Abstract：
:Magnesium is an attractive material for use in biodegradable implants due to its low density, non-toxicity and mechanical properties similar to those of human tissue such as bone. Its biocompatibility makes it amenable for use in a wide range of applications from bone to cardiovascular implants. Here we investigated the corrosion rate in simulated body fluid (SBF) of a series of Mg-Sr alloys, with Sr in the range of 0.3-2.5%, and found that the Mg-0.5 Sr alloy showed the slowest corrosion rate. The degradation rate from this alloy indicated that the daily Sr intake from a typical stent would be 0.01-0.02 mg day⁻¹, which is well below the maximum daily Sr intake levels of 4 mg day⁻¹. Indirect cytotoxicity assays using human umbilical vascular endothelial cells indicated that Mg-0.5 Sr extraction medium did not cause any toxicity or detrimental effect on the viability of the cells. Finally, a tubular Mg-0.5 Sr stent sample, along with a WE43 control stent, was implanted into the right and left dog femoral artery. No thrombosis effect was observed in the Mg-0.5 Sr stent after 3 weeks of implantation while the WE43 stent thrombosed. X-ray diffraction demonstrated the formation of hydroxyapatite and Mg(OH)₂ as a result of the degradation of Mg-0.5 Sr alloy after 3 days in SBF. X-ray photoelectron spectroscopy further showed the possibility of the formation of a hydroxyapatite Sr-substituted layer that presents as a thin layer at the interface between the Mg-0.5 Sr alloy and the corrosion products. We believe that this interfacial layer stabilizes the surface of the Mg-0.5 Sr alloy, and slows down its degradation rate over time.
journal_name
Acta Biomaterjournal_title
Acta biomaterialiaauthors
Bornapour M,Muja N,Shum-Tim D,Cerruti M,Pekguleryuz Mdoi
10.1016/j.actbio.2012.07.045subject
Has Abstractpub_date
2013-02-01 00:00:00pages
5319-30issue
2eissn
1742-7061issn
1878-7568pii
S1742-7061(12)00365-0journal_volume
9pub_type
杂志文章abstract：:Incorporation of hydroxyapatite (HA) within a degradable polymeric scaffold may provide a favorable synthetic microenvironment that more closely mimics natural bone tissue physiology. Both incorporation of HA nanoparticles and alterations of the paracrine cell-cell signaling distance may affect the intercellular signa...
journal_title：Acta biomaterialia
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更新日期：2011-03-01 00:00:00
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journal_title：Acta biomaterialia
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更新日期：2012-01-01 00:00:00
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更新日期：2017-04-15 00:00:00
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更新日期：2018-04-15 00:00:00
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更新日期：2011-04-01 00:00:00
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journal_title：Acta biomaterialia
pub_type： 杂志文章
doi：10.1016/j.actbio.2008.01.016
更新日期：2008-07-01 00:00:00
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更新日期：2018-04-15 00:00:00
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journal_title：Acta biomaterialia
pub_type： 杂志文章
doi：10.1016/j.actbio.2017.11.020
更新日期：2018-01-15 00:00:00
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journal_title：Acta biomaterialia
pub_type： 杂志文章
doi：10.1016/j.actbio.2010.09.014
更新日期：2011-02-01 00:00:00
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pub_type： 杂志文章
doi：10.1016/j.actbio.2013.08.033
更新日期：2014-01-01 00:00:00
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journal_title：Acta biomaterialia
pub_type： 杂志文章,评审
doi：10.1016/j.actbio.2012.11.022
更新日期：2013-03-01 00:00:00
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journal_title：Acta biomaterialia
pub_type： 杂志文章,评审
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更新日期：2015-07-01 00:00:00
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pub_type： 杂志文章
doi：10.1016/j.actbio.2013.01.010
更新日期：2013-11-01 00:00:00
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pub_type： 杂志文章
doi：10.1016/j.actbio.2014.01.032
更新日期：2014-06-01 00:00:00
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journal_title：Acta biomaterialia
pub_type： 杂志文章
doi：10.1016/j.actbio.2017.09.024
更新日期：2017-11-01 00:00:00
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pub_type： 杂志文章
doi：10.1016/j.actbio.2018.04.022
更新日期：2018-06-01 00:00:00
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pub_type： 杂志文章
doi：10.1016/j.actbio.2015.12.026
更新日期：2016-03-01 00:00:00
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更新日期：2009-06-01 00:00:00
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pub_type： 杂志文章
doi：10.1016/j.actbio.2007.06.011
更新日期：2008-01-01 00:00:00
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更新日期：2018-10-01 00:00:00
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journal_title：Acta biomaterialia
pub_type： 临床试验,杂志文章
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更新日期：2008-03-01 00:00:00
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更新日期：2020-02-01 00:00:00
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journal_title：Acta biomaterialia
pub_type： 杂志文章
doi：10.1016/j.actbio.2007.10.007
更新日期：2008-05-01 00:00:00
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pub_type： 杂志文章
doi：10.1016/j.actbio.2015.01.005
更新日期：2015-03-01 00:00:00
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pub_type： 杂志文章
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更新日期：2020-04-15 00:00:00
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journal_title：Acta biomaterialia
pub_type： 杂志文章,评审
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更新日期：2017-10-01 00:00:00
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journal_title：Acta biomaterialia
pub_type： 杂志文章
doi：10.1016/j.actbio.2007.12.007
更新日期：2008-05-01 00:00:00
abstract：:Although novel molecular targeted drugs have been recognized as an effective therapy for non-small cell lung cancer (NSCLC) harboring epidermal growth factor receptor (EGFR) activating mutations, their efficacy fails to meet the expectation due to the acquired resistance in tumors. Up-regulation of the anti-apoptotic ...
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pub_type： 杂志文章
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更新日期：2018-08-01 00:00:00
