Microencapsulation of puerarin nanoparticles by poly(l-lactide) in a supercritical CO(2) process.

Abstract:

:Puerarin nanoparticles were firstly prepared in the process of solution-enhanced dispersion by supercritical CO(2) (SEDS) and then successfully microencapsulated by poly(l-lactide) (PLLA) in a modified SEDS process. By adding an organic non-solvent, an initial puerarin solution with a higher degree of saturation and lower concentration was obtained and applied in the SEDS process. The resulting puerarin nanoparticles were then suspended in PLLA solution and microencapsulated by PLLA in a modified SEDS process, where an 'injector' was employed in the particle suspension delivery system. The puerarin nanoparticles exhibited a good spherical shape, a smooth surface and a narrow particle size distribution with a mean particle size of 188 nm. After microencapsulation the puerarin-PLLA microparticles had a mean size of 675 nm, a drug load of 23.6% and an encapsulation efficiency of 39.4%; after a burst release at the first stage, the drug was released in a sustained process. Compared with the parallel study of a co-precipitation process, this microencapsulation process is a much more promising technique to prepare a drug-polymer carrier for a drug delivery system, especially for protein drugs.

journal_name

Acta Biomater

journal_title

Acta biomaterialia

authors

Chen AZ,Li Y,Chau FT,Lau TY,Hu JY,Zhao Z,Mok DK

doi

10.1016/j.actbio.2009.04.032

subject

Has Abstract

pub_date

2009-10-01 00:00:00

pages

2913-9

issue

8

eissn

1742-7061

issn

1878-7568

pii

S1742-7061(09)00198-6

journal_volume

5

pub_type

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