

journal_title：Acta biomaterialia

authors： Vecchio KS,Zhang X,Massie JB,Wang M,Kim CW

更新日期：2007-11-01 00:00:00

abstract：:Classically, the evaluation of cellular adhesion of cells on substrates is limited to the evaluation of cell attachment after some hours. We have claimed for several years that this evaluation is incomplete concerning the evaluation of cell adhesion and more precisely of the quality of the in vitro cell/biomaterial in...

journal_title：Acta biomaterialia

authors： Bigerelle M,Anselme K

更新日期：2005-09-01 00:00:00

abstract：:Clinically, hypertrophic scarring (HS) is a major concern for patients and has been a challenge for surgeons, as there is a lack of treatments that can intervene early in the formation of HS. This study reports on a Chinese drug, 20(R)-ginsenoside Rg3 (GS-Rg3), which can inhibit in vivo the early formation of HS and l...

journal_title：Acta biomaterialia

authors： Cheng L,Sun X,Hu C,Jin R,Sun B,Shi Y,Zhang L,Cui W,Zhang Y

更新日期：2013-12-01 00:00:00

abstract：:Bone-like materials comprise carbonated-hydroxyapatite nanocrystals (c-Ap) embedding a fibrillar collagen matrix. The mineral particles stiffen the nanocomposite by tight attachment to the protein fibrils creating a high strength and toughness material. The nanometer dimensions of c-Ap crystals make it very challengin...

journal_title：Acta biomaterialia

authors： Forien JB,Uzuhashi J,Ohkubo T,Hono K,Luo L,Schwarcz HP,Deymier AC,Krywka C,Fleck C,Zaslansky P

更新日期：2021-01-15 00:00:00

abstract：UNLABELLED:Novel photo-reactive phospholipid polymers were synthesized for use in the preparation of nonfouling surfaces with protein conjugation capacity. Poly[2-methacryloyloxyethyl phosphorylcholine (MPC)-ran-N-methacryloyl-(l)-tyrosinemethylester (MAT)] (P(MPC/MAT)) was synthesized by conventional radical polymeriz...

journal_title：Acta biomaterialia

authors： Tanaka M,Iwasaki Y

更新日期：2016-08-01 00:00:00

abstract：:The use of biodegradable beta-tricalcium phosphate (β-TCP) scaffolds holds great promise for bone tissue engineering. However, the effects of β-TCP on bone and endothelial cells are not fully understood. This study aimed to investigate cell proliferation and differentiation of mono- or co-cultured human-bone-marrow-de...

journal_title：Acta biomaterialia

authors： Kang Y,Kim S,Fahrenholtz M,Khademhosseini A,Yang Y

更新日期：2013-01-01 00:00:00

abstract：:Molecular imprinting is a new and rapidly evolving technique used to create synthetic receptors and it possesses great potential in a number of applications in the life sciences. Keeping in mind the therapeutic importance of 5-fluorouracil (5-FU) and the technological significance of molecular imprinting polymers, the...

journal_title：Acta biomaterialia

authors： Singh B,Chauhan N

更新日期：2008-09-01 00:00:00