A versatile strategy to create an active tumor-targeted chemo-photothermal therapy nanoplatform: A case of an IR-780 derivative co-assembled with camptothecin prodrug.


:Self-assembled nanovehicles of chemotherapy drug with photothermal agent are regarded as intriguing chemo-photothermal therapy nanoplatform. However, most of the drugs and photothermal agents have poor water solubility and poor interactions to drive the formation of self-assembled nanovehicles, which is a bottleneck of co-assembled drug/photothermal agent for cancer therapy. Here, we proposed a versatile strategy to create self-assembled chemo-photothermal therapy nanoplatform based on the chemical modification of photothermal agent and drug. The IR-780 and camptothecin (CPT) were chosen as the studied models since they are important photothermal agent and anticancer drug, both of which have such poor water solubility with strong itself molecular interactions that they cannot co-assemble together. IR-780 was modified with an active targeting ligand lactobionic acid (LA) to result in amphiphilic IR780-LA while CPT was modified into redox-sensitive prodrug CPT-ss-CPT through a disulfide linkage to realize its assembly. Well-defined nanoparticles (NPs) could be created through the co-assembling of IR780-LA and CPT-ss-CPT. The IR780-LA/CPT-ss-CPT nanoparticles were demonstrated to be an excellent fluorescence imaging-guided, redox-responsive and enhanced synergistic chemo-photothermal therapy nanoplatform against tumors. Specifically, our chemical modification strategy offers a universal way to create self-assembled chemo-photothermal therapy nanoplatform, which solves the bottleneck of co-assembled drug/photothermal agent for cancer therapy. STATEMENT OF SIGNIFICANCE: Self-assembled nanoparticles of chemotherapeutics with photothermic drugs are regarded as intriguing chemo-photothermal therapy nanoplatform. However, most drugs have too poor solubility and interactions to form into self-assembled nanoparticles. We proposed a versatile strategy to create co-assembled chemo-photothermal therapy nanoparticles based on the chemical modification of common drugs. The IR-780 was modified with an active targeting ligand LA to result in amphiphilic IR780-LA molecules, while CPT was modified into redox-sensitive prodrug CPT-ss-CPT through disulfide linkage. Well-defined IR780-LA/CPT-ss-CPT nanoparticles were created through the co-assembling of IR780-LA and CPT-ss-CPT. The nanoparticles were demonstrated to be an excellent fluorescence imaging-guided, redox-responsive, active targeting chemo-photothermal therapy nanoplatform against tumors. Our strategy offers a versatile way to construct smart chemo-photothermal therapy nanoplatform from common drugs.


Acta Biomater


Acta biomaterialia


He W,Jiang Y,Li Q,Zhang D,Li Z,Luan Y




Has Abstract


2019-01-15 00:00:00












  • Influence of the bonding substrate in dental composite polymerization stress testing.

    abstract::Our objective was to compare the polymerization stress (sigma(pol)) of a series of composites obtained using poly(methyl methacrylate) (PMMA) or glass as bonding substrates, and to compare the results with those from in vitro microleakage of composite restorations. The tested hypothesis was that stress values obtained...

    journal_title:Acta biomaterialia

    pub_type: 杂志文章


    authors: Boaro LC,Gonçalves F,Braga RR

    更新日期:2010-02-01 00:00:00

  • Evaluation of an in situ chemically crosslinked hydrogel as a long-term vitreous substitute material.

    abstract::Currently there is no material that can be used as a long-term vitreous substitute, and this remains an unmet clinical need in ophthalmology. In this study, we developed an injectable, in situ chemically crosslinked hydrogel system and evaluated it in a rabbit model. The system consisted of two components, both based ...

    journal_title:Acta biomaterialia

    pub_type: 杂志文章


    authors: Tao Y,Tong X,Zhang Y,Lai J,Huang Y,Jiang YR,Guo BH

    更新日期:2013-02-01 00:00:00

  • Dental mesenchymal stem cells encapsulated in an alginate hydrogel co-delivery microencapsulation system for cartilage regeneration.

    abstract::Dental-derived mesenchymal stem cells (MSCs) are promising candidates for cartilage regeneration, with a high capacity for chondrogenic differentiation. This property helps make dental MSCs an advantageous therapeutic option compared to current treatment modalities. The MSC delivery vehicle is the principal determinan...

