abstract：:Peripheral arterial disease differentially affects the superficial femoral (SFA) and the popliteal (PA) arteries, but their morphometric, structural, mechanical, and physiologic differences are poorly understood. SFAs and PAs from 125 human subjects (age 13-92, average 52±17 years) were compared in terms of radii, wal...

journal_title：Acta biomaterialia

authors： Jadidi M,Razian SA,Anttila E,Doan T,Adamson J,Pipinos M,Kamenskiy A

更新日期：2021-02-01 00:00:00

abstract：:It is important to understand the effects of mechanical stimulation on cell behaviors for homeostasis. Many studies have been performed on cell responses to mechanical stimuli, but the mechanosensing mechanism is still under debate. In the present study, experiments employing molecular dynamics (MD) simulations concer...

journal_title：Acta biomaterialia

authors： Deguchi S,Kato A,Wu P,Hakamada M,Mabuchi M

更新日期：2021-02-01 00:00:00

abstract：:Three-dimensional (3D) porous zinc (Zn) with a moderate degradation rate is a promising candidate for biodegradable bone scaffolds. However, fabrication of such scaffolds with adequate mechanical properties remains a challenge. Moreover, the composition, crystallography and microstructure of the in vivo degradation pr...

journal_title：Acta biomaterialia

authors： He J,Fang J,Wei P,Li Y,Guo H,Mei Q,Ren F

更新日期：2021-02-01 00:00:00

abstract：:Damages in pelvic floor muscles often cause dysfunction of the entire pelvic urogenital system, which is clinically challenging. A bioengineered skeletal muscle construct that mimics structural and functional characteristics of native skeletal muscle could provide a therapeutic option to restore normal muscle function...

journal_title：Acta biomaterialia

authors： Kim JH,Ko IK,Jeon MJ,Kim I,Vanschaayk MM,Atala A,Yoo JJ

更新日期：2021-02-01 00:00:00

abstract：:The influence of amount of intermetallics on the degradation of as-extruded Mg-Nd alloys with different contents of Nd was investigated via immersion testing in DMEM+10% FBS under cell culture conditions and subsequent microstructural characterizations. It is found that the presence of intermetallic particles Mg41Nd5 ...

journal_title：Acta biomaterialia

authors： Zhang Y,Huang Y,Feyerabend F,Blawert C,Gan W,Maawad E,You S,Gavras S,Scharnagl N,Bode J,Vogt C,Zander D,Willumeit-Römer R,Kainer KU,Hort N

更新日期：2021-02-01 00:00:00

abstract：:Tracheal stent placement is a principal treatment for tracheobronchial stenosis, but complications such as mucus plugging, secondary stenosis, migration, and strong foreign body sensation remain unavoidable challenges. In this study, we designed a flexible porous chiral tracheal stent intended to reduce or overcome th...

journal_title：Acta biomaterialia

authors： Liu J,Yao X,Wang Z,Ye J,Luan C,He Y,Lin H,Fu J

更新日期：2021-01-30 00:00:00

abstract：:Arginase 1 (ARG1) inactivates T cells by degrading L-arginine, severely reducing the immunotherapeutic efficacy. Effectively blocking the ARG1 pathway remains a challenge. L-norvaline is a very cheap and negligible side effects inhibitor of ARG1. However, its blockage efficacy for ARG1 is impeded by its high half-maxi...

journal_title：Acta biomaterialia

authors： Ren X,Wang N,Zhou Y,Song A,Jin G,Li Z,Luan Y

更新日期：2021-01-29 00:00:00

abstract：:Tendon adhesion formation describes the development of fibrotic tissue between the tendon and its surrounding tissues, which commonly occurs as a reaction to injury or surgery. Its impact on function and quality of life varies from negligible to severely disabling, depending on the affected area and extent of adhesion...

journal_title：Acta biomaterialia

authors： Zhang Q,Yang Y,Yildirimer L,Xu T,Zhao X

更新日期：2021-01-25 00:00:00

abstract：:The majority of in vitro studies assessing cancer treatments are performed in two-dimensional (2D) monolayers and are subsequently validated in in vivo animal models. However, 2D models fail to accurately model the tumour microenvironment. Furthermore, animal models are not directly applicable to mimic the human scena...

