Abstract：
:Although decayed/fractured teeth can be reconstructed minimally invasively and nearly invisibly using adhesive technology, the clinical longevity of dental composite restorations is still too short. Water sorption is thought to be the principal cause of destabilization of the biomaterial-tooth bond. However, the actual mechanisms of interfacial degradation are far from understood. Here we report how nano-controlled molecular interaction at the biomaterial-hard tissue interface can improve bond durability. The use of functional monomers with a strong chemical affinity for the calcium in hydroxyapatite is essential for long-term durability. Correlative X-ray diffraction and solid-state nuclear magnetic resonance disclosed a time-dependent molecular interaction at the interface with stable ionic bond formation of the monomer to hydroxyapatite competing in time with the deposition of less stable calcium phosphate salts. The advanced tooth-biomaterial interaction model gives not only an insight into the mechanisms of bond degradation, but also provides a basis to develop functional monomers for more durable tooth reconstruction.
journal_name
Acta Biomaterjournal_title
Acta biomaterialiaauthors
Yoshihara K,Yoshida Y,Nagaoka N,Fukegawa D,Hayakawa S,Mine A,Nakamura M,Minagi S,Osaka A,Suzuki K,Van Meerbeek Bdoi
10.1016/j.actbio.2010.03.024subject
Has Abstractpub_date
2010-09-01 00:00:00pages
3573-82issue
9eissn
1742-7061issn
1878-7568pii
S1742-7061(10)00150-9journal_volume
6pub_type
杂志文章abstract：:Despite the rapid progress which has been made in hepatocellular carcinoma (HCC) chemotherapeutics, recurrence of liver cancer still remains a barrier to achieve satisfying prognosis. Herein, we aimed to decipher the role of berberine (BER) in chemotherapy-exacerbated HCC repopulation via developing a nanocarrier co-d...
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