    journal_title:Acta biomaterialia

    pub_type: 杂志文章


    authors: Moshaverinia A,Xu X,Chen C,Akiyama K,Snead ML,Shi S

    更新日期:2013-12-01 00:00:00

  • Janus nanocarrier-based co-delivery of doxorubicin and berberine weakens chemotherapy-exacerbated hepatocellular carcinoma recurrence.

    abstract::Despite the rapid progress which has been made in hepatocellular carcinoma (HCC) chemotherapeutics, recurrence of liver cancer still remains a barrier to achieve satisfying prognosis. Herein, we aimed to decipher the role of berberine (BER) in chemotherapy-exacerbated HCC repopulation via developing a nanocarrier co-d...

    journal_title:Acta biomaterialia

    pub_type: 杂志文章


    authors: Zhang F,Jia Y,Zheng X,Shao D,Zhao Y,Wang Z,Dawulieti J,Liu W,Sun M,Sun W,Pan Y,Cui L,Wang Y,He K,Zhang M,Li J,Dong WF,Chen L

    更新日期:2019-12-01 00:00:00

  • Epidermal growth factor-nanoparticle conjugates change the activity from anti-apoptotic to pro-apoptotic at membrane rafts.

    abstract::The proliferation epidermal growth factor (EGF) is known to acquire contradictory apoptotic activities upon conjugation with gold nanoparticles (GNPs) through hitherto unknown mechanisms. Here, we identified an essential role of membrane rafts in the drastic activity switching of EGF-GNPs through the following intrace...

    journal_title:Acta biomaterialia

    pub_type: 杂志文章


    authors: Yamamoto S,Iwamaru Y,Shimizu Y,Ueda Y,Sato M,Yamaguchi K,Nakanishi J

    更新日期:2019-04-01 00:00:00

  • Novel soybean/gelatine-based bioactive and injectable hydroxyapatite foam: material properties and cell response.

    abstract::Despite their known osteoconductivity, clinical use of calcium phosphate cements is limited both by their relatively slow rate of resorption and by rheological properties incompatible with injectability. Bone in-growth and material resorption have been improved by the development of porous calcium phosphate cements. H...

    journal_title:Acta biomaterialia

    pub_type: 杂志文章


    authors: Perut F,Montufar EB,Ciapetti G,Santin M,Salvage J,Traykova T,Planell JA,Ginebra MP,Baldini N

    更新日期:2011-04-01 00:00:00

  • A study of vascular smooth muscle cell function under cyclic mechanical loading in a polyurethane scaffold with optimized porosity.

    abstract::High porosity and pore interconnectivity are important features of a successful tissue engineering scaffold. The objective of this work was to optimize the pore interconnectivity and to increase the porosity of an elastomeric degradable/polar/hydrophobic/ionic (D-PHI) polyurethane porous scaffold while maintaining its...

    journal_title:Acta biomaterialia

    pub_type: 杂志文章


    authors: Sharifpoor S,Simmons CA,Labow RS,Santerre JP

    更新日期:2010-11-01 00:00:00

  • Can human mesenchymal stem cells survive on a NiTi implant material subjected to cyclic loading?

    abstract::Nickel-titanium shape memory alloys (NiTi-SMAs) exhibit mechanical and chemical properties which make them attractive candidate materials for various types of biomedical applications. However, the high nickel content of NiTi-SMAs may result in adverse tissue reactions, especially when they are considered for load-bear...

    journal_title:Acta biomaterialia

    pub_type: 杂志文章


    authors: Habijan T,Glogowski T,Kühn S,Pohl M,Wittsiepe J,Greulich C,Eggeler G,Schildhauer TA,Köller M

    更新日期:2011-06-01 00:00:00

  • Cytocompatibility and early inflammatory response of human endothelial cells in direct culture with Mg-Zn-Sr alloys.

    abstract::Crystalline Mg-Zinc (Zn)-Strontium (Sr) ternary alloys consist of elements naturally present in the human body and provide attractive mechanical and biodegradable properties for a variety of biomedical applications. The first objective of this study was to investigate the degradation and cytocompatibility of four Mg-4...

    journal_title:Acta biomaterialia

    pub_type: 杂志文章


    authors: Cipriano AF,Sallee A,Tayoba M,Cortez Alcaraz MC,Lin A,Guan RG,Zhao ZY,Liu H

    更新日期:2017-01-15 00:00:00

  • Fibrin hydrogels induce mixed dorsal/ventral spinal neuron identities during differentiation of human induced pluripotent stem cells.

