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Fabrication and evaluation of Zn containing fluoridated hydroxyapatite layer with Zn release ability.

Abstract：

:A biphasic layer with a Zn-containing beta-tricalcium phosphate (ZnTCP) phase and a fluoridated hydroxyapatite (FHA) phase on titanium alloy substrate was prepared by the sol-gel technique. Scanning electron microscopy and energy-dispersive X-ray analysis results showed the ZnTCP/FHA layer to have a heterogeneous surface with microscaled gibbous structures originating from ZnTCP particle agglomeration. This layer had a slow and sustained Zn release behavior. The scratch test result of the ZnTCP/FHA layer was 489+/-4mN, indicating good interface bonding between the layer and substrate. The ZnTCP/FHA layer supported cell growth, and showed a statistically significant increase in cell viability in comparison with another biphasic layer (TCP/FHA) without Zn. This work demonstrates that the present biphasic ZnTCP/FHA layer has the potential to play a significant role in enhancing bone growth when used as the outermost part of bioactive coatings on metallic implants.

journal_name

Acta Biomater

journal_title

Acta biomaterialia

authors

Miao S,Cheng K,Weng W,Du P,Shen G,Han G,Yan W,Zhang S

doi

10.1016/j.actbio.2007.08.013

subject

Has Abstract

pub_date

2008-03-01 00:00:00

pages

441-6

issue

2

eissn

1742-7061

issn

1878-7568

pii

S1742-7061(07)00143-2

journal_volume

4

pub_type

杂志文章

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