journal_title：Acta biomaterialia

authors： Costard LS,Hosn RR,Ramanayake H,O'Briena B C FJ,Curtin CM

更新日期：2021-01-20 00:00:00

abstract：:Bone-like materials comprise carbonated-hydroxyapatite nanocrystals (c-Ap) embedding a fibrillar collagen matrix. The mineral particles stiffen the nanocomposite by tight attachment to the protein fibrils creating a high strength and toughness material. The nanometer dimensions of c-Ap crystals make it very challengin...

journal_title：Acta biomaterialia

authors： Forien JB,Uzuhashi J,Ohkubo T,Hono K,Luo L,Schwarcz HP,Deymier AC,Krywka C,Fleck C,Zaslansky P

更新日期：2021-01-15 00:00:00

abstract：:Osteoarthritis (OA), is a common musculoskeletal disorder that will progressively increase in older populations and is expected to be the most dominant cause of disability in the world population by 2030. The progression of OA is controlled by a multi-factorial pathway that has not been completely elucidated and under...

journal_title：Acta biomaterialia

authors： Rahimi M,Charmi G,Matyjaszewski K,Banquy X,Pietrasik J

更新日期：2021-01-12 00:00:00

abstract：:Tissue engineered vascular grafts (TEVGs) represent a promising therapeutic option for emergency vascular intervention. Although the application of small-diameter TEVGs using patient-specific primary endothelial cells (ECs) to prevent thrombosis and occlusion prior to implantation could be hindered by the long time co...

journal_title：Acta biomaterialia

authors： Luo J,Shi X,Lin Y,Yuan Y,Kural MH,Wang J,Ellis MW,Anderson CW,Zhang SM,Riaz M,Niklason LE,Qyang Y

更新日期：2021-01-01 00:00:00

abstract：:Hydroxyapatite (HA) is the main inorganic component of human bone. Inspired by nacre and cortical bone, hydroxyapatite-based coil scaffolds were successfully prepared. The scaffolds presented "brick and mortar" multi-layered structure of nacre and multi-layered concentric circular structure of cortical bone. Because o...

journal_title：Acta biomaterialia

authors： Feng C,Xue J,Yu X,Zhai D,Lin R,Zhang M,Xia L,Wang X,Yao Q,Chang J,Wu C

更新日期：2021-01-01 00:00:00

abstract：:Recent advances in biomaterials integrate metal nanoparticles with hydrogels to generate composite materials that exhibit new or improved properties. By precisely controlling the composition, arrangement and interactions of their constituents, these hybrid materials facilitate biomedical applications through myriad ap...

journal_title：Acta biomaterialia

authors： Clasky AJ,Watchorn JD,Chen PZ,Gu FX

更新日期：2020-12-19 00:00:00

abstract：:The brown pelican (Pelecanus occidentalis) wields one of the largest bills of any bird and is distinguished by the deployable throat pouch of extensible tissue used to capture prey. Here we report on mechanical properties and microstructure of the pouch skin. It exhibits significant anisotropy, with the transverse dir...

journal_title：Acta biomaterialia

authors： Dike S,Yang W,Pissarenko A,Quan H,Garcia Filho FC,Ritchie RO,Meyers MA

更新日期：2020-12-01 00:00:00

abstract：:Repair or regeneration of load-bearing bones has long been an incentive for the tissue engineering community to develop a plethora of synthetic bone scaffolds. Despite the key role of physical forces and the mechanical environment in bone regeneration, the mechanotransduction concept has rarely been incorporated in st...

journal_title：Acta biomaterialia

authors： Entezari A,Swain MV,Gooding JJ,Roohani I,Li Q

更新日期：2020-12-01 00:00:00

abstract：:Three-dimensional (3D) tissue-engineered in vitro models, particularly multicellular spheroids and organoids, have become important tools to explore disease progression and guide the development of novel therapeutic strategies. These avascular constructs are particularly powerful in oncological research due to their a...

