Optimized in vitro procedure for assessing the cytocompatibility of magnesium-based biomaterials.

abstract：:Nerve fibers of the peripheral nervous system (PNS) have a remarkable ability to regenerate up to an almost complete recovery of normal function following a crush or a Sunderland Type II injury. This process is governed by glial cells, known as Schwann cells, through their unique capacity to dedifferentiate into cells...

journal_title：Acta biomaterialia

authors： Idini M,Wieringa P,Rocchiccioli S,Nieddu G,Ucciferri N,Formato M,Lepedda A,Moroni L

更新日期：2019-09-15 00:00:00

abstract：:We have developed a bioreactor-based millifluidic technique that allows for dynamic culture conditions and measurement of the fluid flow impinging upon a three-dimensional tissue engineering scaffold. Chondrocytes in scaffolds have been shown to require mechanical stimulation to produce an extracellular matrix that re...

journal_title：Acta biomaterialia

authors： Cooper JA Jr,Li WJ,Bailey LO,Hudson SD,Lin-Gibson S,Anseth KS,Tuan RS,Washburn NR

更新日期：2007-01-01 00:00:00

abstract：:Bioactive materials play an important role in facilitating dental pulp repair when living dental pulp is exposed after injuries. Mineral trioxide aggregate is the currently recommended material of choice for pulp repair procedures though has several disadvantages, especially the inconvenience of handling. Little infor...

journal_title：Acta biomaterialia

authors： Zhu L,Yang J,Zhang J,Lei D,Xiao L,Cheng X,Lin Y,Peng B

更新日期：2014-12-01 00:00:00

abstract：:Peripheral arterial disease differentially affects the superficial femoral (SFA) and the popliteal (PA) arteries, but their morphometric, structural, mechanical, and physiologic differences are poorly understood. SFAs and PAs from 125 human subjects (age 13-92, average 52±17 years) were compared in terms of radii, wal...

journal_title：Acta biomaterialia

authors： Jadidi M,Razian SA,Anttila E,Doan T,Adamson J,Pipinos M,Kamenskiy A

更新日期：2021-02-01 00:00:00

abstract：:Surface functionalization has become of paramount importance and is considered a fundamental tool for the development and design of countless devices and engineered systems for key technological areas in biomedical, biotechnological and environmental applications. In this review, surface functionalization strategies f...

journal_title：Acta biomaterialia

authors： Treccani L,Yvonne Klein T,Meder F,Pardun K,Rezwan K

更新日期：2013-07-01 00:00:00

abstract：:The combination of biodegradable metals and additive manufacturing (AM) leads to a revolutionary change of metal implants in many aspects including materials, design, manufacturing, and clinical applications. The AM of nondegradable metals such as titanium and CoCr alloys has proven to be a tremendous success in clini...

journal_title：Acta biomaterialia

authors： Qin Y,Wen P,Guo H,Xia D,Zheng Y,Jauer L,Poprawe R,Voshage M,Schleifenbaum JH

更新日期：2019-10-15 00:00:00

abstract：:One of the challenges of using bioactive bone cements is adjusting their handling properties for clinical application. To resolve the poorer handling properties of bioactive bone cements we developed a novel bioactive bone cement containing a unique polymethylmethacrylate (PMMA) powder, termed SPD-PMMA (40 μm in diame...

journal_title：Acta biomaterialia

authors： Fukuda C,Goto K,Imamura M,Neo M,Nakamura T

更新日期：2011-10-01 00:00:00

abstract：:Current therapeutic angiogenesis strategies are focused on the development of biologically responsive scaffolds that can deliver multiple angiogenic cytokines and/or cells in ischemic regions. Herein, we report on a novel electrospinning approach to fabricate cytokine-containing nanofibrous scaffolds with tunable arch...

journal_title：Acta biomaterialia

authors： Montero RB,Vial X,Nguyen DT,Farhand S,Reardon M,Pham SM,Tsechpenakis G,Andreopoulos FM

更新日期：2012-05-01 00:00:00

abstract：:In order to expand the properties and applications of aliphatic absorbable polyesters, a new biodegradable block copolymer family, poly(ester amide)-b-poly(ε-caprolactone) (PEA-b-PCL), was synthesized and characterized. These copolymers were synthesized by first preparing l-phenylalanine-based poly(ester amide) macroi...

journal_title：Acta biomaterialia

authors： Wu J,Chu CC

更新日期：2012-12-01 00:00:00

abstract：:Using novel nitric oxide (NO)-generating polymeric hydrogels that can be rapidly photopolymerized in situ, we can deliver NO locally at the site of vascular injury. Depending on material design, these poly(ethylene glycol) (PEG)-based hydrogels can generate NO for up to 50 d. This study demonstrates the ability of nit...