    abstract::We hypothesized that generating spinal motor neurons (sMNs) from human induced pluripotent stem cell (hiPSC)-derived neural aggregates (NAs) using a chemically-defined differentiation protocol would be more effective inside of 3D fibrin hydrogels compared to 2D poly-L-ornithine(PLO)/laminin-coated tissue culture plast...

    journal_title:Acta biomaterialia

    pub_type: 杂志文章


    authors: Edgar JM,Robinson M,Willerth SM

    更新日期:2017-03-15 00:00:00

  • Development of biodegradable Mg-Ca alloy sheets with enhanced strength and corrosion properties through the refinement and uniform dispersion of the Mg₂Ca phase by high-ratio differential speed rolling.

    abstract::A novel processing route was proposed for the fabrication of biodegradable Mg-Ca binary alloys with high Ca contents (2-3 wt.%) in sheet form with enhanced biocorrosion resistance by tailoring their microstructures. The effective refinement and dispersion of the Mg2Ca phase in the Mg-Ca alloys using extrusion followed...

    journal_title:Acta biomaterialia

    pub_type: 杂志文章


    authors: Seong JW,Kim WJ

    更新日期:2015-01-01 00:00:00

  • Engineered dermal equivalent tissue in vitro by assembly of microtissue precursors.

    abstract::Tissue-engineered constructs can be fabricated by the assembly of smaller building blocks in order to mimic much of the native biology that is often made from repeating functional units. Our aim was to realize a three-dimensional (3-D) tissue-like construct in vitro by inducing the assembly of functional micrometric t...

    journal_title:Acta biomaterialia

    pub_type: 杂志文章


    authors: Palmiero C,Imparato G,Urciuolo F,Netti P

    更新日期:2010-07-01 00:00:00

  • An interferon-γ-delivery system based on chitosan/poly(γ-glutamic acid) polyelectrolyte complexes modulates macrophage-derived stimulation of cancer cell invasion in vitro.

    abstract::Macrophages represent a large component of the tumour microenvironment and are described to establish interactions with cancer cells, playing crucial roles in several stages of cancer progression. The functional plasticity of macrophages upon stimulation from the environment makes them susceptible to the influence of ...

    journal_title:Acta biomaterialia

    pub_type: 杂志文章


    authors: Cardoso AP,Gonçalves RM,Antunes JC,Pinto ML,Pinto AT,Castro F,Monteiro C,Barbosa MA,Oliveira MJ

    更新日期:2015-09-01 00:00:00

  • Fractionated human adipose tissue as a native biomaterial for the generation of a bone organ by endochondral ossification.

    abstract::Many steps are required to generate bone through endochondral ossification with adipose mesenchymal stromal cells (ASC), from cell isolation to in vitro monolayer expansion, seeding into scaffolds, cartilaginous differentiation and in vivo remodeling. Moreover, monolayer expansion and passaging of ASC strongly decreas...

    journal_title:Acta biomaterialia

    pub_type: 杂志文章


    authors: Guerrero J,Pigeot S,Müller J,Schaefer DJ,Martin I,Scherberich A

    更新日期:2018-09-01 00:00:00

  • Repair of osteochondral defects with biodegradable hydrogel composites encapsulating marrow mesenchymal stem cells in a rabbit model.

    abstract::This work investigated the delivery of marrow mesenchymal stem cells (MSCs), with or without the growth factor transforming growth factor-beta1 (TGF-beta1), from biodegradable hydrogel composites on the repair of osteochondral defects in a rabbit model. Three formulations of oligo(poly(ethylene glycol) fumarate) (OPF)...

    journal_title:Acta biomaterialia

    pub_type: 杂志文章


    authors: Guo X,Park H,Young S,Kretlow JD,van den Beucken JJ,Baggett LS,Tabata Y,Kasper FK,Mikos AG,Jansen JA

    更新日期:2010-01-01 00:00:00

  • Effects of phosphate glass fiber-collagen scaffolds on functional recovery of completely transected rat spinal cords.

    abstract::Phosphate-based glass fibers (PGFs), due to characteristics such as biodegradability and directionality, could be effective as spatial cues for axonal outgrowth following nerve injury. In the present study, PGF-containing cylindrical scaffolds of 1.8mm diameter and 3mm length were developed and implanted into the gap ...

    journal_title:Acta biomaterialia

    pub_type: 杂志文章


    authors: Joo NY,Knowles JC,Lee GS,Kim JW,Kim HW,Son YJ,Hyun JK

    更新日期:2012-05-01 00:00:00

  • Advanced technology-driven therapeutic interventions for prevention of tendon adhesion: design, intrinsic and extrinsic factor considerations.