journal_title：Acta biomaterialia

authors： Roberge CL,Kingsley DM,Faulkner DE,Sloat CJ,Wang L,Barroso M,Intes X,Corr DT

更新日期：2020-11-01 00:00:00

abstract：:Posterior capsular opacification (PCO) is the most common complication of cataract surgery. PCO is due to the proliferation, migration, and epithelial-to-mesenchymal transition of the residual lens epithelial cells (LECs) within the lens capsule. As surface topography influences cellular response, we investigated the ...

journal_title：Acta biomaterialia

authors： Seo Y,Kim S,Lee HS,Park J,Lee K,Jun I,Seo H,Kim YJ,Yoo Y,Choi BC,Seok HK,Kim YC,Ok MR,Choi J,Joo CK,Jeon H

更新日期：2020-10-15 00:00:00

abstract：:Ocular inflammation is one of the leading causes of blindness worldwide, and steroids in topical ophthalmic solutions (e.g. dexamethasone eye drops) are the mainstay of therapy for ocular inflammation. For many non-infectious ocular inflammatory diseases, such as uveitis, eye drops are administered as often as once ev...

journal_title：Acta biomaterialia

authors： Bengani LC,Kobashi H,Ross AE,Zhai H,Salvador-Culla B,Tulsan R,Kolovou PE,Mittal SK,Chauhan SK,Kohane DS,Ciolino JB

更新日期：2020-10-15 00:00:00

abstract：:The uptake and trafficking of NPs is impacted by several attributes such as size, shape, surface charge and importantly by surface ligands that can interact with the cell plasma membrane. We envision that NPs which can be readily modified in aqueous environments will be key to engineering patient-specific nanotherapeu...

journal_title：Acta biomaterialia

authors： Zhang W,Teske N,Samadi M,Sarem M,Shastri VP

更新日期：2020-10-15 00:00:00

abstract：:Vascular damage develops with diverging severity during and after percutaneous coronary intervention with stent placement and is the prevailing stimulus for in-stent restenosis. Previous work has failed to link mechanical data obtained in a realistic in vivo or in vitro environment with data collected during imaging p...

journal_title：Acta biomaterialia

authors： Geith MA,Nothdurfter L,Heiml M,Agrafiotis E,Gruber M,Sommer G,Schratzenstaller TG,Holzapfel GA

更新日期：2020-10-15 00:00:00

abstract：:Cell therapy is a promising strategy to treat ischemic diseases, but the efficacy is limited due to high rate of cell death under low oxygen environment of the ischemic tissues. Sustained release of oxygen to continuously oxygenate the transplanted cells may augment cell survival and improve therapeutic efficacy. We h...

journal_title：Acta biomaterialia

authors： Guan Y,Niu H,Dang Y,Gao N,Guan J

更新日期：2020-10-01 00:00:00

abstract：:To date, there has been little investigation of biodegradable tissue engineered arterial grafts (TEAG) using clinically relevant large animal models. The purpose of this study is to explore how pore size of electrospun scaffolds can be used to balance neoarterial tissue formation with graft structural integrity under ...

journal_title：Acta biomaterialia

authors： Matsuzaki Y,Iwaki R,Reinhardt JW,Chang YC,Miyamoto S,Kelly J,Zbinden J,Blum K,Mirhaidari G,Ulziibayar A,Shoji T,Breuer CK,Shinoka T

更新日期：2020-10-01 00:00:00

abstract：:Heat-treated cancer cells have thermo-resistance due to the up-regulated levels of heat shock proteins (HSP) resulting in low therapeutic efficiency and ineffective ablation of tumors. In this work, we report pH-responsive Ag2S nanodots (Ag2S NDs) loaded with HSP70 inhibitor (QE-PEG-Ag2S) for enhanced photothermal can...

journal_title：Acta biomaterialia

authors： Zhong Y,Zou Y,Liu L,Li R,Xue F,Yi T

更新日期：2020-10-01 00:00:00

abstract：:The active and passive mechanical behavior of a cosmetic tightening product for skin anti-aging is investigated based on a wide range of in vivo and in vitro measurements. The experimental data are used to inform a numerical model of the attained cosmetic effect, which is then implemented in a commercial finite-elemen...