journal_title：Acta biomaterialia

authors： Lipke EA,West JL

更新日期：2005-11-01 00:00:00

abstract：:Immobilization of phosphoproteins on a collagen matrix is important for the induction of intrafibrillar apatite mineralization. Unlike phosphate esters, polyphosphonic acid has no reactive sites for covalent binding to collagen amine groups. Binding of poly(vinyl phosphonic acid) (PVPA), a biomimetic templating analog...

journal_title：Acta biomaterialia

authors： Gu LS,Kim YK,Liu Y,Takahashi K,Arun S,Wimmer CE,Osorio R,Ling JQ,Looney SW,Pashley DH,Tay FR

更新日期：2011-01-01 00:00:00

abstract：:Molecular imprinting is a new and rapidly evolving technique used to create synthetic receptors and it possesses great potential in a number of applications in the life sciences. Keeping in mind the therapeutic importance of 5-fluorouracil (5-FU) and the technological significance of molecular imprinting polymers, the...

journal_title：Acta biomaterialia

authors： Singh B,Chauhan N

更新日期：2008-09-01 00:00:00

abstract：:The design and development of bioactive materials that are inherently conducive for osteointegration and bone regeneration with tunable mechanical properties and degradation remains a challenge. Herein, we report the development of a new class of citrate-based materials with glycerophosphate salts, β-glycerophosphate ...

journal_title：Acta biomaterialia

authors： He Y,Li Q,Ma C,Xie D,Li L,Zhao Y,Shan D,Chomos SK,Dong C,Tierney JW,Sun L,Lu D,Gui L,Yang J

更新日期：2019-07-15 00:00:00

abstract：:CRISPR gene editing technology is strategically foreseen to control diseases by correcting underlying aberrant genetic sequences. In order to overcome drawbacks associated with viral vectors, the establishment of an effective non-viral CRISPR delivery vehicle has become an important goal for nanomaterial scientists. H...

journal_title：Acta biomaterialia

authors： Noureddine A,Maestas-Olguin A,Saada EA,LaBauve AE,Agola JO,Baty KE,Howard T,Sabo JK,Espinoza CRS,Doudna JA,Schoeniger JS,Butler KS,Negrete OA,Brinker CJ,Serda RE

更新日期：2020-09-15 00:00:00

abstract：:Puerarin nanoparticles were firstly prepared in the process of solution-enhanced dispersion by supercritical CO(2) (SEDS) and then successfully microencapsulated by poly(l-lactide) (PLLA) in a modified SEDS process. By adding an organic non-solvent, an initial puerarin solution with a higher degree of saturation and l...

journal_title：Acta biomaterialia

authors： Chen AZ,Li Y,Chau FT,Lau TY,Hu JY,Zhao Z,Mok DK

更新日期：2009-10-01 00:00:00

abstract：:Biodegradable magnesium alloy stents (MAS) could present improved long-term clinical performances over commercial bare metal or drug-eluting stents. However, MAS were found to show limited mechanical support for diseased vessels due to fast degradation. Optimizing stent design through finite element analysis (FEA) is ...

journal_title：Acta biomaterialia

authors： Wu W,Chen S,Gastaldi D,Petrini L,Mantovani D,Yang K,Tan L,Migliavacca F

更新日期：2013-11-01 00:00:00

abstract：:The boundary layers coating articular cartilage in synovial joints constitute unique biomaterials, providing lubricity at levels unmatched by any human-made materials. The underlying molecular mechanism of this lubricity, essential to joint function, is not well understood. Here we study the interactions between surfa...

journal_title：Acta biomaterialia

authors： Zhu L,Seror J,Day AJ,Kampf N,Klein J

更新日期：2017-09-01 00:00:00

abstract：:Several processing technologies and engineering strategies have been combined to create scaffolds with superior performance for efficient tissue regeneration. Cartilage tissue is a good example of that, presenting limited self-healing capacity together with a high elasticity and load-bearing properties. In this work, ...

journal_title：Acta biomaterialia

authors： Ribeiro VP,da Silva Morais A,Maia FR,Canadas RF,Costa JB,Oliveira AL,Oliveira JM,Reis RL

更新日期：2018-05-01 00:00:00

abstract：:Tendon adhesion formation describes the development of fibrotic tissue between the tendon and its surrounding tissues, which commonly occurs as a reaction to injury or surgery. Its impact on function and quality of life varies from negligible to severely disabling, depending on the affected area and extent of adhesion...

journal_title：Acta biomaterialia

authors： Zhang Q,Yang Y,Yildirimer L,Xu T,Zhao X

更新日期：2021-01-25 00:00:00

abstract：:In this study a binary Mg-Zn magnesium alloy was researched as a degradable biomedical material. An Mg-Zn alloy fabricated with high-purity raw materials and using a clean melting process had very low levels of impurities. After solid solution treatment and hot working the grain size of the Mg-Zn alloy was finer and a...

