Abstract:
:Strombus gigas (conch) shells and Tridacna gigas (Giant clam) shells have dense, tailored structures that impart excellent mechanical properties to these shells. In this investigation, conch and clam seashells were converted to hydroxyapatite (HAP) by a hydrothermal method at different temperatures and for different conversion durations. Dense HAP structures were created from these shells throughout the majority of the samples at the relative low temperature of approximately 200 degrees C. The average fracture stress was found to be approximately 137-218MPa for partially converted conch shell samples and approximately 70-150MPa for original and converted clamshell samples, which is close to the mechanical strength of compact human bone. This indicates that the converted shell samples can be used as implants in load-bearing cases. In vivo tests of converted shell samples were performed in rat femoral defects for 6 weeks. The microtomography images at 6 weeks show that the implants did not move, and untreated control defects remain empty with no evidence of a spontaneous fusion. Histological study reveals that there is newly formed bone growing up to and around the implants. There is no evidence of a fibrosis tissue ring around the implants, also indicating that there is no loosening of the implants. In contrast, the untreated controls remain empty with some evidence of a fibrosis ring around the defect hole. These results indicate good biocompatibility and bioactivity of the converted shell implants.
journal_name
Acta Biomaterjournal_title
Acta biomaterialiaauthors
Vecchio KS,Zhang X,Massie JB,Wang M,Kim CWdoi
10.1016/j.actbio.2007.06.003subject
Has Abstractpub_date
2007-11-01 00:00:00pages
910-8issue
6eissn
1742-7061issn
1878-7568pii
S1742-7061(07)00095-5journal_volume
3pub_type
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journal_title:Acta biomaterialia
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更新日期:2008-11-01 00:00:00
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journal_title:Acta biomaterialia
pub_type: 杂志文章
doi:10.1016/j.actbio.2008.01.006
更新日期:2008-07-01 00:00:00
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journal_title:Acta biomaterialia
pub_type: 杂志文章
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更新日期:2015-07-01 00:00:00
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journal_title:Acta biomaterialia
pub_type: 杂志文章
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更新日期:2020-09-15 00:00:00
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journal_title:Acta biomaterialia
pub_type: 杂志文章
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更新日期:2014-08-01 00:00:00
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journal_title:Acta biomaterialia
pub_type: 杂志文章
doi:10.1016/j.actbio.2016.05.040
更新日期:2016-09-01 00:00:00
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journal_title:Acta biomaterialia
pub_type: 杂志文章
doi:10.1016/j.actbio.2009.02.010
更新日期:2009-07-01 00:00:00
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journal_title:Acta biomaterialia
pub_type: 杂志文章
doi:10.1016/j.actbio.2010.09.014
更新日期:2011-02-01 00:00:00
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journal_title:Acta biomaterialia
pub_type: 杂志文章
doi:10.1016/j.actbio.2017.08.036
更新日期:2017-10-15 00:00:00
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journal_title:Acta biomaterialia
pub_type: 杂志文章
doi:10.1016/j.actbio.2007.09.011
更新日期:2008-03-01 00:00:00
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journal_title:Acta biomaterialia
pub_type: 杂志文章,评审
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journal_title:Acta biomaterialia
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更新日期:2009-05-01 00:00:00
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journal_title:Acta biomaterialia
pub_type: 杂志文章
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更新日期:2011-01-01 00:00:00
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pub_type: 杂志文章
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更新日期:2017-11-01 00:00:00
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journal_title:Acta biomaterialia
pub_type: 杂志文章
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更新日期:2019-03-01 00:00:00
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journal_title:Acta biomaterialia
pub_type: 杂志文章
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更新日期:2015-10-01 00:00:00
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journal_title:Acta biomaterialia
pub_type: 杂志文章
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更新日期:2011-04-01 00:00:00
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journal_title:Acta biomaterialia
pub_type: 杂志文章
doi:10.1016/j.actbio.2012.03.028
更新日期:2012-07-01 00:00:00
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journal_title:Acta biomaterialia
pub_type: 杂志文章
doi:10.1016/j.actbio.2012.03.020
更新日期:2012-07-01 00:00:00
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journal_title:Acta biomaterialia
pub_type: 杂志文章
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更新日期:2017-03-01 00:00:00
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journal_title:Acta biomaterialia
pub_type: 杂志文章
doi:10.1016/j.actbio.2011.08.012
更新日期:2012-01-01 00:00:00
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journal_title:Acta biomaterialia
pub_type: 杂志文章
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更新日期:2010-10-01 00:00:00