    abstract::Tendon adhesion formation describes the development of fibrotic tissue between the tendon and its surrounding tissues, which commonly occurs as a reaction to injury or surgery. Its impact on function and quality of life varies from negligible to severely disabling, depending on the affected area and extent of adhesion...

    journal_title:Acta biomaterialia

    pub_type: 杂志文章,评审


    authors: Zhang Q,Yang Y,Yildirimer L,Xu T,Zhao X

    更新日期:2021-01-25 00:00:00

  • Atomic scale modeling of iron-doped biphasic calcium phosphate bioceramics.

    abstract::Biphasic calcium phosphates (BCPs) are bioceramics composed of hydroxyapatite (HAp, Ca10(PO4)6(OH)2) and beta-Tricalcium Phosphate (β-TCP, Ca3(PO4)2). Because their chemical and mineral composition closely resembles that of the mineral component of bone, they are potentially interesting candidates for bone repair surg...

    journal_title:Acta biomaterialia

    pub_type: 杂志文章


    authors: Gomes S,Kaur A,Grenèche JM,Nedelec JM,Renaudin G

    更新日期:2017-03-01 00:00:00

  • Flexible and elastic porous poly(trimethylene carbonate) structures for use in vascular tissue engineering.

    abstract::Biocompatible and elastic porous tubular structures based on poly(1,3-trimethylene carbonate), PTMC, were developed as scaffolds for tissue engineering of small-diameter blood vessels. High-molecular-weight PTMC (M(n) = 4.37 x 10(5)) was cross-linked by gamma-irradiation in an inert nitrogen atmosphere. The resulting ...

    journal_title:Acta biomaterialia

    pub_type: 杂志文章


    authors: Song Y,Kamphuis MM,Zhang Z,Sterk LM,Vermes I,Poot AA,Feijen J,Grijpma DW

    更新日期:2010-04-01 00:00:00

  • Biomimetic collagen scaffolds with anisotropic pore architecture.

    abstract::Sponge-like matrices with a specific three-dimensional structural design resembling the actual extracellular matrix of a particular tissue show significant potential for the regeneration and repair of a broad range of damaged anisotropic tissues. The manipulation of the structure of collagen scaffolds using a freeze-d...

    journal_title:Acta biomaterialia

    pub_type: 杂志文章


    authors: Davidenko N,Gibb T,Schuster C,Best SM,Campbell JJ,Watson CJ,Cameron RE

    更新日期:2012-02-01 00:00:00

  • Antibiofilm elastin-like polypeptide coatings: functionality, stability, and selectivity.

    abstract::Antimicrobial peptides (AMPs) are currently receiving interest as an alternative to conventional antibiotics to treat biomaterial-associated infection. However, the inherent instability of such peptides often limits their efficacy in intended clinical applications. Covalent immobilization of AMPs to surfaces is one st...

    journal_title:Acta biomaterialia

    pub_type: 杂志文章


    authors: Atefyekta S,Pihl M,Lindsay C,Heilshorn SC,Andersson M

    更新日期:2019-01-01 00:00:00

  • Micropillar arrays as potential drug screens: Inhibition of micropillar-mediated activation of the FAK-Src-paxillin signaling pathway by the CK2 inhibitor CX-4945.

    abstract:UNLABELLED:Here, we demonstrate the possible applications of micropillar arrays in screening anti-metastasis drugs. Human lung adenocarcinoma A549 cells incubated in multiwell plates containing micropillars exhibited markedly different physical/biochemical behavior depending on pillar dimensions. In particular, A549 ce...

    journal_title:Acta biomaterialia

    pub_type: 杂志文章


    authors: Kim J,Choi WJ,Moon SH,Jung J,Park JK,Kim SH,Lee JO

    更新日期:2015-11-01 00:00:00

  • Preparation of poly(lactic acid) composite hollow spheres containing calcium carbonates.

    abstract::Poly(lactic acid) composite hollow spheres containing calcium carbonate were prepared by oil-in-water emulsion evaporation to develop injectable bone substitutes incorporated with cells. The spheres were approximately 1.2mm in diameter and had a shell with a thickness in the range of 50-150microm. The hollow in the sp...

    journal_title:Acta biomaterialia

    pub_type: 杂志文章


    authors: Maeda H,Kasuga T

    更新日期:2006-07-01 00:00:00

  • Suture-reinforced electrospun polydioxanone-elastin small-diameter tubes for use in vascular tissue engineering: a feasibility study.