journal_title：Acta biomaterialia

authors： Zhang S,Zhang X,Zhao C,Li J,Song Y,Xie C,Tao H,Zhang Y,He Y,Jiang Y,Bian Y

更新日期：2010-02-01 00:00:00

abstract：:The brain is considered to have a limited capacity to repair damaged tissue and no regenerative capacity following injury. Tissue lost after a stroke is therefore not spontaneously replaced. Extracellular matrix (ECM)-based hydrogels implanted into the stroke cavity can attract endogenous cells. These hydrogels can be...

journal_title：Acta biomaterialia

authors： Ghuman H,Mauney C,Donnelly J,Massensini AR,Badylak SF,Modo M

更新日期：2018-10-15 00:00:00

abstract：:For spinal-fixation applications, implants should have a high Young's modulus to reduce springback during operations, though a low Young's modulus is required to prevent stress shielding for patients after surgeries. In the present study, Ti-29Nb-13Ta-4.6Zr alloy (TNTZ) with a low Young's modulus was modified by addin...

journal_title：Acta biomaterialia

authors： Li Q,Niinomi M,Hieda J,Nakai M,Cho K

更新日期：2013-08-01 00:00:00

abstract：:Despite the critical role tendons play in transmitting loads throughout the musculoskeletal system, little is known about the microstructural mechanisms underlying their mechanical function. Of particular interest is whether collagen fibrils in tendon fascicles bear load independently or if load is transferred between...

journal_title：Acta biomaterialia

authors： Szczesny SE,Elliott DM

更新日期：2014-06-01 00:00:00

abstract：:Biological organisms produce high-performance composite materials, such as bone, wood and insect cuticle, which provide inspiration for the design of novel materials. Ascidians (sea squirts) produce an organic exoskeleton, known as a tunic, which has been studied quite extensively in several species. However, currentl...

journal_title：Acta biomaterialia

authors： Song G,Delroisse J,Schoenaers D,Kim H,Nguyen TC,Horbelt N,Leclère P,Hwang DS,Harrington MJ,Flammang P

更新日期：2020-07-15 00:00:00

abstract：:A novel application of thermally induced phase separation (TIPS) is described enabling the rapid formation of monodisperse porous microspheres. By taking advantage of TIPS processing parameters, the porosity, the pore morphology (bimodal/channel-like/radial towards the centre) and the presence of an open-pore or dense...

journal_title：Acta biomaterialia

authors： Blaker JJ,Knowles JC,Day RM

更新日期：2008-03-01 00:00:00

abstract：:Perinatal tissues are an abundant source of human extracellular matrix proteins, growth factors and stem cells with proved potential use in a wide range of therapeutic applications. Due to their placental origin, these tissues possess unique biological properties, including being angiogenic, anti-inflammatory, anti-fi...

journal_title：Acta biomaterialia

authors： Deus IA,Mano JF,Custódio CA

更新日期：2020-07-01 00:00:00

abstract：:Reverse micelle and chemical hydrolysis techniques have been successfully combined to synthesize composite nanoparticles consisting of a photocatalytic shell of titania and a magnetic core of nickel ferrite. The nature of titania shell, i.e. anatase or brookite, depends on the TiO2 and NiFe2O4 molar ratio. The work pr...

journal_title：Acta biomaterialia

authors： Rana S,Rawat J,Misra RD

更新日期：2005-11-01 00:00:00

abstract：:We report on new types of chitosan-based nanogels via an ortho ester-based linkage, used as drug carriers for efficient chemotherapy. First, we synthesized a novel diacrylamide containing ortho ester (OEAM) as an acid-labile cross-linker. Subsequently, methacrylated succinyl-chitosan (MASCS) was prepared and polymeriz...

journal_title：Acta biomaterialia

authors： Yang G,Wang X,Fu S,Tang R,Wang J

更新日期：2017-09-15 00:00:00

abstract：:Poly(ethylene glycol) PEG-based hydrogels are promising for cell encapsulation and tissue engineering, but are known to elicit a foreign body response (FBR) in vivo. The goal of this study was to investigate the impact of the FBR, and specifically the presence of inflammatory macrophages, on encapsulated cells and the...

journal_title：Acta biomaterialia

authors： Saleh LS,Carles-Carner M,Bryant SJ

更新日期：2018-04-15 00:00:00

abstract：UNLABELLED:Myofibroblasts are critical for connective tissue remodeling and wound healing since they can close wound beds and shape tissues rapidly by generating high traction forces and secreting abundant extracellular matrix proteins and matrix metalloproteinases. However, their presence in excessive numbers is assoc...

journal_title：Acta biomaterialia

authors： Kural MH,Billiar KL

更新日期：2016-03-01 00:00:00