Abstract：
:Polyethylene (PE) and polypropylene (PP) were functionalized at their surfaces with cyclodextrins (CDs) in order to prevent the adhesion and proliferation of Candida albicans on medical devices made from these polymers. The surface functionalization involved the grafting of glycidyl methacrylate (GMA) after oxidative gamma-ray pre-irradiation, followed by the attachment of beta-CD and HP-beta-CD to PE-g-GMA and PP-g-GMA surfaces. The yield of CD functionalization directly depended on the amount of GMA grafted. The presence of CDs on the surface of the polymers did not compromise their cell compatibility, but remarkably changed their protein adsorption profile. In contrast to unmodified PE and PP that adsorb significant amounts of fibrinogen ( approximately 0.047 mg cm(-2)) but not albumin, the CD-modified polyethers promoted the adsorption of albumin (between 0.015 and 0.155 mg cm(-2)) and reduced the adsorption of fibrinogen. Furthermore, functionalization with CDs provided PE and PP with the capability to incorporate the anti-fungal drug miconazole (up to 0.27 mg cm(-2)), leading to reduced biofilm formation by C. albicans in an in vitro biofilm model system. Overall, the results of the work indicate that the novel approach for functionalization of PE and PP is potentially useful to reduce the likelihood of foreign body-related infections.
journal_name
Acta Biomaterjournal_title
Acta biomaterialiaauthors
Nava-Ortiz CA,Burillo G,Concheiro A,Bucio E,Matthijs N,Nelis H,Coenye T,Alvarez-Lorenzo Cdoi
10.1016/j.actbio.2009.10.039subject
Has Abstractpub_date
2010-04-01 00:00:00pages
1398-404issue
4eissn
1742-7061issn
1878-7568pii
S1742-7061(09)00474-7journal_volume
6pub_type
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journal_title：Acta biomaterialia
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journal_title：Acta biomaterialia
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journal_title：Acta biomaterialia
pub_type： 杂志文章,评审
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journal_title：Acta biomaterialia
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abstract：UNLABELLED:Myofibroblasts are critical for connective tissue remodeling and wound healing since they can close wound beds and shape tissues rapidly by generating high traction forces and secreting abundant extracellular matrix proteins and matrix metalloproteinases. However, their presence in excessive numbers is assoc...
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pub_type： 杂志文章
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更新日期：2016-03-01 00:00:00
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journal_title：Acta biomaterialia
pub_type： 杂志文章
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更新日期：2018-10-01 00:00:00
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journal_title：Acta biomaterialia
pub_type： 杂志文章
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更新日期：2017-07-15 00:00:00
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journal_title：Acta biomaterialia
pub_type： 杂志文章
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更新日期：2018-10-15 00:00:00
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journal_title：Acta biomaterialia
pub_type： 杂志文章
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更新日期：2020-04-15 00:00:00
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journal_title：Acta biomaterialia
pub_type： 杂志文章
doi：10.1016/j.actbio.2011.09.005
更新日期：2012-03-01 00:00:00
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journal_title：Acta biomaterialia
pub_type： 杂志文章
doi：10.1016/j.actbio.2018.11.044
更新日期：2019-09-01 00:00:00
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journal_title：Acta biomaterialia
pub_type： 杂志文章
doi：10.1016/j.actbio.2018.07.004
更新日期：2018-09-01 00:00:00
abstract：:Spherical bioactive glass 13-93 particles, with a particle size distribution of 50-125 microm, were combined with bioabsorbable poly-L,DL-lactide 70/30 using twin-screw extrusion. The composite rods containing 0, 20, 30, 40 and 50 wt% of bioactive glass were further self-reinforced by drawing to a diameter of approxim...
journal_title：Acta biomaterialia
pub_type： 杂志文章
doi：10.1016/j.actbio.2004.11.002
更新日期：2005-03-01 00:00:00
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journal_title：Acta biomaterialia
pub_type： 杂志文章
doi：10.1016/j.actbio.2009.11.007
更新日期：2010-06-01 00:00:00
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journal_title：Acta biomaterialia
pub_type： 杂志文章
doi：10.1016/j.actbio.2014.11.031
更新日期：2015-02-01 00:00:00
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pub_type： 杂志文章
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更新日期：2014-08-01 00:00:00
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journal_title：Acta biomaterialia
pub_type： 杂志文章
doi：10.1016/j.actbio.2010.03.010
更新日期：2010-09-01 00:00:00
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journal_title：Acta biomaterialia
pub_type： 杂志文章
doi：10.1016/j.actbio.2007.06.003
更新日期：2007-11-01 00:00:00
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journal_title：Acta biomaterialia
pub_type： 杂志文章
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更新日期：2018-04-15 00:00:00
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journal_title：Acta biomaterialia
pub_type： 杂志文章
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更新日期：2013-09-01 00:00:00
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journal_title：Acta biomaterialia
pub_type： 杂志文章
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更新日期：2009-06-01 00:00:00
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journal_title：Acta biomaterialia
pub_type： 杂志文章
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更新日期：2019-03-01 00:00:00
abstract：OBJECTIVE:An underlying abnormality in collagen turnover is implied in the occurrence of complications and recurrences after mesh augmented pelvic floor repair surgeries. Ascorbic acid is a potent stimulant of collagen synthesis. The aim of this study is to produce ascorbic acid releasing poly-lactic acid (PLA) scaffol...
journal_title：Acta biomaterialia
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更新日期：2016-01-01 00:00:00
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journal_title：Acta biomaterialia
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更新日期：2017-12-01 00:00:00
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journal_title：Acta biomaterialia
pub_type： 杂志文章
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更新日期：2020-01-15 00:00:00
abstract：:The development of polyelectrolyte multilayered coatings on magnesium alloy substrates that can be used for controlled delivery of growth factors and required biomolecules from the surface of these degradable implants could have a significant impact in the field of bone tissue regeneration. The current work reports on...
journal_title：Acta biomaterialia
pub_type： 杂志文章
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更新日期：2013-11-01 00:00:00