journal_title：Acta biomaterialia

authors： Pensalfini M,Rotach M,Hopf R,Bielicki A,Santoprete R,Mazza E

更新日期：2020-10-01 00:00:00

abstract：:Tissue growth in bioscaffolds is influenced significantly by pore geometry, but how this geometric dependence emerges from dynamic cellular processes such as cell proliferation and cell migration remains poorly understood. Here we investigate the influence of pore size on the time required to bridge pores in thin 3D-p...

journal_title：Acta biomaterialia

authors： Buenzli PR,Lanaro M,Wong CS,McLaughlin MP,Allenby MC,Woodruff MA,Simpson MJ

更新日期：2020-09-15 00:00:00

abstract：:Implant-associated infections is one of the most challenging post-operative complications in bone-related implantations. To tackle this clinical issue, we developed a low-cost and durable surface coating for medical grade titanium implants that uses positively charged silane molecules. The in vitro antimicrobial tests...

journal_title：Acta biomaterialia

authors： Shen J,Gao P,Han S,Kao RYT,Wu S,Liu X,Qian S,Chu PK,Cheung KMC,Yeung KWK

更新日期：2020-09-15 00:00:00

abstract：:Tumour microenvironment (TME)-targeting nanoparticles (NPs) were developed based on Methanococcus jannaschii small heat shock proteins (Mj-sHSPs). Transactivator of transcription (TAT) were modified on the surface of Mj-sHSPs (T-HSPs) to enhance their cellular internalization ability (CIA), and a pH/enzyme dual sensit...

journal_title：Acta biomaterialia

authors： Shi K,Wang Y,Zhou X,Gui H,Xu N,Wu S,He C,Zhao Z

更新日期：2020-09-15 00:00:00

abstract：:Antibody-mediated osseous regeneration (AMOR) has been proved as a promising strategy for osteogenic differentiation of induced pluripotent stem cells derived MSCs (iMSCs). The key characteristic of antibody that determines the AMOR potential is largely unknown. The glycosylation profile of immunoglobulin G (IgG) repr...

journal_title：Acta biomaterialia

authors： Wu Q,Yang Y,Xie D,Li S,Liu Y,Shu L,Fu G,Xu Y,Ji P

更新日期：2020-09-15 00:00:00

abstract：:CRISPR gene editing technology is strategically foreseen to control diseases by correcting underlying aberrant genetic sequences. In order to overcome drawbacks associated with viral vectors, the establishment of an effective non-viral CRISPR delivery vehicle has become an important goal for nanomaterial scientists. H...

journal_title：Acta biomaterialia

authors： Noureddine A,Maestas-Olguin A,Saada EA,LaBauve AE,Agola JO,Baty KE,Howard T,Sabo JK,Espinoza CRS,Doudna JA,Schoeniger JS,Butler KS,Negrete OA,Brinker CJ,Serda RE

更新日期：2020-09-15 00:00:00

abstract：:Natural polymer materials have attracted great attention in the field of hemostasis because of their wide range of source, nontoxicity, hydrophilicity, and air permeability. In the present study, two natural polymers composed of carboxymethyl chitosan (CMCS) and sodium carboxymethylcellulose (CMCNa) plus γ-(2,3-epoxyp...

journal_title：Acta biomaterialia

authors： Wang L,Zhong Y,Qian C,Yang D,Nie J,Ma G

更新日期：2020-09-15 00:00:00

abstract：:Abnormal wound healing caused by the over-expression of collagen and fibronectin leads to fibrosis, the major complication of all treatment modalities. A three-layer nanofiber scaffold was designed, optimized, and fabricated. This scaffold comprised two supportive polycaprolactone (PCL)-chitosan layers on the sides an...

journal_title：Acta biomaterialia

authors： Chogan F,Mirmajidi T,Rezayan AH,Sharifi AM,Ghahary A,Nourmohammadi J,Kamali A,Rahaie M