    abstract::This study characterizes the cross-linking of electrospun elastin and the mechanical properties of suture-reinforced 1.5mm internal diameter electrospun tubes composed of blended polydioxanone (PDO) and soluble elastin. Several tube configurations were tested to assess the effects of reinforcement on tube mechanical p...

    journal_title:Acta biomaterialia

    pub_type: 杂志文章


    authors: Smith MJ,McClure MJ,Sell SA,Barnes CP,Walpoth BH,Simpson DG,Bowlin GL

    更新日期:2008-01-01 00:00:00

  • Preparation of designed poly(D,L-lactide)/nanosized hydroxyapatite composite structures by stereolithography.

    abstract::The preparation of scaffolds to facilitate the replacement of damaged tissues and organs by means of tissue engineering has been much investigated. The key properties of the biomaterials used to prepare such scaffolds include biodegradability, biocompatibility and a well-defined three-dimensional 3-Dpore network struc...

    journal_title:Acta biomaterialia

    pub_type: 杂志文章


    authors: Ronca A,Ambrosio L,Grijpma DW

    更新日期:2013-04-01 00:00:00

  • Anti-microbial active composite nanoparticles with magnetic core and photocatalytic shell: TiO2-NiFe2O4 biomaterial system.

    abstract::Reverse micelle and chemical hydrolysis techniques have been successfully combined to synthesize composite nanoparticles consisting of a photocatalytic shell of titania and a magnetic core of nickel ferrite. The nature of titania shell, i.e. anatase or brookite, depends on the TiO2 and NiFe2O4 molar ratio. The work pr...

    journal_title:Acta biomaterialia

    pub_type: 杂志文章


    authors: Rana S,Rawat J,Misra RD

    更新日期:2005-11-01 00:00:00

  • Multi-armed poly(aspartate-g-OEI) copolymers as versatile carriers of pDNA/siRNA.

    abstract::To search for potential non-viral nucleic acids carriers, a series of novel cationic polymers, multi-armed poly(aspartate-graft-oligoethylenimine) (MP-g-OEI) copolymers were designed and synthesized by grafting different types of oligoethylenimine (OEI) to a multi-armed poly(l-aspartic acid) backbone. The as-synthesiz...

    journal_title:Acta biomaterialia

    pub_type: 杂志文章


    authors: Dong X,Lin L,Chen J,Tian H,Xiao C,Guo Z,Li Y,Wei Y,Chen X

    更新日期:2013-06-01 00:00:00

  • T cells modulate IL-4 expression by eosinophil recruitment within decellularized scaffolds to repair nerve defects.

    abstract::Decellularized nerve, or acellular nerve allografts (ANAs), are an increasingly used alternative to nerve autografts to repair nerve gaps to facilitate regeneration. The adaptive immune system, specifically T cells, plays a role in promoting regeneration upon these ANA scaffolds. However, how T cells promote regenerat...

    journal_title:Acta biomaterialia

    pub_type: 杂志文章


    authors: Pan D,Hunter DA,Schellhardt L,Fuchs A,Halevi AE,Snyder-Warwick AK,Mackinnon SE,Wood MD

    更新日期:2020-08-01 00:00:00

  • Peptide-immobilized starch/PEG sponge with rapid shape recovery and dual-function for both uncontrolled and noncompressible hemorrhage.

    abstract::It is challenging for traditional hemostatic sponges to meet the clinic demand for both uncontrolled and noncompressible hemorrhage. With the aim to develop a rapid shape recovery material with both active and passive hemostatic performance, a dual-functional hemostatic sponge (TRAP-Sp) with a macroporous structure an...

    journal_title:Acta biomaterialia

    pub_type: 杂志文章


    authors: Yang X,Liu W,Shi Y,Xi G,Wang M,Liang B,Feng Y,Ren X,Shi C

    更新日期:2019-11-01 00:00:00

  • Cell spreading correlates with calculated logP of amino acid-modified surfaces.

    abstract::The interactions of cells with synthetic surfaces are a critical factor in biomaterials design and it would be invaluable if these interactions could be precisely controlled and predicted. Hydrophobicity or lipophilicity of the surface is commonly used to rationalize cell attachment to materials. In the pharmaceutical...

    journal_title:Acta biomaterialia

    pub_type: 杂志文章


    authors: Rawsterne RE,Todd SJ,Gough JE,Farrar D,Rutten FJ,Alexander MR,Ulijn RV

    更新日期:2007-09-01 00:00:00