更新日期：2020-09-01 00:00:00

abstract：:The biodegradable metallic devices undergo stress/strain-induced corrosion when they are used for load-bearing applications. The stress/strain induced-corrosion behavior causes differences in corrosion rate, corrosion morphology, strain distribution and mechanical performance of the devices. One representative example...

journal_title：Acta biomaterialia

authors： Chen K,Lu Y,Tang H,Gao Y,Zhao F,Gu X,Fan Y

更新日期：2020-09-01 00:00:00

abstract：:Mesenchymal stromal cell (MSC)-derived extracellular vesicles (EVs) (MSC-EVs) exhibit protective effects in damaged or diseased tissues. However, the role of EVs secreted by MSC in hypoxia-ischemic (HI) injury in neonatal mice remains unknown. Systemic administration of MSC-EVs attenuated acute brain damage and neuroi...

journal_title：Acta biomaterialia

authors： Xin D,Li T,Chu X,Ke H,Yu Z,Cao L,Bai X,Liu D,Wang Z

更新日期：2020-09-01 00:00:00

abstract：:Developing a multi-functional radiosensitizer with high efficiency and low toxicity remains challenging. Herein, we report a mesoporous heterostructure radiosensitizer (UCNP@NBOF-FePc-PFA) containing Lu-based upconversion nanophosphor (UCNP) and Bi-based nanomaterial loaded with iron phthalocyanine for X-ray and NIR l...

journal_title：Acta biomaterialia

authors： Liu J,Zhang J,Huang F,Deng Y,Li B,Ouyang R,Miao Y,Sun Y,Li Y

更新日期：2020-09-01 00:00:00

abstract：:Corneal collagen cross-linking (CXL) treatment can restore vision in patients suffering from keratoconus and corneal injury, by improving the mechanical properties of the cornea. The correlation between ultraviolet-A (UVA) irradiant energies of standard CXL (SCXL) and corneal visco-hyperelastic mechanical behavior rem...

journal_title：Acta biomaterialia

authors： Liu T,Shen M,Li H,Zhang Y,Mu B,Zhao X,Wang Y

更新日期：2020-09-01 00:00:00

abstract：:Osteoporosis is one of the most prevalent age-related diseases worldwide and is characterized by a systemic deterioration of bone strength (bone mineral density and bone quality) with a resulting increase in fragility fractures. Due to the complex osteoporotic pathological environment, it is a huge challenge to induce...

journal_title：Acta biomaterialia

authors： Zhao Y,Li Z,Jiang Y,Liu H,Feng Y,Wang Z,Liu H,Wang J,Yang B,Lin Q

更新日期：2020-09-01 00:00:00

abstract：:Successful osteochondral defect repair requires regenerating the subchondral bone whilst simultaneously promoting the development of an overlying layer of articular cartilage that is resistant to vascularization and endochondral ossification. During skeletal development articular cartilage also functions as a surface ...

journal_title：Acta biomaterialia

authors： Critchley S,Sheehy EJ,Cunniffe G,Diaz-Payno P,Carroll SF,Jeon O,Alsberg E,Brama PAJ,Kelly DJ

更新日期：2020-09-01 00:00:00

abstract：:Decellularized nerve, or acellular nerve allografts (ANAs), are an increasingly used alternative to nerve autografts to repair nerve gaps to facilitate regeneration. The adaptive immune system, specifically T cells, plays a role in promoting regeneration upon these ANA scaffolds. However, how T cells promote regenerat...

journal_title：Acta biomaterialia

authors： Pan D,Hunter DA,Schellhardt L,Fuchs A,Halevi AE,Snyder-Warwick AK,Mackinnon SE,Wood MD

更新日期：2020-08-01 00:00:00

abstract：:Abdominal aortic aneurysms (AAAs), a prototypic proteolytic cardiovascular disorder, are localized expansions of the aortal wall. Chronically upregulated and overexpressed proteases irreversibly degrade and disrupt the elastic matrix, which provides stretch and recoil properties to the aortal wall. Adult vascular smoo...

journal_title：Acta biomaterialia

authors： Camardo A,Carney S,Ramamurthi A

更新日期：2020-08-01 00:00:00